UniProtKB - Q96RT6 (CTGE2_HUMAN)
Protein
cTAGE family member 2
Gene
CTAGE1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: GO_Central
- protein secretion Source: GO_Central
- vesicle cargo loading Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q96RT6 |
Names & Taxonomyi
Protein namesi | Recommended name: cTAGE family member 2Short name: Protein cTAGE-2 Alternative name(s): Cancer/testis antigen 21.2 Short name: CT21.2 |
Gene namesi | Name:CTAGE1 Synonyms:CTAGE2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24346, CTAGE1 |
MIMi | 608856, gene |
neXtProti | NX_Q96RT6 |
VEuPathDBi | HostDB:ENSG00000212710.4 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass membrane protein Curated
Endoplasmic reticulum
- endoplasmic reticulum exit site Source: GO_Central
- endoplasmic reticulum membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 13 – 30 | HelicalSequence analysisAdd BLAST | 18 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 64693 |
OpenTargetsi | ENSG00000212710 |
PharmGKBi | PA134933936 |
Miscellaneous databases
Pharosi | Q96RT6, Tdark |
Genetic variation databases
BioMutai | CTAGE1 |
DMDMi | 209572622 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000189538 | 1 – 745 | cTAGE family member 2Add BLAST | 745 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 267 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q96RT6 |
jPOSTi | Q96RT6 |
MassIVEi | Q96RT6 |
PaxDbi | Q96RT6 |
PeptideAtlasi | Q96RT6 |
PRIDEi | Q96RT6 |
ProteomicsDBi | 78028 [Q96RT6-1] |
PTM databases
iPTMneti | Q96RT6 |
PhosphoSitePlusi | Q96RT6 |
Expressioni
Tissue specificityi
Testis. Not found in tumor.
Gene expression databases
Bgeei | ENSG00000212710, Expressed in sperm and 24 other tissues |
ExpressionAtlasi | Q96RT6, baseline and differential |
Genevisiblei | Q96RT6, HS |
Organism-specific databases
HPAi | ENSG00000212710, Tissue enriched (testis) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 122233, 5 interactors |
IntActi | Q96RT6, 6 interactors |
MINTi | Q96RT6 |
STRINGi | 9606.ENSP00000375220 |
Miscellaneous databases
RNActi | Q96RT6, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 84 – 254 | Sequence analysisAdd BLAST | 171 | |
Coiled coili | 290 – 411 | Sequence analysisAdd BLAST | 122 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 658 – 743 | Pro-richAdd BLAST | 86 |
Sequence similaritiesi
Belongs to the cTAGE family.Curated
Keywords - Domaini
Coiled coil, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QUND, Eukaryota |
GeneTreei | ENSGT00950000182767 |
HOGENOMi | CLU_002106_2_0_1 |
InParanoidi | Q96RT6 |
OMAi | EXLLQEA |
PhylomeDBi | Q96RT6 |
TreeFami | TF333137 |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketNote: Additional isoforms (cTAGE-1B, cTAGE-1C and cTAGE-2s) exist.
Isoform 2 (identifier: Q96RT6-1) [UniParc]FASTAAdd to basket
Also known as: cTAGE-2
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRPDSHPYGF PWELVIRAAV AGFFAVLFLW RSFRSVTSRL YVRREKKFAV
60 70 80 90 100
ALSGLIEEKC KLLEKFSLVQ KEYEGYEVES SLKNASFEKE ATEAQSLEAT
110 120 130 140 150
CEKLNRFNSE LVHEILCLEK ELKEEKSKHS EQNELMADIS KRIQSLEDES
160 170 180 190 200
KSLKSQVAEA KMTFKRFQAN EERLEIEIQD AWKENSELQE SQKQLLQEAE
210 220 230 240 250
VWKEQVSELI KQKRTFEDSK VHAEQVLNDK ENHIKTLTER LLKMKDGVAM
260 270 280 290 300
LEEDVTDDDN LELEMNSESE DGAYLDNPPK GALKKLIHAA KLNASLKTLE
310 320 330 340 350
GERNQIYIQL SEVDKTKEEL TEHIKNLQTE QASLQSENTH FESENQKLQQ
360 370 380 390 400
KLKVMTELYQ ENEMKLYRKL IVEEKCRLEK EEKLSKVDEM ISHATEELET
410 420 430 440 450
YRKRAKDLKE FEKTIHFYQK KIILHEKKAH DNWSAAWTAE RNLNDLRKEN
460 470 480 490 500
AHNRQKLTEI EFKIKLLEKD PYGLDVPNTA FGRQHSPYGP SPLGWPSSET
510 520 530 540 550
RASLYPPTLL EGPLRLSPLL PRGGGRGSRG PGNPPDHQIT KERGESSCDR
