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Entry version 140 (29 Sep 2021)
Sequence version 1 (01 Dec 2001)
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Protein

Chloride channel CLIC-like protein 1

Gene

CLCC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Seems to act as a chloride ion channel (PubMed:30157172).

Plays a role in retina development (PubMed:30157172).

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • chloride channel activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChloride channel, Ion channel
Biological processIon transport, Transport
LigandChloride

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q96S66

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q96S66

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.36.1.1, the intracellular chloride channel (icc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chloride channel CLIC-like protein 1
Alternative name(s):
Mid-1-related chloride channel protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CLCC1
Synonyms:KIAA0761, MCLC
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29675, CLCC1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617539, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96S66

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000121940

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Transmembranei217 – 237HelicalSequence analysisAdd BLAST21
Transmembranei330 – 350HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Retinitis pigmentosa 32 (RP32)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of retinitis pigmentosa, a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. RP32 inheritance is autosomal recessive.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08312525D → E in RP32; reduces ion channel activity; no impact on interaction with CALR; no impact on ER localization. 1 PublicationCorresponds to variant dbSNP:rs750180668Ensembl.1

Keywords - Diseasei

Retinitis pigmentosa

Organism-specific databases

DisGeNET

More...
DisGeNETi
23155

MalaCards human disease database

More...
MalaCardsi
CLCC1
MIMi609913, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000121940

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142672105

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96S66, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CLCC1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74752121

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000029768219 – 551Chloride channel CLIC-like protein 1Add BLAST533

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei438PhosphoserineCombined sources1
Modified residuei464PhosphoserineCombined sources1
Modified residuei482PhosphothreonineCombined sources1
Modified residuei509PhosphoserineCombined sources1
Modified residuei524PhosphoserineCombined sources1
Modified residuei532PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96S66

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96S66

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q96S66

MaxQB - The MaxQuant DataBase

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MaxQBi
Q96S66

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96S66

PeptideAtlas

More...
PeptideAtlasi
Q96S66

PRoteomics IDEntifications database

More...
PRIDEi
Q96S66

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
78077 [Q96S66-1]
78078 [Q96S66-2]
78079 [Q96S66-3]
78080 [Q96S66-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q96S66

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q96S66

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96S66

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q96S66

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the retina of the eye, with extensive expression in the lamina cribrosa, optic nerve, ganglion cell layer, inner nuclear layer, outer nuclear layer and retinal pigment epithelium.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000121940, Expressed in amniotic fluid and 242 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96S66, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96S66, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000121940, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with mitochondrial protein PIGBOS1 (via C-terminus); the interaction occurs at the mitochondria-associated endoplasmic reticulum (ER) membrane, a zone of contact between the ER and mitochondrial membranes, but does not appear to play a role in ER-mitochondria tethering and is not affected by ER stress (PubMed:31653868).

Interacts with CALR (PubMed:30157172).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
116769, 95 interactors

Protein interaction database and analysis system

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IntActi
Q96S66, 38 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000349456

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96S66, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni363 – 415DisorderedSequence analysisAdd BLAST53
Regioni447 – 551DisorderedSequence analysisAdd BLAST105

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi372 – 395Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi481 – 512Polar residuesSequence analysisAdd BLAST32

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the chloride channel MCLC family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502QSP7, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00390000016611

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_034552_1_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96S66

Identification of Orthologs from Complete Genome Data

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OMAi
ELWTYVH

Database for complete collections of gene phylogenies

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PhylomeDBi
Q96S66

TreeFam database of animal gene trees

More...
TreeFami
TF328890

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009231, Chloride_chnl_CLIC-like

The PANTHER Classification System

More...
PANTHERi
PTHR34093, PTHR34093, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05934, MCLC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96S66-1) [UniParc]FASTAAdd to basket
Also known as: hMCLC-1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLCSLLLCEC LLLVAGYAHD DDWIDPTDML NYDAASGTMR KSQAKYGISG
60 70 80 90 100
EKDVSPDLSC ADEISECYHK LDSLTYKIDE CEKKKREDYE SQSNPVFRRY
110 120 130 140 150
LNKILIEAGK LGLPDENKGD MHYDAEIILK RETLLEIQKF LNGEDWKPGA
160 170 180 190 200
LDDALSDILI NFKFHDFETW KWRFEDSFGV DPYNVLMVLL CLLCIVVLVA
210 220 230 240 250
TELWTYVRWY TQLRRVLIIS FLFSLGWNWM YLYKLAFAQH QAEVAKMEPL
260 270 280 290 300
NNVCAKKMDW TGSIWEWFRS SWTYKDDPCQ KYYELLLVNP IWLVPPTKAL
310 320 330 340 350
AVTFTTFVTE PLKHIGKGTG EFIKALMKEI PALLHLPVLI IMALAILSFC
360 370 380 390 400
YGAGKSVHVL RHIGGPESEP PQALRPRDRR RQEEIDYRPD GGAGDADFHY
410 420 430 440 450
RGQMGPTEQG PYAKTYEGRR EILRERDVDL RFQTGNKSPE VLRAFDVPDA
460 470 480 490 500
EAREHPTVVP SHKSPVLDTK PKETGGILGE GTPKESSTES SQSAKPVSGQ
510 520 530 540 550
DTSGNTEGSP AAEKAQLKSE AAGSPDQGST YSPARGVAGP RGQDPVSSPC

