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Entry version 168 (07 Oct 2020)
Sequence version 3 (03 Apr 2007)
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Protein

Gamma-tubulin complex component 6

Gene

TUBGCP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q96RT7

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes
R-HSA-380320, Recruitment of NuMA to mitotic centrosomes

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Gamma-tubulin complex component 6
Short name:
GCP-6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TUBGCP6
Synonyms:GCP6, KIAA1669
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000128159.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18127, TUBGCP6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610053, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96RT7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Microcephaly and chorioretinopathy, autosomal recessive, 1 (MCCRP1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA syndrome characterized by microcephaly, cognitive impairment, underdeveloped retina and choroid, and epilepsy in some patients. The more anterior parts of the retina, near the periphery and pars plana, have a grayish hue and diminutive vasculature similar to retinopathy of prematurity. Visual impairment becomes evident during the first year of life.
Related information in OMIM

Organism-specific databases

DisGeNET

More...
DisGeNETi
85378

MalaCards human disease database

More...
MalaCardsi
TUBGCP6
MIMi251270, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000128159

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
2518, Autosomal recessive chorioretinopathy-microcephaly syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38507

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96RT7, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TUBGCP6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
143811395

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000781311 – 1819Gamma-tubulin complex component 6Add BLAST1819

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96RT7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96RT7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96RT7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96RT7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96RT7

PeptideAtlas

More...
PeptideAtlasi
Q96RT7

PRoteomics IDEntifications database

More...
PRIDEi
Q96RT7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
78029 [Q96RT7-1]
78030 [Q96RT7-2]
78031 [Q96RT7-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q96RT7, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96RT7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96RT7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000128159, Expressed in right hemisphere of cerebellum and 139 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96RT7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96RT7, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000128159, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
124505, 40 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q96RT7

Protein interaction database and analysis system

More...
IntActi
Q96RT7, 33 interactors

Molecular INTeraction database

More...
MINTi
Q96RT7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000248846

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96RT7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96RT7

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1027 – 10531Add BLAST27
Repeati1054 – 10802Add BLAST27
Repeati1081 – 11073Add BLAST27
Repeati1108 – 11344Add BLAST27
Repeati1135 – 11615Add BLAST27
Repeati1162 – 11886Add BLAST27
Repeati1189 – 12157Add BLAST27
Repeati1216 – 12428Add BLAST27
Repeati1243 – 12699Add BLAST27

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1027 – 12699 X 27 AA tandem repeatsAdd BLAST243

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TUBGCP family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2000, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157810

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002518_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96RT7

KEGG Orthology (KO)

More...
KOi
K16573

Identification of Orthologs from Complete Genome Data

More...
OMAi
HIRVGEN

Database of Orthologous Groups

More...
OrthoDBi
110079at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96RT7

TreeFam database of animal gene trees

More...
TreeFami
TF106321

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.1900, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007259, GCP
IPR040457, GCP_C
IPR042241, GCP_C_sf
IPR041470, GCP_N

