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Protein

Chloride channel CLIC-like protein 1

Gene

CLCC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Seems to act as a chloride ion channel.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionChloride channel, Ion channel
Biological processIon transport, Transport
LigandChloride

Protein family/group databases

TCDBi1.A.36.1.1 the intracellular chloride channel (icc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Chloride channel CLIC-like protein 1
Alternative name(s):
Mid-1-related chloride channel protein 1
Gene namesi
Name:CLCC1
Synonyms:KIAA0761, MCLC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000121940.15
HGNCiHGNC:29675 CLCC1
MIMi617539 gene
neXtProtiNX_Q96S66

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Transmembranei217 – 237HelicalSequence analysisAdd BLAST21
Transmembranei330 – 350HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23155
OpenTargetsiENSG00000121940
PharmGKBiPA142672105

Polymorphism and mutation databases

DMDMi74752121

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000029768219 – 551Chloride channel CLIC-like protein 1Add BLAST533

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei438PhosphoserineCombined sources1
Modified residuei464PhosphoserineCombined sources1
Modified residuei482PhosphothreonineCombined sources1
Modified residuei509PhosphoserineCombined sources1
Modified residuei524PhosphoserineCombined sources1
Modified residuei532PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96S66
MaxQBiQ96S66
PaxDbiQ96S66
PeptideAtlasiQ96S66
PRIDEiQ96S66
ProteomicsDBi78077
78078 [Q96S66-2]
78079 [Q96S66-3]
78080 [Q96S66-4]

PTM databases

iPTMnetiQ96S66
PhosphoSitePlusiQ96S66
SwissPalmiQ96S66

Expressioni

Gene expression databases

BgeeiENSG00000121940 Expressed in 228 organ(s), highest expression level in amniotic fluid
CleanExiHS_CLCC1
ExpressionAtlasiQ96S66 baseline and differential
GenevisibleiQ96S66 HS

Organism-specific databases

HPAiHPA009087
HPA013210

Interactioni

Protein-protein interaction databases

BioGridi116769, 34 interactors
IntActiQ96S66, 17 interactors
MINTiQ96S66
STRINGi9606.ENSP00000349456

Structurei

3D structure databases

ProteinModelPortaliQ96S66
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chloride channel MCLC family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJAP Eukaryota
ENOG41108E0 LUCA
GeneTreeiENSGT00390000016611
HOGENOMiHOG000231351
HOVERGENiHBG060364
InParanoidiQ96S66
KOiK22188
OMAiNWMYLYK
OrthoDBiEOG091G0BRS
PhylomeDBiQ96S66
TreeFamiTF328890

Family and domain databases

InterProiView protein in InterPro
IPR009231 Chloride_chnl_CLIC-like
PANTHERiPTHR34093 PTHR34093, 1 hit
PfamiView protein in Pfam
PF05934 MCLC, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.iShow all

Isoform 1 (identifier: Q96S66-1) [UniParc]FASTAAdd to basket
Also known as: hMCLC-1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLCSLLLCEC LLLVAGYAHD DDWIDPTDML NYDAASGTMR KSQAKYGISG
60 70 80 90 100
EKDVSPDLSC ADEISECYHK LDSLTYKIDE CEKKKREDYE SQSNPVFRRY
110 120 130 140 150
LNKILIEAGK LGLPDENKGD MHYDAEIILK RETLLEIQKF LNGEDWKPGA
160 170 180 190 200
LDDALSDILI NFKFHDFETW KWRFEDSFGV DPYNVLMVLL CLLCIVVLVA
210 220 230 240 250
TELWTYVRWY TQLRRVLIIS FLFSLGWNWM YLYKLAFAQH QAEVAKMEPL
260 270 280 290 300
NNVCAKKMDW TGSIWEWFRS SWTYKDDPCQ KYYELLLVNP IWLVPPTKAL
310 320 330 340 350
AVTFTTFVTE PLKHIGKGTG EFIKALMKEI PALLHLPVLI IMALAILSFC
360 370 380 390 400
YGAGKSVHVL RHIGGPESEP PQALRPRDRR RQEEIDYRPD GGAGDADFHY
410 420 430 440 450
RGQMGPTEQG PYAKTYEGRR EILRERDVDL RFQTGNKSPE VLRAFDVPDA
460 470 480 490 500
EAREHPTVVP SHKSPVLDTK PKETGGILGE GTPKESSTES SQSAKPVSGQ
510 520 530 540 550
DTSGNTEGSP AAEKAQLKSE AAGSPDQGST YSPARGVAGP RGQDPVSSPC

