Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q96RU8 (TRIB1_HUMAN)

Entry version 162 (02 Jun 2021)
Sequence version 2 (06 Dec 2005)
Previous versions | rss
Add a publicationFeedback
Protein

Tribbles homolog 1

Gene

TRIB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase (PubMed:27041596).

The COP1-binding motif is masked by autoinhibitory interactions with the protein kinase domain (PubMed:26455797).

Serves to alter COP1 substrate specificity by directing the activity of COP1 toward CEBPA (PubMed:27041596).

Binds selectively the recognition sequence of CEBPA (PubMed:26455797).

Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1-dependent manner (By similarity).

Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity).

Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity (PubMed:15299019, PubMed:26455797).

By similarity1 Publication2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionProtein kinase inhibitor

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96RU8

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-9031628, NGF-stimulated transcription

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q96RU8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tribbles homolog 1
Short name:
TRB-1
Alternative name(s):
G-protein-coupled receptor-induced gene 2 protein
Short name:
GIG-2
SKIP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRIB1Imported
Synonyms:C8FWImported, GIG2Imported, TRB1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:16891, TRIB1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609461, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96RU8

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000173334.3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi355D → A: Decreased interaction with COP1. 1 Publication1
Mutagenesisi356Q → A: Decreased interaction with COP1. 1 Publication1
Mutagenesisi357I → A: Decreased interaction with COP1. 1 Publication1
Mutagenesisi358V → I or A: Loss of interaction with COP1. 1 Publication1
Mutagenesisi359P → A: Strongly decreased interaction with COP1. 1 Publication1
Mutagenesisi360E → A: Decreased interaction with COP1. 1 Publication1
Mutagenesisi361Y → A: No effect on interaction with COP1. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		10221

Open Targets

More...OpenTargetsi		ENSG00000173334

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134963922

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96RU8, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4524042

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TRIB1

Domain mapping of disease mutations (DMDM)

More...DMDMi		83305929

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001318591 – 372Tribbles homolog 1Add BLAST372

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96RU8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96RU8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96RU8

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96RU8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96RU8

PeptideAtlas

More...PeptideAtlasi		Q96RU8

PRoteomics IDEntifications database

More...PRIDEi		Q96RU8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		4625
78041 [Q96RU8-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96RU8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96RU8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in most human tissues with the highest levels in skeletal muscle, thyroid gland, pancreas, peripheral blood leukocytes, and bone marrow.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000173334, Expressed in thyroid gland and 236 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96RU8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96RU8, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000173334, Tissue enhanced (bone marrow, thyroid gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer (PubMed:26455797).

Interacts (via protein kinase domain) with CEBPA (PubMed:20410507, PubMed:26455797).

Interacts with COP1 (PubMed:20410507, PubMed:27041596).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115516, 30 interactors

Database of interacting proteins

More...DIPi		DIP-34542N

Protein interaction database and analysis system

More...IntActi		Q96RU8, 24 interactors

Molecular INTeraction database

More...MINTi		Q96RU8

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000312150

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96RU8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1372
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96RU8

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 338Protein kinasePROSITE-ProRule annotationAdd BLAST338

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 23DisorderedSequence analysisAdd BLAST23
Regioni52 – 86DisorderedSequence analysisAdd BLAST35

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi355 – 360COP1-bindingBy similarity6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi59 – 76Pro residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The protein kinase active site is incompatible with ATP binding and is inactive (PubMed:26455797).1 Publication
The C-terminus (351-372) is required for interaction with COP1 (PubMed:27041596).1 Publication
The COP1-binding motif (355-360) is required for regulation activity (By similarity).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0583, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182986

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000288_13_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96RU8

Identification of Orthologs from Complete Genome Data

More...OMAi		FFERDFG

Database of Orthologous Groups

More...OrthoDBi		1362510at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96RU8

TreeFam database of animal gene trees

More...TreeFami		TF329785

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR024105, TRB1
IPR024104, Tribbles/Ser_Thr_kinase_40

