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Protein

Cysteine/serine-rich nuclear protein 1

Gene

CSRNP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity (By similarity). May have a tumor-suppressor function. May play a role in apoptosis.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processApoptosis, Transcription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cysteine/serine-rich nuclear protein 1
Short name:
CSRNP-1
Alternative name(s):
Axin-1 up-regulated gene 1 protein
Protein URAX1
TGF-beta-induced apoptosis protein 3
Short name:
TAIP-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CSRNP1
Synonyms:AXUD1, TAIP3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000144655.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14300 CSRNP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606458 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96S65

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
64651

Open Targets

More...
OpenTargetsi
ENSG00000144655

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25200

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CSRNP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
308153432

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001147861 – 589Cysteine/serine-rich nuclear protein 1Add BLAST589

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96S65

PeptideAtlas

More...
PeptideAtlasi
Q96S65

PRoteomics IDEntifications database

More...
PRIDEi
Q96S65

ProteomicsDB human proteome resource

More...
ProteomicsDBi
78076

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96S65

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96S65

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Most abundantly expressed in lung, placenta, skeletal muscle, pancreas and leukocyte. Frequently down-regulated in lung, kidney, liver and colon cancers compared with their corresponding normal tissues.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000144655 Expressed in 192 organ(s), highest expression level in lung

CleanEx database of gene expression profiles

More...
CleanExi
HS_AXUD1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96S65 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96S65 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA045207
HPA058463

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122227, 23 interactors

Protein interaction database and analysis system

More...
IntActi
Q96S65, 9 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000273153

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q96S65

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96S65

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi17 – 40Ser-richAdd BLAST24
Compositional biasi237 – 275Cys-richAdd BLAST39

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AXUD1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3813 Eukaryota
ENOG410XREB LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154028

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000039987

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96S65

KEGG Orthology (KO)

More...
KOi
K17494

Identification of Orthologs from Complete Genome Data

More...
OMAi
PRHSACR

Database of Orthologous Groups

More...
OrthoDBi
EOG091G04PA

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96S65

TreeFam database of animal gene trees

More...
TreeFami
TF323969

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031972 CSRNP_N
IPR023260 Cys/Ser-rich_nuc_prot

The PANTHER Classification System

More...
PANTHERi
PTHR13580 PTHR13580, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16019 CSRNP_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR02031 CYSSERRICHNP

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q96S65-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTGLLKRKFD QLDEDNSSVS SSSSSSGCQS RSCSPSSSVS RAWDSEEEGP
60 70 80 90 100
WDQMPLPDRD FCGPRSFTPL SILKRARRER PGRVAFDGIT VFYFPRCQGF
110 120 130 140 150
TSVPSRGGCT LGMALRHSAC RRFSLAEFAQ EQARARHEKL RQRLKEEKLE
160 170 180 190 200
MLQWKLSAAG VPQAEAGLPP VVDAIDDASV EEDLAVAVAG GRLEEVSFLQ
210 220 230 240 250
PYPARRRRAL LRASGVRRID REEKRELQAL RQSREDCGCH CDRICDPETC
260 270 280 290 300
SCSLAGIKCQ MDHTAFPCGC CREGCENPMG RVEFNQARVQ THFIHTLTRL
310 320 330 340 350
QLEQEAESFR ELEAPAQGSP PSPGEEALVP TFPLAKPPMN NELGDNSCSS
360 370 380 390 400
DMTDSSTASS SASGTSEAPD CPTHPGLPGP GFQPGVDDDS LARILSFSDS
410 420 430 440 450
DFGGEEEEEE EGSVGNLDNL SCFHPADIFG TSDPGGLASW THSYSGCSFT
460 470 480 490 500
SGVLDENANL DASCFLNGGL EGSREGSLPG TSVPPSMDAG RSSSVDLSLS
510 520 530 540 550
SCDSFELLQA LPDYSLGPHY TSQKVSDSLD NIEAPHFPLP GLSPPGDASS
560 570 580
CFLESLMGFS EPAAEALDPF IDSQFEDTVP ASLMEPVPV
Length:589
Mass (Da):63,508
Last modified:October 5, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBAF4951B6F96ADD8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_055100453V → I3 PublicationsCorresponds to variant dbSNP:rs1274958Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB053121 mRNA Translation: BAB61065.1
AB063301 mRNA Translation: BAB79450.1
AC092053 Genomic DNA No translation available.
BC038949 mRNA Translation: AAH38949.1
AL117565 mRNA Translation: CAH10719.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2682.1

NCBI Reference Sequences

More...
RefSeqi
NP_001307489.1, NM_001320560.1
NP_149016.2, NM_033027.3
XP_016862537.1, XM_017007048.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.370950

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000273153; ENSP00000273153; ENSG00000144655
ENST00000514182; ENSP00000422532; ENSG00000144655

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
64651

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:64651

UCSC genome browser

More...
UCSCi
uc003cjg.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB053121 mRNA Translation: BAB61065.1
AB063301 mRNA Translation: BAB79450.1
AC092053 Genomic DNA No translation available.
BC038949 mRNA Translation: AAH38949.1
AL117565 mRNA Translation: CAH10719.1
CCDSiCCDS2682.1
RefSeqiNP_001307489.1, NM_001320560.1
NP_149016.2, NM_033027.3
XP_016862537.1, XM_017007048.1
UniGeneiHs.370950

3D structure databases

ProteinModelPortaliQ96S65
SMRiQ96S65
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122227, 23 interactors
IntActiQ96S65, 9 interactors
STRINGi9606.ENSP00000273153

PTM databases

iPTMnetiQ96S65
PhosphoSitePlusiQ96S65

Polymorphism and mutation databases

BioMutaiCSRNP1
DMDMi308153432

Proteomic databases

PaxDbiQ96S65
PeptideAtlasiQ96S65
PRIDEiQ96S65
ProteomicsDBi78076

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
64651
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000273153; ENSP00000273153; ENSG00000144655
ENST00000514182; ENSP00000422532; ENSG00000144655
GeneIDi64651
KEGGihsa:64651
UCSCiuc003cjg.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
64651
DisGeNETi64651
EuPathDBiHostDB:ENSG00000144655.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CSRNP1

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0003186
HGNCiHGNC:14300 CSRNP1
HPAiHPA045207
HPA058463
MIMi606458 gene
neXtProtiNX_Q96S65
OpenTargetsiENSG00000144655
PharmGKBiPA25200

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3813 Eukaryota
ENOG410XREB LUCA
GeneTreeiENSGT00940000154028
HOGENOMiHOG000039987
InParanoidiQ96S65
KOiK17494
OMAiPRHSACR
OrthoDBiEOG091G04PA
PhylomeDBiQ96S65
TreeFamiTF323969

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CSRNP1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
64651

Protein Ontology

More...
PROi
PR:Q96S65

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000144655 Expressed in 192 organ(s), highest expression level in lung
CleanExiHS_AXUD1
ExpressionAtlasiQ96S65 baseline and differential
GenevisibleiQ96S65 HS

Family and domain databases

InterProiView protein in InterPro
IPR031972 CSRNP_N
IPR023260 Cys/Ser-rich_nuc_prot
PANTHERiPTHR13580 PTHR13580, 1 hit
PfamiView protein in Pfam
PF16019 CSRNP_N, 1 hit
PRINTSiPR02031 CYSSERRICHNP

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCSRN1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96S65
Secondary accession number(s): Q69YY5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: October 5, 2010
Last modified: December 5, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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