G
Length:551
Mass (Da):62,023
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i08709A80E99F2E15
GO
Isoform 2 (identifier: Q96S66-2) [UniParc]FASTAAdd to basket
Also known as: hMCLC-2

The sequence of this isoform differs from the canonical sequence as follows:
     114-163: Missing.

Show »
Length:501
Mass (Da):56,267
Checksum:i2AAB4D99DA5EB327
GO
Isoform 3 (identifier: Q96S66-3) [UniParc]FASTAAdd to basket
Also known as: hMCLC-3

The sequence of this isoform differs from the canonical sequence as follows:
     114-234: Missing.

Show »
Length:430
Mass (Da):47,437
Checksum:iDB73E1B97B4B9660
GO
Isoform 4 (identifier: Q96S66-4) [UniParc]FASTAAdd to basket
Also known as: hMCLC-4

The sequence of this isoform differs from the canonical sequence as follows:
     114-298: Missing.

Show »
Length:366
Mass (Da):39,838
Checksum:i6214C106333DBAEC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T1P5Q5T1P5_HUMAN
Chloride channel CLIC-like protein ...
CLCC1
262Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PGA4A0A6Q8PGA4_HUMAN
Chloride channel CLIC-like protein ...
CLCC1
477Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PEZ7A0A6Q8PEZ7_HUMAN
Chloride channel CLIC-like protein ...
CLCC1
568Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PG30A0A6Q8PG30_HUMAN
Chloride channel CLIC-like protein ...
CLCC1
523Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PG75A0A6Q8PG75_HUMAN
Chloride channel CLIC-like protein ...
CLCC1
473Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PFF7A0A6Q8PFF7_HUMAN
Chloride channel CLIC-like protein ...
CLCC1
431Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PG14A0A6Q8PG14_HUMAN
Chloride channel CLIC-like protein ...
CLCC1
436Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PHQ1A0A6Q8PHQ1_HUMAN
Chloride channel CLIC-like protein ...
CLCC1
540Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PF11A0A6Q8PF11_HUMAN
Chloride channel CLIC-like protein ...
CLCC1
255Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PFH1A0A6Q8PFH1_HUMAN
Chloride channel CLIC-like protein ...
CLCC1
113Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08312525D → E in RP32; reduces ion channel activity; no impact on interaction with CALR; no impact on ER localization. 1 PublicationCorresponds to variant dbSNP:rs750180668Ensembl.1
Natural variantiVAR_034673368S → R. Corresponds to variant dbSNP:rs168107Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_027347114 – 298Missing in isoform 4. 1 PublicationAdd BLAST185
Alternative sequenceiVSP_027348114 – 234Missing in isoform 3. 1 PublicationAdd BLAST121
Alternative sequenceiVSP_027349114 – 163Missing in isoform 2. 2 PublicationsAdd BLAST50

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB052915 mRNA Translation: BAB59018.1
AB052916 mRNA Translation: BAB79261.1
AB052917 mRNA Translation: BAB79262.1
AB052918 mRNA Translation: BAB79263.1
AB018304 mRNA Translation: BAA34481.2
AL449266 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56345.1
CH471122 Genomic DNA Translation: EAW56346.1
BC002939 mRNA Translation: AAH02939.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41362.1 [Q96S66-1]
CCDS60214.1 [Q96S66-4]
CCDS60215.1 [Q96S66-3]
CCDS793.1 [Q96S66-2]

NCBI Reference Sequences

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RefSeqi
NP_001041675.1, NM_001048210.2 [Q96S66-1]
NP_001265131.1, NM_001278202.1 [Q96S66-3]
NP_001265132.1, NM_001278203.1 [Q96S66-4]
NP_055942.1, NM_015127.4 [Q96S66-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000302500; ENSP00000306552; ENSG00000121940 [Q96S66-3]
ENST00000348264; ENSP00000337243; ENSG00000121940 [Q96S66-4]
ENST00000356970; ENSP00000349456; ENSG00000121940 [Q96S66-1]
ENST00000369969; ENSP00000358986; ENSG00000121940 [Q96S66-1]
ENST00000369970; ENSP00000358987; ENSG00000121940 [Q96S66-2]
ENST00000674849; ENSP00000502251; ENSG00000121940 [Q96S66-1]
ENST00000675508; ENSP00000502836; ENSG00000121940 [Q96S66-1]
ENST00000675654; ENSP00000502648; ENSG00000121940 [Q96S66-1]
ENST00000675956; ENSP00000502457; ENSG00000121940 [Q96S66-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23155

