UniProtKB - Q96RU3 (FNBP1_HUMAN)
Formin-binding protein 1
FNBP1
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 166 | Mediates end-to-end attachment of dimers | 1 |
GO - Molecular functioni
- identical protein binding Source: IntAct
- lipid binding Source: UniProtKB-KW
GO - Biological processi
- endocytosis Source: UniProtKB-KW
- membrane organization Source: Reactome
- signal transduction Source: InterPro
Keywordsi
Biological process | Endocytosis |
Ligand | Lipid-binding |
Enzyme and pathway databases
PathwayCommonsi | Q96RU3 |
Reactomei | R-HSA-8856828, Clathrin-mediated endocytosis |
Names & Taxonomyi
Protein namesi | Recommended name: Formin-binding protein 1Alternative name(s): Formin-binding protein 17 Short name: hFBP17 |
Gene namesi | Name:FNBP1 Synonyms:FBP17, KIAA0554 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17069, FNBP1 |
MIMi | 606191, gene |
neXtProti | NX_Q96RU3 |
VEuPathDBi | HostDB:ENSG00000187239.16 |
Subcellular locationi
Cytoskeleton
Lysosome
Plasma membrane
Cytoplasm and Cytosol
Other locations
Note: Enriched in cortical regions coincident with F-actin. Also localizes to endocytic vesicles and lysosomes.
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Cytosol
- cytosol Source: Reactome
Lysosome
- lysosome Source: UniProtKB-SubCell
Plasma Membrane
- clathrin-coated pit Source: UniProtKB-SubCell
- plasma membrane Source: HPA
Other locations
- cell cortex Source: UniProtKB-SubCell
- cytoplasmic vesicle Source: UniProtKB-KW
- intracellular membrane-bounded organelle Source: HPA
Keywords - Cellular componenti
Cell membrane, Coated pit, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Lysosome, MembranePathology & Biotechi
Involvement in diseasei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 7 | L → E: Impairs membrane tubulation but does not affect lipid-binding. 1 Publication | 1 | |
Mutagenesisi | 33 | K → E: Abolishes membrane invagination. 2 Publications | 1 | |
Mutagenesisi | 33 | K → Q: Impairs lipid-binding and induction of membrane tubulation; when associated with Q-35. 2 Publications | 1 | |
Mutagenesisi | 35 | R → Q: Impairs lipid-binding and induction of membrane tubulation; when associated with Q-33. 1 Publication | 1 | |
Mutagenesisi | 51 – 52 | KK → QQ: Impairs lipid-binding and induction of membrane tubulation. 1 Publication | 2 | |
Mutagenesisi | 113 – 114 | RK → QQ: Impairs lipid-binding and induction of membrane tubulation. 1 Publication | 2 | |
Mutagenesisi | 165 | T → A: Abolishes membrane invagination. 1 Publication | 1 | |
Mutagenesisi | 166 | K → A: Abolishes membrane invagination. 1 Publication | 1 | |
Mutagenesisi | 168 | D → A, N or R: No significant effect. 1 Publication | 1 | |
Mutagenesisi | 210 | P → A: Disrupts helix kink and moderately increases diameter of the induced tubular membrane. 1 Publication | 1 | |
Mutagenesisi | 515 – 520 | Missing : Abrogates interaction with TNKS. 1 Publication | 6 | |
Mutagenesisi | 515 | R → A: Impairs interaction with TNKS. 1 Publication | 1 | |
Mutagenesisi | 519 | D → A: Impairs interaction with TNKS; when associated with A-515. 1 Publication | 1 | |
Mutagenesisi | 602 | P → L: Abrogates interaction with DNM1, DNM2 and DNM3. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 23048 |
OpenTargetsi | ENSG00000187239 |
PharmGKBi | PA128394597 |
Miscellaneous databases
Pharosi | Q96RU3, Tbio |
Genetic variation databases
BioMutai | FNBP1 |
DMDMi | 118572321 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000261430 | 1 – 617 | Formin-binding protein 1Add BLAST | 617 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 66 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 110 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 296 | PhosphoserineCombined sources | 1 | |
Modified residuei | 299 | PhosphoserineCombined sources | 1 | |
Modified residuei | 349 | PhosphoserineCombined sources | 1 | |
Modified residuei | 359 | PhosphoserineCombined sources | 1 | |
Modified residuei | 497 | PhosphoserineBy similarity | 1 | |
Modified residuei | 500 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 521 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q96RU3 |
jPOSTi | Q96RU3 |
MassIVEi | Q96RU3 |
MaxQBi | Q96RU3 |
PaxDbi | Q96RU3 |
PeptideAtlasi | Q96RU3 |
PRIDEi | Q96RU3 |
ProteomicsDBi | 20367 78035 [Q96RU3-1] 78036 [Q96RU3-2] 78037 [Q96RU3-3] 78038 [Q96RU3-4] |
PTM databases
iPTMneti | Q96RU3 |
MetOSitei | Q96RU3 |
PhosphoSitePlusi | Q96RU3 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000187239, Expressed in corpus callosum and 247 other tissues |
ExpressionAtlasi | Q96RU3, baseline and differential |
Genevisiblei | Q96RU3, HS |
Organism-specific databases
HPAi | ENSG00000187239, Low tissue specificity |
Interactioni
Subunit structurei
Interacts specifically with GTP-bound RND2 and CDC42.
