FNBP1

Functionⁱ

May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL.By similarity5 Publications

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	166	Mediates end-to-end attachment of dimers		1

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

endocytosis Source: UniProtKB-KW
membrane organization Source: Reactome
signal transduction Source: InterPro

Complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Endocytosis
Ligand	Lipid-binding

Enzyme and pathway databases

PathwayCommonsⁱ	Q96RU3
Reactomeⁱ	R-HSA-8856828, Clathrin-mediated endocytosis

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Formin-binding protein 1 Alternative name(s): Formin-binding protein 17 Short name: hFBP17
Gene namesⁱ	Name:FNBP1 Synonyms:FBP17, KIAA0554
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17069, FNBP1
MIMⁱ	606191, gene
neXtProtⁱ	NX_Q96RU3
VEuPathDBⁱ	HostDB:ENSG00000187239.16

Keywords - Cellular componentⁱ

Cell membrane, Coated pit, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Lysosome, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

A chromosomal aberration involving FNBP1 is found in acute leukemias. Translocation t(9;11)(q34;q23) with KMT2A/MLL1. The relatively low incidence of the KMT2A/MLL1-FNBP1 fusion protein in acute leukemia may reflect the marginal capacity of this fusion protein to induce cellular transformation.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	7	L → E: Impairs membrane tubulation but does not affect lipid-binding. 1 Publication	1
Mutagenesisⁱ	33	K → E: Abolishes membrane invagination. 2 Publications	1
Mutagenesisⁱ	33	K → Q: Impairs lipid-binding and induction of membrane tubulation; when associated with Q-35. 2 Publications	1
Mutagenesisⁱ	35	R → Q: Impairs lipid-binding and induction of membrane tubulation; when associated with Q-33. 1 Publication	1
Mutagenesisⁱ	51 – 52	KK → QQ: Impairs lipid-binding and induction of membrane tubulation. 1 Publication	2
Mutagenesisⁱ	113 – 114	RK → QQ: Impairs lipid-binding and induction of membrane tubulation. 1 Publication	2
Mutagenesisⁱ	165	T → A: Abolishes membrane invagination. 1 Publication	1
Mutagenesisⁱ	166	K → A: Abolishes membrane invagination. 1 Publication	1
Mutagenesisⁱ	168	D → A, N or R: No significant effect. 1 Publication	1
Mutagenesisⁱ	210	P → A: Disrupts helix kink and moderately increases diameter of the induced tubular membrane. 1 Publication	1
Mutagenesisⁱ	515 – 520	Missing : Abrogates interaction with TNKS. 1 Publication	6
Mutagenesisⁱ	515	R → A: Impairs interaction with TNKS. 1 Publication	1
Mutagenesisⁱ	519	D → A: Impairs interaction with TNKS; when associated with A-515. 1 Publication	1
Mutagenesisⁱ	602	P → L: Abrogates interaction with DNM1, DNM2 and DNM3. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	23048
Open Targets More...OpenTargetsⁱ	ENSG00000187239
PharmGKBⁱ	PA128394597

Miscellaneous databases

Pharosⁱ	Q96RU3, Tbio

Pharosⁱ

Q96RU3, Tbio

Genetic variation databases

BioMutaⁱ	FNBP1
DMDMⁱ	118572321

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000261430	1 – 617	Formin-binding protein 1Add BLAST		617

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	66	N6-acetyllysineCombined sources	1
Modified residueⁱ	110	N6-acetyllysineCombined sources	1
Modified residueⁱ	296	PhosphoserineCombined sources	1
Modified residueⁱ	299	PhosphoserineCombined sources	1
Modified residueⁱ	349	PhosphoserineCombined sources	1
Modified residueⁱ	359	PhosphoserineCombined sources	1
Modified residueⁱ	497	PhosphoserineBy similarity	1
Modified residueⁱ	500	PhosphotyrosineBy similarity	1
Modified residueⁱ	521	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q96RU3
jPOSTⁱ	Q96RU3
MassIVEⁱ	Q96RU3
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96RU3
PaxDbⁱ	Q96RU3
PeptideAtlas More...PeptideAtlasⁱ	Q96RU3
PRIDEⁱ	Q96RU3
ProteomicsDBⁱ	20367 78035 [Q96RU3-1] 78036 [Q96RU3-2] 78037 [Q96RU3-3] 78038 [Q96RU3-4]

PTM databases

iPTMnetⁱ	Q96RU3
MetOSiteⁱ	Q96RU3
PhosphoSitePlusⁱ	Q96RU3

Expressionⁱ

Tissue specificityⁱ

Very highly expressed in the epithelial cells of the gastrointestinal tract, respiratory, reproductive and urinary systems. Also highly expressed in brown adipose tissue, cardiomyocytes, enteric ganglia and glucagon producing cells of the pancreas. Expressed in germ cells of the testis and all regions of the brain.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000187239, Expressed in corpus callosum and 247 other tissues
ExpressionAtlasⁱ	Q96RU3, baseline and differential
Genevisibleⁱ	Q96RU3, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000187239, Low tissue specificity

HPAⁱ

ENSG00000187239, Low tissue specificity

Interactionⁱ

Subunit structureⁱ

Interacts specifically with GTP-bound RND2 and CDC42.

Interacts with PDE6G and microtubules (By similarity). Homodimerizes, the dimers can polymerize end-to-end to form filamentous structures.

Interacts with AKAP9, ARHGAP17, DAAM1, DIAPH1, DIAPH2, DNM1, DNM2, DNM3, FASLG/FASL, SNX2 and WASL/N-WASP. May interact with TNKS.

By similarity11 Publications

Binary interactionsⁱ

Hide details

Q96RU3

With	#Exp.	IntAct
DNM1 [Q05193]	5	EBI-1111248,EBI-713135
FASLG [P48023]	4	EBI-1111248,EBI-495538
itself	3	EBI-1111248,EBI-1111248
GABARAP [O95166]	2	EBI-1111248,EBI-712001
SNX2 [O60749]	4	EBI-1111248,EBI-1046690
TNKS [O95271]	4	EBI-1111248,EBI-1105254
Inpp5d [P97573] from Rattus norvegicus.	2	EBI-1111248,EBI-8008869

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- Ref.10
  "A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis."
  Kamioka Y., Fukuhara S., Sawa H., Nagashima K., Masuda M., Matsuda M., Mochizuki N.
  J. Biol. Chem. 279:40091-40099(2004) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, SELF-ASSOCIATION, INTERACTION WITH DNM1; DNM2 AND DNM3, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF PRO-602.
- Ref.27
  "Curved EFC/F-BAR-domain dimers are joined end to end into a filament for membrane invagination in endocytosis."
  Shimada A., Niwa H., Tsujita K., Suetsugu S., Nitta K., Hanawa-Suetsugu K., Akasaka R., Nishino Y., Toyama M., Chen L., Liu Z.-J., Wang B.C., Yamamoto M., Terada T., Miyazawa A., Tanaka A., Sugano S., Shirouzu M.
  , Nagayama K., Takenawa T., Yokoyama S.
  Cell 129:761-772(2007) [PubMed] [Europe PMC] [Abstract]
  Cited for: X-RAY CRYSTALLOGRAPHY (2.61 ANGSTROMS) OF 1-300, FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, DOMAIN F-BAR, COILED-COIL DOMAIN, MUTAGENESIS OF LYS-33; THR-165; LYS-166; ASP-168 AND PRO-210.

