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Protein

Ribosomal protein S6 kinase delta-1

Gene

RPS6KC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell (PubMed:12077123). Plays a role in the recruitment of PRDX3 to early endosomes (PubMed:15750338).2 Publications

Caution

Instead of Lys-820, Arg-820 is found at the binding site.Curated

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei820ATPPROSITE-ProRule annotation1
Active sitei929Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi801 – 809ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • phosphatidylinositol binding Source: InterPro
  • protein serine/threonine kinase activity Source: ProtInc

GO - Biological processi

  • signal transduction Source: ProtInc

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Lipid-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ96S38

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal protein S6 kinase delta-1 (EC:2.7.11.1)
Short name:
S6K-delta-1
Alternative name(s):
52 kDa ribosomal protein S6 kinase
Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein
SPHK1-binding protein
Gene namesi
Name:RPS6KC1
Synonyms:RPK118
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000136643.11
HGNCiHGNC:10439 RPS6KC1
MIMi617517 gene
neXtProtiNX_Q96S38

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000136643
PharmGKBiPA34854

Chemistry databases

ChEMBLiCHEMBL1795193

Polymorphism and mutation databases

BioMutaiRPS6KC1
DMDMi94717650

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002331271 – 1066Ribosomal protein S6 kinase delta-1Add BLAST1066

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei282PhosphoserineCombined sources1
Modified residuei423PhosphoserineCombined sources1
Modified residuei427PhosphoserineCombined sources1
Modified residuei449PhosphoserineBy similarity1
Modified residuei455PhosphoserineCombined sources1
Modified residuei494PhosphoserineBy similarity1
Modified residuei528PhosphoserineCombined sources1
Modified residuei583PhosphoserineCombined sources1
Modified residuei605PhosphoserineCombined sources1
Modified residuei608PhosphoserineBy similarity1
Modified residuei640PhosphoserineBy similarity1
Modified residuei661PhosphoserineCombined sources1
Modified residuei664PhosphoserineCombined sources1
Modified residuei667PhosphoserineCombined sources1
Modified residuei794PhosphoserineBy similarity1
Modified residuei872PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96S38
MaxQBiQ96S38
PaxDbiQ96S38
PeptideAtlasiQ96S38
PRIDEiQ96S38
ProteomicsDBi78062
TopDownProteomicsiQ96S38-1 [Q96S38-1]

PTM databases

iPTMnetiQ96S38
PhosphoSitePlusiQ96S38

Expressioni

Tissue specificityi

Highly expressed in testis, skeletal muscle, brain, heart, placenta, kidney and liver and weakly expressed in thymus, small intestine, lung and colon.1 Publication

Gene expression databases

BgeeiENSG00000136643
CleanExiHS_RPS6KC1
ExpressionAtlasiQ96S38 baseline and differential
GenevisibleiQ96S38 HS

Organism-specific databases

HPAiHPA026531
HPA031565

Interactioni

Subunit structurei

Interacts with SPHK1 and phosphatidylinositol 3-phosphate (PubMed:12077123). Interacts (via PX domain) with PRDX3 (PubMed:15750338).2 Publications

Protein-protein interaction databases

BioGridi117810, 7 interactors
IntActiQ96S38, 8 interactors
STRINGi9606.ENSP00000355927

Structurei

3D structure databases

ProteinModelPortaliQ96S38
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 132PXPROSITE-ProRule annotationAdd BLAST125
Domaini277 – 305MITAdd BLAST29
Domaini344 – 445Protein kinase 1PROSITE-ProRule annotationAdd BLAST102
Domaini794 – 1056Protein kinase 2PROSITE-ProRule annotationAdd BLAST263

Domaini

The PX domain is essential for its localization to the early endosomes.1 Publication
The first protein kinase domain appears to be a pseudokinase domain as it does not contain the classical characteristics, such as the ATP-binding motif, ATP-binding site and active site.

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. S6 kinase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0603 Eukaryota
KOG2101 Eukaryota
ENOG410ZH1N LUCA
GeneTreeiENSGT00890000139413
HOGENOMiHOG000049101
HOVERGENiHBG078266
InParanoidiQ96S38
KOiK20839
OMAiVPNMVCL
OrthoDBiEOG091G0CNL
PhylomeDBiQ96S38
TreeFamiTF323964