G
Length:551
Mass (Da):62,023
Last modified:December 1, 2001 - v1
Checksum:i08709A80E99F2E15
GO
Isoform 2 (identifier: Q96S66-2) [UniParc]FASTAAdd to basket
Also known as: hMCLC-2

The sequence of this isoform differs from the canonical sequence as follows:
     114-163: Missing.

Show »
Length:501
Mass (Da):56,267
Checksum:i2AAB4D99DA5EB327
GO
Isoform 3 (identifier: Q96S66-3) [UniParc]FASTAAdd to basket
Also known as: hMCLC-3

The sequence of this isoform differs from the canonical sequence as follows:
     114-234: Missing.

Show »
Length:430
Mass (Da):47,437
Checksum:iDB73E1B97B4B9660
GO
Isoform 4 (identifier: Q96S66-4) [UniParc]FASTAAdd to basket
Also known as: hMCLC-4

The sequence of this isoform differs from the canonical sequence as follows:
     114-298: Missing.

Show »
Length:366
Mass (Da):39,838
Checksum:i6214C106333DBAEC
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T1P5Q5T1P5_HUMAN
Chloride channel CLIC-like protein ...
CLCC1
262Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034673368S → R. Corresponds to variant dbSNP:rs168107Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_027347114 – 298Missing in isoform 4. 1 PublicationAdd BLAST185
Alternative sequenceiVSP_027348114 – 234Missing in isoform 3. 1 PublicationAdd BLAST121
Alternative sequenceiVSP_027349114 – 163Missing in isoform 2. 2 PublicationsAdd BLAST50

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB052915 mRNA Translation: BAB59018.1
AB052916 mRNA Translation: BAB79261.1
AB052917 mRNA Translation: BAB79262.1
AB052918 mRNA Translation: BAB79263.1
AB018304 mRNA Translation: BAA34481.2
AL449266 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56345.1
CH471122 Genomic DNA Translation: EAW56346.1
BC002939 mRNA Translation: AAH02939.1
CCDSiCCDS41362.1 [Q96S66-1]
CCDS60214.1 [Q96S66-4]
CCDS60215.1 [Q96S66-3]
CCDS793.1 [Q96S66-2]
RefSeqiNP_001041675.1, NM_001048210.2 [Q96S66-1]
NP_001265131.1, NM_001278202.1 [Q96S66-3]
NP_001265132.1, NM_001278203.1 [Q96S66-4]
NP_055942.1, NM_015127.4 [Q96S66-2]
UniGeneiHs.658489

Genome annotation databases

EnsembliENST00000302500; ENSP00000306552; ENSG00000121940 [Q96S66-3]
ENST00000348264; ENSP00000337243; ENSG00000121940 [Q96S66-4]
ENST00000356970; ENSP00000349456; ENSG00000121940 [Q96S66-1]
ENST00000369968; ENSP00000358985; ENSG00000121940 [Q96S66-4]
ENST00000369969; ENSP00000358986; ENSG00000121940 [Q96S66-3]
ENST00000369970; ENSP00000358987; ENSG00000121940 [Q96S66-2]
GeneIDi23155
KEGGihsa:23155
UCSCiuc009wes.2 human [Q96S66-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCLCC1_HUMAN
AccessioniPrimary (citable) accession number: Q96S66
Secondary accession number(s): O94861
, Q8WYP8, Q8WYP9, Q9BU25
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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