CAMKK2

Functionⁱ

Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca²⁺ signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.By similarity4 Publications

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.

Activity regulationⁱ

Activated by Ca²⁺/calmodulin. Binding of calmodulin may relieve intrasteric autoinhibition. Autophosphorylation does not alter activity or regulation by Ca²⁺/calmodulin. In part, activity is independent on Ca²⁺/calmodulin (By similarity).By similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	194	ATPPROSITE-ProRule annotation		1
Active siteⁱ	312	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	171 – 179	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
calcium ion binding
Source: UniProtKB
Inferred from direct assayⁱ
- 11395482
calmodulin binding
Source: UniProtKB
Traceable author statementⁱ
- 11395482
calmodulin-dependent protein kinase activity Source: UniProtKB-EC
protein tyrosine kinase activity
Source: UniProtKB
Traceable author statementⁱ
- 11395482

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

calcium-mediated signaling
Source: UniProtKB
Traceable author statementⁱ
- 11395482
CAMKK-AMPK signaling cascade
Source: ParkinsonsUK-UCL
Inferred from mutant phenotypeⁱ
- 26103054
cellular response to reactive oxygen species
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 26103054
MAPK cascade
Source: UniProtKB
Traceable author statementⁱ
- 11395482
positive regulation of autophagy of mitochondrion
Source: ParkinsonsUK-UCL
Inferred by curatorⁱ
- 26103054
positive regulation of protein phosphorylation
Source: ParkinsonsUK-UCL
Inferred from mutant phenotypeⁱ
- 26103054
positive regulation of transcription, DNA-templated
Source: UniProtKB
Traceable author statementⁱ
- 11395482
protein autophosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 11395482
protein phosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 11395482
regulation of protein kinase activity
Source: UniProtKB
Traceable author statementⁱ
- 11395482

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	2.7.11.17 2681
SignaLinkⁱ	Q96RR4
SIGNORⁱ	Q96RR4

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Calcium/calmodulin-dependent protein kinase kinase 2 (EC:2.7.11.17) Short name: CaM-KK 2 Short name: CaM-kinase kinase 2 Short name: CaMKK 2 Alternative name(s): Calcium/calmodulin-dependent protein kinase kinase beta Short name: CaM-KK beta Short name: CaM-kinase kinase beta Short name: CaMKK beta
Gene namesⁱ	Name:CAMKK2 Synonyms:CAMKKB, KIAA0787
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000110931.18
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1470 CAMKK2
MIMⁱ	615002 gene
neXtProtⁱ	NX_Q96RR4

Keywords - Cellular componentⁱ

Cell projection, Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10645
Open Targets More...OpenTargetsⁱ	ENSG00000110931
PharmGKBⁱ	PA26052

Chemistry databases

ChEMBLⁱ	CHEMBL5284
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1957

Polymorphism and mutation databases

BioMutaⁱ	CAMKK2
DMDMⁱ	317373374

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000086144	2 – 588	Calcium/calmodulin-dependent protein kinase kinase 2Add BLAST		587

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylserineCombined sources	1
Modified residueⁱ	100	PhosphoserineBy similarity	1
Modified residueⁱ	114	PhosphoserineCombined sources	1
Modified residueⁱ	129	PhosphoserineCombined sources	1
Modified residueⁱ	133	PhosphoserineBy similarity	1
Modified residueⁱ	137	PhosphoserineBy similarity	1
Modified residueⁱ	495	PhosphoserineCombined sources	1
Modified residueⁱ	511	PhosphoserineCombined sources	1
Modified residueⁱ	572	PhosphoserineBy similarity	1
Isoform 5 (identifier: Q96RR4-5)
Modified residueⁱ	479	PhosphoserineCombined sources	1
Isoform 3 (identifier: Q96RR4-3)
Modified residueⁱ	522	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Autophosphorylated and phosphorylated by PKA. Each isoform may show a different pattern of phosphorylation.1 Publication

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q96RR4
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96RR4
PaxDbⁱ	Q96RR4
PeptideAtlas More...PeptideAtlasⁱ	Q96RR4
PRIDEⁱ	Q96RR4
ProteomicsDBⁱ	78009 78010 [Q96RR4-2] 78011 [Q96RR4-3] 78012 [Q96RR4-4] 78013 [Q96RR4-5] 78014 [Q96RR4-6] 78015 [Q96RR4-7]

PTM databases

iPTMnetⁱ	Q96RR4
PhosphoSitePlusⁱ	Q96RR4

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed with higher levels in the brain. Intermediate levels are detected in spleen, prostate, thyroid and leukocytes. The lowest level is in lung.1 Publication

Inductionⁱ

Isoform 1 is up-regulated by PKA pathway.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000110931 Expressed in 232 organ(s), highest expression level in cerebellum
CleanExⁱ	HS_CAMKK2
ExpressionAtlasⁱ	Q96RR4 baseline and differential
Genevisibleⁱ	Q96RR4 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA017389

