UniProtKB - Q96RS2 (Q96RS2_HUMAN)
40S ribosomal protein SA
RPSA
Functioni
Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.
UniRule annotationMiscellaneous
GO - Molecular functioni
- laminin binding Source: UniProtKB-UniRule
- laminin receptor activity Source: UniProtKB-UniRule
- structural constituent of ribosome Source: UniProtKB-UniRule
GO - Biological processi
- ribosomal small subunit assembly Source: UniProtKB-UniRule
- translation Source: UniProtKB-UniRule
Keywordsi
Molecular function | ReceptorUniRule annotationARBA annotation, Ribonucleoprotein, Ribosomal proteinUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: 40S ribosomal protein SAUniRule annotationAlternative name(s): 37 kDa laminin receptor precursorUniRule annotation Short name: 37LRPUniRule annotation 37/67 kDa laminin receptorUniRule annotation Short name: LRP/LRUniRule annotation 67 kDa laminin receptorUniRule annotation Short name: 67LRUniRule annotation Laminin receptor 1UniRule annotation Short name: LamRUniRule annotation Laminin-binding protein precursor p40UniRule annotation Short name: LBP/p40UniRule annotation |
Gene namesi | Name:RPSAUniRule annotation |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Nucleus
- Nucleus UniRule annotation
Plasma membrane
- Cell membrane UniRule annotation
Cytoplasm and Cytosol
- Cytoplasm UniRule annotationARBA annotation
Note: 67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus. Co-localizes with PPP1R16B in the cell membrane.UniRule annotation
Cytosol
- cytosolic small ribosomal subunit Source: UniProtKB-UniRule
Nucleus
- nucleus Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membraneUniRule annotationARBA annotation, CytoplasmUniRule annotationARBA annotation, Membrane, NucleusUniRule annotationARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedUniRule annotation |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineUniRule annotation | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 115 – 116 | Cleavage; by ST3; site 1UniRule annotation | 2 | |
Sitei | 133 – 134 | Cleavage; by ST3; site 2UniRule annotation | 2 |
Keywords - PTMi
AcetylationUniRule annotationARBA annotationProteomic databases
MaxQBi | Q96RS2 |
PTM databases
SwissPalmi | Q96RS2 |
Interactioni
Subunit structurei
Monomer (37LRP) and homodimer (67LR).
Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S).
Interacts with RPS21.
Interacts with several laminins including at least LAMB1.
Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat).
Interacts with PPP1CA only in the presence of PPP1R16B.
UniRule annotationGO - Molecular functioni
- laminin binding Source: UniProtKB-UniRule
- laminin receptor activity Source: UniProtKB-UniRule
Protein-protein interaction databases
IntActi | Q96RS2, 5 interactors |
MINTi | Q96RS2 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 202 – 295 | 40S_SA_CInterPro annotationAdd BLAST | 94 | |
Repeati | 230 – 232 | [DE]-W-[ST] 1UniRule annotation | 3 | |
Repeati | 247 – 249 | [DE]-W-[ST] 2UniRule annotation | 3 | |
Repeati | 266 – 268 | [DE]-W-[ST] 3UniRule annotation | 3 | |
Repeati | 275 – 277 | [DE]-W-[ST] 4UniRule annotation | 3 | |
Repeati | 293 – 295 | [DE]-W-[ST] 5UniRule annotation | 3 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 54 – 113 | Interaction with PPP1R16BUniRule annotationAdd BLAST | 60 | |
Regioni | 161 – 180 | Laminin-bindingUniRule annotationAdd BLAST | 20 | |
Regioni | 205 – 229 | Laminin-bindingUniRule annotationAdd BLAST | 25 | |
Regioni | 242 – 295 | Laminin-bindingUniRule annotationAdd BLAST | 54 | |
Regioni | 258 – 295 | DisorderedSequence analysisAdd BLAST | 38 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 210 – 230 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysis, RepeatUniRule annotationARBA annotationFamily and domain databases
CDDi | cd01425, RPS2, 1 hit |
HAMAPi | MF_03015, Ribosomal_S2_euk, 1 hit MF_03016, Ribosomal_S2_laminin_receptor, 1 hit |
InterProi | View protein in InterPro IPR027504, 40S_ribosomal_SA IPR032281, 40S_SA_C IPR001865, Ribosomal_S2 IPR018130, Ribosomal_S2_CS IPR027498, Ribosomal_S2_euk IPR005707, Ribosomal_S2_euk/arc IPR023591, Ribosomal_S2_flav_dom_sf |
PANTHERi | PTHR11489, PTHR11489, 1 hit |
Pfami | View protein in Pfam PF16122, 40S_SA_C, 1 hit PF00318, Ribosomal_S2, 2 hits |
PRINTSi | PR00395, RIBOSOMALS2 |
SUPFAMi | SSF52313, SSF52313, 1 hit |
TIGRFAMsi | TIGR01012, uS2_euk_arch, 1 hit |
PROSITEi | View protein in PROSITE PS00962, RIBOSOMAL_S2_1, 1 hit PS00963, RIBOSOMAL_S2_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MSGALDVLQM KEEDVLKFLA AGTHLGGTNL DFQMEQYIYK RKSDGIYIIN
60 70 80 90 100
LKRTWEKLLL TARAIVAIEN PADVSVISSR NTGQRAVLKF AAATGATPIA
110 120 130 140 150
GRFTPGTFTN QIQAAFREPR LLVVSDPRAD HQPLTEASYV NLPTIALCNT
160 170 180 190 200
DSPLHYVDIA IPCNNKGTHS VGLMWWMLAR EVLRMRGTIS REHPWEVMPD
210 220 230 240 250
LYFYRDPEEI EKEEQAAAEK AMTREELQGE WTAPAPEFTA TQPEVADWSE
260 270 280 290
GVQVPSVPIQ QFPTEDWSTQ RATEDWSAAP TAQATEWVGA TTDWS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF284768 mRNA Translation: AAK69721.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF284768 mRNA Translation: AAK69721.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q96RS2, 5 interactors |
MINTi | Q96RS2 |
PTM databases
SwissPalmi | Q96RS2 |
Proteomic databases
MaxQBi | Q96RS2 |
Miscellaneous databases
ChiTaRSi | RPSA, human |
Family and domain databases
CDDi | cd01425, RPS2, 1 hit |
HAMAPi | MF_03015, Ribosomal_S2_euk, 1 hit MF_03016, Ribosomal_S2_laminin_receptor, 1 hit |
InterProi | View protein in InterPro IPR027504, 40S_ribosomal_SA IPR032281, 40S_SA_C IPR001865, Ribosomal_S2 IPR018130, Ribosomal_S2_CS IPR027498, Ribosomal_S2_euk IPR005707, Ribosomal_S2_euk/arc IPR023591, Ribosomal_S2_flav_dom_sf |
PANTHERi | PTHR11489, PTHR11489, 1 hit |
Pfami | View protein in Pfam PF16122, 40S_SA_C, 1 hit PF00318, Ribosomal_S2, 2 hits |
PRINTSi | PR00395, RIBOSOMALS2 |
SUPFAMi | SSF52313, SSF52313, 1 hit |
TIGRFAMsi | TIGR01012, uS2_euk_arch, 1 hit |
PROSITEi | View protein in PROSITE PS00962, RIBOSOMAL_S2_1, 1 hit PS00963, RIBOSOMAL_S2_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q96RS2_HUMAN | |
Accessioni | Q96RS2Primary (citable) accession number: Q96RS2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 1, 2001 |
Last sequence update: | December 1, 2001 | |
Last modified: | May 25, 2022 | |
This is version 104 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |