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Entry version 181 (13 Feb 2019)
Sequence version 2 (17 Oct 2006)
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Protein

Erbin

Gene

ERBIN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and proinflammatory cytokine secretion (PubMed:16203728).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ErbB-2 class receptor binding Source: UniProtKB
  • signaling receptor binding Source: UniProtKB
  • structural constituent of cytoskeleton Source: UniProtKB

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1227986 Signaling by ERBB2
R-HSA-8863795 Downregulation of ERBB2 signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q96RT1

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q96RT1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Erbin1 Publication
Alternative name(s):
Densin-180-like protein
Erbb2-interacting protein1 Publication
Protein LAP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ERBIN1 Publication
Synonyms:ERBB2IP1 Publication, KIAA1225Imported, LAP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000112851.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:15842 ERBIN

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606944 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96RT1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55914

Open Targets

More...
OpenTargetsi
ENSG00000112851

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27845

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ERBIN

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116242614

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001883011 – 1412ErbinAdd BLAST1412

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei440PhosphoserineCombined sources1
Modified residuei444PhosphoserineBy similarity1
Modified residuei483PhosphotyrosineBy similarity1
Modified residuei485PhosphothreonineCombined sources1
Modified residuei569PhosphoserineCombined sources1
Modified residuei598PhosphoserineBy similarity1
Modified residuei602PhosphoserineCombined sources1
Modified residuei603PhosphoserineCombined sources1
Modified residuei620PhosphoserineCombined sources1
Modified residuei715PhosphoserineBy similarity1
Modified residuei852PhosphoserineCombined sources1
Modified residuei857PhosphoserineCombined sources1
Modified residuei872PhosphoserineCombined sources1
Modified residuei917PhosphothreonineCombined sources1
Modified residuei920PhosphotyrosineCombined sources1
Modified residuei931PhosphoserineCombined sources1
Modified residuei972PhosphotyrosineCombined sources1
Modified residuei1104PhosphotyrosineBy similarity1
Modified residuei1158PhosphoserineCombined sources1
Modified residuei1179PhosphoserineCombined sources1
Modified residuei1286PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96RT1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96RT1

MaxQB - The MaxQuant DataBase

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MaxQBi
Q96RT1

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96RT1

PeptideAtlas

More...
PeptideAtlasi
Q96RT1

PRoteomics IDEntifications database

More...
PRIDEi
Q96RT1

ProteomicsDB human proteome resource

More...
ProteomicsDBi
78021
78022 [Q96RT1-2]
78023 [Q96RT1-3]
78024 [Q96RT1-4]
78025 [Q96RT1-5]
78026 [Q96RT1-6]
78027 [Q96RT1-7]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96RT1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q96RT1

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q96RT1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in brain, heart, kidney, muscle and stomach, followed by liver, spleen and intestine.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000112851 Expressed in 238 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96RT1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96RT1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA048606
HPA059863

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ERBB2, BPAG1 and ITGB4 (PubMed:10878805, PubMed:11375975, PubMed:12444095). May favor the localization of ERBB2, by restricting its presence to the basolateral membrane of epithelial cells. Also found to interact with ARVCF and delta catenin (PubMed:11821434). Interacts (via C-terminus) with DST Isoform 3 (via N-terminus) (PubMed:11375975). Interacts with NOD2 (via CARD domain) (PubMed:16203728).6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120997, 116 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q96RT1

Protein interaction database and analysis system

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IntActi
Q96RT1, 57 interactors

Molecular INTeraction database

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MINTi
Q96RT1

STRING: functional protein association networks

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STRINGi
9606.ENSP00000370330

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11412
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MFGX-ray1.25A1321-1412[»]
1MFLX-ray1.88A1321-1412[»]
1N7TNMR-A1314-1412[»]
2H3LX-ray1.00A/B1314-1412[»]
2QBWX-ray1.80A1330-1410[»]
3CH8X-ray1.90A1330-1410[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q96RT1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96RT1