Family and domain databases

CDDicd05576 STKc_RPK118_like, 1 hit
Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR007330 MIT
IPR036181 MIT_dom_sf
IPR001683 Phox
IPR000719 Prot_kinase_dom
IPR036871 PX_dom_sf
IPR035051 S6K-delta-1
IPR035053 STK_RPK118-like
PANTHERiPTHR15508:SF2 PTHR15508:SF2, 1 hit
PfamiView protein in Pfam
PF04212 MIT, 1 hit
PF00069 Pkinase, 1 hit
PF00787 PX, 1 hit
SMARTiView protein in SMART
SM00745 MIT, 1 hit
SM00312 PX, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF116846 SSF116846, 1 hit
SSF56112 SSF56112, 2 hits
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS50195 PX, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96S38-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSYRERSAD LARFYTVTEP QRHPRGYTVY KVTARVVSRR NPEDVQEIIV
60 70 80 90 100
WKRYSDFKKL HKELWQIHKN LFRHSELFPP FAKGIVFGRF DETVIEERRQ
110 120 130 140 150
CAEDLLQFSA NIPALYNSKQ LEDFFKGGII NDSSELIGPA EAHSDSLIDT
160 170 180 190 200
FPECSTEGFS SDSDLVSLTV DVDSLAELDD GMASNQNSPI RTFGLNLSSD
210 220 230 240 250
SSALGAVASD SEQSKTEEER ESRSLFPGSL KPKLGKRDYL EKAGELIKLA
260 270 280 290 300
LKKEEEDDYE AASDFYRKGV DLLLEGVQGE SSPTRREAVK RRTAEYLMRA
310 320 330 340 350
ESISSLYGKP QLDDVSQPPG SLSSRPLWNL RSPAEELKAF RVLGVIDKVL
360 370 380 390 400
LVMDTRTEQT FILKGLRKSS EYSRNRKTII PRCVPNMVCL HKYIISEESV
410 420 430 440 450
FLVLQHAEGG KLWSYISKFL NRSPEESFDI KEVKKPTLAK VHLQQPTSSP
460 470 480 490 500
QDSSSFESRG SDGGSMLKAL PLKSSLTPSS QDDSNQEDDG QDSSPKWPDS
510 520 530 540 550
GSSSEEECTT SYLTLCNEYG QEKIEPGSLN EEPFMKTEGN GVDTKAIKSF
560 570 580 590 600
PAHLAADSDS PSTQLRAHEL KFFPNDDPEA VSSPRTSDSL SRSKNSPMEF
610 620 630 640 650
FRIDSKDSAS ELLGLDFGEK LYSLKSEPLK PFFTLPDGDS ASRSFNTSES
660 670 680 690 700
KVEFKAQDTI SRGSDDSVPV ISFKDAAFDD VSGTDEGRPD LLVNLPGELE
710 720 730 740 750
STREAAAMGP TKFTQTNIGI IENKLLEAPD VLCLRLSTEQ CQAHEEKGIE
760 770 780 790 800
ELSDPSGPKS YSITEKHYAQ EDPRMLFVAA VDHSSSGDMS LLPSSDPKFQ
810 820 830 840 850
GLGVVESAVT ANNTEESLFR ICSPLSGANE YIASTDTLKT EEVLLFTDQT
860 870 880 890 900
DDLAKEEPTS LFQRDSETKG ESGLVLEGDK EIHQIFEDLD KKLALASRFY
910 920 930 940 950
IPEGCIQRWA AEMVVALDAL HREGIVCRDL NPNNILLNDR GHIQLTYFSR
960 970 980 990 1000
WSEVEDSCDS DAIERMYCAP EVGAITEETE ACDWWSLGAV LFELLTGKTL
1010 1020 1030 1040 1050
VECHPAGINT HTTLNMPECV SEEARSLIQQ LLQFNPLERL GAGVAGVEDI
1060
KSHPFFTPVD WAELMR
Length:1,066
Mass (Da):118,682
Last modified:May 2, 2006 - v2
Checksum:i670EE5965F3B8274
GO
Isoform 2 (identifier: Q96S38-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     36-47: Missing.

Note: No experimental confirmation available.
Show »
Length:1,054
Mass (Da):117,273
Checksum:iF514E37BF7CCC4F0
GO

Sequence cautioni

The sequence CAB92850 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35R → G in BAB63956 (PubMed:12077123).Curated1
Sequence conflicti250A → V in BAB63956 (PubMed:12077123).Curated1
Sequence conflicti1065Missing (PubMed:10552933).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04064742P → T1 PublicationCorresponds to variant dbSNP:rs56087470Ensembl.1
Natural variantiVAR_04064896E → K1 PublicationCorresponds to variant dbSNP:rs56032860Ensembl.1
Natural variantiVAR_040649319P → L1 PublicationCorresponds to variant dbSNP:rs56369827Ensembl.1
Natural variantiVAR_040650424P → L1 PublicationCorresponds to variant dbSNP:rs56183862Ensembl.1
Natural variantiVAR_040651546A → P1 PublicationCorresponds to variant dbSNP:rs35281247Ensembl.1
Natural variantiVAR_040652554L → I in a lung neuroendocrine carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_051635561P → R. Corresponds to variant dbSNP:rs17020314Ensembl.1
Natural variantiVAR_040653575N → S1 PublicationCorresponds to variant dbSNP:rs56060894Ensembl.1
Natural variantiVAR_040654663G → A in an ovarian mucinous carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_040655853L → F1 PublicationCorresponds to variant dbSNP:rs34080597Ensembl.1
Natural variantiVAR_0406561003C → Y in a lung adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0406571022E → K in a breast infiltrating ductal carcinoma sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04633336 – 47Missing in isoform 2. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB070706 mRNA Translation: BAB63956.1
AF477978 mRNA Translation: AAL84818.1
AK122921 mRNA No translation available.
AK122989 mRNA Translation: BAG53836.1
AL645860 Genomic DNA No translation available.
AL512449 Genomic DNA No translation available.
AL583826 Genomic DNA No translation available.
CH471100 Genomic DNA Translation: EAW93362.1
CH471100 Genomic DNA Translation: EAW93363.1
BC104769 mRNA Translation: AAI04770.1
AF037447 mRNA Translation: AAF13027.1
AL356893 mRNA Translation: CAB92850.1 Different initiation.
CCDSiCCDS1513.1 [Q96S38-1]
CCDS44317.1 [Q96S38-2]
RefSeqiNP_001129610.1, NM_001136138.2 [Q96S38-2]
NP_036556.2, NM_012424.4 [Q96S38-1]
UniGeneiHs.591416

Genome annotation databases

EnsembliENST00000366959; ENSP00000355926; ENSG00000136643 [Q96S38-2]
ENST00000366960; ENSP00000355927; ENSG00000136643 [Q96S38-1]
GeneIDi26750
KEGGihsa:26750
UCSCiuc001hkd.5 human [Q96S38-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKS6C1_HUMAN
AccessioniPrimary (citable) accession number: Q96S38
Secondary accession number(s): B1APS8
, B3KVM4, D3DTA4, Q8TDD3, Q9NSF4, Q9UL66
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 2, 2006
Last modified: June 20, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

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