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UniProtKB - Q96RR4 (KKCC2_HUMAN)

Entry version 167 (05 Jun 2019)
Sequence version 2 (11 Jan 2011)
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Protein

Calcium/calmodulin-dependent protein kinase kinase 2

Gene

CAMKK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca2+ signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.By similarity4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by Ca2+/calmodulin. Binding of calmodulin may relieve intrasteric autoinhibition. Autophosphorylation does not alter activity or regulation by Ca2+/calmodulin. In part, activity is independent on Ca2+/calmodulin (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei194ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei312Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi171 – 179ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.7.11.17 2681

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-111932 CaMK IV-mediated phosphorylation of CREB
R-HSA-442729 CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
R-HSA-9619229 Activation of RAC1 downstream of NMDARs
R-HSA-9619483 Activation of AMPK downstream of NMDARs

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q96RR4

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q96RR4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calcium/calmodulin-dependent protein kinase kinase 2 (EC:2.7.11.17)
Short name:
CaM-KK 2
Short name:
CaM-kinase kinase 2
Short name:
CaMKK 2
Alternative name(s):
Calcium/calmodulin-dependent protein kinase kinase beta
Short name:
CaM-KK beta
Short name:
CaM-kinase kinase beta
Short name:
CaMKK beta
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CAMKK2
Synonyms:CAMKKB, KIAA0787
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:1470 CAMKK2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		615002 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96RR4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		10645

Open Targets

More...OpenTargetsi		ENSG00000110931

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26052

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL5284

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		1957

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CAMKK2

Domain mapping of disease mutations (DMDM)

More...DMDMi		317373374

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000861442 – 588Calcium/calmodulin-dependent protein kinase kinase 2Add BLAST587

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei100PhosphoserineBy similarity1
Modified residuei114PhosphoserineCombined sources1
Modified residuei129PhosphoserineCombined sources1
Modified residuei133PhosphoserineBy similarity1
Modified residuei137PhosphoserineBy similarity1
Modified residuei495PhosphoserineCombined sources1
Modified residuei511PhosphoserineCombined sources1
Modified residuei572PhosphoserineBy similarity1
Isoform 5 (identifier: Q96RR4-5)
Modified residuei479PhosphoserineCombined sources1
Isoform 3 (identifier: Q96RR4-3)
Modified residuei522PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylated and phosphorylated by PKA. Each isoform may show a different pattern of phosphorylation.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96RR4

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96RR4

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96RR4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96RR4

PeptideAtlas

More...PeptideAtlasi		Q96RR4

PRoteomics IDEntifications database

More...PRIDEi		Q96RR4

ProteomicsDB human proteome resource

More...ProteomicsDBi		78009
78010 [Q96RR4-2]
78011 [Q96RR4-3]
78012 [Q96RR4-4]
78013 [Q96RR4-5]
78014 [Q96RR4-6]
78015 [Q96RR4-7]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96RR4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96RR4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed with higher levels in the brain. Intermediate levels are detected in spleen, prostate, thyroid and leukocytes. The lowest level is in lung.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Isoform 1 is up-regulated by PKA pathway.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000110931 Expressed in 232 organ(s), highest expression level in cerebellum

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96RR4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96RR4 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA017389

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with calmodulin.By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		115889, 31 interactors

Protein interaction database and analysis system

More...IntActi		Q96RR4, 20 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000312741

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q96RR4

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1588
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96RR4

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q96RR4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini165 – 446Protein kinasePROSITE-ProRule annotationAdd BLAST282

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni204 – 226RP domainAdd BLAST23
Regioni472 – 477Autoinhibitory domainBy similarity6
Regioni475 – 500Calmodulin-bindingBy similarityAdd BLAST26

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition.
The RP domain (arginine/proline-rich) is involved in the recognition of CAMKI and CAMK4 as substrates.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0585 Eukaryota
ENOG410YHHF LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161828

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96RR4

KEGG Orthology (KO)

More...KOi		K07359

Identification of Orthologs from Complete Genome Data

More...OMAi		SEGQKPC

Database of Orthologous Groups

More...OrthoDBi		856506at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96RR4