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q96RT1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati23 – 44LRR 1Add BLAST22
Repeati47 – 68LRR 2Add BLAST22
Repeati70 – 91LRR 3Add BLAST22
Repeati93 – 114LRR 4Add BLAST22
Repeati116 – 137LRR 5Add BLAST22
Repeati139 – 161LRR 6Add BLAST23
Repeati162 – 183LRR 7Add BLAST22
Repeati185 – 206LRR 8Add BLAST22
Repeati208 – 229LRR 9Add BLAST22
Repeati231 – 252LRR 10Add BLAST22
Repeati254 – 275LRR 11Add BLAST22
Repeati277 – 298LRR 12Add BLAST22
Repeati300 – 321LRR 13Add BLAST22
Repeati323 – 344LRR 14Add BLAST22
Repeati346 – 367LRR 15Add BLAST22
Repeati369 – 391LRR 16Add BLAST23
Repeati392 – 413LRR 17Add BLAST22
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1321 – 1410PDZPROSITE-ProRule annotationAdd BLAST90

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi930 – 934Poly-Ser5

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LAP (LRR and PDZ) protein family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410KCZ0 Eukaryota
COG4886 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000159526

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000060229

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052305

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96RT1

KEGG Orthology (KO)

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KOi
K12796

Identification of Orthologs from Complete Genome Data

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OMAi
FHYGSSR

Database for complete collections of gene phylogenies

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PhylomeDBi
Q96RT1

TreeFam database of animal gene trees

More...
TreeFami
TF351429

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.80.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR032927 Erbin
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR001478 PDZ
IPR036034 PDZ_sf

The PANTHER Classification System

More...
PANTHERi
PTHR44896 PTHR44896, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF13855 LRR_8, 4 hits
PF00595 PDZ, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00369 LRR_TYP, 12 hits
SM00228 PDZ, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50156 SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450 LRR, 15 hits
PS50106 PDZ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (9+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 9 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 9 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96RT1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTTKRSLFVR LVPCRCLRGE EETVTTLDYS HCSLEQVPKE IFTFEKTLEE
60 70 80 90 100
LYLDANQIEE LPKQLFNCQS LHKLSLPDND LTTLPASIAN LINLRELDVS
110 120 130 140 150
KNGIQEFPEN IKNCKVLTIV EASVNPISKL PDGFSQLLNL TQLYLNDAFL
160 170 180 190 200
EFLPANFGRL TKLQILELRE NQLKMLPKTM NRLTQLERLD LGSNEFTEVP
210 220 230 240 250
EVLEQLSGLK EFWMDANRLT FIPGFIGSLK QLTYLDVSKN NIEMVEEGIS
260 270 280 290 300
TCENLQDLLL SSNSLQQLPE TIGSLKNITT LKIDENQLMY LPDSIGGLIS
310 320 330 340 350
VEELDCSFNE VEALPSSIGQ LTNLRTFAAD HNYLQQLPPE IGSWKNITVL
360 370 380 390 400
FLHSNKLETL PEEMGDMQKL KVINLSDNRL KNLPFSFTKL QQLTAMWLSD
410 420 430 440 450
NQSKPLIPLQ KETDSETQKM VLTNYMFPQQ PRTEDVMFIS DNESFNPSLW
460 470 480 490 500
EEQRKQRAQV AFECDEDKDE REAPPREGNL KRYPTPYPDE LKNMVKTVQT
510 520 530 540 550
IVHRLKDEET NEDSGRDLKP HEDQQDINKD VGVKTSESTT TVKSKVDERE
560 570 580 590 600
KYMIGNSVQK ISEPEAEISP GSLPVTANMK ASENLKHIVN HDDVFEESEE
610 620 630 640 650
LSSDEEMKMA EMRPPLIETS INQPKVVALS NNKKDDTKET DSLSDEVTHN
660 670 680 690 700
SNQNNSNCSS PSRMSDSVSL NTDSSQDTSL CSPVKQTHID INSKIRQEDE
710 720 730 740 750
NFNSLLQNGD ILNSSTEEKF KAHDKKDFNL PEYDLNVEER LVLIEKSVDS
760 770 780 790 800
TATADDTHKL DHINMNLNKL ITNDTFQPEI MERSKTQDIV LGTSFLSINS
810 820 830 840 850
KEETEHLENG NKYPNLESVN KVNGHSEETS QSPNRTEPHD SDCSVDLGIS
860 870 880 890 900
KSTEDLSPQK SGPVGSVVKS HSITNMEIGG LKIYDILSDN GPQQPSTTVK
910 920 930 940 950
ITSAVDGKNI VRSKSATLLY DQPLQVFTGS SSSSDLISGT KAIFKFDSNH
960 970 980 990 1000
NPEEPNIIRG PTSGPQSAPQ IYGPPQYNIQ YSSSAAVKDT LWHSKQNPQI
1010 1020 1030 1040 1050
DHASFPPQLL PRSESTENQS YAKHSANMNF SNHNNVRANT AYHLHQRLGP
1060 1070 1080 1090 1100
ARHGEMWAIS PNDRLIPAVT RSTIQRQSSV SSTASVNLGD PGSTRRAQIP
1110 1120 1130 1140 1150
EGDYLSYREF HSAGRTPPMM PGSQRPLSAR TYSIDGPNAS RPQSARPSIN
1160 1170 1180 1190 1200
EIPERTMSVS DFNYSRTSPS KRPNARVGSE HSLLDPPGKS KVPRDWREQV
1210 1220 1230 1240 1250
LRHIEAKKLE KKHPQTSSSG DPCQDGIFIS GQQNYSSATL SHKDVPPDSL
1260 1270 1280 1290 1300
MKMPLSNGQM GQPLRPQANY SQIHHPPQAS VARHPSREQL IDYLMLKVAH
1310 1320 1330 1340 1350
QPPYTQPHCS PRQGHELAKQ EIRVRVEKDP ELGFSISGGV GGRGNPFRPD
1360 1370 1380 1390 1400
DDGIFVTRVQ PEGPASKLLQ PGDKIIQANG YSFINIEHGQ AVSLLKTFQN
1410
TVELIIVREV SS
Length:1,412
Mass (Da):158,298
Last modified:October 17, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i304DFC81578CF671
GO
Isoform 2 (identifier: Q96RT1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1212-1252: Missing.

