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Protein

Lipase maturation factor 1

Gene

LMF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the maturation of specific proteins in the endoplasmic reticulum. Required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway. Each LMF1 molecule chaperones 50 or more molecules of LPL.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8963889 Assembly of active LPL and LIPC lipase complexes

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lipase maturation factor 1
Alternative name(s):
Transmembrane protein 112
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LMF1
Synonyms:C16orf26, TMEM112
ORF Names:HMFN1876, JFP11
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000103227.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14154 LMF1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611761 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96S06

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 49CytoplasmicSequence analysisAdd BLAST49
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei50 – 72HelicalSequence analysisAdd BLAST23
Topological domaini73 – 127LumenalSequence analysisAdd BLAST55
Transmembranei128 – 151HelicalSequence analysisAdd BLAST24
Topological domaini152 – 207CytoplasmicSequence analysisAdd BLAST56
Transmembranei208 – 221HelicalSequence analysisAdd BLAST14
Topological domaini222 – 292LumenalSequence analysisAdd BLAST71
Transmembranei293 – 321HelicalSequence analysisAdd BLAST29
Topological domaini322 – 367CytoplasmicSequence analysisAdd BLAST46
Transmembranei368 – 388HelicalSequence analysisAdd BLAST21
Topological domaini389 – 567LumenalSequence analysisAdd BLAST179

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Combined lipase deficiency (CLD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionCharacterized by repeated episodes of pancreatitis, tuberous xanthomas and lipodystrophy and is caused by deficiency of both lipoprotein lipase (LPL) and hepatic triglyceride lipase (HTGL).
See also OMIM:246650

Organism-specific databases

DisGeNET

More...
DisGeNETi
64788

MalaCards human disease database

More...
MalaCardsi
LMF1
MIMi246650 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000103227

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
444490 Familial chylomicronemia syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25540

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LMF1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74717262

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002767391 – 567Lipase maturation factor 1Add BLAST567

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96S06

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96S06

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96S06

PeptideAtlas

More...
PeptideAtlasi
Q96S06

PRoteomics IDEntifications database

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PRIDEi
Q96S06

ProteomicsDB human proteome resource

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ProteomicsDBi
78050

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q96S06

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q96S06

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000103227 Expressed in 216 organ(s), highest expression level in C1 segment of cervical spinal cord

CleanEx database of gene expression profiles

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CleanExi
HS_LMF1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96S06 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96S06 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with LPL and SEL1L.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
122298, 20 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000262301

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q96S06

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96S06

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the lipase maturation factor family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IHGU Eukaryota
ENOG410XPYW LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00530000063702

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000242315

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG101974

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96S06

Identification of Orthologs from Complete Genome Data

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OMAi
NFAWLNW

Database of Orthologous Groups

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OrthoDBi
EOG091G05XZ

Database for complete collections of gene phylogenies

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PhylomeDBi
Q96S06

TreeFam database of animal gene trees

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TreeFami
TF314339

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR009613 LMF

The PANTHER Classification System

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PANTHERi
PTHR14463 PTHR14463, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06762 LMF1, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96S06-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRPDSPTMAA PAESLRRRKT GYSDPEPESP PAPGRGPAGS PAHLHTGTFW
60 70 80 90 100
LTRIVLLKAL AFVYFVAFLV AFHQNKQLIG DRGLLPCRVF LKNFQQYFQD
110 120 130 140 150
RTSWEVFSYM PTILWLMDWS DMNSNLDLLA LLGLGISSFV LITGCANMLL
160 170 180 190 200
MAALWGLYMS LVNVGHVWYS FGWESQLLET GFLGIFLCPL WTLSRLPQHT
210 220 230 240 250
PTSRIVLWGF RWLIFRIMLG AGLIKIRGDR CWRDLTCMDF HYETQPMPNP
260 270 280 290 300
VAYYLHHSPW WFHRFETLSN HFIELLVPFF LFLGRRACII HGVLQILFQA
310 320 330 340 350
VLIVSGNLSF LNWLTMVPSL ACFDDATLGF LFPSGPGSLK DRVLQMQRDI
360 370 380 390 400
RGARPEPRFG SVVRRAANVS LGVLLAWLSV PVVLNLLSSR QVMNTHFNSL
410 420 430 440 450
HIVNTYGAFG SITKERAEVI LQGTASSNAS APDAMWEDYE FKCKPGDPSR
460 470 480 490 500
RPCLISPYHY RLDWLMWFAA FQTYEHNDWI IHLAGKLLAS DAEALSLLAH
510 520 530 540 550
NPFAGRPPPR WVRGEHYRYK FSRPGGRHAA EGKWWVRKRI GAYFPPLSLE
560
ELRPYFRDRG WPLPGPL
Length:567
Mass (Da):64,873
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6D4C80741D1DD0D5
GO
Isoform 2 (identifier: Q96S06-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-237: Missing.