TreeFam database of animal gene trees

More...TreeFami		TF313013

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96RR4-1) [UniParc]FASTAAdd to basket
Also known as: Beta1, CAMKK2+E16

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSCVSSQPS SNRAAPQDEL GGRGSSSSES QKPCEALRGL SSLSIHLGME 
        60         70         80         90        100
SFIVVTECEP GCAVDLGLAR DRPLEADGQE VPLDTSGSQA RPHLSGRKLS 
       110        120        130        140        150
LQERSQGGLA AGGSLDMNGR CICPSLPYSP VSSPQSSPRL PRRPTVESHH 
       160        170        180        190        200
VSITGMQDCV QLNQYTLKDE IGKGSYGVVK LAYNENDNTY YAMKVLSKKK 
       210        220        230        240        250
LIRQAGFPRR PPPRGTRPAP GGCIQPRGPI EQVYQEIAIL KKLDHPNVVK 
       260        270        280        290        300
LVEVLDDPNE DHLYMVFELV NQGPVMEVPT LKPLSEDQAR FYFQDLIKGI 
       310        320        330        340        350
EYLHYQKIIH RDIKPSNLLV GEDGHIKIAD FGVSNEFKGS DALLSNTVGT 
       360        370        380        390        400
PAFMAPESLS ETRKIFSGKA LDVWAMGVTL YCFVFGQCPF MDERIMCLHS 
       410        420        430        440        450
KIKSQALEFP DQPDIAEDLK DLITRMLDKN PESRIVVPEI KLHPWVTRHG 
       460        470        480        490        500
AEPLPSEDEN CTLVEVTEEE VENSVKHIPS LATVILVKTM IRKRSFGNPF 
       510        520        530        540        550
EGSRREERSL SAPGNLLTKK PTRECESLSE LKEARQRRQP PGHRPAPRGG 
       560        570        580 
GGSALVRGSP CVESCWAPAP GSPARMHPLR PEEAMEPE
Note: Major isoform.
Length:588
Mass (Da):64,746
Last modified:January 11, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i04E3583561341167
GO
Isoform 2 (identifier: Q96RR4-2) [UniParc]FASTAAdd to basket
Also known as: Beta2

The sequence of this isoform differs from the canonical sequence as follows:
     533-533: E → T
     534-554: Missing.
     555-588: Missing.

Note: Major isoform.
Show »
Length:533
Mass (Da):58,899
Checksum:i98FAAB0FB8C4CACF
GO
Isoform 3 (identifier: Q96RR4-3) [UniParc]FASTAAdd to basket
Also known as: Beta1delta16, CAMKK2-E16

The sequence of this isoform differs from the canonical sequence as follows:
     520-532: KPTRECESLSELK → QGSEDNLQGTDPP
     533-541: EARQRRQPP → PVGEEEVLL
     542-554: Missing.
     555-588: Missing.

Show »
Length:541
Mass (Da):59,602
Checksum:iD9A56C3D780C0DDE
GO
Isoform 4 (identifier: Q96RR4-4) [UniParc]FASTAAdd to basket
Also known as: Beta1delta14

The sequence of this isoform differs from the canonical sequence as follows:
     442-484: Missing.

Show »
Length:545
Mass (Da):59,971
Checksum:iEE849E31E0416BC3
GO
Isoform 5 (identifier: Q96RR4-5) [UniParc]FASTAAdd to basket
Also known as: Beta1delta14/16, beta-3x

The sequence of this isoform differs from the canonical sequence as follows:
     442-484: Missing.
     520-532: KPTRECESLSELK → QGSEDNLQGTDPP
     533-541: EARQRRQPP → PVGEEEVLL
     542-554: Missing.
     555-588: Missing.

Note: Inactive. Does not activate CAMK1 and CAMK4.Combined sources
Show »
Length:498
Mass (Da):54,827
Checksum:i6D051947DDCB69E1
GO
Isoform 6 (identifier: Q96RR4-6) [UniParc]FASTAAdd to basket
Also known as: Beta2delta14

The sequence of this isoform differs from the canonical sequence as follows:
     442-484: Missing.
     533-533: E → T
     534-554: Missing.
     555-588: Missing.