Show »
Length:1,371
Mass (Da):153,926
Checksum:iC8F24683B0C4324D
GO
Isoform 3 (identifier: Q96RT1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1212-1252: Missing.
     1268-1278: Missing.

Show »
Length:1,360
Mass (Da):152,653
Checksum:iA56B9384680DA710
GO
Isoform 4 (identifier: Q96RT1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1212-1252: Missing.
     1353-1377: Missing.

Show »
Length:1,346
Mass (Da):151,252
Checksum:i19D7B81B5A934C2E
GO
Isoform 5 (identifier: Q96RT1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1212-1252: Missing.
     1253-1267: Missing.

Show »
Length:1,356
Mass (Da):152,290
Checksum:i9662C85F03C8F08B
GO
Isoform 6 (identifier: Q96RT1-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1212-1252: Missing.
     1322-1352: Missing.

Show »
Length:1,340
Mass (Da):150,602
Checksum:i12B24ADE16A5F537
GO
Isoform 7 (identifier: Q96RT1-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1212-1252: Missing.
     1253-1267: Missing.
     1268-1278: Missing.
     1279-1321: Missing.

Show »
Length:1,302
Mass (Da):146,086
Checksum:iE436063ACDA2C1A4
GO
Isoform 8 (identifier: Q96RT1-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1212-1252: KHPQTSSSGD...KDVPPDSLMK → SMLSRSFNSN...RRGSGGHIFR

Note: No experimental confirmation available.
Show »
Length:1,419
Mass (Da):159,024
Checksum:i9E18163421DBE278
GO
Isoform 9 (identifier: Q96RT1-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     531-534: Missing.
     1212-1252: Missing.

