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Entry version 169 (29 Sep 2021)
Sequence version 1 (01 Dec 2001)
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Protein

Gamma-tubulin complex component 5

Gene

TUBGCP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q96RT8

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes
R-HSA-380320, Recruitment of NuMA to mitotic centrosomes

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q96RT8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Gamma-tubulin complex component 5
Short name:
GCP-5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TUBGCP5
Synonyms:GCP5, KIAA1899
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18600, TUBGCP5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608147, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96RT8

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000275835

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
114791

Open Targets

More...
OpenTargetsi
ENSG00000275835

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38599

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96RT8, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TUBGCP5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20454926

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000781291 – 1024Gamma-tubulin complex component 5Add BLAST1024

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96RT8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96RT8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96RT8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96RT8

PeptideAtlas

More...
PeptideAtlasi
Q96RT8

PRoteomics IDEntifications database

More...
PRIDEi
Q96RT8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
19119
78032 [Q96RT8-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96RT8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96RT8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, with highest levels in heart and skeletal muscle and moderate levels in brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000275835, Expressed in sural nerve and 218 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96RT8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96RT8, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000275835, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
125353, 44 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q96RT8

Protein interaction database and analysis system

More...
IntActi
Q96RT8, 37 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000480316

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96RT8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11024
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96RT8

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni155 – 203DisorderedSequence analysisAdd BLAST49
Regioni521 – 545DisorderedSequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi185 – 203Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi528 – 545Polar residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TUBGCP family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4344, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155962

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_011574_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96RT8

Identification of Orthologs from Complete Genome Data

More...
OMAi
RTNQFEV

Database of Orthologous Groups

More...
OrthoDBi
110079at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96RT8

TreeFam database of animal gene trees

More...
TreeFami
TF329759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.1900, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007259, GCP
IPR040457, GCP_C
IPR042241, GCP_C_sf
IPR041470, GCP_N

The PANTHER Classification System

More...
PANTHERi
PTHR19302, PTHR19302, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04130, GCP_C_terminal, 1 hit
PF17681, GCP_N_terminal, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 14 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96RT8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARHGPPWSR LDAQQERDVR ELVRGVAGLQ DEADPNFQLA LNFAWSNFRF
60 70 80 90 100
HRFLDVNSHK IEKTIEGIYE KFVIHSDLSK AASWKRLTEE FLNAPLPSIK
110 120 130 140 150
EIKTDAHYSI LSLLLCLSDS PSNSSYVETP RNKEVEKKDD FDWGKYLMED
160 170 180 190 200
EEMDIGPYMD TPNWSEESEE ENDQQPLSRE DSGIQVDRTP LEEQDQNRKL
210 220 230 240 250
DPCISWKDEP DDRSWLEHHV VHQYWTARPS QFPHSLHLHS NLAAVWDQHL
260 270 280 290 300
YSSDPLYVPD DRVLVTETQV IRETLWLLSG VKKLFIFQLI DGKVTVRNNI
310 320 330 340 350
IVTHLTHSCL RSVLEQIAAY GQVVFRLQEF IDEVMGHSSE SMLPGSGSVP
360 370 380 390 400
KKSTEAPFRT YQAFMWALYK YFISFKEELA EIEKCIINND TTITLAIVVD
410 420 430 440 450
KLAPRLSQLK VLHKVFSTGV AEVPPDTRNV VRASHLLNTL YKAILEYDNV
460 470 480 490 500
GEASEQTVSL LFSLWVETVR PYLQTVDEWI VHGHLWDGAR EFIIQRNKNV
510 520 530 540 550
PVNHRDFWYA TYTLYSVSEK TENEEKMSDN ASASSGSDQG PSSRQHTMVS
560 570 580 590 600
FLKPVLKQII MAGKSMQLLK NLQCAESTTC QAGARDAERK SLYTLFLESV
610 620 630 640 650
QSRLRHGEDS TPQVLTEQQA TKENLMKMQS IAESHLELDD VHDPLLAINF
660 670 680 690 700
ARMYLEQSDF HEKFAGGDVC VDRSSESVTC QTFELTLRSC LYPHIDKQYL
710 720 730 740 750
DCCGNLMQTL KKDYRLVEYL QAMRNFFLME GGDTMYDFYT SIFDKIREKE
760 770 780 790 800
TWQNVSFLNV QLQEAVGQRY PEDSSRLSIS FENVDTAKKK LPVHILDGLT
810 820 830 840 850
LSYKVPWPVD IVISLECQKI YNQVFLLLLQ IKWAKYSLDV LLFGELVSTA
860 870 880 890 900
EKPRLKEGLI HEQDTVAQFG PQKEPVRQQI HRMFLLRVKL MHFVNSLHNY
910 920 930 940 950
IMTRILHSTG LEFQHQVEEA KDLDQLIKIH YRYLSTIHDR CLLREKVSFV
960 970 980 990 1000
KEAIMKVLNL ALMFADGWQA GLGTWRMESI EKMESDFKNC HMFLVTILNK
1010 1020
AVCRGSFPHL ESLALSLMAG MEQS
Length:1,024
Mass (Da):118,321
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i21350677DF126CD1
GO
Isoform 2 (identifier: Q96RT8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1010-1024: LESLALSLMAGMEQS → CEYIMLKYFYLCISL

Show »
Length:1,024
Mass (Da):118,643
Checksum:i6CDE6207A9F6EF6E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X1Z1A0A087X1Z1_HUMAN
Gamma-tubulin complex component
TUBGCP5
1,026Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JQX1A0A0G2JQX1_HUMAN
Gamma-tubulin complex component
TUBGCP5
1,024Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JSA7A0A0G2JSA7_HUMAN
Gamma-tubulin complex component
TUBGCP5
1,026Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JPW5A0A0G2JPW5_HUMAN
Gamma-tubulin complex component
TUBGCP5
1,024Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X006A0A087X006_HUMAN
Gamma-tubulin complex component
TUBGCP5
226Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JQI0A0A0G2JQI0_HUMAN
Gamma-tubulin complex component
TUBGCP5
148Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WVL9A0A087WVL9_HUMAN
Gamma-tubulin complex component 5
TUBGCP5
194Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WVZ8A0A087WVZ8_HUMAN
Gamma-tubulin complex component 5
TUBGCP5
167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JQK2A0A0G2JQK2_HUMAN
Gamma-tubulin complex component 5
TUBGCP5
194Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JS51A0A0G2JS51_HUMAN
Gamma-tubulin complex component 5
TUBGCP5
167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH46182 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AK056416 differs from that shown. Reason: Frameshift.Curated
The sequence AK056416 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated
The sequence BAB67792 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti198R → G in AAH71560 (PubMed:15489334).Curated1
Sequence conflicti994L → F in AK056416 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049252662E → D. Corresponds to variant dbSNP:rs35612840Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0474961010 – 1024LESLA…GMEQS → CEYIMLKYFYLCISL in isoform 2. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF272884 mRNA Translation: AAK77662.1
AB067486 mRNA Translation: BAB67792.2 Different initiation.
AK056416 mRNA No translation available.
AC116166 Genomic DNA No translation available.
BC046182 mRNA Translation: AAH46182.1 Different initiation.
BC071560 mRNA Translation: AAH71560.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS73697.1 [Q96RT8-2]
CCDS73698.1 [Q96RT8-1]

NCBI Reference Sequences

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RefSeqi
NP_001096080.1, NM_001102610.1 [Q96RT8-2]
NP_443135.3, NM_052903.4 [Q96RT8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000615383; ENSP00000480316; ENSG00000275835 [Q96RT8-1]
ENST00000620435; ENSP00000481853; ENSG00000275835 [Q96RT8-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
114791