560 570 580 590 600
LTDPHRAPSD AGPLAPPWEQ DYRMMFPPPG QSYPDSALPP QRQDRFYSNC
610 620 630 640 650
ARLSGPAELR SFNMPSLDKM DGSMPSEMES SRNDTKDNLG NLKVPDSSLP
660 670 680 690 700
AENEATGPGF VPPPLAPIRG LLFPVDTRGP FIRRGPPFPP PPPGTVFGAS
710 720 730 740
PDYFSPRDVP GPPRAPFAMR NVYLPRGFLP YRPPRPAFFP PAPTF
Sequence cautioni
The sequence AAK63198 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 179 | Q → R in AAK63198 (PubMed:12839582).Curated | 1 | |
Sequence conflicti | 312 | E → G in AAK63198 (PubMed:12839582).Curated | 1 | |
Sequence conflicti | 430 | H → R in AAK63198 (PubMed:12839582).Curated | 1 | |
Sequence conflicti | 635 | T → A in AAK63198 (PubMed:12839582).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_046956 | 682 | I → V. Corresponds to variant dbSNP:rs9946136Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF273058 mRNA Translation: AAK63198.1 Frameshift. AC099849 Genomic DNA No translation available. BC132871 mRNA Translation: AAI32872.1 |
CCDSi | CCDS45837.1 [Q96RT6-1] |
RefSeqi | NP_758441.2, NM_172241.2 [Q96RT6-1] |
Genome annotation databases
Ensembli | ENST00000391403; ENSP00000375220; ENSG00000212710 [Q96RT6-1] ENST00000634260; ENSP00000489019; ENSG00000282841 [Q96RT6-1] |
GeneIDi | 64693 |
KEGGi | hsa:64693 |
UCSCi | uc002ktv.2, human [Q96RT6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF273058 mRNA Translation: AAK63198.1 Frameshift. AC099849 Genomic DNA No translation available. BC132871 mRNA Translation: AAI32872.1 |
CCDSi | CCDS45837.1 [Q96RT6-1] |
RefSeqi | NP_758441.2, NM_172241.2 [Q96RT6-1] |
3D structure databases
SMRi | Q96RT6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 122233, 5 interactors |
IntActi | Q96RT6, 6 interactors |
MINTi | Q96RT6 |
STRINGi | 9606.ENSP00000375220 |
PTM databases
iPTMneti | Q96RT6 |
PhosphoSitePlusi | Q96RT6 |
Genetic variation databases
BioMutai | CTAGE1 |
DMDMi | 209572622 |
Proteomic databases
EPDi | Q96RT6 |
jPOSTi | Q96RT6 |
MassIVEi | Q96RT6 |
PaxDbi | Q96RT6 |
PeptideAtlasi | Q96RT6 |
PRIDEi | Q96RT6 |
ProteomicsDBi | 78028 [Q96RT6-1] |
Protocols and materials databases
Antibodypediai | 4258, 119 antibodies |
DNASUi | 64693 |
Genome annotation databases
Ensembli | ENST00000391403; ENSP00000375220; ENSG00000212710 [Q96RT6-1] ENST00000634260; ENSP00000489019; ENSG00000282841 [Q96RT6-1] |
GeneIDi | 64693 |
KEGGi | hsa:64693 |
UCSCi | uc002ktv.2, human [Q96RT6-1] |
Organism-specific databases
CTDi | 64693 |
DisGeNETi | 64693 |
GeneCardsi | CTAGE1 |
HGNCi | HGNC:24346, CTAGE1 |
HPAi | ENSG00000212710, Tissue enriched (testis) |
MIMi | 608856, gene |
neXtProti | NX_Q96RT6 |
OpenTargetsi | ENSG00000212710 |
PharmGKBi | PA134933936 |
VEuPathDBi | HostDB:ENSG00000212710.4 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QUND, Eukaryota |
GeneTreei | ENSGT00950000182767 |
HOGENOMi | CLU_002106_2_0_1 |
InParanoidi | Q96RT6 |
OMAi | EXLLQEA |
PhylomeDBi | Q96RT6 |
TreeFami | TF333137 |
Enzyme and pathway databases
PathwayCommonsi | Q96RT6 |
Miscellaneous databases
BioGRID-ORCSi | 64693, 12 hits in 923 CRISPR screens |
GenomeRNAii | 64693 |
Pharosi | Q96RT6, Tdark |
RNActi | Q96RT6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000212710, Expressed in sperm and 24 other tissues |
ExpressionAtlasi | Q96RT6, baseline and differential |
Genevisiblei | Q96RT6, HS |
Family and domain databases
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CTGE2_HUMAN | |
Accessioni | Q96RT6Primary (citable) accession number: Q96RT6 Secondary accession number(s): A2RUF2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 4, 2005 |
Last sequence update: | October 14, 2008 | |
Last modified: | April 7, 2021 | |
This is version 125 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families