Note: No experimental confirmation available.
Show »
Length:1,367
Mass (Da):153,543
Checksum:iC1F031AD4CA0746B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DIP2B4DIP2_HUMAN
Erbin
ERBIN
610Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YA04H0YA04_HUMAN
Erbin
ERBIN
197Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9E8H0Y9E8_HUMAN
Erbin
ERBIN
158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH50692 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA91538 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti271T → P in AAI15013 (PubMed:15489334).Curated1
Sequence conflicti547D → G in AAI15013 (PubMed:15489334).Curated1
Sequence conflicti805E → G in BAA91538 (PubMed:14702039).Curated1
Sequence conflicti813Y → C in AAK69431 (PubMed:11375975).Curated1
Sequence conflicti848G → C in BAG65463 (PubMed:14702039).Curated1
Sequence conflicti1047R → S in BAG65463 (PubMed:14702039).Curated1
Sequence conflicti1205E → G in AAI15013 (PubMed:15489334).Curated1
Sequence conflicti1267Q → P in AAI15013 (PubMed:15489334).Curated1
Sequence conflicti1328K → R in AAI15013 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_019346274S → L1 PublicationCorresponds to variant dbSNP:rs3213837Ensembl.1
Natural variantiVAR_068905313A → V1 PublicationCorresponds to variant dbSNP:rs191137999Ensembl.1
Natural variantiVAR_028304746K → E. Corresponds to variant dbSNP:rs16894812Ensembl.1
Natural variantiVAR_046673914K → R. Corresponds to variant dbSNP:rs34521887Ensembl.1
Natural variantiVAR_0466741089G → V. Corresponds to variant dbSNP:rs35601230Ensembl.1
Natural variantiVAR_0193471112S → L. Corresponds to variant dbSNP:rs3805466Ensembl.1
Natural variantiVAR_0193481207K → E1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_047389531 – 534Missing in isoform 9. 1 Publication4
Alternative sequenceiVSP_0108021212 – 1252Missing in isoform 2, isoform 3, isoform 4, isoform 5, isoform 6, isoform 7 and isoform 9. 5 PublicationsAdd BLAST41
Alternative sequenceiVSP_0445361212 – 1252KHPQT…DSLMK → SMLSRSFNSNFTTVSSFHCG SSRDLHGSQGSLALSVADRR GSGGHIFR in isoform 8. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_0108031253 – 1267Missing in isoform 5 and isoform 7. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_0108041268 – 1278Missing in isoform 3 and isoform 7. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_0108051279 – 1321Missing in isoform 7. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_0108061322 – 1352Missing in isoform 6. 1 PublicationAdd BLAST31
Alternative sequenceiVSP_0108071353 – 1377Missing in isoform 4. 2 PublicationsAdd BLAST25

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF263744 mRNA Translation: AAF77048.1
AF276423 mRNA Translation: AAK69431.1
AB033051 mRNA Translation: BAA86539.2
AK001180 mRNA Translation: BAA91538.1 Different initiation.
AK304693 mRNA Translation: BAG65463.1
AC010359 Genomic DNA No translation available.
AC025442 Genomic DNA No translation available.
BC050692 mRNA Translation: AAH50692.1 Sequence problems.
BC115012 mRNA Translation: AAI15013.1
BC126464 mRNA Translation: AAI26465.1
BC144075 mRNA Translation: AAI44076.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34172.1 [Q96RT1-7]
CCDS3990.1 [Q96RT1-2]
CCDS58951.1 [Q96RT1-9]
CCDS58952.1 [Q96RT1-8]
CCDS58953.1 [Q96RT1-1]
CCDS58954.1 [Q96RT1-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001006600.1, NM_001006600.2 [Q96RT1-7]
NP_001240626.1, NM_001253697.1 [Q96RT1-1]
NP_001240627.1, NM_001253698.1 [Q96RT1-4]
NP_001240628.1, NM_001253699.1 [Q96RT1-8]
NP_001240630.1, NM_001253701.1 [Q96RT1-9]
NP_061165.1, NM_018695.3 [Q96RT1-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.591774
Hs.597241

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000284037; ENSP00000284037; ENSG00000112851 [Q96RT1-1]
ENST00000380935; ENSP00000370322; ENSG00000112851 [Q96RT1-7]
ENST00000380938; ENSP00000370325; ENSG00000112851 [Q96RT1-4]
ENST00000380943; ENSP00000370330; ENSG00000112851 [Q96RT1-2]
ENST00000506030; ENSP00000426632; ENSG00000112851 [Q96RT1-8]
ENST00000508515; ENSP00000422015; ENSG00000112851 [Q96RT1-7]
ENST00000511297; ENSP00000422766; ENSG00000112851 [Q96RT1-9]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55914

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55914

UCSC genome browser

More...
UCSCi
uc003jui.3 human [Q96RT1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF263744 mRNA Translation: AAF77048.1
AF276423 mRNA Translation: AAK69431.1
AB033051 mRNA Translation: BAA86539.2
AK001180 mRNA Translation: BAA91538.1 Different initiation.
AK304693 mRNA Translation: BAG65463.1
AC010359 Genomic DNA No translation available.
AC025442 Genomic DNA No translation available.
BC050692 mRNA Translation: AAH50692.1 Sequence problems.
BC115012 mRNA Translation: AAI15013.1
BC126464 mRNA Translation: AAI26465.1
BC144075 mRNA Translation: AAI44076.1
CCDSiCCDS34172.1 [Q96RT1-7]
CCDS3990.1 [Q96RT1-2]
CCDS58951.1 [Q96RT1-9]
CCDS58952.1 [Q96RT1-8]
CCDS58953.1 [Q96RT1-1]
CCDS58954.1 [Q96RT1-4]
RefSeqiNP_001006600.1, NM_001006600.2 [Q96RT1-7]
NP_001240626.1, NM_001253697.1 [Q96RT1-1]
NP_001240627.1, NM_001253698.1 [Q96RT1-4]
NP_001240628.1, NM_001253699.1 [Q96RT1-8]
NP_001240630.1, NM_001253701.1 [Q96RT1-9]
NP_061165.1, NM_018695.3 [Q96RT1-2]
UniGeneiHs.591774
Hs.597241