Interacts with PDE6G and microtubules (By similarity). Homodimerizes, the dimers can polymerize end-to-end to form filamentous structures.
Interacts with AKAP9, ARHGAP17, DAAM1, DIAPH1, DIAPH2, DNM1, DNM2, DNM3, FASLG/FASL, SNX2 and WASL/N-WASP. May interact with TNKS.
By similarity11 PublicationsBinary interactionsi
Hide detailsQ96RU3
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 116686, 32 interactors |
DIPi | DIP-35355N |
ELMi | Q96RU3 |
IntActi | Q96RU3, 30 interactors |
MINTi | Q96RU3 |
STRINGi | 9606.ENSP00000413625 |
Miscellaneous databases
RNActi | Q96RU3, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q96RU3 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q96RU3 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 264 | F-BARPROSITE-ProRule annotationAdd BLAST | 264 | |
Domaini | 404 – 481 | REM-1PROSITE-ProRule annotationAdd BLAST | 78 | |
Domaini | 550 – 611 | SH3PROSITE-ProRule annotationAdd BLAST | 62 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 335 | Interaction with microtubulesBy similarityAdd BLAST | 335 | |
Regioni | 1 – 79 | Required for self-association and induction of membrane tubulationAdd BLAST | 79 | |
Regioni | 251 – 617 | Required for self-association and induction of membrane tubulationAdd BLAST | 367 | |
Regioni | 400 – 552 | Interaction with RND2By similarityAdd BLAST | 153 | |
Regioni | 495 – 617 | Interaction with PDE6GBy similarityAdd BLAST | 123 | |
Regioni | 514 – 617 | Required for interaction with TNKS1 PublicationAdd BLAST | 104 | |
Regioni | 535 – 617 | Interaction with DNM1 and DNM31 PublicationAdd BLAST | 83 | |
Regioni | 550 – 617 | Interaction with ARHGAP17, DAAM1, DIAPH1 and DIAPH22 PublicationsAdd BLAST | 68 | |
Regioni | 553 – 610 | Interaction with FASLGAdd BLAST | 58 | |
Regioni | 553 – 609 | Interaction with DNM2 and WASLAdd BLAST | 57 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 67 – 259 | 1 PublicationAdd BLAST | 193 | |
Coiled coili | 398 – 490 | By similarityAdd BLAST | 93 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 340 – 345 | Poly-Pro | 6 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coil, SH3 domainPhylogenomic databases
eggNOGi | KOG3565, Eukaryota |
GeneTreei | ENSGT00950000183047 |
InParanoidi | Q96RU3 |
OMAi | IPMNEGE |
OrthoDBi | 348563at2759 |
PhylomeDBi | Q96RU3 |
TreeFami | TF351162 |
Family and domain databases
CDDi | cd07676, F-BAR_FBP17, 1 hit |
Gene3Di | 1.20.1270.60, 1 hit |
InterProi | View protein in InterPro IPR027267, AH/BAR_dom_sf IPR031160, F_BAR IPR001060, FCH_dom IPR028532, FNBP1/FBP17 IPR037449, FNBP1_F-BAR IPR011072, HR1_rho-bd IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
PANTHERi | PTHR15735:SF13, PTHR15735:SF13, 1 hit |
Pfami | View protein in Pfam PF00611, FCH, 1 hit PF14604, SH3_9, 1 hit |
SMARTi | View protein in SMART SM00055, FCH, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF103657, SSF103657, 1 hit SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS51741, F_BAR, 1 hit PS51860, REM_1, 1 hit PS50002, SH3, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSWGTELWDQ FDNLEKHTQW GIDILEKYIK FVKERTEIEL SYAKQLRNLS
60 70 80 90 100
KKYQPKKNSK EEEEYKYTSC KAFISNLNEM NDYAGQHEVI SENMASQIIV
110 120 130 140 150
DLARYVQELK QERKSNFHDG RKAQQHIETC WKQLESSKRR FERDCKEADR
