TRIB1

Functionⁱ

Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase (PubMed:27041596). The COP1-binding motif is masked by autoinhibitory interactions with the protein kinase domain (PubMed:26455797). Serves to alter COP1 substrate specificity by directing the activity of COP1 toward CEBPA (PubMed:27041596). Binds selectively the recognition sequence of CEBPA (PubMed:26455797). Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1-dependent manner (By similarity). Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity). Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity (PubMed:15299019, PubMed:26455797).By similarity1 Publication2 Publications

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

JNK cascade
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17452330
negative regulation of DNA-binding transcription factor activity
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 15299019
negative regulation of lipopolysaccharide-mediated signaling pathway
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17452330
negative regulation of neutrophil differentiation Source: Ensembl
negative regulation of protein kinase activity
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 15299019
negative regulation of smooth muscle cell migration
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17452330
negative regulation of smooth muscle cell proliferation
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17452330
positive regulation of eosinophil differentiation Source: Ensembl
positive regulation of macrophage differentiation Source: Ensembl
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 20410507
regulation of MAP kinase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 15299019
response to lipopolysaccharide
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17452330

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Protein kinase inhibitor

Molecular function

Protein kinase inhibitor

Enzyme and pathway databases

SignaLinkⁱ	Q96RU8

SignaLinkⁱ

Q96RU8

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tribbles homolog 1 Short name: TRB-1 Alternative name(s): G-protein-coupled receptor-induced gene 2 protein Short name: GIG-2 SKIP1
Gene namesⁱ	Name:TRIB1Imported Synonyms:C8FWImported, GIG2Imported, TRB1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 8

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000173334.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16891 TRIB1
MIMⁱ	609461 gene
neXtProtⁱ	NX_Q96RU8

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	355	D → A: Decreased interaction with COP1. 1 Publication	1
Mutagenesisⁱ	356	Q → A: Decreased interaction with COP1. 1 Publication	1
Mutagenesisⁱ	357	I → A: Decreased interaction with COP1. 1 Publication	1
Mutagenesisⁱ	358	V → I or A: Loss of interaction with COP1. 1 Publication	1
Mutagenesisⁱ	359	P → A: Strongly decreased interaction with COP1. 1 Publication	1
Mutagenesisⁱ	360	E → A: Decreased interaction with COP1. 1 Publication	1
Mutagenesisⁱ	361	Y → A: No effect on interaction with COP1. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10221
Open Targets More...OpenTargetsⁱ	ENSG00000173334
PharmGKBⁱ	PA134963922

Polymorphism and mutation databases

BioMutaⁱ	TRIB1
DMDMⁱ	83305929

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000131859	1 – 372	Tribbles homolog 1Add BLAST		372

Proteomic databases

EPDⁱ	Q96RU8
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96RU8
PaxDbⁱ	Q96RU8
PeptideAtlas More...PeptideAtlasⁱ	Q96RU8
PRIDEⁱ	Q96RU8
ProteomicsDBⁱ	78041

PTM databases

iPTMnetⁱ	Q96RU8
PhosphoSitePlusⁱ	Q96RU8

Expressionⁱ

Tissue specificityⁱ

Expressed in most human tissues with the highest levels in skeletal muscle, thyroid gland, pancreas, peripheral blood leukocytes, and bone marrow.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000173334 Expressed in 220 organ(s), highest expression level in thyroid gland
CleanExⁱ	HS_TRIB1
ExpressionAtlasⁱ	Q96RU8 baseline and differential
Genevisibleⁱ	Q96RU8 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA063982

HPAⁱ

HPA063982

Interactionⁱ

Subunit structureⁱ

Monomer (PubMed:26455797). Interacts (via protein kinase domain) with CEBPA (PubMed:20410507, PubMed:26455797). Interacts with COP1 (PubMed:20410507, PubMed:27041596).3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
CEBPA	P49715-1	2	EBI-16180744,EBI-16180754
STK40	Q8N2I9	2	EBI-492555,EBI-716112

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	115516, 23 interactors
Database of interacting proteins More...DIPⁱ	DIP-34542N
IntActⁱ	Q96RU8, 16 interactors
Molecular INTeraction database More...MINTⁱ	Q96RU8
STRINGⁱ	9606.ENSP00000312150