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	116686, 32 interactors
Database of interacting proteins More...DIPⁱ	DIP-35355N
ELMⁱ	Q96RU3
IntActⁱ	Q96RU3, 30 interactors
Molecular INTeraction database More...MINTⁱ	Q96RU3
STRINGⁱ	9606.ENSP00000413625

Miscellaneous databases

RNActⁱ	Q96RU3, protein

RNActⁱ

Q96RU3, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	3 – 6	Combined sources	4
Turnⁱ	7 – 9	Combined sources	3
Helixⁱ	11 – 52	Combined sources	42
Helixⁱ	68 – 160	Combined sources	93
Helixⁱ	166 – 206	Combined sources	41
Helixⁱ	208 – 238	Combined sources	31
Helixⁱ	241 – 257	Combined sources	17
Helixⁱ	261 – 272	Combined sources	12

Show more details

3D structure databases

SMRⁱ	Q96RU3
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q96RU3

EvolutionaryTraceⁱ

Q96RU3

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	1 – 264	F-BARPROSITE-ProRule annotationAdd BLAST	264
Domainⁱ	404 – 481	REM-1PROSITE-ProRule annotationAdd BLAST	78
Domainⁱ	550 – 611	SH3PROSITE-ProRule annotationAdd BLAST	62

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	1 – 335	Interaction with microtubulesBy similarityAdd BLAST	335
Regionⁱ	1 – 79	Required for self-association and induction of membrane tubulationAdd BLAST	79
Regionⁱ	251 – 617	Required for self-association and induction of membrane tubulationAdd BLAST	367
Regionⁱ	400 – 552	Interaction with RND2By similarityAdd BLAST	153
Regionⁱ	495 – 617	Interaction with PDE6GBy similarityAdd BLAST	123
Regionⁱ	514 – 617	Required for interaction with TNKS1 PublicationAdd BLAST	104
Regionⁱ	535 – 617	Interaction with DNM1 and DNM31 PublicationAdd BLAST	83
Regionⁱ	550 – 617	Interaction with ARHGAP17, DAAM1, DIAPH1 and DIAPH22 PublicationsAdd BLAST	68
Regionⁱ	553 – 610	Interaction with FASLGAdd BLAST	58
Regionⁱ	553 – 609	Interaction with DNM2 and WASLAdd BLAST	57

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	67 – 259	1 PublicationAdd BLAST		193
Coiled coilⁱ	398 – 490	By similarityAdd BLAST		93

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	340 – 345	Poly-Pro		6

Domainⁱ

The F-BAR domain binds the phospholipid membrane with its concave surface. The end-to-end polymerization of dimers of these domains provides a curved surface that fits best membranes with around 600 A diameter, and may drive tubulation.1 Publication

Sequence similaritiesⁱ

Belongs to the FNBP1 family.Curated

Keywords - Domainⁱ

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGⁱ	KOG3565, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00950000183047
InParanoidⁱ	Q96RU3
OMAⁱ	IPMNEGE
Database of Orthologous Groups More...OrthoDBⁱ	348563at2759
PhylomeDBⁱ	Q96RU3
TreeFamⁱ	TF351162

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07676, F-BAR_FBP17, 1 hit
Gene3Dⁱ	1.20.1270.60, 1 hit
InterProⁱ	View protein in InterPro IPR027267, AH/BAR_dom_sf IPR031160, F_BAR IPR001060, FCH_dom IPR028532, FNBP1/FBP17 IPR037449, FNBP1_F-BAR IPR011072, HR1_rho-bd IPR036028, SH3-like_dom_sf IPR001452, SH3_domain
PANTHERⁱ	PTHR15735:SF13, PTHR15735:SF13, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00611, FCH, 1 hit PF14604, SH3_9, 1 hit
SMARTⁱ	View protein in SMART SM00055, FCH, 1 hit SM00326, SH3, 1 hit
SUPFAMⁱ	SSF103657, SSF103657, 1 hit SSF50044, SSF50044, 1 hit
PROSITEⁱ	View protein in PROSITE PS51741, F_BAR, 1 hit PS51860, REM_1, 1 hit PS50002, SH3, 1 hit