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MFGX-ray1.25A1321-1412[»]
1MFLX-ray1.88A1321-1412[»]
1N7TNMR-A1314-1412[»]
2H3LX-ray1.00A/B1314-1412[»]
2QBWX-ray1.80A1330-1410[»]
3CH8X-ray1.90A1330-1410[»]
ProteinModelPortaliQ96RT1
SMRiQ96RT1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120997, 116 interactors
ELMiQ96RT1
IntActiQ96RT1, 57 interactors
MINTiQ96RT1
STRINGi9606.ENSP00000370330

PTM databases

iPTMnetiQ96RT1
PhosphoSitePlusiQ96RT1
SwissPalmiQ96RT1

Polymorphism and mutation databases

BioMutaiERBIN
DMDMi116242614

Proteomic databases

EPDiQ96RT1
jPOSTiQ96RT1
MaxQBiQ96RT1
PaxDbiQ96RT1
PeptideAtlasiQ96RT1
PRIDEiQ96RT1
ProteomicsDBi78021
78022 [Q96RT1-2]
78023 [Q96RT1-3]
78024 [Q96RT1-4]
78025 [Q96RT1-5]
78026 [Q96RT1-6]
78027 [Q96RT1-7]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000284037; ENSP00000284037; ENSG00000112851 [Q96RT1-1]
ENST00000380935; ENSP00000370322; ENSG00000112851 [Q96RT1-7]
ENST00000380938; ENSP00000370325; ENSG00000112851 [Q96RT1-4]
ENST00000380943; ENSP00000370330; ENSG00000112851 [Q96RT1-2]
ENST00000506030; ENSP00000426632; ENSG00000112851 [Q96RT1-8]
ENST00000508515; ENSP00000422015; ENSG00000112851 [Q96RT1-7]
ENST00000511297; ENSP00000422766; ENSG00000112851 [Q96RT1-9]
GeneIDi55914
KEGGihsa:55914
UCSCiuc003jui.3 human [Q96RT1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55914
DisGeNETi55914
EuPathDBiHostDB:ENSG00000112851.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ERBIN
HGNCiHGNC:15842 ERBIN
HPAiHPA048606
HPA059863
MIMi606944 gene
neXtProtiNX_Q96RT1
OpenTargetsiENSG00000112851
PharmGKBiPA27845

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410KCZ0 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00940000159526
HOGENOMiHOG000060229
HOVERGENiHBG052305
InParanoidiQ96RT1
KOiK12796
OMAiFHYGSSR
PhylomeDBiQ96RT1
TreeFamiTF351429

Enzyme and pathway databases

ReactomeiR-HSA-1227986 Signaling by ERBB2
R-HSA-8863795 Downregulation of ERBB2 signaling
SignaLinkiQ96RT1
SIGNORiQ96RT1

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ERBIN human
EvolutionaryTraceiQ96RT1

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Erbin_(protein)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55914

Protein Ontology

More...
PROi
PR:Q96RT1

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000112851 Expressed in 238 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ96RT1 baseline and differential
GenevisibleiQ96RT1 HS

Family and domain databases

Gene3Di3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR032927 Erbin
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR001478 PDZ
IPR036034 PDZ_sf
PANTHERiPTHR44896 PTHR44896, 1 hit
PfamiView protein in Pfam
PF13855 LRR_8, 4 hits
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 12 hits
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 15 hits
PS50106 PDZ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiERBIN_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96RT1
Secondary accession number(s): A0AVR1
, B4E3F1, B7ZLV9, E7EQW9, E9PCR8, Q1RMD0, Q86W38, Q9NR18, Q9NW48, Q9ULJ5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 17, 2006
Last modified: February 13, 2019
This is version 181 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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