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Protein

Gamma-tubulin complex component 5

Gene

TUBGCP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.

GO - Molecular functioni

  • gamma-tubulin binding Source: GO_Central
  • microtubule binding Source: UniProtKB
  • structural constituent of cytoskeleton Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-tubulin complex component 5
Short name:
GCP-5
Gene namesi
Name:TUBGCP5
Synonyms:GCP5, KIAA1899
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000275835.4
HGNCiHGNC:18600 TUBGCP5
MIMi608147 gene
neXtProtiNX_Q96RT8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi114791
OpenTargetsiENSG00000275835
PharmGKBiPA38599

Polymorphism and mutation databases

BioMutaiTUBGCP5
DMDMi20454926

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000781291 – 1024Gamma-tubulin complex component 5Add BLAST1024

Proteomic databases

EPDiQ96RT8
MaxQBiQ96RT8
PaxDbiQ96RT8
PeptideAtlasiQ96RT8
PRIDEiQ96RT8
ProteomicsDBi78032

PTM databases

iPTMnetiQ96RT8
PhosphoSitePlusiQ96RT8

Expressioni

Tissue specificityi

Widely expressed, with highest levels in heart and skeletal muscle and moderate levels in brain.1 Publication

Gene expression databases

BgeeiENSG00000275835 Expressed in 208 organ(s), highest expression level in testis
CleanExiHS_TUBGCP5
ExpressionAtlasiQ96RT8 baseline and differential
GenevisibleiQ96RT8 HS

Organism-specific databases

HPAiHPA039366
HPA040366

Interactioni

Subunit structurei

Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi125353, 37 interactors
IntActiQ96RT8, 30 interactors
MINTiQ96RT8
STRINGi9606.ENSP00000283645

Structurei

3D structure databases

ProteinModelPortaliQ96RT8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TUBGCP family.Curated

Phylogenomic databases

eggNOGiKOG4344 Eukaryota
ENOG410ZYW9 LUCA
GeneTreeiENSGT00850000132278
HOGENOMiHOG000290706
HOVERGENiHBG025895
InParanoidiQ96RT8
KOiK16572
OrthoDBiEOG091G0ABS
PhylomeDBiQ96RT8
TreeFamiTF329759