The PANTHER Classification System

More...PANTHERi		PTHR22961, PTHR22961, 1 hit
PTHR22961:SF17, PTHR22961:SF17, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50011, PROTEIN_KINASE_DOM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96RU8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRVGPVRSAM SGASQPRGPA LLFPATRGVP AKRLLDADDA AAVAAKCPRL 
        60         70         80         90        100
SECSSPPDYL SPPGSPCSPQ PPPAAPGAGG GSGSAPGPSR IADYLLLPLA 
       110        120        130        140        150
EREHVSRALC IHTGRELRCK VFPIKHYQDK IRPYIQLPSH SNITGIVEVI 
       160        170        180        190        200
LGETKAYVFF EKDFGDMHSY VRSRKRLREE EAARLFKQIV SAVAHCHQSA 
       210        220        230        240        250
IVLGDLKLRK FVFSTEERTQ LRLESLEDTH IMKGEDDALS DKHGCPAYVS 
       260        270        280        290        300
PEILNTTGTY SGKAADVWSL GVMLYTLLVG RYPFHDSDPS ALFSKIRRGQ 
       310        320        330        340        350
FCIPEHISPK ARCLIRSLLR REPSERLTAP EILLHPWFES VLEPGYIDSE 
       360        370 
IGTSDQIVPE YQEDSDISSF FC
Length:372
Mass (Da):41,009
Last modified:December 6, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5F54E50924B1365B
GO
Isoform 2 (identifier: Q96RU8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-166: Missing.

Show »
Length:206
Mass (Da):23,473
Checksum:i0B6CE8BD11BBC895
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RFH4E5RFH4_HUMAN
Tribbles homolog 1
TRIB1
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti149 – 150VI → SV in CAA04119 (PubMed:9342215).Curated2
Sequence conflicti163D → S (PubMed:15299019).Curated1
Sequence conflicti163D → S (PubMed:9342215).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_042364173S → R1 PublicationCorresponds to variant dbSNP:rs56285697Ensembl.1
Natural variantiVAR_042365215T → M1 PublicationCorresponds to variant dbSNP:rs34349706Ensembl.1
Natural variantiVAR_042366267V → I1 PublicationCorresponds to variant dbSNP:rs56056430Ensembl.1
Natural variantiVAR_042367298R → C1 PublicationCorresponds to variant dbSNP:rs55953723Ensembl.1
Natural variantiVAR_042368360E → A1 PublicationCorresponds to variant dbSNP:rs35454769Ensembl.1
Natural variantiVAR_042369360E → D1 PublicationCorresponds to variant dbSNP:rs16900603EnsemblClinVar.1
Natural variantiVAR_042370371F → L in a lung large cell carcinoma sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0548941 – 166Missing in isoform 2. 1 PublicationAdd BLAST166

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF250310 mRNA Translation: AAK58174.1
AF205437 mRNA Translation: AAG35663.1
AK297539 mRNA Translation: BAG59938.1
AL832388 mRNA Translation: CAI46181.1
FJ515869 Genomic DNA Translation: ACS13752.1
AC091114 Genomic DNA No translation available.
CH471060 Genomic DNA Translation: EAW92085.1
BC063292 mRNA Translation: AAH63292.1
AJ000480 mRNA Translation: CAA04119.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS6357.1 [Q96RU8-1]
CCDS64971.1 [Q96RU8-2]

NCBI Reference Sequences

More...RefSeqi		NP_001269914.1, NM_001282985.1 [Q96RU8-2]
NP_079471.1, NM_025195.3 [Q96RU8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000311922; ENSP00000312150; ENSG00000173334 [Q96RU8-1]
ENST00000520847; ENSP00000429063; ENSG00000173334 [Q96RU8-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10221

