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Protein

Protein cramped-like

Gene

CRAMP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein cramped-likeCurated
Alternative name(s):
Cramped chromatin regulator homolog 1Imported
Hematological and neurological expressed 1-like protein
Gene namesi
Name:CRAMP1Imported
Synonyms:C16orf34, CRAMP1L, HN1L, KIAA1426
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000007545.15
HGNCiHGNC:14122 CRAMP1
neXtProtiNX_Q96RY5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000007545
PharmGKBiPA26861

Polymorphism and mutation databases

BioMutaiCRAMP1L
DMDMi308153609

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002644711 – 1269Protein cramped-likeAdd BLAST1269

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei307PhosphoserineCombined sources1
Modified residuei1268PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96RY5
MaxQBiQ96RY5
PaxDbiQ96RY5
PeptideAtlasiQ96RY5
PRIDEiQ96RY5
ProteomicsDBi78048

PTM databases

iPTMnetiQ96RY5
PhosphoSitePlusiQ96RY5

Expressioni

Gene expression databases

BgeeiENSG00000007545
CleanExiHS_CRAMP1L
HS_HN1L
ExpressionAtlasiQ96RY5 baseline and differential
GenevisibleiQ96RY5 HS

Organism-specific databases

HPAiHPA041752

Interactioni

Protein-protein interaction databases

BioGridi121637, 14 interactors
IntActiQ96RY5, 3 interactors
MINTiQ96RY5
STRINGi9606.ENSP00000293925

Structurei

3D structure databases

ProteinModelPortaliQ96RY5
SMRiQ96RY5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini161 – 224SANTPROSITE-ProRule annotationAdd BLAST64

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1069 – 1246Ser-richAdd BLAST178

Sequence similaritiesi

Belongs to the cramped family.Curated

Phylogenomic databases

eggNOGiENOG410IFWT Eukaryota
ENOG4110SYD LUCA
GeneTreeiENSGT00390000003337
HOGENOMiHOG000049034
HOVERGENiHBG079959
InParanoidiQ96RY5
OMAiTVRYKGR
OrthoDBiEOG091G050A
PhylomeDBiQ96RY5
TreeFamiTF328521

Family and domain databases

InterProiView protein in InterPro
IPR001005 SANT/Myb
IPR017884 SANT_dom
SMARTiView protein in SMART
SM00717 SANT, 1 hit
PROSITEiView protein in PROSITE
PS51293 SANT, 1 hit

Sequencei

Sequence statusi: Complete.

Q96RY5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVKLGDGGS GEDGLKKLGK RAADEESLEG EGAGGADAAE ESSGTKRDEK
60 70 80 90 100
TPRAGADGPP APPGAPQAPS PPQGSPQDQH HFLRSSVRPQ SKRPRKDPPS
110 120 130 140 150
AVGSGNAGGS GPRGKGAEGG GSSSGNVSGV APAAPAGGSR SSSRNLGSSG
160 170 180 190 200
GEKEEGKKVR RQWESWSTED KNTFFEGLYE HGKDFEAIQN NIALKYKKKG
210 220 230 240 250
KPASMVKNKE QVRHFYYRTW HKITKYIDFD HVFSRGLKKS SQELYGLICY
260 270 280 290 300
GELRKKIGGC MDDKNATKLN ELIQVGATTV RYKGRNLRIK APMCRALKKL
310 320 330 340 350
CDPDGLSDEE DQKPVRLPLK VPIELQPRNN HAWARVQSLA QNPRLRMIVE
360 370 380 390 400
LHRKVSSLIE FLKQKWALHE VRVRKTLEER QLQDSCSAPM QEKVTLHLFP
410 420 430 440 450
GENCTLTPLP GVARVVHSKA FCTVHWQEGG RCKQSAKDAH VLPPAQILGI
460 470 480 490 500
QSGQGTARGQ VKCPRSGAEG KGVGRPPPAA DALQSSGESS PESAPGEGAA
510 520 530 540 550
LSLSSPDAPD RPPPRHQDTG PCLEKTPAEG RDSPTREPGA LPCACGQLPD
560 570 580 590 600
LEDELSLLDP LPRYLKSCQD LIVPEQCRCA DTRPGSEQPP LGGAASPEVL
610 620 630 640 650
APVSKEAADL APTGPSPRPG PGLLLDVCTK DLADAPAEEL QEKGSPAGPP
660 670 680 690 700
PSQGQPAARP PKEVPASRLA QQLREEGWNL QTSESLTLAE VYLMMGKPSK
710 720 730 740 750
LQLEYDWLGP GRQDPRPGSL PTALHKQRLL SCLLKLISTE VNPKLALEAN
760 770 780 790 800
TISTASVRPA QEEQSMTPPG KVVTVSSRSP RCPRNQASLR SSKTFPPSSA
810 820 830 840 850
PCSSGLRNPP RPLLVPGPSS TGSNDSDGGL FAVPTTLPPN SRHGKLFSPS
860 870 880 890 900
KEAELTFRQH LNSISMQSDF FLPKPRKLRN RHLRKPLVVQ RTLLPRPSEN
910 920 930 940 950
QSHNVCSFSI LSNSSVTGRG SFRPIQSSLT KAALSRPIVP KVLPPQATSH
960 970 980 990 1000
LASAIDLAAT SAGILSGNPL PALDTEGLSG ISPLSSDEVT GAISGQDSTG
1010 1020 1030 1040 1050
THQDGDTLPT VGGSDPFVSI PSRPEQEPVA DSFQGSSVLS LSELPKAPLQ
1060 1070 1080 1090 1100
NGLSIPLSSS ESSSTRLSPP DVSALLDISL PGPPEDALSQ GEPATHISDS
1110 1120 1130 1140 1150
IIEIAISSGQ YGEGVPLSPA KLNGSDSSKS LPSPSSSPQP HWIASPTHDP
1160 1170 1180 1190 1200
QWYPSDSTDS SLSSLFASFI SPEKSRKMLP TPIGTNSGTS LLGPSLLDGN
1210 1220 1230 1240 1250
SRDSFVSRSL ADVAEVVDSQ LVCMMNENSI DYISRFNDLA QELSIAEPGR
1260
REALFDGGGG GPAVSDLSQ
Length:1,269
Mass (Da):134,718
Last modified:October 5, 2010 - v3
Checksum:i16D630909A42618B
GO

Sequence cautioni

The sequence AAK61288 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAD38692 differs from that shown. Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti246G → D in BAA92664 (PubMed:10718198).Curated1
Sequence conflicti503L → S in BAA92664 (PubMed:10718198).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006639 Genomic DNA Translation: AAK61288.1 Sequence problems.
AL031009 Genomic DNA No translation available.
AL031708 Genomic DNA No translation available.
Z97652 Genomic DNA No translation available.
AL833832 mRNA Translation: CAD38692.1 Sequence problems.
AB037847 mRNA Translation: BAA92664.2
CCDSiCCDS10440.2
RefSeqiNP_065876.3, NM_020825.3
UniGeneiHs.513261
Hs.603676

Genome annotation databases

EnsembliENST00000293925; ENSP00000293925; ENSG00000007545
ENST00000397412; ENSP00000380559; ENSG00000007545
GeneIDi57585
KEGGihsa:57585
UCSCiuc010uvh.3 human

Similar proteinsi

Entry informationi

Entry nameiCRML_HUMAN
AccessioniPrimary (citable) accession number: Q96RY5
Secondary accession number(s): A8MZL1
, B1AJY1, Q8NDN1, Q9P2C1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 5, 2010
Last modified: July 18, 2018
This is version 128 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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