HPAⁱ

HPA017389

Interactionⁱ

Subunit structureⁱ

Interacts with calmodulin.By similarity

GO - Molecular functionⁱ

calmodulin binding
Source: UniProtKB
Traceable author statementⁱ
- 11395482

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	115889, 31 interactors
IntActⁱ	Q96RR4, 19 interactors
STRINGⁱ	9606.ENSP00000312741

Chemistry databases

BindingDBⁱ

Q96RR4

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	165 – 172	Combined sources	8
Beta strandⁱ	175 – 184	Combined sources	10
Turnⁱ	185 – 188	Combined sources	4
Beta strandⁱ	189 – 197	Combined sources	9
Helixⁱ	198 – 204	Combined sources	7
Helixⁱ	231 – 242	Combined sources	12
Beta strandⁱ	251 – 256	Combined sources	6
Beta strandⁱ	260 – 268	Combined sources	9
Beta strandⁱ	273 – 275	Combined sources	3
Helixⁱ	286 – 305	Combined sources	20
Helixⁱ	315 – 317	Combined sources	3
Beta strandⁱ	318 – 320	Combined sources	3
Beta strandⁱ	326 – 328	Combined sources	3
Beta strandⁱ	338 – 341	Combined sources	4
Beta strandⁱ	343 – 346	Combined sources	4
Helixⁱ	351 – 353	Combined sources	3
Helixⁱ	356 – 358	Combined sources	3
Beta strandⁱ	364 – 367	Combined sources	4
Helixⁱ	368 – 385	Combined sources	18
Helixⁱ	395 – 404	Combined sources	10
Beta strandⁱ	411 – 413	Combined sources	3
Helixⁱ	417 – 426	Combined sources	10
Turnⁱ	431 – 433	Combined sources	3
Helixⁱ	437 – 440	Combined sources	4
Helixⁱ	444 – 447	Combined sources	4
Turnⁱ	448 – 451	Combined sources	4
Helixⁱ	457 – 461	Combined sources	5

Show more details

3D structure databases

ProteinModelPortalⁱ	Q96RR4
SMRⁱ	Q96RR4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q96RR4

EvolutionaryTraceⁱ

Q96RR4

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	165 – 446	Protein kinasePROSITE-ProRule annotationAdd BLAST		282

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	204 – 226	RP domainAdd BLAST	23
Regionⁱ	472 – 477	Autoinhibitory domainBy similarity	6
Regionⁱ	475 – 500	Calmodulin-bindingBy similarityAdd BLAST	26

Domainⁱ

The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition.

The RP domain (arginine/proline-rich) is involved in the recognition of CAMKI and CAMK4 as substrates.By similarity

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	KOG0585 Eukaryota ENOG410YHHF LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063214
HOVERGENⁱ	HBG052262
InParanoidⁱ	Q96RR4
KEGG Orthology (KO) More...KOⁱ	K07359
OMAⁱ	SEGQKPC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01DB
PhylomeDBⁱ	Q96RR4
TreeFamⁱ	TF313013

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (7+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 7 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q96RR4-1) [UniParc]FASTA Add to basket

Also known as: Beta1, CAMKK2+E16

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSCVSSQPS SNRAAPQDEL GGRGSSSSES QKPCEALRGL SSLSIHLGME 
        60         70         80         90        100
SFIVVTECEP GCAVDLGLAR DRPLEADGQE VPLDTSGSQA RPHLSGRKLS 
       110        120        130        140        150
LQERSQGGLA AGGSLDMNGR CICPSLPYSP VSSPQSSPRL PRRPTVESHH 
       160        170        180        190        200
VSITGMQDCV QLNQYTLKDE IGKGSYGVVK LAYNENDNTY YAMKVLSKKK 
       210        220        230        240        250
LIRQAGFPRR PPPRGTRPAP GGCIQPRGPI EQVYQEIAIL KKLDHPNVVK 
       260        270        280        290        300
LVEVLDDPNE DHLYMVFELV NQGPVMEVPT LKPLSEDQAR FYFQDLIKGI 
       310        320        330        340        350
EYLHYQKIIH RDIKPSNLLV GEDGHIKIAD FGVSNEFKGS DALLSNTVGT 
       360        370        380        390        400
PAFMAPESLS ETRKIFSGKA LDVWAMGVTL YCFVFGQCPF MDERIMCLHS 
       410        420        430        440        450
KIKSQALEFP DQPDIAEDLK DLITRMLDKN PESRIVVPEI KLHPWVTRHG 
       460        470        480        490        500
AEPLPSEDEN CTLVEVTEEE VENSVKHIPS LATVILVKTM IRKRSFGNPF 
       510        520        530        540        550
EGSRREERSL SAPGNLLTKK PTRECESLSE LKEARQRRQP PGHRPAPRGG 
       560        570        580 
GGSALVRGSP CVESCWAPAP GSPARMHPLR PEEAMEPE

Note: Major isoform.

Length:588

Mass (Da):64,746

Last modified:January 11, 2011 - v2

Checksum:ⁱ04E3583561341167

GO

Isoform 2 (identifier: Q96RR4-2) [UniParc]FASTA Add to basket

Also known as: Beta2

The sequence of this isoform differs from the canonical sequence as follows:
     533-533: E → T
     534-554: Missing.
     555-588: Missing.