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10221

UCSC genome browser

More...UCSCi		uc003yrx.4, human [Q96RU8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF250310 mRNA Translation: AAK58174.1
AF205437 mRNA Translation: AAG35663.1
AK297539 mRNA Translation: BAG59938.1
AL832388 mRNA Translation: CAI46181.1
FJ515869 Genomic DNA Translation: ACS13752.1
AC091114 Genomic DNA No translation available.
CH471060 Genomic DNA Translation: EAW92085.1
BC063292 mRNA Translation: AAH63292.1
AJ000480 mRNA Translation: CAA04119.1
CCDSiCCDS6357.1 [Q96RU8-1]
CCDS64971.1 [Q96RU8-2]
RefSeqiNP_001269914.1, NM_001282985.1 [Q96RU8-2]
NP_079471.1, NM_025195.3 [Q96RU8-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5CEKX-ray2.80A83-343[»]
5CEMX-ray2.10A83-371[»]
5IGOX-ray1.60U/V/W/X354-361[»]
5IGQX-ray3.90U354-364[»]
V/W/X/Y/Z354-361[»]
6DC0X-ray2.80A/B90-343[»]
SMRiQ96RU8
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115516, 30 interactors
DIPiDIP-34542N
IntActiQ96RU8, 24 interactors
MINTiQ96RU8
STRINGi9606.ENSP00000312150

Chemistry databases

ChEMBLiCHEMBL4524042

PTM databases

iPTMnetiQ96RU8
PhosphoSitePlusiQ96RU8

Genetic variation databases

BioMutaiTRIB1
DMDMi83305929

Proteomic databases

EPDiQ96RU8
jPOSTiQ96RU8
MassIVEiQ96RU8
MaxQBiQ96RU8
PaxDbiQ96RU8
PeptideAtlasiQ96RU8
PRIDEiQ96RU8
ProteomicsDBi4625
78041 [Q96RU8-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		27210, 376 antibodies

The DNASU plasmid repository

More...DNASUi		10221

Genome annotation databases

EnsembliENST00000311922; ENSP00000312150; ENSG00000173334 [Q96RU8-1]
ENST00000520847; ENSP00000429063; ENSG00000173334 [Q96RU8-2]
GeneIDi10221
KEGGihsa:10221
UCSCiuc003yrx.4, human [Q96RU8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10221
DisGeNETi10221

GeneCards: human genes, protein and diseases

More...GeneCardsi		TRIB1
HGNCiHGNC:16891, TRIB1
HPAiENSG00000173334, Tissue enhanced (bone marrow, thyroid gland)
MIMi609461, gene
neXtProtiNX_Q96RU8
OpenTargetsiENSG00000173334
PharmGKBiPA134963922
VEuPathDBiHostDB:ENSG00000173334.3

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0583, Eukaryota
GeneTreeiENSGT00950000182986
HOGENOMiCLU_000288_13_1_1
InParanoidiQ96RU8
OMAiFFERDFG
OrthoDBi1362510at2759
PhylomeDBiQ96RU8
TreeFamiTF329785

Enzyme and pathway databases

PathwayCommonsiQ96RU8
ReactomeiR-HSA-9031628, NGF-stimulated transcription
SignaLinkiQ96RU8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10221, 29 hits in 1029 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TRIB1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TRIB1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10221
PharosiQ96RU8, Tbio

Protein Ontology

More...PROi		PR:Q96RU8
RNActiQ96RU8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000173334, Expressed in thyroid gland and 236 other tissues
ExpressionAtlasiQ96RU8, baseline and differential
GenevisibleiQ96RU8, HS

Family and domain databases

InterProiView protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR024105, TRB1
IPR024104, Tribbles/Ser_Thr_kinase_40
PANTHERiPTHR22961, PTHR22961, 1 hit
PTHR22961:SF17, PTHR22961:SF17, 1 hit
PfamiView protein in Pfam
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011, PROTEIN_KINASE_DOM, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRIB1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96RU8
Secondary accession number(s): B4DMM6
, C5HU08, O15180, Q9H2Y8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: June 2, 2021
This is version 162 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again