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Protein

Cysteine/serine-rich nuclear protein 1

Gene

CSRNP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity (By similarity). May have a tumor-suppressor function. May play a role in apoptosis.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processApoptosis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine/serine-rich nuclear protein 1
Short name:
CSRNP-1
Alternative name(s):
Axin-1 up-regulated gene 1 protein
Protein URAX1
TGF-beta-induced apoptosis protein 3
Short name:
TAIP-3
Gene namesi
Name:CSRNP1
Synonyms:AXUD1, TAIP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000144655.14
HGNCiHGNC:14300 CSRNP1
MIMi606458 gene
neXtProtiNX_Q96S65

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi64651
OpenTargetsiENSG00000144655
PharmGKBiPA25200

Polymorphism and mutation databases

BioMutaiCSRNP1
DMDMi308153432

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001147861 – 589Cysteine/serine-rich nuclear protein 1Add BLAST589

Proteomic databases

PaxDbiQ96S65
PeptideAtlasiQ96S65
PRIDEiQ96S65
ProteomicsDBi78076

PTM databases

iPTMnetiQ96S65
PhosphoSitePlusiQ96S65

Expressioni

Tissue specificityi

Ubiquitous. Most abundantly expressed in lung, placenta, skeletal muscle, pancreas and leukocyte. Frequently down-regulated in lung, kidney, liver and colon cancers compared with their corresponding normal tissues.1 Publication

Gene expression databases

BgeeiENSG00000144655
CleanExiHS_AXUD1
ExpressionAtlasiQ96S65 baseline and differential
GenevisibleiQ96S65 HS

Organism-specific databases

HPAiHPA045207
HPA058463

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi122227, 23 interactors
IntActiQ96S65, 9 interactors
STRINGi9606.ENSP00000273153

Structurei

3D structure databases

ProteinModelPortaliQ96S65
SMRiQ96S65
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi17 – 40Ser-richAdd BLAST24
Compositional biasi237 – 275Cys-richAdd BLAST39

Sequence similaritiesi

Belongs to the AXUD1 family.Curated

Phylogenomic databases

eggNOGiKOG3813 Eukaryota
ENOG410XREB LUCA
GeneTreeiENSGT00390000015510
HOGENOMiHOG000039987
InParanoidiQ96S65
KOiK17494
OMAiPRHSACR
OrthoDBiEOG091G04PA
PhylomeDBiQ96S65
TreeFamiTF323969

Family and domain databases

InterProiView protein in InterPro
IPR031972 CSRNP_N
IPR023260 Cys/Ser-rich_nuc_prot
PANTHERiPTHR13580 PTHR13580, 1 hit
PfamiView protein in Pfam
PF16019 CSRNP_N, 1 hit
PRINTSiPR02031 CYSSERRICHNP

Sequencei

Sequence statusi: Complete.

Q96S65-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGLLKRKFD QLDEDNSSVS SSSSSSGCQS RSCSPSSSVS RAWDSEEEGP
60 70 80 90 100
WDQMPLPDRD FCGPRSFTPL SILKRARRER PGRVAFDGIT VFYFPRCQGF
110 120 130 140 150
TSVPSRGGCT LGMALRHSAC RRFSLAEFAQ EQARARHEKL RQRLKEEKLE
160 170 180 190 200
MLQWKLSAAG VPQAEAGLPP VVDAIDDASV EEDLAVAVAG GRLEEVSFLQ
210 220 230 240 250
PYPARRRRAL LRASGVRRID REEKRELQAL RQSREDCGCH CDRICDPETC
260 270 280 290 300
SCSLAGIKCQ MDHTAFPCGC CREGCENPMG RVEFNQARVQ THFIHTLTRL
310 320 330 340 350
QLEQEAESFR ELEAPAQGSP PSPGEEALVP TFPLAKPPMN NELGDNSCSS
360 370 380 390 400
DMTDSSTASS SASGTSEAPD CPTHPGLPGP GFQPGVDDDS LARILSFSDS
410 420 430 440 450
DFGGEEEEEE EGSVGNLDNL SCFHPADIFG TSDPGGLASW THSYSGCSFT
460 470 480 490 500
SGVLDENANL DASCFLNGGL EGSREGSLPG TSVPPSMDAG RSSSVDLSLS
510 520 530 540 550
SCDSFELLQA LPDYSLGPHY TSQKVSDSLD NIEAPHFPLP GLSPPGDASS
560 570 580
CFLESLMGFS EPAAEALDPF IDSQFEDTVP ASLMEPVPV
Length:589
Mass (Da):63,508
Last modified:October 5, 2010 - v2
Checksum:iBAF4951B6F96ADD8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055100453V → I3 PublicationsCorresponds to variant dbSNP:rs1274958Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB053121 mRNA Translation: BAB61065.1
AB063301 mRNA Translation: BAB79450.1
AC092053 Genomic DNA No translation available.
BC038949 mRNA Translation: AAH38949.1
AL117565 mRNA Translation: CAH10719.1
CCDSiCCDS2682.1
RefSeqiNP_001307489.1, NM_001320560.1
NP_149016.2, NM_033027.3
XP_016862537.1, XM_017007048.1
UniGeneiHs.370950

Genome annotation databases

EnsembliENST00000273153; ENSP00000273153; ENSG00000144655
ENST00000514182; ENSP00000422532; ENSG00000144655
GeneIDi64651
KEGGihsa:64651
UCSCiuc003cjg.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCSRN1_HUMAN
AccessioniPrimary (citable) accession number: Q96S65
Secondary accession number(s): Q69YY5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: October 5, 2010
Last modified: July 18, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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