160 170 180 190 200
AQQYFEKMDA DINVTKADVE KARQQAQIRH QMAEDSKADY SSILQKFNHE
210 220 230 240 250
QHEYYHTHIP NIFQKIQEME ERRIVRMGES MKTYAEVDRQ VIPIIGKCLD
260 270 280 290 300
GIVKAAESID QKNDSQLVIE AYKSGFEPPG DIEFEDYTQP MKRTVSDNSL
310 320 330 340 350
SNSRGEGKPD LKFGGKSKGK LWPFIKKNKL MSLLTSPHQP PPPPPASASP
360 370 380 390 400
SAVPNGPQSP KQQKEPLSHR FNEFMTSKPK IHCFRSLKRG LSLKLGATPE
410 420 430 440 450
DFSNLPPEQR RKKLQQKVDE LNKEIQKEMD QRDAITKMKD VYLKNPQMGD
460 470 480 490 500
PASLDHKLAE VSQNIEKLRV ETQKFEAWLA EVEGRLPARS EQARRQSGLY
510 520 530 540 550
DSQNPPTVNN CAQDRESPDG SYTEEQSQES EMKVLATDFD DEFDDEEPLP
560 570 580 590 600
AIGTCKALYT FEGQNEGTIS VVEGETLYVI EEDKGDGWTR IRRNEDEEGY
610
VPTSYVEVCL DKNAKDS
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB7ZL14 | B7ZL14_HUMAN | FNBP1 protein | FNBP1 | 551 | Annotation score: | ||
H0Y7W6 | H0Y7W6_HUMAN | Formin-binding protein 1 | FNBP1 | 568 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 388 | K → E in BAA91451 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_029388 | 490 | S → N1 PublicationCorresponds to variant dbSNP:rs1023000Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_021693 | 329 – 394 | Missing in isoform 4. 1 PublicationAdd BLAST | 66 | |
Alternative sequenceiVSP_021694 | 330 – 358 | Missing in isoform 3. 1 PublicationAdd BLAST | 29 | |
Alternative sequenceiVSP_021695 | 391 – 395 | Missing in isoform 2 and isoform 5. 2 Publications | 5 | |
Alternative sequenceiVSP_021696 | 616 – 617 | DS → GAKTYI in isoform 2 and isoform 3. 1 Publication | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF265550 mRNA Translation: AAK49824.1 Different initiation. AB011126 mRNA Translation: BAA25480.1 Different initiation. AK000975 mRNA Translation: BAA91451.1 Different initiation. AK023681 mRNA Translation: BAB14638.1 AL136141 Genomic DNA No translation available. AL158207 Genomic DNA No translation available. BC062463 mRNA Translation: AAH62463.1 Sequence problems. BC101755 mRNA Translation: AAI01756.1 BC143513 mRNA Translation: AAI43514.1 |
CCDSi | CCDS48040.1 [Q96RU3-1] CCDS87699.1 [Q96RU3-3] |
RefSeqi | NP_055848.1, NM_015033.2 [Q96RU3-1] XP_005251880.1, XM_005251823.2 [Q96RU3-2] XP_005251881.1, XM_005251824.2 [Q96RU3-5] XP_005251886.1, XM_005251829.2 |
Genome annotation databases
Ensembli | ENST00000355681; ENSP00000347907; ENSG00000187239 [Q96RU3-3] ENST00000420781; ENSP00000407548; ENSG00000187239 [Q96RU3-5] ENST00000446176; ENSP00000413625; ENSG00000187239 [Q96RU3-1] |
GeneIDi | 23048 |
KEGGi | hsa:23048 |
UCSCi | uc004byw.2, human [Q96RU3-1] |
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF265550 mRNA Translation: AAK49824.1 Different initiation. AB011126 mRNA Translation: BAA25480.1 Different initiation. AK000975 mRNA Translation: BAA91451.1 Different initiation. AK023681 mRNA Translation: BAB14638.1 AL136141 Genomic DNA No translation available. AL158207 Genomic DNA No translation available. BC062463 mRNA Translation: AAH62463.1 Sequence problems. BC101755 mRNA Translation: AAI01756.1 BC143513 mRNA Translation: AAI43514.1 |
CCDSi | CCDS48040.1 [Q96RU3-1] CCDS87699.1 [Q96RU3-3] |
RefSeqi | NP_055848.1, NM_015033.2 [Q96RU3-1] XP_005251880.1, XM_005251823.2 [Q96RU3-2] XP_005251881.1, XM_005251824.2 [Q96RU3-5] XP_005251886.1, XM_005251829.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2EFL | X-ray | 2.61 | A | 1-300 | [»] | |
SMRi | Q96RU3 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116686, 32 interactors |
DIPi | DIP-35355N |
ELMi | Q96RU3 |
IntActi | Q96RU3, 30 interactors |
MINTi | Q96RU3 |
STRINGi | 9606.ENSP00000413625 |
PTM databases
iPTMneti | Q96RU3 |
MetOSitei | Q96RU3 |
PhosphoSitePlusi | Q96RU3 |
Genetic variation databases
BioMutai | FNBP1 |
DMDMi | 118572321 |
Proteomic databases
EPDi | Q96RU3 |
jPOSTi | Q96RU3 |
MassIVEi | Q96RU3 |
MaxQBi | Q96RU3 |
PaxDbi | Q96RU3 |
PeptideAtlasi | Q96RU3 |
PRIDEi | Q96RU3 |
ProteomicsDBi | 20367 78035 [Q96RU3-1] 78036 [Q96RU3-2] 78037 [Q96RU3-3] 78038 [Q96RU3-4] |
Protocols and materials databases
Antibodypediai | 31452, 188 antibodies |
Genome annotation databases
Ensembli | ENST00000355681; ENSP00000347907; ENSG00000187239 [Q96RU3-3] ENST00000420781; ENSP00000407548; ENSG00000187239 [Q96RU3-5] ENST00000446176; ENSP00000413625; ENSG00000187239 [Q96RU3-1] |
GeneIDi | 23048 |
KEGGi | hsa:23048 |
UCSCi | uc004byw.2, human [Q96RU3-1] |
Organism-specific databases
CTDi | 23048 |
DisGeNETi | 23048 |
GeneCardsi | FNBP1 |
HGNCi | HGNC:17069, FNBP1 |
HPAi | ENSG00000187239, Low tissue specificity |
MIMi | 606191, gene |
neXtProti | NX_Q96RU3 |
OpenTargetsi | ENSG00000187239 |
PharmGKBi | PA128394597 |
VEuPathDBi | HostDB:ENSG00000187239.16 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3565, Eukaryota |
GeneTreei | ENSGT00950000183047 |
InParanoidi | Q96RU3 |
OMAi | IPMNEGE |
OrthoDBi | 348563at2759 |
PhylomeDBi | Q96RU3 |
TreeFami | TF351162 |
Enzyme and pathway databases
PathwayCommonsi | Q96RU3 |
Reactomei | R-HSA-8856828, Clathrin-mediated endocytosis |
Miscellaneous databases
BioGRID-ORCSi | 23048, 12 hits in 994 CRISPR screens |
ChiTaRSi | FNBP1, human |
EvolutionaryTracei | Q96RU3 |
GeneWikii | FNBP1 |
GenomeRNAii | 23048 |
Pharosi | Q96RU3, Tbio |
PROi | PR:Q96RU3 |
RNActi | Q96RU3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000187239, Expressed in corpus callosum and 247 other tissues |
ExpressionAtlasi | Q96RU3, baseline and differential |
Genevisiblei | Q96RU3, HS |
Family and domain databases
CDDi | cd07676, F-BAR_FBP17, 1 hit |
Gene3Di | 1.20.1270.60, 1 hit |
InterProi | View protein in InterPro IPR027267, AH/BAR_dom_sf IPR031160, F_BAR IPR001060, FCH_dom IPR028532, FNBP1/FBP17 IPR037449, FNBP1_F-BAR IPR011072, HR1_rho-bd IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
PANTHERi | PTHR15735:SF13, PTHR15735:SF13, 1 hit |
Pfami | View protein in Pfam PF00611, FCH, 1 hit PF14604, SH3_9, 1 hit |
SMARTi | View protein in SMART SM00055, FCH, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF103657, SSF103657, 1 hit SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS51741, F_BAR, 1 hit PS51860, REM_1, 1 hit PS50002, SH3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FNBP1_HUMAN | |
Accessioni | Q96RU3Primary (citable) accession number: Q96RU3 Secondary accession number(s): B7ZL12 Q9NWD1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 28, 2006 |
Last sequence update: | November 28, 2006 | |
Last modified: | April 7, 2021 | |
This is version 164 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families