Sequences (5+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 5 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q96RU3-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSWGTELWDQ FDNLEKHTQW GIDILEKYIK FVKERTEIEL SYAKQLRNLS 
        60         70         80         90        100
KKYQPKKNSK EEEEYKYTSC KAFISNLNEM NDYAGQHEVI SENMASQIIV 
       110        120        130        140        150
DLARYVQELK QERKSNFHDG RKAQQHIETC WKQLESSKRR FERDCKEADR 
       160        170        180        190        200
AQQYFEKMDA DINVTKADVE KARQQAQIRH QMAEDSKADY SSILQKFNHE 
       210        220        230        240        250
QHEYYHTHIP NIFQKIQEME ERRIVRMGES MKTYAEVDRQ VIPIIGKCLD 
       260        270        280        290        300
GIVKAAESID QKNDSQLVIE AYKSGFEPPG DIEFEDYTQP MKRTVSDNSL 
       310        320        330        340        350
SNSRGEGKPD LKFGGKSKGK LWPFIKKNKL MSLLTSPHQP PPPPPASASP 
       360        370        380        390        400
SAVPNGPQSP KQQKEPLSHR FNEFMTSKPK IHCFRSLKRG LSLKLGATPE 
       410        420        430        440        450
DFSNLPPEQR RKKLQQKVDE LNKEIQKEMD QRDAITKMKD VYLKNPQMGD 
       460        470        480        490        500
PASLDHKLAE VSQNIEKLRV ETQKFEAWLA EVEGRLPARS EQARRQSGLY 
       510        520        530        540        550
DSQNPPTVNN CAQDRESPDG SYTEEQSQES EMKVLATDFD DEFDDEEPLP 
       560        570        580        590        600
AIGTCKALYT FEGQNEGTIS VVEGETLYVI EEDKGDGWTR IRRNEDEEGY 
       610 
VPTSYVEVCL DKNAKDS

Length:617

Mass (Da):71,307

Last modified:November 28, 2006 - v2

Checksum:ⁱF06E847C6E631EC3

GO

Isoform 2 (identifier: Q96RU3-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
391-395: Missing.
616-617: DS → GAKTYI

« Hide

        10         20         30         40         50
MSWGTELWDQ FDNLEKHTQW GIDILEKYIK FVKERTEIEL SYAKQLRNLS 
        60         70         80         90        100
KKYQPKKNSK EEEEYKYTSC KAFISNLNEM NDYAGQHEVI SENMASQIIV 
       110        120        130        140        150
DLARYVQELK QERKSNFHDG RKAQQHIETC WKQLESSKRR FERDCKEADR 
       160        170        180        190        200
AQQYFEKMDA DINVTKADVE KARQQAQIRH QMAEDSKADY SSILQKFNHE 
       210        220        230        240        250
QHEYYHTHIP NIFQKIQEME ERRIVRMGES MKTYAEVDRQ VIPIIGKCLD 
       260        270        280        290        300
GIVKAAESID QKNDSQLVIE AYKSGFEPPG DIEFEDYTQP MKRTVSDNSL 
       310        320        330        340        350
SNSRGEGKPD LKFGGKSKGK LWPFIKKNKL MSLLTSPHQP PPPPPASASP 
       360        370        380        390        400
SAVPNGPQSP KQQKEPLSHR FNEFMTSKPK IHCFRSLKRG GATPEDFSNL 
       410        420        430        440        450
PPEQRRKKLQ QKVDELNKEI QKEMDQRDAI TKMKDVYLKN PQMGDPASLD 
       460        470        480        490        500
HKLAEVSQNI EKLRVETQKF EAWLAEVEGR LPARSEQARR QSGLYDSQNP 
       510        520        530        540        550
PTVNNCAQDR ESPDGSYTEE QSQESEMKVL ATDFDDEFDD EEPLPAIGTC 
       560        570        580        590        600
KALYTFEGQN EGTISVVEGE TLYVIEEDKG DGWTRIRRNE DEEGYVPTSY 
       610 
VEVCLDKNAK GAKTYI

Show »

Length:616

Mass (Da):71,184

Checksum:ⁱE82282A5164793B3

GO

Isoform 3 (identifier: Q96RU3-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
330-358: Missing.
616-617: DS → GAKTYI

« Hide

        10         20         30         40         50
MSWGTELWDQ FDNLEKHTQW GIDILEKYIK FVKERTEIEL SYAKQLRNLS 
        60         70         80         90        100
KKYQPKKNSK EEEEYKYTSC KAFISNLNEM NDYAGQHEVI SENMASQIIV 
       110        120        130        140        150
DLARYVQELK QERKSNFHDG RKAQQHIETC WKQLESSKRR FERDCKEADR 
       160        170        180        190        200
AQQYFEKMDA DINVTKADVE KARQQAQIRH QMAEDSKADY SSILQKFNHE 
       210        220        230        240        250
QHEYYHTHIP NIFQKIQEME ERRIVRMGES MKTYAEVDRQ VIPIIGKCLD 
       260        270        280        290        300
GIVKAAESID QKNDSQLVIE AYKSGFEPPG DIEFEDYTQP MKRTVSDNSL 
       310        320        330        340        350
SNSRGEGKPD LKFGGKSKGK LWPFIKKNKS PKQQKEPLSH RFNEFMTSKP 
       360        370        380        390        400
KIHCFRSLKR GLSLKLGATP EDFSNLPPEQ RRKKLQQKVD ELNKEIQKEM 
       410        420        430        440        450
DQRDAITKMK DVYLKNPQMG DPASLDHKLA EVSQNIEKLR VETQKFEAWL 
       460        470        480        490        500
AEVEGRLPAR SEQARRQSGL YDSQNPPTVN NCAQDRESPD GSYTEEQSQE 
       510        520        530        540        550
SEMKVLATDF DDEFDDEEPL PAIGTCKALY TFEGQNEGTI SVVEGETLYV 
       560        570        580        590 
IEEDKGDGWT RIRRNEDEEG YVPTSYVEVC LDKNAKGAKT YI

Show »

Length:592

Mass (Da):68,883

Checksum:ⁱ0CB6B44D9E174667

GO

Isoform 4 (identifier: Q96RU3-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
329-394: Missing.

« Hide

        10         20         30         40         50
MSWGTELWDQ FDNLEKHTQW GIDILEKYIK FVKERTEIEL SYAKQLRNLS 
        60         70         80         90        100
KKYQPKKNSK EEEEYKYTSC KAFISNLNEM NDYAGQHEVI SENMASQIIV 
       110        120        130        140        150
DLARYVQELK QERKSNFHDG RKAQQHIETC WKQLESSKRR FERDCKEADR 
       160        170        180        190        200
AQQYFEKMDA DINVTKADVE KARQQAQIRH QMAEDSKADY SSILQKFNHE 
       210        220        230        240        250
QHEYYHTHIP NIFQKIQEME ERRIVRMGES MKTYAEVDRQ VIPIIGKCLD 
       260        270        280        290        300
GIVKAAESID QKNDSQLVIE AYKSGFEPPG DIEFEDYTQP MKRTVSDNSL 
       310        320        330        340        350
SNSRGEGKPD LKFGGKSKGK LWPFIKKNLG ATPEDFSNLP PEQRRKKLQQ 
       360        370        380        390        400
KVDELNKEIQ KEMDQRDAIT KMKDVYLKNP QMGDPASLDH KLAEVSQNIE 
       410        420        430        440        450
KLRVETQKFE AWLAEVEGRL PARSEQARRQ SGLYDSQNPP TVNNCAQDRE 
       460        470        480        490        500
SPDGSYTEEQ SQESEMKVLA TDFDDEFDDE EPLPAIGTCK ALYTFEGQNE 
       510        520        530        540        550
GTISVVEGET LYVIEEDKGD GWTRIRRNED EEGYVPTSYV EVCLDKNAKD 

S

Show »

Length:551

Mass (Da):64,056

Checksum:ⁱBA7F73CA1A28A467

GO

Isoform 5 (identifier: Q96RU3-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
391-395: Missing.