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23155

UCSC genome browser

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UCSCi
uc009wes.2, human [Q96S66-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB052915 mRNA Translation: BAB59018.1
AB052916 mRNA Translation: BAB79261.1
AB052917 mRNA Translation: BAB79262.1
AB052918 mRNA Translation: BAB79263.1
AB018304 mRNA Translation: BAA34481.2
AL449266 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56345.1
CH471122 Genomic DNA Translation: EAW56346.1
BC002939 mRNA Translation: AAH02939.1
CCDSiCCDS41362.1 [Q96S66-1]
CCDS60214.1 [Q96S66-4]
CCDS60215.1 [Q96S66-3]
CCDS793.1 [Q96S66-2]
RefSeqiNP_001041675.1, NM_001048210.2 [Q96S66-1]
NP_001265131.1, NM_001278202.1 [Q96S66-3]
NP_001265132.1, NM_001278203.1 [Q96S66-4]
NP_055942.1, NM_015127.4 [Q96S66-2]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi116769, 95 interactors
IntActiQ96S66, 38 interactors
STRINGi9606.ENSP00000349456

Protein family/group databases

TCDBi1.A.36.1.1, the intracellular chloride channel (icc) family

PTM databases

iPTMnetiQ96S66
MetOSiteiQ96S66
PhosphoSitePlusiQ96S66
SwissPalmiQ96S66

Genetic variation databases

BioMutaiCLCC1
DMDMi74752121

Proteomic databases

EPDiQ96S66
jPOSTiQ96S66
MassIVEiQ96S66
MaxQBiQ96S66
PaxDbiQ96S66
PeptideAtlasiQ96S66
PRIDEiQ96S66
ProteomicsDBi78077 [Q96S66-1]
78078 [Q96S66-2]
78079 [Q96S66-3]
78080 [Q96S66-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
2391, 144 antibodies

The DNASU plasmid repository

More...
DNASUi
23155

Genome annotation databases

EnsembliENST00000302500; ENSP00000306552; ENSG00000121940 [Q96S66-3]
ENST00000348264; ENSP00000337243; ENSG00000121940 [Q96S66-4]
ENST00000356970; ENSP00000349456; ENSG00000121940 [Q96S66-1]
ENST00000369969; ENSP00000358986; ENSG00000121940 [Q96S66-1]
ENST00000369970; ENSP00000358987; ENSG00000121940 [Q96S66-2]
ENST00000674849; ENSP00000502251; ENSG00000121940 [Q96S66-1]
ENST00000675508; ENSP00000502836; ENSG00000121940 [Q96S66-1]
ENST00000675654; ENSP00000502648; ENSG00000121940 [Q96S66-1]
ENST00000675956; ENSP00000502457; ENSG00000121940 [Q96S66-1]
GeneIDi23155
KEGGihsa:23155
UCSCiuc009wes.2, human [Q96S66-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23155
DisGeNETi23155

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CLCC1
HGNCiHGNC:29675, CLCC1
HPAiENSG00000121940, Low tissue specificity
MalaCardsiCLCC1
MIMi609913, phenotype
617539, gene
neXtProtiNX_Q96S66
OpenTargetsiENSG00000121940
PharmGKBiPA142672105
VEuPathDBiHostDB:ENSG00000121940

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QSP7, Eukaryota
GeneTreeiENSGT00390000016611
HOGENOMiCLU_034552_1_1_1
InParanoidiQ96S66
OMAiELWTYVH
PhylomeDBiQ96S66
TreeFamiTF328890

Enzyme and pathway databases

PathwayCommonsiQ96S66
SIGNORiQ96S66

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
23155, 82 hits in 1028 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CLCC1, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CLCC1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23155
PharosiQ96S66, Tbio

Protein Ontology

More...
PROi
PR:Q96S66
RNActiQ96S66, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000121940, Expressed in amniotic fluid and 242 other tissues
ExpressionAtlasiQ96S66, baseline and differential
GenevisibleiQ96S66, HS

Family and domain databases

InterProiView protein in InterPro
IPR009231, Chloride_chnl_CLIC-like
PANTHERiPTHR34093, PTHR34093, 1 hit
PfamiView protein in Pfam
PF05934, MCLC, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCLCC1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96S66
Secondary accession number(s): O94861
, Q8WYP8, Q8WYP9, Q9BU25
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: December 1, 2001
Last modified: September 29, 2021
This is version 140 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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