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	89 – 91	Combined sources	3
Beta strandⁱ	94 – 98	Combined sources	5
Beta strandⁱ	103 – 110	Combined sources	8
Turnⁱ	111 – 113	Combined sources	3
Beta strandⁱ	116 – 123	Combined sources	8
Helixⁱ	124 – 130	Combined sources	7
Helixⁱ	132 – 135	Combined sources	4
Beta strandⁱ	137 – 139	Combined sources	3
Turnⁱ	141 – 143	Combined sources	3
Beta strandⁱ	146 – 151	Combined sources	6
Beta strandⁱ	153 – 160	Combined sources	8
Helixⁱ	167 – 174	Combined sources	8
Helixⁱ	179 – 198	Combined sources	20
Helixⁱ	208 – 210	Combined sources	3
Beta strandⁱ	211 – 215	Combined sources	5
Beta strandⁱ	221 – 223	Combined sources	3
Beta strandⁱ	240 – 243	Combined sources	4
Helixⁱ	251 – 254	Combined sources	4
Helixⁱ	262 – 279	Combined sources	18
Helixⁱ	289 – 297	Combined sources	9
Beta strandⁱ	305 – 307	Combined sources	3
Helixⁱ	309 – 318	Combined sources	10
Helixⁱ	323 – 325	Combined sources	3
Helixⁱ	329 – 332	Combined sources	4
Helixⁱ	336 – 341	Combined sources	6
Beta strandⁱ	360 – 362	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q96RU8
SMRⁱ	Q96RU8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	1 – 338	Protein kinasePROSITE-ProRule annotationAdd BLAST		338

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	355 – 360	COP1-bindingBy similarity		6

Domainⁱ

The protein kinase active site is incompatible with ATP binding and is inactive (PubMed:26455797).1 Publication

The C-terminus (351-372) is required for interaction with COP1 (PubMed:27041596).1 Publication

The COP1-binding motif (355-360) is required for regulation activity (By similarity).By similarity

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0583 Eukaryota COG0515 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150878
HOGENOMⁱ	HOG000231872
HOVERGENⁱ	HBG067729
InParanoidⁱ	Q96RU8
KEGG Orthology (KO) More...KOⁱ	K08814
OMAⁱ	THGCPAY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G07JM
PhylomeDBⁱ	Q96RU8
TreeFamⁱ	TF329785

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR024105 TRB1 IPR024104 Tribbles/Ser_Thr_kinase_40
PANTHERⁱ	PTHR22961 PTHR22961, 1 hit PTHR22961:SF17 PTHR22961:SF17, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q96RU8-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRVGPVRSAM SGASQPRGPA LLFPATRGVP AKRLLDADDA AAVAAKCPRL 
        60         70         80         90        100
SECSSPPDYL SPPGSPCSPQ PPPAAPGAGG GSGSAPGPSR IADYLLLPLA 
       110        120        130        140        150
EREHVSRALC IHTGRELRCK VFPIKHYQDK IRPYIQLPSH SNITGIVEVI 
       160        170        180        190        200
LGETKAYVFF EKDFGDMHSY VRSRKRLREE EAARLFKQIV SAVAHCHQSA 
       210        220        230        240        250
IVLGDLKLRK FVFSTEERTQ LRLESLEDTH IMKGEDDALS DKHGCPAYVS 
       260        270        280        290        300
PEILNTTGTY SGKAADVWSL GVMLYTLLVG RYPFHDSDPS ALFSKIRRGQ 
       310        320        330        340        350
FCIPEHISPK ARCLIRSLLR REPSERLTAP EILLHPWFES VLEPGYIDSE 
       360        370 
IGTSDQIVPE YQEDSDISSF FC

Length:372

Mass (Da):41,009

Last modified:December 6, 2005 - v2

Checksum:ⁱ5F54E50924B1365B

GO

Isoform 2 (identifier: Q96RU8-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-166: Missing.