The PANTHER Classification System

More...
PANTHERi
PTHR19302, PTHR19302, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04130, GCP_C_terminal, 1 hit
PF17681, GCP_N_terminal, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96RT7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASITQLFDD LCEALLPAAK THLGQRSVNR KRAKRSLKKV AYNALFTNLF
60 70 80 90 100
QDETQQLQPD MSKLPARNKI LMLSFDLRVG GLGPKADRLE ELVEELEAAP
110 120 130 140 150
CCPLLEVGSV LDLLVQLAGS GPPQVLPRKR DYFLNNKHVG RNVPYSGYDC
160 170 180 190 200
DDLSVFEMDV QSLISREECL CHSMIQETLQ VMEAAPGTGL PTVGLFSFGD
210 220 230 240 250
PCGDRFERDT RVSLFGALVH SRTYDMDVRL GLPPVPDNAD LSGLAIKVPP
260 270 280 290 300
SVDQWEDEGF QSASNLTPDS QSEPSVTPDV DLWEAALTYE ASKRRCWERV
310 320 330 340 350
GCPPGHREEP YLTEAGRDAF DKFCRLHQGE LQLLAGGVLQ APQPVLVKEC
360 370 380 390 400
ELVKDVLNVL IGVVSATFSL CQPAQAFVVK RGVHVSGASP ESISSLLSEV
410 420 430 440 450
AEYGTCYTRL SHFSLQPVLD SLYSKGLVFQ AFTSGLRRYL QYYRACVLST
460 470 480 490 500
PPTLSLLTIG FLFKKLGRQL RYLAELCGVG AVLPGTCGGG PRAAFPTGVK
510 520 530 540 550
LLSYLYQEAL HNCSNEHYPV LLSLLKTSCE PYTRFIHDWV YSGVFRDAYG
560 570 580 590 600
EFMIQVNHEY LSFRDKLYWT HGYVLISKEV EDCVPVFLKH IAHDIYVCGK
610 620 630 640 650
TINLLKLCCP RHYLCWSDVP VPRISVIFSL EELKEIEKDC AVYVGRMERV
660 670 680 690 700
ARHSSVSKEE KELRMEIAKQ ELIAHAREAA SRVLSALSDR QMSERMALDA
710 720 730 740 750
RKREQFQRLK EQFVKDQERR QAARQEELDD DFSYARELRD RERRLKSLEE
760 770 780 790 800
ELERKARQAL VDHYSKLSAE AARREQKALW RIQRHRLESA RLRFLLEDEK
810 820 830 840 850
HIQEMLKAVS EAHQPQEPPD VLLSVHPQVT SPGPEHPEGG QGCDSGSAEQ
860 870 880 890 900
HSPAWDGWNR PGLLTPQPLK PLAVGAGGRG LQQAEGARPF SDSLSIGDFL
910 920 930 940 950
PVGPGAEPSV QTGMVPLLEV ALQTINLDLP PSAPGEAPAA ASTQPSRPQE
960 970 980 990 1000
YDFSTVLRPA VATSPAPGPL QAAECSLGSS GLQLWEDSCG KMDACGSASR
1010 1020 1030 1040 1050
ETLLPSHPPR RAALEEGSSQ PTERLFGQVS GGGLPTGDYA SEIAPTRPRW
1060 1070 1080 1090 1100
NTHGHVSDAS IRVGENVSDV APTQPRWNTH GHVSNASISL GESVSDVAPT
1110 1120 1130 1140 1150
RPRWNIHGHV SNASIRVGEN VSDVAPTRPR WNTHGHVSNA SIRVGENVSD
1160 1170 1180 1190 1200
VAPTRPRWNT HGHVSDASIS LGESVSDMAP ARPRWNTHGH VSDASISLGE
1210 1220 1230 1240 1250
SVSDMAPTRP RWNTHGHVSD TSIRVGENVS DVAPIRSRCN THGHVSDASI
1260 1270 1280 1290 1300
SLGEPVSDVV STRPRWNTHV PIPPPHMVLG ALSPEAEPNT PRPQQSPPGH
1310 1320 1330 1340 1350
TSQSALSLGA QSTVLDCGPR LPVEVGPSLS SPSSGCGEGS ISVGENVSDV
1360 1370 1380 1390 1400
APTQPWWPNT PGDSVSEELG PGRSGDTEDL SPNWPLNSQE DTAAQSSPGR
1410 1420 1430 1440 1450
GEEAEASAAE AQGGEQAYLA GLAGQYHLER YPDSYESMSE PPIAHLLRPV
1460 1470 1480 1490 1500
LPRAFAFPVD PQVQSAADET AVQLSELLTL PVLMKRSITA PLAAHISLVN
1510 1520 1530 1540 1550
KAAVDYFFVE LHLEAHYEAL RHFLLMEDGE FAQSLSDLLF EKLGAGQTPG
1560 1570 1580 1590 1600
ELLNPLVLNS VLSKALQCSL HGDTPHASNL SLALKYLPEV FAPNAPDVLS
1610 1620 1630 1640 1650
CLELRYKVDW PLNIVITEGC VSKYSGVFSF LLQLKLMMWA LKDVCFHLKR
1660 1670 1680 1690 1700
TALLSHMAGS VQFRQLQLFK HEMQHFVKVI QGYIANQILH VTWCEFRARL
1710 1720 1730 1740 1750
ATVGDLEEIQ RAHAEYLHKA VFRGLLTEKA APVMNVIHSI FSLVLKFRSQ
1760 1770 1780 1790 1800
LISQAWGPPG GPRGAEHPNF ALMQQSYNTF KYYSHFLFKV VTKLVNRGYQ
1810
PHLEDFLLRI NFNNYYQDA
Length:1,819
Mass (Da):200,498
Last modified:April 3, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i265F89F318996157
GO
Isoform 2 (identifier: Q96RT7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1724-1757: Missing.

Show »
Length:1,785
Mass (Da):196,761
Checksum:i58972A0B8E54CEBF
GO
Isoform 3 (identifier: Q96RT7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1652-1662: Missing.
     1724-1729: Missing.

Show »
Length:1,802
Mass (Da):198,761
Checksum:i14228549220D0E42
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C2H5H7C2H5_HUMAN
Gamma-tubulin complex component
TUBGCP6
488Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C358H7C358_HUMAN
Gamma-tubulin complex component
TUBGCP6
277Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EQL8E7EQL8_HUMAN
Gamma-tubulin complex component 6
TUBGCP6
1,493Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH42165 differs from that shown. Reason: Frameshift.Curated
The sequence BAB33339 differs from that shown. Intron retention.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_055852104L → P. Corresponds to variant dbSNP:rs8137873EnsemblClinVar.1
Natural variantiVAR_031594567L → S1 PublicationCorresponds to variant dbSNP:rs4838865EnsemblClinVar.1
Natural variantiVAR_055853624I → M. Corresponds to variant dbSNP:rs35573482Ensembl.1
Natural variantiVAR_055854884A → V. Corresponds to variant dbSNP:rs34455105Ensembl.1
Natural variantiVAR_0558551232V → M. Corresponds to variant dbSNP:rs17248287Ensembl.1
Natural variantiVAR_0558561364S → C. Corresponds to variant dbSNP:rs5771107Ensembl.1
Natural variantiVAR_0558571377T → A1 PublicationCorresponds to variant dbSNP:rs11703226EnsemblClinVar.1
Natural variantiVAR_0558581621V → L1 PublicationCorresponds to variant dbSNP:rs4838864Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0172081652 – 1662Missing in isoform 3. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_0016241724 – 1757Missing in isoform 2. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_0172091724 – 1729Missing in isoform 3. 1 Publication6