« Hide

        10         20         30         40         50
MSSCVSSQPS SNRAAPQDEL GGRGSSSSES QKPCEALRGL SSLSIHLGME 
        60         70         80         90        100
SFIVVTECEP GCAVDLGLAR DRPLEADGQE VPLDTSGSQA RPHLSGRKLS 
       110        120        130        140        150
LQERSQGGLA AGGSLDMNGR CICPSLPYSP VSSPQSSPRL PRRPTVESHH 
       160        170        180        190        200
VSITGMQDCV QLNQYTLKDE IGKGSYGVVK LAYNENDNTY YAMKVLSKKK 
       210        220        230        240        250
LIRQAGFPRR PPPRGTRPAP GGCIQPRGPI EQVYQEIAIL KKLDHPNVVK 
       260        270        280        290        300
LVEVLDDPNE DHLYMVFELV NQGPVMEVPT LKPLSEDQAR FYFQDLIKGI 
       310        320        330        340        350
EYLHYQKIIH RDIKPSNLLV GEDGHIKIAD FGVSNEFKGS DALLSNTVGT 
       360        370        380        390        400
PAFMAPESLS ETRKIFSGKA LDVWAMGVTL YCFVFGQCPF MDERIMCLHS 
       410        420        430        440        450
KIKSQALEFP DQPDIAEDLK DLITRMLDKN PESRIVVPEI KLHPWVTRHG 
       460        470        480        490        500
AEPLPSEDEN CTLVEVTEEE VENSVKHIPS LATVILVKTM IRKRSFGNPF 
       510        520        530 
EGSRREERSL SAPGNLLTKK PTRECESLSE LKT

Note: Major isoform.

Show »

Length:533

Mass (Da):58,899

Checksum:ⁱ98FAAB0FB8C4CACF

GO

Isoform 3 (identifier: Q96RR4-3) [UniParc]FASTA Add to basket

Also known as: Beta1delta16, CAMKK2-E16

The sequence of this isoform differs from the canonical sequence as follows:
     520-532: KPTRECESLSELK → QGSEDNLQGTDPP
     533-541: EARQRRQPP → PVGEEEVLL
     542-554: Missing.
     555-588: Missing.

« Hide

        10         20         30         40         50
MSSCVSSQPS SNRAAPQDEL GGRGSSSSES QKPCEALRGL SSLSIHLGME 
        60         70         80         90        100
SFIVVTECEP GCAVDLGLAR DRPLEADGQE VPLDTSGSQA RPHLSGRKLS 
       110        120        130        140        150
LQERSQGGLA AGGSLDMNGR CICPSLPYSP VSSPQSSPRL PRRPTVESHH 
       160        170        180        190        200
VSITGMQDCV QLNQYTLKDE IGKGSYGVVK LAYNENDNTY YAMKVLSKKK 
       210        220        230        240        250
LIRQAGFPRR PPPRGTRPAP GGCIQPRGPI EQVYQEIAIL KKLDHPNVVK 
       260        270        280        290        300
LVEVLDDPNE DHLYMVFELV NQGPVMEVPT LKPLSEDQAR FYFQDLIKGI 
       310        320        330        340        350
EYLHYQKIIH RDIKPSNLLV GEDGHIKIAD FGVSNEFKGS DALLSNTVGT 
       360        370        380        390        400
PAFMAPESLS ETRKIFSGKA LDVWAMGVTL YCFVFGQCPF MDERIMCLHS 
       410        420        430        440        450
KIKSQALEFP DQPDIAEDLK DLITRMLDKN PESRIVVPEI KLHPWVTRHG 
       460        470        480        490        500
AEPLPSEDEN CTLVEVTEEE VENSVKHIPS LATVILVKTM IRKRSFGNPF 
       510        520        530        540 
EGSRREERSL SAPGNLLTKQ GSEDNLQGTD PPPVGEEEVL L

Show »

Length:541

Mass (Da):59,602

Checksum:ⁱD9A56C3D780C0DDE

GO

Isoform 4 (identifier: Q96RR4-4) [UniParc]FASTA Add to basket

Also known as: Beta1delta14

The sequence of this isoform differs from the canonical sequence as follows:
442-484: Missing.

« Hide

        10         20         30         40         50
MSSCVSSQPS SNRAAPQDEL GGRGSSSSES QKPCEALRGL SSLSIHLGME 
        60         70         80         90        100
SFIVVTECEP GCAVDLGLAR DRPLEADGQE VPLDTSGSQA RPHLSGRKLS 
       110        120        130        140        150
LQERSQGGLA AGGSLDMNGR CICPSLPYSP VSSPQSSPRL PRRPTVESHH 
       160        170        180        190        200
VSITGMQDCV QLNQYTLKDE IGKGSYGVVK LAYNENDNTY YAMKVLSKKK 
       210        220        230        240        250
LIRQAGFPRR PPPRGTRPAP GGCIQPRGPI EQVYQEIAIL KKLDHPNVVK 
       260        270        280        290        300
LVEVLDDPNE DHLYMVFELV NQGPVMEVPT LKPLSEDQAR FYFQDLIKGI 
       310        320        330        340        350
EYLHYQKIIH RDIKPSNLLV GEDGHIKIAD FGVSNEFKGS DALLSNTVGT 
       360        370        380        390        400
PAFMAPESLS ETRKIFSGKA LDVWAMGVTL YCFVFGQCPF MDERIMCLHS 
       410        420        430        440        450
KIKSQALEFP DQPDIAEDLK DLITRMLDKN PESRIVVPEI KILVKTMIRK 
       460        470        480        490        500
RSFGNPFEGS RREERSLSAP GNLLTKKPTR ECESLSELKE ARQRRQPPGH 
       510        520        530        540 
RPAPRGGGGS ALVRGSPCVE SCWAPAPGSP ARMHPLRPEE AMEPE

Show »

Length:545

Mass (Da):59,971

Checksum:ⁱEE849E31E0416BC3

GO

Isoform 5 (identifier: Q96RR4-5) [UniParc]FASTA Add to basket

Also known as: Beta1delta14/16, beta-3x

The sequence of this isoform differs from the canonical sequence as follows:
     442-484: Missing.
     520-532: KPTRECESLSELK → QGSEDNLQGTDPP
     533-541: EARQRRQPP → PVGEEEVLL
     542-554: Missing.
     555-588: Missing.

« Hide

        10         20         30         40         50
MSSCVSSQPS SNRAAPQDEL GGRGSSSSES QKPCEALRGL SSLSIHLGME 
        60         70         80         90        100
SFIVVTECEP GCAVDLGLAR DRPLEADGQE VPLDTSGSQA RPHLSGRKLS 
       110        120        130        140        150
LQERSQGGLA AGGSLDMNGR CICPSLPYSP VSSPQSSPRL PRRPTVESHH 
       160        170        180        190        200
VSITGMQDCV QLNQYTLKDE IGKGSYGVVK LAYNENDNTY YAMKVLSKKK 
       210        220        230        240        250
LIRQAGFPRR PPPRGTRPAP GGCIQPRGPI EQVYQEIAIL KKLDHPNVVK 
       260        270        280        290        300
LVEVLDDPNE DHLYMVFELV NQGPVMEVPT LKPLSEDQAR FYFQDLIKGI 
       310        320        330        340        350
EYLHYQKIIH RDIKPSNLLV GEDGHIKIAD FGVSNEFKGS DALLSNTVGT 
       360        370        380        390        400
PAFMAPESLS ETRKIFSGKA LDVWAMGVTL YCFVFGQCPF MDERIMCLHS 
       410        420        430        440        450
KIKSQALEFP DQPDIAEDLK DLITRMLDKN PESRIVVPEI KILVKTMIRK 
       460        470        480        490 
RSFGNPFEGS RREERSLSAP GNLLTKQGSE DNLQGTDPPP VGEEEVLL

Note: Inactive. Does not activate CAMK1 and CAMK4.Combined sources

Show »

Length:498

Mass (Da):54,827

Checksum:ⁱ6D051947DDCB69E1

GO

Isoform 6 (identifier: Q96RR4-6) [UniParc]FASTA Add to basket

Also known as: Beta2delta14

The sequence of this isoform differs from the canonical sequence as follows:
     442-484: Missing.
     533-533: E → T
     534-554: Missing.
     555-588: Missing.

« Hide

        10         20         30         40         50
MSSCVSSQPS SNRAAPQDEL GGRGSSSSES QKPCEALRGL SSLSIHLGME 
        60         70         80         90        100
SFIVVTECEP GCAVDLGLAR DRPLEADGQE VPLDTSGSQA RPHLSGRKLS 
       110        120        130        140        150
LQERSQGGLA AGGSLDMNGR CICPSLPYSP VSSPQSSPRL PRRPTVESHH 
       160        170        180        190        200
VSITGMQDCV QLNQYTLKDE IGKGSYGVVK LAYNENDNTY YAMKVLSKKK 
       210        220        230        240        250
LIRQAGFPRR PPPRGTRPAP GGCIQPRGPI EQVYQEIAIL KKLDHPNVVK 
       260        270        280        290        300
LVEVLDDPNE DHLYMVFELV NQGPVMEVPT LKPLSEDQAR FYFQDLIKGI 
       310        320        330        340        350
EYLHYQKIIH RDIKPSNLLV GEDGHIKIAD FGVSNEFKGS DALLSNTVGT 
       360        370        380        390        400
PAFMAPESLS ETRKIFSGKA LDVWAMGVTL YCFVFGQCPF MDERIMCLHS 
       410        420        430        440        450
KIKSQALEFP DQPDIAEDLK DLITRMLDKN PESRIVVPEI KILVKTMIRK 
       460        470        480        490
RSFGNPFEGS RREERSLSAP GNLLTKKPTR ECESLSELKT

Note: Inactive. Does not activate CAMK1 and CAMK4.

Show »

Length:490

Mass (Da):54,124

Checksum:ⁱ0821956F65E543C4

GO

Isoform 7 (identifier: Q96RR4-7) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
533-554: EARQRRQPPGHRPAPRGGGGSA → GTKKKKGLDSMTSTVAAGWLDRRV
555-588: Missing.

« Hide

        10         20         30         40         50
MSSCVSSQPS SNRAAPQDEL GGRGSSSSES QKPCEALRGL SSLSIHLGME 
        60         70         80         90        100
SFIVVTECEP GCAVDLGLAR DRPLEADGQE VPLDTSGSQA RPHLSGRKLS 
       110        120        130        140        150
LQERSQGGLA AGGSLDMNGR CICPSLPYSP VSSPQSSPRL PRRPTVESHH 
       160        170        180        190        200
VSITGMQDCV QLNQYTLKDE IGKGSYGVVK LAYNENDNTY YAMKVLSKKK 
       210        220        230        240        250
LIRQAGFPRR PPPRGTRPAP GGCIQPRGPI EQVYQEIAIL KKLDHPNVVK 
       260        270        280        290        300
LVEVLDDPNE DHLYMVFELV NQGPVMEVPT LKPLSEDQAR FYFQDLIKGI 
       310        320        330        340        350
EYLHYQKIIH RDIKPSNLLV GEDGHIKIAD FGVSNEFKGS DALLSNTVGT 
       360        370        380        390        400
PAFMAPESLS ETRKIFSGKA LDVWAMGVTL YCFVFGQCPF MDERIMCLHS 
       410        420        430        440        450
KIKSQALEFP DQPDIAEDLK DLITRMLDKN PESRIVVPEI KLHPWVTRHG 
       460        470        480        490        500
AEPLPSEDEN CTLVEVTEEE VENSVKHIPS LATVILVKTM IRKRSFGNPF 
       510        520        530        540        550
EGSRREERSL SAPGNLLTKK PTRECESLSE LKGTKKKKGL DSMTSTVAAG 

WLDRRV

Show »

Length:556

Mass (Da):61,386

Checksum:ⁱ47E33706CE77489C

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F5H4I7	F5H4I7_HUMAN	Calcium/calmodulin-dependent protei... Calcium/calmodulin-dependent protein kinase kinase 2	CAMKK2	125	Annotation score:
F5GZ00	F5GZ00_HUMAN	Calcium/calmodulin-dependent protei... Calcium/calmodulin-dependent protein kinase kinase 2	CAMKK2	343	Annotation score:
F5H360	F5H360_HUMAN	Calcium/calmodulin-dependent protei... Calcium/calmodulin-dependent protein kinase kinase 2	CAMKK2	87	Annotation score:

Sequence cautionⁱ

The sequence AAC72943 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BAA34507 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence CAD38990 differs from that shown. Intron retention.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	206	G → A in AAD31507 (PubMed:9822657).Curated	1
Sequence conflictⁱ	331	F → I in BAF84761 (PubMed:14702039).Curated	1
Sequence conflictⁱ	347	T → Y in AAD31507 (PubMed:9822657).Curated	1
Sequence conflictⁱ	371	L → K in AAD31507 (PubMed:9822657).Curated	1
Sequence conflictⁱ	554	A → H in AAK91829 (PubMed:11395482).Curated	1
Sequence conflictⁱ	557	R → N in AAK91829 (PubMed:11395482).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_032788	10	S → N1 PublicationCorresponds to variant dbSNP:rs28360477Ensembl.	1
Natural variantⁱVAR_020532	85	T → S4 PublicationsCorresponds to variant dbSNP:rs3817190Ensembl.	1
Natural variantⁱVAR_040610	123	C → Y1 PublicationCorresponds to variant dbSNP:rs35403710Ensembl.	1
Natural variantⁱVAR_040611	127	P → L in a lung neuroendocrine carcinoma sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_040612	182	A → T in a colorectal adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1207121718Ensembl.	1
Natural variantⁱVAR_020533	363	R → C. Corresponds to variant dbSNP:rs1132780Ensembl.	1
Natural variantⁱVAR_040613	492	R → H1 PublicationCorresponds to variant dbSNP:rs34129994Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_012142	442 – 484	Missing in isoform 4, isoform 5 and isoform 6. 2 PublicationsAdd BLAST	43
Alternative sequenceⁱVSP_012143	520 – 532	KPTRE…LSELK → QGSEDNLQGTDPP in isoform 3 and isoform 5. 4 PublicationsAdd BLAST	13
Alternative sequenceⁱVSP_012148	533 – 554	EARQR…GGGSA → GTKKKKGLDSMTSTVAAGWL DRRV in isoform 7. 2 PublicationsAdd BLAST	22
Alternative sequenceⁱVSP_012144	533 – 541	EARQRRQPP → PVGEEEVLL in isoform 3 and isoform 5. 4 Publications	9
Alternative sequenceⁱVSP_012146	533	E → T in isoform 2 and isoform 6. 3 Publications	1
Alternative sequenceⁱVSP_012147	534 – 554	Missing in isoform 2 and isoform 6. 3 PublicationsAdd BLAST	21
Alternative sequenceⁱVSP_012145	542 – 554	Missing in isoform 3 and isoform 5. 4 PublicationsAdd BLAST	13
Alternative sequenceⁱVSP_012149	555 – 588	Missing in isoform 2, isoform 3, isoform 5, isoform 6 and isoform 7. 8 PublicationsAdd BLAST	34

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB081337 mRNA Translation: BAC19841.1 AF287630 mRNA Translation: AAK64600.1 AF287631 mRNA Translation: AAK64601.1 AF321385 mRNA Translation: AAL37215.1 AF321386 mRNA Translation: AAL37216.1 AF321387 mRNA Translation: AAL37217.1 AF321388 mRNA Translation: AAL37218.1 AF321401 AF321578 Genomic DNA Translation: AAK91830.1 AF321402 AF321578 Genomic DNA Translation: AAK91829.1 AF140507 mRNA Translation: AAD31507.1 AB081336 mRNA Translation: BAC19840.1 AB018330 mRNA Translation: BAA34507.2 Different initiation. AK292072 mRNA Translation: BAF84761.1 AC069209 Genomic DNA No translation available. BC000318 mRNA Translation: AAH00318.2 BC026060 mRNA Translation: AAH26060.1 AF101264 mRNA Translation: AAD04566.1 AL834322 mRNA Translation: CAD38990.1 Sequence problems. AF091074 mRNA Translation: AAC72943.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS44999.1 [Q96RR4-2] CCDS53837.1 [Q96RR4-6] CCDS58283.1 [Q96RR4-7] CCDS9216.1 [Q96RR4-1] CCDS9217.1 [Q96RR4-4] CCDS9218.1 [Q96RR4-3] CCDS9219.1 [Q96RR4-5]
PIRⁱ	JE0191
NCBI Reference Sequences More...RefSeqⁱ	NP_001257414.1, NM_001270485.1 [Q96RR4-1] NP_001257415.1, NM_001270486.1 [Q96RR4-7] NP_006540.3, NM_006549.3 [Q96RR4-1] NP_705719.2, NM_153499.2 [Q96RR4-3] NP_705720.1, NM_153500.1 [Q96RR4-5] NP_757363.1, NM_172214.2 [Q96RR4-2] NP_757364.1, NM_172215.2 [Q96RR4-6] NP_757365.1, NM_172216.1 [Q96RR4-4] NP_757380.1, NM_172226.2 [Q96RR4-3] XP_005253880.1, XM_005253823.1 [Q96RR4-2] XP_005253881.1, XM_005253824.3 [Q96RR4-5] XP_011536065.1, XM_011537763.1 [Q96RR4-7] XP_016874187.1, XM_017018698.1 XP_016874190.1, XM_017018701.1 XP_016874191.1, XM_017018702.1 [Q96RR4-7] XP_016874193.1, XM_017018704.1
UniGeneⁱ	Hs.297343

Genome annotation databases

Ensemblⁱ	ENST00000324774; ENSP00000312741; ENSG00000110931 [Q96RR4-1] ENST00000337174; ENSP00000336634; ENSG00000110931 [Q96RR4-3] ENST00000347034; ENSP00000321230; ENSG00000110931 [Q96RR4-4] ENST00000392473; ENSP00000376265; ENSG00000110931 [Q96RR4-2] ENST00000392474; ENSP00000376266; ENSG00000110931 [Q96RR4-7] ENST00000402834; ENSP00000384591; ENSG00000110931 [Q96RR4-1] ENST00000404169; ENSP00000384600; ENSG00000110931 [Q96RR4-1] ENST00000412367; ENSP00000388368; ENSG00000110931 [Q96RR4-3] ENST00000446440; ENSP00000388273; ENSG00000110931 [Q96RR4-6] ENST00000538733; ENSP00000445944; ENSG00000110931 [Q96RR4-5]
GeneIDⁱ	10645
KEGGⁱ	hsa:10645
UCSC genome browser More...UCSCⁱ	uc001tzt.4 human [Q96RR4-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96RR4	Calcium/calmodulin-dependent protein kinase kinase 2, beta, isoform CRA_f		HUMAN		588	UniRef100_Q96RR4
CAMKK2 isoform 10		PANTR		588
Q96RR4-2	CAMKK2 isoform 2		PANTR		533	UniRef100_A0A2I3SSH6
UPI0007DBB4C3		PANTR		570
Q96RR4-3	Calcium/calmodulin-dependent protein kinase kinase 2, beta, isoform CRA_b		HUMAN		541	UniRef100_A0A024RBP6
CAMKK2 isoform 12		PANTR		541
Uncharacterized protein		PANPA		541
Q96RR4-4	Calcium/calmodulin-dependent protein kinase kinase 2, beta, isoform CRA_d		HUMAN		545	UniRef100_A0A024RBP8
CAMKK2 isoform 3		PANTR		545
Uncharacterized protein		PANPA		545
Q96RR4-5	Calcium/calmodulin-dependent protein kinase kinase 2, beta, isoform CRA_e		HUMAN		498	UniRef100_A0A024RBQ3
CAMKK2 isoform 5		PANTR		498
Q96RR4-6	CAMKK2 isoform 4		PANTR		490	UniRef100_A0A2J8MDG7
Uncharacterized protein		PANPA		490

Protein	Similar proteins		Species	Score	Length	Source
Q96RR4	Calcium/calmodulin-dependent protein kinase kinase 2, beta, isoform CRA_f		HUMAN		588	UniRef90_Q96RR4
CAMKK2 isoform 10		PANTR		588
Uncharacterized protein		CERAT		588
Uncharacterized protein		MANLE		588
Uncharacterized protein		PAPAN		588
+74
Q96RR4-2	Isoform 2 of Calcium/calmodulin-dependent protein kinase kinase 2		RAT		540	UniRef90_O88831-2
Uncharacterized protein		MACNE		648
Calcium/calmodulin dependent protein kinase kinase 2		SAIBB		588
Uncharacterized protein		MACMU		588
Calcium/calmodulin dependent protein kinase kinase 2		GORGO		588
+124
Q96RR4-3	Isoform 2 of Calcium/calmodulin-dependent protein kinase kinase 2		RAT		540	UniRef90_O88831-2
Uncharacterized protein		MACNE		648
Calcium/calmodulin dependent protein kinase kinase 2		SAIBB		588
Uncharacterized protein		MACMU		588
Calcium/calmodulin dependent protein kinase kinase 2		GORGO		588
+124
Q96RR4-4	Calcium/calmodulin-dependent protein kinase kinase 2, beta, isoform CRA_d		HUMAN		545	UniRef90_A0A024RBP8
CAMKK2 isoform 3		PANTR		545
Uncharacterized protein		PANPA		545
Uncharacterized protein		MACNE		611
Calcium/calmodulin dependent protein kinase kinase 2		GORGO		545
+12
Q96RR4-5	Calcium/calmodulin-dependent protein kinase kinase 2, beta, isoform CRA_e		HUMAN		498	UniRef90_A0A024RBQ3
CAMKK2 isoform 5		PANTR		498
Calcium/calmodulin dependent protein kinase kinase 2		SAIBB		545
Uncharacterized protein		Cebus capucinus imitator		545
Calcium/calmodulin dependent protein kinase kinase 2		CALJA		545
+78
Q96RR4-6	Calcium/calmodulin-dependent protein kinase kinase 2, beta, isoform CRA_e		HUMAN		498	UniRef90_A0A024RBQ3
CAMKK2 isoform 5		PANTR		498
Calcium/calmodulin dependent protein kinase kinase 2		SAIBB		545
Uncharacterized protein		Cebus capucinus imitator		545
Calcium/calmodulin dependent protein kinase kinase 2		CALJA		545
+78

Protein	Similar proteins		Species	Score	Length	Source
Q96RR4	Calcium/calmodulin-dependent protein kinase kinase 2		MOUSE		588	UniRef50_Q96RR4
Calcium/calmodulin-dependent protein kinase kinase 2		RAT		587
Calcium/calmodulin-dependent protein kinase kinase 2, beta, isoform CRA_f		HUMAN		588
CAMKK2 isoform 10		PANTR		588
Uncharacterized protein		PAPAN		588
+619

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB081337 mRNA Translation: BAC19841.1 AF287630 mRNA Translation: AAK64600.1 AF287631 mRNA Translation: AAK64601.1 AF321385 mRNA Translation: AAL37215.1 AF321386 mRNA Translation: AAL37216.1 AF321387 mRNA Translation: AAL37217.1 AF321388 mRNA Translation: AAL37218.1 AF321401 AF321578 Genomic DNA Translation: AAK91830.1 AF321402 AF321578 Genomic DNA Translation: AAK91829.1 AF140507 mRNA Translation: AAD31507.1 AB081336 mRNA Translation: BAC19840.1 AB018330 mRNA Translation: BAA34507.2 Different initiation. AK292072 mRNA Translation: BAF84761.1 AC069209 Genomic DNA No translation available. BC000318 mRNA Translation: AAH00318.2 BC026060 mRNA Translation: AAH26060.1 AF101264 mRNA Translation: AAD04566.1 AL834322 mRNA Translation: CAD38990.1 Sequence problems. AF091074 mRNA Translation: AAC72943.1 Different initiation.
CCDSⁱ	CCDS44999.1 [Q96RR4-2] CCDS53837.1 [Q96RR4-6] CCDS58283.1 [Q96RR4-7] CCDS9216.1 [Q96RR4-1] CCDS9217.1 [Q96RR4-4] CCDS9218.1 [Q96RR4-3] CCDS9219.1 [Q96RR4-5]
PIRⁱ	JE0191
RefSeqⁱ	NP_001257414.1, NM_001270485.1 [Q96RR4-1] NP_001257415.1, NM_001270486.1 [Q96RR4-7] NP_006540.3, NM_006549.3 [Q96RR4-1] NP_705719.2, NM_153499.2 [Q96RR4-3] NP_705720.1, NM_153500.1 [Q96RR4-5] NP_757363.1, NM_172214.2 [Q96RR4-2] NP_757364.1, NM_172215.2 [Q96RR4-6] NP_757365.1, NM_172216.1 [Q96RR4-4] NP_757380.1, NM_172226.2 [Q96RR4-3] XP_005253880.1, XM_005253823.1 [Q96RR4-2] XP_005253881.1, XM_005253824.3 [Q96RR4-5] XP_011536065.1, XM_011537763.1 [Q96RR4-7] XP_016874187.1, XM_017018698.1 XP_016874190.1, XM_017018701.1 XP_016874191.1, XM_017018702.1 [Q96RR4-7] XP_016874193.1, XM_017018704.1
UniGeneⁱ	Hs.297343

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2ZV2	X-ray	2.40	A	158-448	[»]
	5UY6	X-ray	1.70	A	161-449	[»]
	5UYJ	X-ray	1.60	A	161-449	[»]
	5VT1	X-ray	1.90	A	161-449	[»]
	6BKU	X-ray	2.00	A	162-449	[»]
	6BLE	X-ray	1.90	A	161-449	[»]
	6BQL	X-ray	2.00	A	161-449	[»]
	6BQP	X-ray	1.95	A	161-449	[»]
	6BQQ	X-ray	1.80	A	161-449	[»]
	6BRC	X-ray	2.20	A/B	161-449	[»]
	6CMJ	X-ray	2.40	A/B	149-465	[»]
	6EWW	X-ray	2.68	E/F/G/H	97-104	[»]
	6FEL	X-ray	2.84	E/F/G/H	508-515	[»]
ProteinModelPortalⁱ	Q96RR4
SMRⁱ	Q96RR4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115889, 31 interactors
IntActⁱ	Q96RR4, 19 interactors
STRINGⁱ	9606.ENSP00000312741

Chemistry databases

BindingDBⁱ	Q96RR4
ChEMBLⁱ	CHEMBL5284
GuidetoPHARMACOLOGYⁱ	1957

PTM databases

iPTMnetⁱ	Q96RR4
PhosphoSitePlusⁱ	Q96RR4

Polymorphism and mutation databases

BioMutaⁱ	CAMKK2
DMDMⁱ	317373374

Proteomic databases

EPDⁱ	Q96RR4
MaxQBⁱ	Q96RR4
PaxDbⁱ	Q96RR4
PeptideAtlasⁱ	Q96RR4
PRIDEⁱ	Q96RR4
ProteomicsDBⁱ	78009 78010 [Q96RR4-2] 78011 [Q96RR4-3] 78012 [Q96RR4-4] 78013 [Q96RR4-5] 78014 [Q96RR4-6] 78015 [Q96RR4-7]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	10645
Structural Biology Knowledgebase	Search...

Genome annotation databases

Organism-specific databases

CTDⁱ	10645
DisGeNETⁱ	10645
EuPathDBⁱ	HostDB:ENSG00000110931.18
GeneCardsⁱ	CAMKK2
H-InvDBⁱ	HIX0011079 HIX0171630 HIX0171665
HGNCⁱ	HGNC:1470 CAMKK2
HPAⁱ	HPA017389
MIMⁱ	615002 gene
neXtProtⁱ	NX_Q96RR4
OpenTargetsⁱ	ENSG00000110931
PharmGKBⁱ	PA26052
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0585 Eukaryota ENOG410YHHF LUCA
GeneTreeⁱ	ENSGT00530000063214
HOVERGENⁱ	HBG052262
InParanoidⁱ	Q96RR4
KOⁱ	K07359
OMAⁱ	SEGQKPC
OrthoDBⁱ	EOG091G01DB
PhylomeDBⁱ	Q96RR4
TreeFamⁱ	TF313013

Enzyme and pathway databases

BRENDAⁱ	2.7.11.17 2681
SignaLinkⁱ	Q96RR4
SIGNORⁱ	Q96RR4

Miscellaneous databases

ChiTaRSⁱ	CAMKK2 human
EvolutionaryTraceⁱ	Q96RR4
GeneWikiⁱ	CAMKK2
GenomeRNAiⁱ	10645
Protein Ontology More...PROⁱ	PR:Q96RR4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000110931 Expressed in 232 organ(s), highest expression level in cerebellum
CleanExⁱ	HS_CAMKK2
ExpressionAtlasⁱ	Q96RR4 baseline and differential
Genevisibleⁱ	Q96RR4 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KKCC2_HUMAN
Accessionⁱ	Q96RR4Primary (citable) accession number: Q96RR4 Secondary accession number(s): A8K7Q7 Q9Y5N2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 7, 2004
	Last sequence update:	January 11, 2011
	Last modified:	November 7, 2018
	This is version 162 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM
Human and mouse protein kinases
Human and mouse protein kinases: classification and index

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UniProtKB - Q96RR4 (KKCC2_HUMAN)

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Calcium/calmodulin-dependent protein kinase kinase 2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Keywords - PTMi

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<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

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Keywords - Coding sequence diversityi

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

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Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