Family and domain databases

InterProiView protein in InterPro
IPR007259 GCP
PANTHERiPTHR19302 PTHR19302, 1 hit
PfamiView protein in Pfam
PF04130 Spc97_Spc98, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 14 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96RT8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARHGPPWSR LDAQQERDVR ELVRGVAGLQ DEADPNFQLA LNFAWSNFRF
60 70 80 90 100
HRFLDVNSHK IEKTIEGIYE KFVIHSDLSK AASWKRLTEE FLNAPLPSIK
110 120 130 140 150
EIKTDAHYSI LSLLLCLSDS PSNSSYVETP RNKEVEKKDD FDWGKYLMED
160 170 180 190 200
EEMDIGPYMD TPNWSEESEE ENDQQPLSRE DSGIQVDRTP LEEQDQNRKL
210 220 230 240 250
DPCISWKDEP DDRSWLEHHV VHQYWTARPS QFPHSLHLHS NLAAVWDQHL
260 270 280 290 300
YSSDPLYVPD DRVLVTETQV IRETLWLLSG VKKLFIFQLI DGKVTVRNNI
310 320 330 340 350
IVTHLTHSCL RSVLEQIAAY GQVVFRLQEF IDEVMGHSSE SMLPGSGSVP
360 370 380 390 400
KKSTEAPFRT YQAFMWALYK YFISFKEELA EIEKCIINND TTITLAIVVD
410 420 430 440 450
KLAPRLSQLK VLHKVFSTGV AEVPPDTRNV VRASHLLNTL YKAILEYDNV
460 470 480 490 500
GEASEQTVSL LFSLWVETVR PYLQTVDEWI VHGHLWDGAR EFIIQRNKNV
510 520 530 540 550
PVNHRDFWYA TYTLYSVSEK TENEEKMSDN ASASSGSDQG PSSRQHTMVS
560 570 580 590 600
FLKPVLKQII MAGKSMQLLK NLQCAESTTC QAGARDAERK SLYTLFLESV
610 620 630 640 650
QSRLRHGEDS TPQVLTEQQA TKENLMKMQS IAESHLELDD VHDPLLAINF
660 670 680 690 700
ARMYLEQSDF HEKFAGGDVC VDRSSESVTC QTFELTLRSC LYPHIDKQYL
710 720 730 740 750
DCCGNLMQTL KKDYRLVEYL QAMRNFFLME GGDTMYDFYT SIFDKIREKE
760 770 780 790 800
TWQNVSFLNV QLQEAVGQRY PEDSSRLSIS FENVDTAKKK LPVHILDGLT
810 820 830 840 850
LSYKVPWPVD IVISLECQKI YNQVFLLLLQ IKWAKYSLDV LLFGELVSTA
860 870 880 890 900
EKPRLKEGLI HEQDTVAQFG PQKEPVRQQI HRMFLLRVKL MHFVNSLHNY
910 920 930 940 950
IMTRILHSTG LEFQHQVEEA KDLDQLIKIH YRYLSTIHDR CLLREKVSFV
960 970 980 990 1000
KEAIMKVLNL ALMFADGWQA GLGTWRMESI EKMESDFKNC HMFLVTILNK
1010 1020
AVCRGSFPHL ESLALSLMAG MEQS
Length:1,024
Mass (Da):118,321
Last modified:December 1, 2001 - v1
Checksum:i21350677DF126CD1
GO
Isoform 2 (identifier: Q96RT8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1010-1024: LESLALSLMAGMEQS → CEYIMLKYFYLCISL

Note: No experimental confirmation available.
Show »
Length:1,024
Mass (Da):118,643
Checksum:i6CDE6207A9F6EF6E
GO

Computationally mapped potential isoform sequencesi

There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X1Z1A0A087X1Z1_HUMAN
Gamma-tubulin complex component
TUBGCP5
1,026Annotation score:
A0A087WVZ8A0A087WVZ8_HUMAN
Gamma-tubulin complex component
TUBGCP5
167Annotation score:
A0A087X006A0A087X006_HUMAN
Gamma-tubulin complex component
TUBGCP5
226Annotation score:
A0A087WVL9A0A087WVL9_HUMAN
Gamma-tubulin complex component
TUBGCP5
194Annotation score:
A0A0G2JPW5A0A0G2JPW5_HUMAN
Gamma-tubulin complex component
TUBGCP5
1,024Annotation score:
A0A0G2JQI0A0A0G2JQI0_HUMAN
Gamma-tubulin complex component
TUBGCP5
148Annotation score:
A0A0G2JQX1A0A0G2JQX1_HUMAN
Gamma-tubulin complex component
TUBGCP5
1,024Annotation score:
A0A0G2JSA7A0A0G2JSA7_HUMAN
Gamma-tubulin complex component
TUBGCP5
1,026Annotation score:
A0A0G2JS51A0A0G2JS51_HUMAN
Gamma-tubulin complex component
TUBGCP5
167Annotation score:
A0A0G2JQK2A0A0G2JQK2_HUMAN
Gamma-tubulin complex component
TUBGCP5
194Annotation score:
There are more potential isoformsShow all

Sequence cautioni

The sequence AAH46182 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AK056416 differs from that shown. Reason: Frameshift at position 713.Curated
The sequence AK056416 differs from that shown. Reason: Erroneous termination at position 405. Translated as Arg.Curated
The sequence BAB67792 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti198R → G in AAH71560 (PubMed:15489334).Curated1
Sequence conflicti994L → F in AK056416 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049252662E → D. Corresponds to variant dbSNP:rs35612840Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0474961010 – 1024LESLA…GMEQS → CEYIMLKYFYLCISL in isoform 2. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF272884 mRNA Translation: AAK77662.1
AB067486 mRNA Translation: BAB67792.2 Different initiation.
AK056416 mRNA No translation available.
AC116166 Genomic DNA No translation available.
BC046182 mRNA Translation: AAH46182.1 Different initiation.
BC071560 mRNA Translation: AAH71560.1
CCDSiCCDS73697.1 [Q96RT8-2]
CCDS73698.1 [Q96RT8-1]
RefSeqiNP_001096080.1, NM_001102610.1 [Q96RT8-2]
NP_443135.3, NM_052903.4 [Q96RT8-1]
UniGeneiHs.533898