« Hide

        10         20         30         40         50
MHSYVRSRKR LREEEAARLF KQIVSAVAHC HQSAIVLGDL KLRKFVFSTE 
        60         70         80         90        100
ERTQLRLESL EDTHIMKGED DALSDKHGCP AYVSPEILNT TGTYSGKAAD 
       110        120        130        140        150
VWSLGVMLYT LLVGRYPFHD SDPSALFSKI RRGQFCIPEH ISPKARCLIR 
       160        170        180        190        200
SLLRREPSER LTAPEILLHP WFESVLEPGY IDSEIGTSDQ IVPEYQEDSD 

ISSFFC

Note: No experimental confirmation available.

Show »

Length:206

Mass (Da):23,473

Checksum:ⁱ0B6CE8BD11BBC895

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	E5RFH4	E5RFH4_HUMAN		Tribbles homolog 1 Tribbles homolog 1	TRIB1	141	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	149 – 150	VI → SV in CAA04119 (PubMed:9342215).Curated	2
Sequence conflictⁱ	163	D → S (PubMed:15299019).Curated	1
Sequence conflictⁱ	163	D → S (PubMed:9342215).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_042364	173	S → R1 PublicationCorresponds to variant dbSNP:rs56285697Ensembl.	1
Natural variantⁱVAR_042365	215	T → M1 PublicationCorresponds to variant dbSNP:rs34349706Ensembl.	1
Natural variantⁱVAR_042366	267	V → I1 PublicationCorresponds to variant dbSNP:rs56056430Ensembl.	1
Natural variantⁱVAR_042367	298	R → C1 PublicationCorresponds to variant dbSNP:rs55953723Ensembl.	1
Natural variantⁱVAR_042368	360	E → A1 PublicationCorresponds to variant dbSNP:rs35454769Ensembl.	1
Natural variantⁱVAR_042369	360	E → D1 PublicationCorresponds to variant dbSNP:rs16900603Ensembl.	1
Natural variantⁱVAR_042370	371	F → L in a lung large cell carcinoma sample; somatic mutation. 1 Publication	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_054894	1 – 166	Missing in isoform 2. 1 PublicationAdd BLAST		166

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF250310 mRNA Translation: AAK58174.1 AF205437 mRNA Translation: AAG35663.1 AK297539 mRNA Translation: BAG59938.1 AL832388 mRNA Translation: CAI46181.1 FJ515869 Genomic DNA Translation: ACS13752.1 AC091114 Genomic DNA No translation available. CH471060 Genomic DNA Translation: EAW92085.1 BC063292 mRNA Translation: AAH63292.1 AJ000480 mRNA Translation: CAA04119.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6357.1 [Q96RU8-1] CCDS64971.1 [Q96RU8-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001269914.1, NM_001282985.1 [Q96RU8-2] NP_079471.1, NM_025195.3 [Q96RU8-1]
UniGeneⁱ	Hs.444947

Genome annotation databases

Ensemblⁱ	ENST00000311922; ENSP00000312150; ENSG00000173334 [Q96RU8-1] ENST00000520847; ENSP00000429063; ENSG00000173334 [Q96RU8-2]
GeneIDⁱ	10221
KEGGⁱ	hsa:10221
UCSC genome browser More...UCSCⁱ	uc003yrx.4 human [Q96RU8-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q96RU8	Isoform 2 of Tribbles homolog 1		HUMAN		206	UniRef100_Q96RU8
Tribbles homolog 1		HUMAN		141

Protein	Similar proteins		Species	Score	Length	Source
Q96RU8	Tribbles homolog 1		MOUSE		372	UniRef90_Q96RU8
Isoform 2 of Tribbles homolog 1		HUMAN		206
tribbles homolog 1 isoform X1		NEOSC		375
tribbles homolog 1		URSMA		206
tribbles homolog 1 isoform X1		MESAU		373
+106

Protein	Similar proteins		Species	Score	Length	Source
Q96RU8	Tribbles homolog 1		MOUSE		372	UniRef50_Q96RU8
Isoform 2 of Tribbles homolog 1		HUMAN		206
tribbles homolog 1 isoform X1		NEOSC		375
tribbles homolog 1		URSMA		206
tribbles homolog 1 isoform X1		MESAU		373
+195

