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Entry version 166 (29 Sep 2021)
Sequence version 3 (11 Jan 2011)
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Protein

Trimethylguanosine synthase

Gene

TGS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m7G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.

4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=30 µM for m7GDP1 Publication
  2. KM=5 µM for S-adenosyl-L-methionine1 Publication

pH dependencei

Optimum pH is 8.5-9.5.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei719S-adenosyl-L-methionineBy similarity1
Binding sitei7667-methylguanosine1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processTranscription, Transcription regulation
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q96RS0

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1368082, RORA activates gene expression
R-HSA-1368108, BMAL1:CLOCK,NPAS2 activates circadian gene expression
R-HSA-191859, snRNP Assembly
R-HSA-1989781, PPARA activates gene expression
R-HSA-2151201, Transcriptional activation of mitochondrial biogenesis
R-HSA-2426168, Activation of gene expression by SREBF (SREBP)
R-HSA-381340, Transcriptional regulation of white adipocyte differentiation
R-HSA-400206, Regulation of lipid metabolism by PPARalpha
R-HSA-400253, Circadian Clock
R-HSA-9707564, Cytoprotection by HMOX1
R-HSA-9707616, Heme signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Trimethylguanosine synthase (EC:2.1.1.-1 Publication)
Alternative name(s):
CLL-associated antigen KW-2
Cap-specific guanine-N2 methyltransferase
Hepatocellular carcinoma-associated antigen 137
Nuclear receptor coactivator 6-interacting protein
PRIP-interacting protein with methyltransferase motif
Short name:
PIMT
Short name:
PIPMT
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TGS1
Synonyms:HCA137, NCOA6IP, PIMT
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17843, TGS1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606461, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96RS0

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000137574

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi655F → A: Loss of catalytic activity. 1 Publication1
Mutagenesisi673T → A: Decreases catalytic activity to 13 percent of wild type. 1 Publication1
Mutagenesisi696D → A: Loss of catalytic activity. 1 Publication1
Mutagenesisi704N → A: Decreases catalytic activity to 5 percent of wild type. 1 Publication1
Mutagenesisi719D → A: Loss of catalytic activity. 1 Publication1
Mutagenesisi731N → A: Decreases catalytic activity to 4 percent of wild type. 1 Publication1
Mutagenesisi763S → A: Decreases catalytic activity to 26 percent of wild type. 2 Publications1
Mutagenesisi766W → A: Loss of catalytic activity. 2 Publications1
Mutagenesisi807R → A: Decreases catalytic activity to 6 percent of wild type. 1 Publication1
Mutagenesisi808N → A: Decreases catalytic activity to 11 percent of wild type. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
96764

Open Targets

More...
OpenTargetsi
ENSG00000137574

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162405660

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96RS0, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TGS1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373500

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002044681 – 853Trimethylguanosine synthaseAdd BLAST853

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei55PhosphoserineCombined sources1
Modified residuei60PhosphothreonineCombined sources1
Modified residuei85PhosphoserineCombined sources1
Modified residuei89PhosphoserineCombined sources1
Modified residuei96PhosphoserineCombined sources1
Modified residuei141PhosphoserineCombined sources1
Modified residuei146PhosphotyrosineCombined sources1
Modified residuei154PhosphoserineCombined sources1
Modified residuei189PhosphoserineCombined sources1
Modified residuei412PhosphoserineCombined sources1
Modified residuei438PhosphoserineCombined sources1
Modified residuei578PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q96RS0

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96RS0

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q96RS0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96RS0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96RS0

PeptideAtlas

More...
PeptideAtlasi
Q96RS0

PRoteomics IDEntifications database

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PRIDEi
Q96RS0

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
78017

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96RS0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96RS0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed. High expression in heart, skeletal muscle, kidney, liver and placenta.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000137574, Expressed in amniotic fluid and 230 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96RS0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96RS0, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000137574, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May form homooligomers.

Interacts with CREBBP/CBP, EED/WAIT1, EP300/P300, NCOA6/PRIP, PPARBP/PBP and SMN.