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:114791

UCSC genome browser

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UCSCi
uc001yuq.3, human [Q96RT8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF272884 mRNA Translation: AAK77662.1
AB067486 mRNA Translation: BAB67792.2 Different initiation.
AK056416 mRNA No translation available.
AC116166 Genomic DNA No translation available.
BC046182 mRNA Translation: AAH46182.1 Different initiation.
BC071560 mRNA Translation: AAH71560.1
CCDSiCCDS73697.1 [Q96RT8-2]
CCDS73698.1 [Q96RT8-1]
RefSeqiNP_001096080.1, NM_001102610.1 [Q96RT8-2]
NP_443135.3, NM_052903.4 [Q96RT8-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6L81X-ray2.20A/C1-119[»]
6V69electron microscopy4.20J1-1024[»]
6V6Selectron microscopy4.30J1-1024[»]
7AS4electron microscopy4.13J1-1024[»]
SMRiQ96RT8
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi125353, 44 interactors
CORUMiQ96RT8
IntActiQ96RT8, 37 interactors
STRINGi9606.ENSP00000480316

PTM databases

iPTMnetiQ96RT8
PhosphoSitePlusiQ96RT8

Genetic variation databases

BioMutaiTUBGCP5
DMDMi20454926

Proteomic databases

jPOSTiQ96RT8
MassIVEiQ96RT8
MaxQBiQ96RT8
PaxDbiQ96RT8
PeptideAtlasiQ96RT8
PRIDEiQ96RT8
ProteomicsDBi19119
78032 [Q96RT8-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
72633, 143 antibodies

The DNASU plasmid repository

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DNASUi
114791

Genome annotation databases

EnsembliENST00000615383; ENSP00000480316; ENSG00000275835 [Q96RT8-1]
ENST00000620435; ENSP00000481853; ENSG00000275835 [Q96RT8-2]
GeneIDi114791
KEGGihsa:114791
UCSCiuc001yuq.3, human [Q96RT8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
114791
DisGeNETi114791

GeneCards: human genes, protein and diseases

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GeneCardsi
TUBGCP5
HGNCiHGNC:18600, TUBGCP5
HPAiENSG00000275835, Low tissue specificity
MIMi608147, gene
neXtProtiNX_Q96RT8
OpenTargetsiENSG00000275835
PharmGKBiPA38599
VEuPathDBiHostDB:ENSG00000275835

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4344, Eukaryota
GeneTreeiENSGT00940000155962
HOGENOMiCLU_011574_0_0_1
InParanoidiQ96RT8
OMAiRTNQFEV
OrthoDBi110079at2759
PhylomeDBiQ96RT8
TreeFamiTF329759

Enzyme and pathway databases

PathwayCommonsiQ96RT8
ReactomeiR-HSA-380270, Recruitment of mitotic centrosome proteins and complexes
R-HSA-380320, Recruitment of NuMA to mitotic centrosomes
SIGNORiQ96RT8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
114791, 689 hits in 1019 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TUBGCP5, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TUBGCP5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
114791
PharosiQ96RT8, Tbio

Protein Ontology

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PROi
PR:Q96RT8
RNActiQ96RT8, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000275835, Expressed in sural nerve and 218 other tissues
ExpressionAtlasiQ96RT8, baseline and differential
GenevisibleiQ96RT8, HS

Family and domain databases

Gene3Di1.20.120.1900, 1 hit
InterProiView protein in InterPro
IPR007259, GCP
IPR040457, GCP_C
IPR042241, GCP_C_sf
IPR041470, GCP_N
PANTHERiPTHR19302, PTHR19302, 1 hit
PfamiView protein in Pfam
PF04130, GCP_C_terminal, 1 hit
PF17681, GCP_N_terminal, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGCP5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96RT8
Secondary accession number(s): E9PB12, Q6IQ52, Q96PY8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: December 1, 2001
Last modified: September 29, 2021
This is version 169 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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