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF250310 mRNA Translation: AAK58174.1 AF205437 mRNA Translation: AAG35663.1 AK297539 mRNA Translation: BAG59938.1 AL832388 mRNA Translation: CAI46181.1 FJ515869 Genomic DNA Translation: ACS13752.1 AC091114 Genomic DNA No translation available. CH471060 Genomic DNA Translation: EAW92085.1 BC063292 mRNA Translation: AAH63292.1 AJ000480 mRNA Translation: CAA04119.1
CCDSⁱ	CCDS6357.1 [Q96RU8-1] CCDS64971.1 [Q96RU8-2]
RefSeqⁱ	NP_001269914.1, NM_001282985.1 [Q96RU8-2] NP_079471.1, NM_025195.3 [Q96RU8-1]
UniGeneⁱ	Hs.444947

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5CEK	X-ray	2.80	A	83-343	[»]
	5CEM	X-ray	2.10	A	83-371	[»]
	5IGO	X-ray	1.60	U/V/W/X	354-361	[»]
	5IGQ	X-ray	3.90	U	354-364	[»]
				V/W/X/Y/Z	354-361	[»]
ProteinModelPortalⁱ	Q96RU8
SMRⁱ	Q96RU8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115516, 23 interactors
DIPⁱ	DIP-34542N
IntActⁱ	Q96RU8, 16 interactors
MINTⁱ	Q96RU8
STRINGⁱ	9606.ENSP00000312150

PTM databases

iPTMnetⁱ	Q96RU8
PhosphoSitePlusⁱ	Q96RU8

Polymorphism and mutation databases

BioMutaⁱ	TRIB1
DMDMⁱ	83305929

Proteomic databases

EPDⁱ	Q96RU8
MaxQBⁱ	Q96RU8
PaxDbⁱ	Q96RU8
PeptideAtlasⁱ	Q96RU8
PRIDEⁱ	Q96RU8
ProteomicsDBⁱ	78041

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	10221
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000311922; ENSP00000312150; ENSG00000173334 [Q96RU8-1] ENST00000520847; ENSP00000429063; ENSG00000173334 [Q96RU8-2]
GeneIDⁱ	10221
KEGGⁱ	hsa:10221
UCSCⁱ	uc003yrx.4 human [Q96RU8-1]

Organism-specific databases

CTDⁱ	10221
DisGeNETⁱ	10221
EuPathDBⁱ	HostDB:ENSG00000173334.3
GeneCardsⁱ	TRIB1
HGNCⁱ	HGNC:16891 TRIB1
HPAⁱ	HPA063982
MIMⁱ	609461 gene
neXtProtⁱ	NX_Q96RU8
OpenTargetsⁱ	ENSG00000173334
PharmGKBⁱ	PA134963922
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0583 Eukaryota COG0515 LUCA
GeneTreeⁱ	ENSGT00930000150878
HOGENOMⁱ	HOG000231872
HOVERGENⁱ	HBG067729
InParanoidⁱ	Q96RU8
KOⁱ	K08814
OMAⁱ	THGCPAY
OrthoDBⁱ	EOG091G07JM
PhylomeDBⁱ	Q96RU8
TreeFamⁱ	TF329785

Enzyme and pathway databases

SignaLinkⁱ	Q96RU8

SignaLinkⁱ

Q96RU8

Miscellaneous databases

ChiTaRSⁱ	TRIB1 human
GeneWikiⁱ	TRIB1
GenomeRNAiⁱ	10221
Protein Ontology More...PROⁱ	PR:Q96RU8
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000173334 Expressed in 220 organ(s), highest expression level in thyroid gland
CleanExⁱ	HS_TRIB1
ExpressionAtlasⁱ	Q96RU8 baseline and differential
Genevisibleⁱ	Q96RU8 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR024105 TRB1 IPR024104 Tribbles/Ser_Thr_kinase_40
PANTHERⁱ	PTHR22961 PTHR22961, 1 hit PTHR22961:SF17 PTHR22961:SF17, 1 hit
Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50011 PROTEIN_KINASE_DOM, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TRIB1_HUMAN
Accessionⁱ	Q96RU8Primary (citable) accession number: Q96RU8 Secondary accession number(s): B4DMM6 , C5HU08, O15180, Q9H2Y8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
	Last sequence update:	December 6, 2005
	Last modified:	November 7, 2018
	This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM
Human and mouse protein kinases
Human and mouse protein kinases: classification and index

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UniProtKB - Q96RU8 (TRIB1_HUMAN)

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Tribbles homolog 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