Genome annotation databases

EnsembliENST00000615383; ENSP00000480316; ENSG00000275835 [Q96RT8-1]
ENST00000620435; ENSP00000481853; ENSG00000275835 [Q96RT8-2]
GeneIDi114791
KEGGihsa:114791
UCSCiuc001yuq.3 human [Q96RT8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF272884 mRNA Translation: AAK77662.1
AB067486 mRNA Translation: BAB67792.2 Different initiation.
AK056416 mRNA No translation available.
AC116166 Genomic DNA No translation available.
BC046182 mRNA Translation: AAH46182.1 Different initiation.
BC071560 mRNA Translation: AAH71560.1
CCDSiCCDS73697.1 [Q96RT8-2]
CCDS73698.1 [Q96RT8-1]
RefSeqiNP_001096080.1, NM_001102610.1 [Q96RT8-2]
NP_443135.3, NM_052903.4 [Q96RT8-1]
UniGeneiHs.533898

3D structure databases

ProteinModelPortaliQ96RT8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125353, 37 interactors
IntActiQ96RT8, 30 interactors
MINTiQ96RT8
STRINGi9606.ENSP00000283645

PTM databases

iPTMnetiQ96RT8
PhosphoSitePlusiQ96RT8

Polymorphism and mutation databases

BioMutaiTUBGCP5
DMDMi20454926

Proteomic databases

EPDiQ96RT8
MaxQBiQ96RT8
PaxDbiQ96RT8
PeptideAtlasiQ96RT8
PRIDEiQ96RT8
ProteomicsDBi78032

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000615383; ENSP00000480316; ENSG00000275835 [Q96RT8-1]
ENST00000620435; ENSP00000481853; ENSG00000275835 [Q96RT8-2]
GeneIDi114791
KEGGihsa:114791
UCSCiuc001yuq.3 human [Q96RT8-1]

Organism-specific databases

CTDi114791
DisGeNETi114791
EuPathDBiHostDB:ENSG00000275835.4
GeneCardsiTUBGCP5
HGNCiHGNC:18600 TUBGCP5
HPAiHPA039366
HPA040366
MIMi608147 gene
neXtProtiNX_Q96RT8
OpenTargetsiENSG00000275835
PharmGKBiPA38599
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4344 Eukaryota
ENOG410ZYW9 LUCA
GeneTreeiENSGT00850000132278
HOGENOMiHOG000290706
HOVERGENiHBG025895
InParanoidiQ96RT8
KOiK16572
OrthoDBiEOG091G0ABS
PhylomeDBiQ96RT8
TreeFamiTF329759

Enzyme and pathway databases

ReactomeiR-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes

Miscellaneous databases

ChiTaRSiTUBGCP5 human
GeneWikiiTUBGCP5
GenomeRNAii114791
PROiPR:Q96RT8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000275835 Expressed in 208 organ(s), highest expression level in testis
CleanExiHS_TUBGCP5
ExpressionAtlasiQ96RT8 baseline and differential
GenevisibleiQ96RT8 HS

Family and domain databases

InterProiView protein in InterPro
IPR007259 GCP
PANTHERiPTHR19302 PTHR19302, 1 hit
PfamiView protein in Pfam
PF04130 Spc97_Spc98, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGCP5_HUMAN
AccessioniPrimary (citable) accession number: Q96RT8
Secondary accession number(s): E9PB12, Q6IQ52, Q96PY8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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