« Hide

        10         20         30         40         50
MSWGTELWDQ FDNLEKHTQW GIDILEKYIK FVKERTEIEL SYAKQLRNLS 
        60         70         80         90        100
KKYQPKKNSK EEEEYKYTSC KAFISNLNEM NDYAGQHEVI SENMASQIIV 
       110        120        130        140        150
DLARYVQELK QERKSNFHDG RKAQQHIETC WKQLESSKRR FERDCKEADR 
       160        170        180        190        200
AQQYFEKMDA DINVTKADVE KARQQAQIRH QMAEDSKADY SSILQKFNHE 
       210        220        230        240        250
QHEYYHTHIP NIFQKIQEME ERRIVRMGES MKTYAEVDRQ VIPIIGKCLD 
       260        270        280        290        300
GIVKAAESID QKNDSQLVIE AYKSGFEPPG DIEFEDYTQP MKRTVSDNSL 
       310        320        330        340        350
SNSRGEGKPD LKFGGKSKGK LWPFIKKNKL MSLLTSPHQP PPPPPASASP 
       360        370        380        390        400
SAVPNGPQSP KQQKEPLSHR FNEFMTSKPK IHCFRSLKRG GATPEDFSNL 
       410        420        430        440        450
PPEQRRKKLQ QKVDELNKEI QKEMDQRDAI TKMKDVYLKN PQMGDPASLD 
       460        470        480        490        500
HKLAEVSQNI EKLRVETQKF EAWLAEVEGR LPARSEQARR QSGLYDSQNP 
       510        520        530        540        550
PTVNNCAQDR ESPDGSYTEE QSQESEMKVL ATDFDDEFDD EEPLPAIGTC 
       560        570        580        590        600
KALYTFEGQN EGTISVVEGE TLYVIEEDKG DGWTRIRRNE DEEGYVPTSY 
       610 
VEVCLDKNAK DS

Show »

Length:612

Mass (Da):70,752

Checksum:ⁱ9E2543B3EDF09004

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B7ZL14	B7ZL14_HUMAN	FNBP1 protein FNBP1 protein (Formin-binding protein 1)	FNBP1	551	Annotation score:
H0Y7W6	H0Y7W6_HUMAN	Formin-binding protein 1 Formin-binding protein 1	FNBP1	568	Annotation score:

Sequence cautionⁱ

The sequence AAH62463 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

The sequence AAK49824 differs from that shown. Reason: Erroneous initiation.Curated

The sequence BAA25480 differs from that shown. Reason: Erroneous initiation.Curated

The sequence BAA91451 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	388	K → E in BAA91451 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_029388	490	S → N1 PublicationCorresponds to variant dbSNP:rs1023000Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_021693	329 – 394	Missing in isoform 4. 1 PublicationAdd BLAST	66
Alternative sequenceⁱVSP_021694	330 – 358	Missing in isoform 3. 1 PublicationAdd BLAST	29
Alternative sequenceⁱVSP_021695	391 – 395	Missing in isoform 2 and isoform 5. 2 Publications	5
Alternative sequenceⁱVSP_021696	616 – 617	DS → GAKTYI in isoform 2 and isoform 3. 1 Publication	2

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF265550 mRNA Translation: AAK49824.1 Different initiation. AB011126 mRNA Translation: BAA25480.1 Different initiation. AK000975 mRNA Translation: BAA91451.1 Different initiation. AK023681 mRNA Translation: BAB14638.1 AL136141 Genomic DNA No translation available. AL158207 Genomic DNA No translation available. BC062463 mRNA Translation: AAH62463.1 Sequence problems. BC101755 mRNA Translation: AAI01756.1 BC143513 mRNA Translation: AAI43514.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS48040.1 [Q96RU3-1] CCDS87699.1 [Q96RU3-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_055848.1, NM_015033.2 [Q96RU3-1] XP_005251880.1, XM_005251823.2 [Q96RU3-2] XP_005251881.1, XM_005251824.2 [Q96RU3-5] XP_005251886.1, XM_005251829.2