5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
125179, 49 interactors

Database of interacting proteins

More...
DIPi
DIP-49970N

Protein interaction database and analysis system

More...
IntActi
Q96RS0, 43 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000260129

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96RS0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1853
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96RS0

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q96RS0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni53 – 80DisorderedSequence analysisAdd BLAST28
Regioni149 – 187DisorderedSequence analysisAdd BLAST39
Regioni334 – 461DisorderedSequence analysisAdd BLAST128
Regioni527 – 632DisorderedSequence analysisAdd BLAST106
Regioni631 – 846Sufficient for catalytic activityAdd BLAST216

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi334 – 402Polar residuesSequence analysisAdd BLAST69
Compositional biasi403 – 434Basic and acidic residuesSequence analysisAdd BLAST32
Compositional biasi543 – 567Basic and acidic residuesSequence analysisAdd BLAST25
Compositional biasi568 – 582Polar residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2730, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000018056

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_016892_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96RS0

Identification of Orthologs from Complete Genome Data

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OMAi
VNKPMDE

Database of Orthologous Groups

More...
OrthoDBi
176302at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96RS0

TreeFam database of animal gene trees

More...
TreeFami
TF313065

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019012, RNA_cap_Gua-N2-MeTrfase
IPR029063, SAM-dependent_MTases

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09445, Methyltransf_15, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53335, SSF53335, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q96RS0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCCEKWSRVA EMFLFIEERE DCKILCLCSR AFVEDRKLYN LGLKGYYIRD
60 70 80 90 100
SGNNSGDQAT EEEEGGYSCG TAESHDSKGI GLDESELDSE AELMRSMGLP
110 120 130 140 150
LQFGRITAHK DFEVSMNTRN KVKIKKKKHQ KKYLDEIVQE SWRKEYEEDD
160 170 180 190 200
ILASDDPSSI EQYENTRTYE LQSKKDTETE NPPVENTLSP KLEITEKWEK
210 220 230 240 250
YWNEYGGGLL WQSWQEKHPG QALSSEPWNF PDTKEEWEQH YSQLYWYYLE
260 270 280 290 300
QFQYWEAQGW TFDASQSCDT DTYTSKTEAD DKNDEKCMKV DLVSFPSSPI
310 320 330 340 350
MVDNDSSGTS DKDHSEILDG ISNIKLNSEE VTQSQLDSCT SHDGHQQLSE
360 370 380 390 400
VSSKRECPAS GQSEPRNGGT NEESNSSGNT NTDPPAEDSQ KSSGANTSKD
410 420 430 440 450
RPHASGTDGD ESEEDPPEHK PSKLKRSHEL DIDENPASDF DDSGSLLGFK
460 470 480 490 500
YGSGQKYGGI PNFSHRQVRY LEKNVKLKSK YLDMRRQIKM KNKHIFFTKE
510 520 530 540 550
SEKPFFKKSK ILSKVEKFLT WVNKPMDEEA SQESSSHDNV HDASTSSDSE
560 570 580 590 600
EQDMSVKKGD DLLETNNPEP EKCQSVSSAG ELETENYERD SLLATVPDEQ
610 620 630 640 650
DCVTQEVPDS RQAETEAEVK KKKNKKKNKK VNGLPPEIAA VPELAKYWAQ
660 670 680 690 700
RYRLFSRFDD GIKLDREGWF SVTPEKIAEH IAGRVSQSFK CDVVVDAFCG
710 720 730 740 750
VGGNTIQFAL TGMRVIAIDI DPVKIALARN NAEVYGIADK IEFICGDFLL
760 770 780 790 800
LASFLKADVV FLSPPWGGPD YATAETFDIR TMMSPDGFEI FRLSKKITNN
810 820 830 840 850
IVYFLPRNAD IDQVASLAGP GGQVEIEQNF LNNKLKTITA YFGDLIRRPA

SET
Length:853
Mass (Da):96,620
Last modified:January 11, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFF670AFBE0979443
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RJW7E5RJW7_HUMAN
Trimethylguanosine synthase
TGS1
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH11999 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB15516 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti566Missing in AAK27730 (PubMed:11517327).Curated1
Sequence conflicti624N → T in AAK83025 (PubMed:12097419).Curated1
Sequence conflicti628N → T in AAK83025 (PubMed:12097419).Curated1
Sequence conflicti681I → F in AAK27730 (PubMed:11517327).Curated1
Sequence conflicti771Y → H in AAL99922 (PubMed:12200376).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02473416I → T3 PublicationsCorresponds to variant dbSNP:rs1818Ensembl.1
Natural variantiVAR_024735160I → V. Corresponds to variant dbSNP:rs3213971EnsemblClinVar.1
Natural variantiVAR_056241299P → S. Corresponds to variant dbSNP:rs11986329EnsemblClinVar.1
Natural variantiVAR_024736511I → T. Corresponds to variant dbSNP:rs10100659Ensembl.1
Natural variantiVAR_024737576V → I. Corresponds to variant dbSNP:rs16922259EnsemblClinVar.1
Natural variantiVAR_056242595T → A. Corresponds to variant dbSNP:rs10109493Ensembl.1
Natural variantiVAR_024738754F → C. Corresponds to variant dbSNP:rs7823773Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY028423 mRNA Translation: AAK27730.1
AF432215 mRNA Translation: AAL99922.1
AF286340 mRNA Translation: AAK83025.1
AC100817 Genomic DNA No translation available.
AY534911 mRNA Translation: AAT02709.1
BC011999 mRNA Translation: AAH11999.1 Different initiation.
AK026648 mRNA Translation: BAB15516.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34894.1