Note: No experimental confirmation available.
Show »
Length:330
Mass (Da):37,888
Checksum:i977FE1D0D0756515
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BVI4H3BVI4_HUMAN
Lipase maturation factor
LMF1 LA16c-360B4.1, hCG_22432
350Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BN37H3BN37_HUMAN
Lipase maturation factor
LMF1
198Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BP58H3BP58_HUMAN
Lipase maturation factor
LMF1
150Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DFZ0B4DFZ0_HUMAN
Lipase maturation factor 1
LMF1
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BSB7H3BSB7_HUMAN
Lipase maturation factor 1
LMF1
168Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BUN8H3BUN8_HUMAN
Lipase maturation factor 1
LMF1
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQC9H3BQC9_HUMAN
Lipase maturation factor 1
LMF1
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H802F5H802_HUMAN
Lipase maturation factor 1
LMF1
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQT4H3BQT4_HUMAN
Lipase maturation factor 1
LMF1
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB15295 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti36G → D in BAB15295 (PubMed:14702039).Curated1
Sequence conflicti36G → D in BAD38655 (PubMed:15616553).Curated1
Sequence conflicti93N → D in BAB14218 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053829164V → A. Corresponds to variant dbSNP:rs35663121Ensembl.1
Natural variantiVAR_030487203S → P1 PublicationCorresponds to variant dbSNP:rs11540337Ensembl.1
Natural variantiVAR_053830364R → Q. Corresponds to variant dbSNP:rs35168378Ensembl.1
Natural variantiVAR_030488562P → R. Corresponds to variant dbSNP:rs4984948Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0573881 – 237Missing in isoform 2. 1 PublicationAdd BLAST237

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK022743 mRNA Translation: BAB14218.1
AK025955 mRNA Translation: BAB15295.1 Different initiation.
AK093050 mRNA Translation: BAG52642.1
AE006465 Genomic DNA Translation: AAK61259.1
AC009041 Genomic DNA No translation available.
AL008727 Genomic DNA No translation available.
AL031008 Genomic DNA No translation available.
AL031716 Genomic DNA No translation available.
KF456135 Genomic DNA No translation available.
KF456139 Genomic DNA No translation available.
KF456141 Genomic DNA No translation available.
KF456144 Genomic DNA No translation available.
Z93041 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85700.1
AB075873 mRNA Translation: BAD38655.1
BC010738 mRNA Translation: AAH10738.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS45373.1 [Q96S06-1]

NCBI Reference Sequences

More...
RefSeqi
NP_073610.2, NM_022773.2 [Q96S06-1]
XP_006720991.1, XM_006720928.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.71912
Hs.745022

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000262301; ENSP00000262301; ENSG00000103227 [Q96S06-1]
ENST00000543238; ENSP00000437418; ENSG00000103227 [Q96S06-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
64788

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:64788

UCSC genome browser

More...
UCSCi
uc010bri.4 human
uc059otd.1 human [Q96S06-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022743 mRNA Translation: BAB14218.1
AK025955 mRNA Translation: BAB15295.1 Different initiation.
AK093050 mRNA Translation: BAG52642.1
AE006465 Genomic DNA Translation: AAK61259.1
AC009041 Genomic DNA No translation available.
AL008727 Genomic DNA No translation available.
AL031008 Genomic DNA No translation available.
AL031716 Genomic DNA No translation available.
KF456135 Genomic DNA No translation available.
KF456139 Genomic DNA No translation available.
KF456141 Genomic DNA No translation available.
KF456144 Genomic DNA No translation available.
Z93041 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85700.1
AB075873 mRNA Translation: BAD38655.1
BC010738 mRNA Translation: AAH10738.2
CCDSiCCDS45373.1 [Q96S06-1]
RefSeqiNP_073610.2, NM_022773.2 [Q96S06-1]
XP_006720991.1, XM_006720928.2
UniGeneiHs.71912
Hs.745022

3D structure databases

ProteinModelPortaliQ96S06
SMRiQ96S06
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122298, 20 interactors
STRINGi9606.ENSP00000262301

PTM databases

iPTMnetiQ96S06
PhosphoSitePlusiQ96S06

Polymorphism and mutation databases

BioMutaiLMF1
DMDMi74717262

Proteomic databases

EPDiQ96S06
MaxQBiQ96S06
PaxDbiQ96S06
PeptideAtlasiQ96S06
PRIDEiQ96S06
ProteomicsDBi78050

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
64788
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262301; ENSP00000262301; ENSG00000103227 [Q96S06-1]
ENST00000543238; ENSP00000437418; ENSG00000103227 [Q96S06-2]
GeneIDi64788
KEGGihsa:64788
UCSCiuc010bri.4 human
uc059otd.1 human [Q96S06-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
64788
DisGeNETi64788
EuPathDBiHostDB:ENSG00000103227.18

GeneCards: human genes, protein and diseases

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GeneCardsi
LMF1
HGNCiHGNC:14154 LMF1
MalaCardsiLMF1
MIMi246650 phenotype
611761 gene
neXtProtiNX_Q96S06
OpenTargetsiENSG00000103227
Orphaneti444490 Familial chylomicronemia syndrome
PharmGKBiPA25540

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IHGU Eukaryota
ENOG410XPYW LUCA
GeneTreeiENSGT00530000063702
HOGENOMiHOG000242315
HOVERGENiHBG101974
InParanoidiQ96S06
OMAiNFAWLNW
OrthoDBiEOG091G05XZ
PhylomeDBiQ96S06
TreeFamiTF314339

Enzyme and pathway databases

ReactomeiR-HSA-8963889 Assembly of active LPL and LIPC lipase complexes

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LMF1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TMEM112

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
64788

Protein Ontology

More...
PROi
PR:Q96S06

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000103227 Expressed in 216 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_LMF1
ExpressionAtlasiQ96S06 baseline and differential
GenevisibleiQ96S06 HS

Family and domain databases

InterProiView protein in InterPro
IPR009613 LMF
PANTHERiPTHR14463 PTHR14463, 1 hit
PfamiView protein in Pfam
PF06762 LMF1, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLMF1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96S06
Secondary accession number(s): B3KS80
, Q68CJ3, Q96FJ4, Q9H6G4, Q9H9K7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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