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Protein

Ran-binding protein 9

Gene

RANBP9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation. Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA.7 Publications

Caution

According to some authors (PubMed:9817760) RANBP9 would be located in centrosomes and involved in microtubule assembly, but other authors infirmed these results in (PubMed:11470507).2 Publications

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • Ran GTPase binding Source: ProtInc
  • Ras guanyl-nucleotide exchange factor activity Source: Reactome

GO - Biological processi

  • axon guidance Source: Reactome
  • MAPK cascade Source: Reactome
  • microtubule nucleation Source: ProtInc
  • negative regulation of ERK1 and ERK2 cascade Source: CACAO
  • protein-containing complex assembly Source: ProtInc

Enzyme and pathway databases

ReactomeiR-HSA-373760 L1CAM interactions
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-8851805 MET activates RAS signaling
SignaLinkiQ96S59
SIGNORiQ96S59

Names & Taxonomyi

Protein namesi
Recommended name:
Ran-binding protein 9
Short name:
RanBP9
Alternative name(s):
BPM-L
BPM90
Ran-binding protein M
Short name:
RanBPM
RanBP7
Gene namesi
Name:RANBP9
Synonyms:RANBPM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000010017.12
HGNCiHGNC:13727 RANBP9
MIMi603854 gene
neXtProtiNX_Q96S59

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10048
OpenTargetsiENSG00000010017
PharmGKBiPA34215

Polymorphism and mutation databases

BioMutaiRANBP9
DMDMi61215334

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000971691 – 729Ran-binding protein 9Add BLAST729

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei405N6-acetyllysineCombined sources1
Modified residuei477PhosphoserineBy similarity1
Modified residuei487PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated in response to stress. Can be phosphorylated by the cleaved p110 form of CDC2L1 (p110C).2 Publications
Ubiquitinated. Polyubiquitination targets the protein for rapid degradation via the ubiquitin system. Can be deubiquitinated by USP11.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ96S59
MaxQBiQ96S59
PaxDbiQ96S59
PeptideAtlasiQ96S59
PRIDEiQ96S59
ProteomicsDBi78074
78075 [Q96S59-2]

PTM databases

iPTMnetiQ96S59
PhosphoSitePlusiQ96S59
SwissPalmiQ96S59

Expressioni

Tissue specificityi

Ubiquitously expressed, with highest levels in testes, placenta, heart, and muscle, and lowest levels in lung. Within the brain, expressed predominantly by neurons in the gray matter of cortex, the granular layer of cerebellum and the Purkinje cells.3 Publications

Gene expression databases

BgeeiENSG00000010017
CleanExiHS_RANBP9
ExpressionAtlasiQ96S59 baseline and differential
GenevisibleiQ96S59 HS

Organism-specific databases

HPAiCAB033767
HPA050007

Interactioni

Subunit structurei

Interacts with NGFR and DDX4 (By similarity). Interacts with GTP-bound Ran, AR, CDC2L1/p110C, CALB1, S100A7, USP11, MKLN1, SOS1 or SOS2, GID8, and FMR1. Interacts with the Dyrk kinases HIPK2, DYRK1A, and DYRK1B. Interacts with TP73 isoform Alpha but not with TP53. Interacts with the HGF receptor MET and the integrins ITGB1 and ITGB2, but not with ITGAL. Part of a complex consisting of RANBP9, MKLN1 and GID8. Part of a complex consisting of RANBP9, RAN, DYRK1B and COPS5. Directly interacts with RANBP10. Interacts with TEX19 (By similarity).By similarity15 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • Ran GTPase binding Source: ProtInc
  • Ras guanyl-nucleotide exchange factor activity Source: Reactome

Protein-protein interaction databases

BioGridi115359, 149 interactors
CORUMiQ96S59
IntActiQ96S59, 65 interactors
MINTiQ96S59
STRINGi9606.ENSP00000011619

Structurei

Secondary structure

1729
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi150 – 154Combined sources5
Turni160 – 162Combined sources3
Beta strandi168 – 174Combined sources7
Beta strandi178 – 181Combined sources4
Turni182 – 185Combined sources4
Beta strandi186 – 189Combined sources4
Helixi196 – 198Combined sources3
Beta strandi200 – 206Combined sources7
Helixi210 – 212Combined sources3
Beta strandi213 – 224Combined sources12
Turni225 – 227Combined sources3
Beta strandi231 – 235Combined sources5
Beta strandi241 – 243Combined sources3
Beta strandi251 – 255Combined sources5
Turni256 – 258Combined sources3
Beta strandi260 – 263Combined sources4
Beta strandi280 – 286Combined sources7
Turni287 – 290Combined sources4
Beta strandi291 – 296Combined sources6
Beta strandi299 – 305Combined sources7
Beta strandi313 – 318Combined sources6
Beta strandi323 – 332Combined sources10
Helixi338 – 343Combined sources6

3D structure databases

ProteinModelPortaliQ96S59
SMRiQ96S59
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini147 – 334B30.2/SPRYPROSITE-ProRule annotationAdd BLAST188
Domaini365 – 397LisHPROSITE-ProRule annotationAdd BLAST33
Domaini403 – 460CTLHPROSITE-ProRule annotationAdd BLAST58

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni401 – 407Interaction with CALB1Curated7
Regioni615 – 729Interaction with FMR11 PublicationAdd BLAST115

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi5 – 10Poly-Pro6
Compositional biasi11 – 18Poly-Gln8
Compositional biasi21 – 24Poly-Pro4
Compositional biasi25 – 131Ala-richAdd BLAST107
Compositional biasi62 – 66Poly-Ala5
Compositional biasi71 – 77Poly-Pro7
Compositional biasi82 – 92Poly-ProAdd BLAST11

Domaini

The SPRY domain mediates the interaction with MET, AR, and CDC2L1.