Genome annotation databases

Ensemblⁱ	ENST00000355681; ENSP00000347907; ENSG00000187239 [Q96RU3-3] ENST00000420781; ENSP00000407548; ENSG00000187239 [Q96RU3-5] ENST00000446176; ENSP00000413625; ENSG00000187239 [Q96RU3-1]
GeneIDⁱ	23048
KEGGⁱ	hsa:23048
UCSC genome browser More...UCSCⁱ	uc004byw.2, human [Q96RU3-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Chromosomal rearrangement

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96RU3	Uncharacterized protein		PONAB		692	UniRef90_Q96RU3
Formin binding protein 1		HORSE		626
formin-binding protein 1 isoform X6		SHEEP		622
formin-binding protein 1 isoform X7		SAPAP		622
formin-binding protein 1 isoform X6		pale spear-nosed bat		622
+160
Q96RU3-2	Formin binding protein 1		MACMU		651	UniRef90_Q96RU3-2
Formin binding protein 1		AILME		650
formin-binding protein 1 isoform X2		pale spear-nosed bat		649
Uncharacterized protein		CHLSB		647
Formin binding protein 1		SURSU		645
+385

Protein	Similar proteins		Species	Score	Length	Source
Q96RU3	Uncharacterized protein		PONAB		692	UniRef50_Q96RU3
Formin binding protein 1		HORSE		626
formin-binding protein 1 isoform X6		SHEEP		622
formin-binding protein 1 isoform X5		PHYMC		622
formin-binding protein 1 isoform X6		Ursus arctos horribilis		622
+162
Q96RU3-2	Formin-binding protein 1 homolog		XENLA		610	UniRef50_Q96RU3-2
Formin binding protein 1		MACMU		651
Formin binding protein 1		AILME		650
formin-binding protein 1 isoform X2		pale spear-nosed bat		649
Uncharacterized protein		CHLSB		647
+3288

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF265550 mRNA Translation: AAK49824.1 Different initiation. AB011126 mRNA Translation: BAA25480.1 Different initiation. AK000975 mRNA Translation: BAA91451.1 Different initiation. AK023681 mRNA Translation: BAB14638.1 AL136141 Genomic DNA No translation available. AL158207 Genomic DNA No translation available. BC062463 mRNA Translation: AAH62463.1 Sequence problems. BC101755 mRNA Translation: AAI01756.1 BC143513 mRNA Translation: AAI43514.1
CCDSⁱ	CCDS48040.1 [Q96RU3-1] CCDS87699.1 [Q96RU3-3]
RefSeqⁱ	NP_055848.1, NM_015033.2 [Q96RU3-1] XP_005251880.1, XM_005251823.2 [Q96RU3-2] XP_005251881.1, XM_005251824.2 [Q96RU3-5] XP_005251886.1, XM_005251829.2

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2EFL	X-ray	2.61	A	1-300	[»]
SMRⁱ	Q96RU3
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	116686, 32 interactors
DIPⁱ	DIP-35355N
ELMⁱ	Q96RU3
IntActⁱ	Q96RU3, 30 interactors
MINTⁱ	Q96RU3
STRINGⁱ	9606.ENSP00000413625

PTM databases

iPTMnetⁱ	Q96RU3
MetOSiteⁱ	Q96RU3
PhosphoSitePlusⁱ	Q96RU3

Genetic variation databases

BioMutaⁱ	FNBP1
DMDMⁱ	118572321

Proteomic databases

EPDⁱ	Q96RU3
jPOSTⁱ	Q96RU3
MassIVEⁱ	Q96RU3
MaxQBⁱ	Q96RU3
PaxDbⁱ	Q96RU3
PeptideAtlasⁱ	Q96RU3
PRIDEⁱ	Q96RU3
ProteomicsDBⁱ	20367 78035 [Q96RU3-1] 78036 [Q96RU3-2] 78037 [Q96RU3-3] 78038 [Q96RU3-4]