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF272887 mRNA Translation: AAK82968.1
AL022328 Genomic DNA No translation available.
AB051456 mRNA Translation: BAB33339.1 Sequence problems.
BC023573 mRNA Translation: AAH23573.1
BC042165 mRNA Translation: AAH42165.1 Frameshift.

The Consensus CDS (CCDS) project

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CCDSi
CCDS14087.1 [Q96RT7-1]

NCBI Reference Sequences

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RefSeqi
NP_065194.2, NM_020461.3 [Q96RT7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000248846; ENSP00000248846; ENSG00000128159 [Q96RT7-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
85378

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:85378

UCSC genome browser

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UCSCi
uc003bkb.2, human [Q96RT7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF272887 mRNA Translation: AAK82968.1
AL022328 Genomic DNA No translation available.
AB051456 mRNA Translation: BAB33339.1 Sequence problems.
BC023573 mRNA Translation: AAH23573.1
BC042165 mRNA Translation: AAH42165.1 Frameshift.
CCDSiCCDS14087.1 [Q96RT7-1]
RefSeqiNP_065194.2, NM_020461.3 [Q96RT7-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6V6Celectron microscopy4.50L1-1819[»]
6V6Selectron microscopy4.30L1-1819[»]
6X0Uelectron microscopy3.60D1-1819[»]
SMRiQ96RT7
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi124505, 40 interactors
CORUMiQ96RT7
IntActiQ96RT7, 33 interactors
MINTiQ96RT7
STRINGi9606.ENSP00000248846

PTM databases

GlyGeniQ96RT7, 1 site
iPTMnetiQ96RT7
PhosphoSitePlusiQ96RT7

Polymorphism and mutation databases

BioMutaiTUBGCP6
DMDMi143811395

Proteomic databases

EPDiQ96RT7
jPOSTiQ96RT7
MassIVEiQ96RT7
MaxQBiQ96RT7
PaxDbiQ96RT7
PeptideAtlasiQ96RT7
PRIDEiQ96RT7
ProteomicsDBi78029 [Q96RT7-1]
78030 [Q96RT7-2]
78031 [Q96RT7-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
52528, 109 antibodies

Genome annotation databases

EnsembliENST00000248846; ENSP00000248846; ENSG00000128159 [Q96RT7-1]
GeneIDi85378
KEGGihsa:85378
UCSCiuc003bkb.2, human [Q96RT7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
85378
DisGeNETi85378
EuPathDBiHostDB:ENSG00000128159.11

GeneCards: human genes, protein and diseases

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GeneCardsi
TUBGCP6
HGNCiHGNC:18127, TUBGCP6
HPAiENSG00000128159, Low tissue specificity
MalaCardsiTUBGCP6
MIMi251270, phenotype
610053, gene
neXtProtiNX_Q96RT7
OpenTargetsiENSG00000128159
Orphaneti2518, Autosomal recessive chorioretinopathy-microcephaly syndrome
PharmGKBiPA38507

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2000, Eukaryota
GeneTreeiENSGT00940000157810
HOGENOMiCLU_002518_0_0_1
InParanoidiQ96RT7
KOiK16573
OMAiHIRVGEN
OrthoDBi110079at2759
PhylomeDBiQ96RT7
TreeFamiTF106321

Enzyme and pathway databases

PathwayCommonsiQ96RT7
ReactomeiR-HSA-380270, Recruitment of mitotic centrosome proteins and complexes
R-HSA-380320, Recruitment of NuMA to mitotic centrosomes

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
85378, 651 hits in 873 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TUBGCP6, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TUBGCP6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
85378
PharosiQ96RT7, Tbio

Protein Ontology

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PROi
PR:Q96RT7
RNActiQ96RT7, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000128159, Expressed in right hemisphere of cerebellum and 139 other tissues
ExpressionAtlasiQ96RT7, baseline and differential
GenevisibleiQ96RT7, HS

Family and domain databases

Gene3Di1.20.120.1900, 1 hit
InterProiView protein in InterPro
IPR007259, GCP
IPR040457, GCP_C
IPR042241, GCP_C_sf
IPR041470, GCP_N
PANTHERiPTHR19302, PTHR19302, 1 hit
PfamiView protein in Pfam
PF04130, GCP_C_terminal, 1 hit
PF17681, GCP_N_terminal, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGCP6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96RT7
Secondary accession number(s): Q5JZ80
, Q6PJ40, Q86YE9, Q9BY91, Q9UGX3, Q9UGX4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: April 3, 2007
Last modified: October 7, 2020
This is version 168 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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