Sequence similaritiesi

Belongs to the RANBP9/10 family.Curated

Phylogenomic databases

eggNOGiKOG1477 Eukaryota
ENOG410XPCC LUCA
GeneTreeiENSGT00530000063160
HOGENOMiHOG000008133
HOVERGENiHBG053444
InParanoidiQ96S59
OMAiCDTEMEV
OrthoDBiEOG091G032F
PhylomeDBiQ96S59
TreeFamiTF331658

Family and domain databases

CDDicd12909 SPRY_RanBP9_10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR013144 CRA_dom
IPR024964 CTLH/CRA
IPR006595 CTLH_C
IPR006594 LisH
IPR003877 SPRY_dom
IPR035782 SPRY_RanBP9/10
PfamiView protein in Pfam
PF10607 CLTH, 1 hit
PF08513 LisH, 1 hit
PF00622 SPRY, 1 hit
SMARTiView protein in SMART
SM00757 CRA, 1 hit
SM00668 CTLH, 1 hit
SM00667 LisH, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50897 CTLH, 1 hit
PS50896 LISH, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96S59-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGQPPPPPP QQQQQQQQLS PPPPAALAPV SGVVLPAPPA VSAGSSPAGS
60 70 80 90 100
PGGGAGGEGL GAAAAALLLH PPPPPPPATA APPPPPPPPP PPASAAAPAS
110 120 130 140 150
GPPAPPGLAA GPGPAGGAPT PALVAGSSAA APFPHGDSAL NEQEKELQRR
160 170 180 190 200
LKRLYPAVDE QETPLPRSWS PKDKFSYIGL SQNNLRVHYK GHGKTPKDAA
210 220 230 240 250
SVRATHPIPA ACGIYYFEVK IVSKGRDGYM GIGLSAQGVN MNRLPGWDKH
260 270 280 290 300
SYGYHGDDGH SFCSSGTGQP YGPTFTTGDV IGCCVNLINN TCFYTKNGHS
310 320 330 340 350
LGIAFTDLPP NLYPTVGLQT PGEVVDANFG QHPFVFDIED YMREWRTKIQ
360 370 380 390 400
AQIDRFPIGD REGEWQTMIQ KMVSSYLVHH GYCATAEAFA RSTDQTVLEE
410 420 430 440 450
LASIKNRQRI QKLVLAGRMG EAIETTQQLY PSLLERNPNL LFTLKVRQFI
460 470 480 490 500
EMVNGTDSEV RCLGGRSPKS QDSYPVSPRP FSSPSMSPSH GMNIHNLASG
510 520 530 540 550
KGSTAHFSGF ESCSNGVISN KAHQSYCHSN KHQSSNLNVP ELNSINMSRS
560 570 580 590 600
QQVNNFTSND VDMETDHYSN GVGETSSNGF LNGSSKHDHE MEDCDTEMEV
610 620 630 640 650
DSSQLRRQLC GGSQAAIERM IHFGRELQAM SEQLRRDCGK NTANKKMLKD
660 670 680 690 700
AFSLLAYSDP WNSPVGNQLD PIQREPVCSA LNSAILETHN LPKQPPLALA
710 720
MGQATQCLGL MARSGIGSCA FATVEDYLH
Length:729
Mass (Da):77,847
Last modified:December 1, 2001 - v1
Checksum:i50DF1127B7FDA6C8
GO
Isoform 2 (identifier: Q96S59-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-341: Missing.

Show »
Length:388
Mass (Da):43,064
Checksum:i28332F38EEB013B8
GO
Isoform 3 (identifier: Q96S59-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-229: Missing.

Note: No experimental confirmation available.
Show »
Length:500
Mass (Da):55,082
Checksum:iCB0A1FD22BCF1B82
GO

Sequence cautioni

The sequence AAH19886 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH52781 differs from that shown. Reason: Frameshift at positions 13, 30 and 34.Curated
The sequence AAK15469 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA23216 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti87P → S in BAA23216 (PubMed:9817760).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0131751 – 341Missing in isoform 2. 1 PublicationAdd BLAST341
Alternative sequenceiVSP_0560491 – 229Missing in isoform 3. 1 PublicationAdd BLAST229

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB055311 mRNA Translation: BAB62525.1
AK313334 mRNA Translation: BAG36138.1
AL441883 Genomic DNA No translation available.
Z93020 Genomic DNA No translation available.
BC019886 mRNA Translation: AAH19886.1 Sequence problems.
BC052781 mRNA Translation: AAH52781.1 Frameshift.
BC063849 mRNA Translation: AAH63849.1
AB008515 mRNA Translation: BAA23216.1 Different initiation.
AF306510 mRNA Translation: AAK15469.1 Different initiation.
CCDSiCCDS4529.1 [Q96S59-1]
RefSeqiNP_005484.2, NM_005493.2 [Q96S59-1]
XP_006715008.1, XM_006714945.2 [Q96S59-3]
UniGeneiHs.708182

Genome annotation databases

EnsembliENST00000011619; ENSP00000011619; ENSG00000010017 [Q96S59-1]
GeneIDi10048
KEGGihsa:10048
UCSCiuc003nbb.3 human [Q96S59-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRANB9_HUMAN
AccessioniPrimary (citable) accession number: Q96S59
Secondary accession number(s): A0PJA2
, B2R8E1, O94764, Q6P3T7, Q7LBR2, Q7Z7F9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: December 1, 2001
Last modified: July 18, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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