NCBI Reference Sequences

More...
RefSeqi
NP_001304831.1, NM_001317902.1
NP_079107.6, NM_024831.7

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000260129; ENSP00000260129; ENSG00000137574

Database of genes from NCBI RefSeq genomes

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GeneIDi
96764

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:96764

UCSC genome browser

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UCSCi
uc003xsj.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY028423 mRNA Translation: AAK27730.1
AF432215 mRNA Translation: AAL99922.1
AF286340 mRNA Translation: AAK83025.1
AC100817 Genomic DNA No translation available.
AY534911 mRNA Translation: AAT02709.1
BC011999 mRNA Translation: AAH11999.1 Different initiation.
AK026648 mRNA Translation: BAB15516.1 Different initiation.
CCDSiCCDS34894.1
RefSeqiNP_001304831.1, NM_001317902.1
NP_079107.6, NM_024831.7

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3EGIX-ray2.21A/B/C/D653-853[»]
3GDHX-ray2.00A/B/C618-853[»]
SMRiQ96RS0
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi125179, 49 interactors
DIPiDIP-49970N
IntActiQ96RS0, 43 interactors
STRINGi9606.ENSP00000260129

PTM databases

iPTMnetiQ96RS0
PhosphoSitePlusiQ96RS0

Genetic variation databases

BioMutaiTGS1
DMDMi317373500

Proteomic databases

EPDiQ96RS0
jPOSTiQ96RS0
MassIVEiQ96RS0
MaxQBiQ96RS0
PaxDbiQ96RS0
PeptideAtlasiQ96RS0
PRIDEiQ96RS0
ProteomicsDBi78017

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
11709, 158 antibodies

The DNASU plasmid repository

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DNASUi
96764

Genome annotation databases

EnsembliENST00000260129; ENSP00000260129; ENSG00000137574
GeneIDi96764
KEGGihsa:96764
UCSCiuc003xsj.5, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
96764
DisGeNETi96764

GeneCards: human genes, protein and diseases

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GeneCardsi
TGS1
HGNCiHGNC:17843, TGS1
HPAiENSG00000137574, Low tissue specificity
MIMi606461, gene
neXtProtiNX_Q96RS0
OpenTargetsiENSG00000137574
PharmGKBiPA162405660
VEuPathDBiHostDB:ENSG00000137574

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2730, Eukaryota
GeneTreeiENSGT00390000018056
HOGENOMiCLU_016892_0_0_1
InParanoidiQ96RS0
OMAiVNKPMDE
OrthoDBi176302at2759
PhylomeDBiQ96RS0
TreeFamiTF313065

Enzyme and pathway databases

PathwayCommonsiQ96RS0
ReactomeiR-HSA-1368082, RORA activates gene expression
R-HSA-1368108, BMAL1:CLOCK,NPAS2 activates circadian gene expression
R-HSA-191859, snRNP Assembly
R-HSA-1989781, PPARA activates gene expression
R-HSA-2151201, Transcriptional activation of mitochondrial biogenesis
R-HSA-2426168, Activation of gene expression by SREBF (SREBP)
R-HSA-381340, Transcriptional regulation of white adipocyte differentiation
R-HSA-400206, Regulation of lipid metabolism by PPARalpha
R-HSA-400253, Circadian Clock
R-HSA-9707564, Cytoprotection by HMOX1
R-HSA-9707616, Heme signaling

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
96764, 525 hits in 1024 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TGS1, human
EvolutionaryTraceiQ96RS0

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TGS1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
96764
PharosiQ96RS0, Tbio

Protein Ontology

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PROi
PR:Q96RS0
RNActiQ96RS0, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000137574, Expressed in amniotic fluid and 230 other tissues
ExpressionAtlasiQ96RS0, baseline and differential
GenevisibleiQ96RS0, HS

Family and domain databases

InterProiView protein in InterPro
IPR019012, RNA_cap_Gua-N2-MeTrfase
IPR029063, SAM-dependent_MTases
PfamiView protein in Pfam
PF09445, Methyltransf_15, 1 hit
SUPFAMiSSF53335, SSF53335, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTGS1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96RS0
Secondary accession number(s): A6NJQ5
, Q5GH23, Q8TDG9, Q96QU3, Q9H5V3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: January 11, 2011
Last modified: September 29, 2021
This is version 166 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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