Protocols and materials databases

Antibodypediaⁱ	31452, 188 antibodies

Antibodypediaⁱ

31452, 188 antibodies

Genome annotation databases

Ensemblⁱ	ENST00000355681; ENSP00000347907; ENSG00000187239 [Q96RU3-3] ENST00000420781; ENSP00000407548; ENSG00000187239 [Q96RU3-5] ENST00000446176; ENSP00000413625; ENSG00000187239 [Q96RU3-1]
GeneIDⁱ	23048
KEGGⁱ	hsa:23048
UCSCⁱ	uc004byw.2, human [Q96RU3-1]

Organism-specific databases

CTDⁱ	23048
DisGeNETⁱ	23048
GeneCardsⁱ	FNBP1
HGNCⁱ	HGNC:17069, FNBP1
HPAⁱ	ENSG00000187239, Low tissue specificity
MIMⁱ	606191, gene
neXtProtⁱ	NX_Q96RU3
OpenTargetsⁱ	ENSG00000187239
PharmGKBⁱ	PA128394597
VEuPathDBⁱ	HostDB:ENSG00000187239.16
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3565, Eukaryota
GeneTreeⁱ	ENSGT00950000183047
InParanoidⁱ	Q96RU3
OMAⁱ	IPMNEGE
OrthoDBⁱ	348563at2759
PhylomeDBⁱ	Q96RU3
TreeFamⁱ	TF351162

Enzyme and pathway databases

PathwayCommonsⁱ	Q96RU3
Reactomeⁱ	R-HSA-8856828, Clathrin-mediated endocytosis

Miscellaneous databases

BioGRID-ORCSⁱ	23048, 12 hits in 994 CRISPR screens
ChiTaRSⁱ	FNBP1, human
EvolutionaryTraceⁱ	Q96RU3
GeneWikiⁱ	FNBP1
GenomeRNAiⁱ	23048
Pharosⁱ	Q96RU3, Tbio
Protein Ontology More...PROⁱ	PR:Q96RU3
RNActⁱ	Q96RU3, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000187239, Expressed in corpus callosum and 247 other tissues
ExpressionAtlasⁱ	Q96RU3, baseline and differential
Genevisibleⁱ	Q96RU3, HS

Family and domain databases

CDDⁱ	cd07676, F-BAR_FBP17, 1 hit
Gene3Dⁱ	1.20.1270.60, 1 hit
InterProⁱ	View protein in InterPro IPR027267, AH/BAR_dom_sf IPR031160, F_BAR IPR001060, FCH_dom IPR028532, FNBP1/FBP17 IPR037449, FNBP1_F-BAR IPR011072, HR1_rho-bd IPR036028, SH3-like_dom_sf IPR001452, SH3_domain
PANTHERⁱ	PTHR15735:SF13, PTHR15735:SF13, 1 hit
Pfamⁱ	View protein in Pfam PF00611, FCH, 1 hit PF14604, SH3_9, 1 hit
SMARTⁱ	View protein in SMART SM00055, FCH, 1 hit SM00326, SH3, 1 hit
SUPFAMⁱ	SSF103657, SSF103657, 1 hit SSF50044, SSF50044, 1 hit
PROSITEⁱ	View protein in PROSITE PS51741, F_BAR, 1 hit PS51860, REM_1, 1 hit PS50002, SH3, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FNBP1_HUMAN
Accessionⁱ	Q96RU3Primary (citable) accession number: Q96RU3 Secondary accession number(s): B7ZL12 Q9NWD1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
	Last sequence update:	November 28, 2006
	Last modified:	April 7, 2021
	This is version 164 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Reference proteome

Documents

Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

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Supporting data

UniProtKB - Q96RU3 (FNBP1_HUMAN)

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Formin-binding protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Lysosome

Plasma membrane

Cytoplasm and Cytosol

Other locations

Cytoskeleton

Cytosol

Lysosome

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Miscellaneous databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Q96RU3

GO - Molecular functioni

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Coiled coil

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