Note: Inactive. Does not activate CAMK1 and CAMK4.
Show »
Length:490
Mass (Da):54,124
Checksum:i0821956F65E543C4
GO
Isoform 7 (identifier: Q96RR4-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     533-554: EARQRRQPPGHRPAPRGGGGSA → GTKKKKGLDSMTSTVAAGWLDRRV
     555-588: Missing.

Show »
Length:556
Mass (Da):61,386
Checksum:i47E33706CE77489C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H4I7F5H4I7_HUMAN
Calcium/calmodulin-dependent protei...
CAMKK2
125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GZ00F5GZ00_HUMAN
Calcium/calmodulin-dependent protei...
CAMKK2
343Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H360F5H360_HUMAN
Calcium/calmodulin-dependent protei...
CAMKK2
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC72943 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA34507 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAD38990 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti206G → A in AAD31507 (PubMed:9822657).Curated1
Sequence conflicti331F → I in BAF84761 (PubMed:14702039).Curated1
Sequence conflicti347T → Y in AAD31507 (PubMed:9822657).Curated1
Sequence conflicti371L → K in AAD31507 (PubMed:9822657).Curated1
Sequence conflicti554A → H in AAK91829 (PubMed:11395482).Curated1
Sequence conflicti557R → N in AAK91829 (PubMed:11395482).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03278810S → N1 PublicationCorresponds to variant dbSNP:rs28360477Ensembl.1
Natural variantiVAR_02053285T → S4 PublicationsCorresponds to variant dbSNP:rs3817190Ensembl.1
Natural variantiVAR_040610123C → Y1 PublicationCorresponds to variant dbSNP:rs35403710Ensembl.1
Natural variantiVAR_040611127P → L in a lung neuroendocrine carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_040612182A → T in a colorectal adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1207121718Ensembl.1
Natural variantiVAR_020533363R → C. Corresponds to variant dbSNP:rs1132780Ensembl.1
Natural variantiVAR_040613492R → H1 PublicationCorresponds to variant dbSNP:rs34129994Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_012142442 – 484Missing in isoform 4, isoform 5 and isoform 6. 2 PublicationsAdd BLAST43
Alternative sequenceiVSP_012143520 – 532KPTRE…LSELK → QGSEDNLQGTDPP in isoform 3 and isoform 5. 4 PublicationsAdd BLAST13
Alternative sequenceiVSP_012148533 – 554EARQR…GGGSA → GTKKKKGLDSMTSTVAAGWL DRRV in isoform 7. 2 PublicationsAdd BLAST22
Alternative sequenceiVSP_012144533 – 541EARQRRQPP → PVGEEEVLL in isoform 3 and isoform 5. 4 Publications9
Alternative sequenceiVSP_012146533E → T in isoform 2 and isoform 6. 3 Publications1
Alternative sequenceiVSP_012147534 – 554Missing in isoform 2 and isoform 6. 3 PublicationsAdd BLAST21
Alternative sequenceiVSP_012145542 – 554Missing in isoform 3 and isoform 5. 4 PublicationsAdd BLAST13
Alternative sequenceiVSP_012149555 – 588Missing in isoform 2, isoform 3, isoform 5, isoform 6 and isoform 7. 8 PublicationsAdd BLAST34

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB081337 mRNA Translation: BAC19841.1
AF287630 mRNA Translation: AAK64600.1
AF287631 mRNA Translation: AAK64601.1
AF321385 mRNA Translation: AAL37215.1
AF321386 mRNA Translation: AAL37216.1
AF321387 mRNA Translation: AAL37217.1
AF321388 mRNA Translation: AAL37218.1
AF321401
, AF321390, AF321391, AF321392, AF321393, AF321394, AF321395, AF321396, AF321397, AF321398, AF321399, AF321400, AF321575, AF321576, AF321577, AF321578 Genomic DNA Translation: AAK91830.1
AF321402
, AF321390, AF321391, AF321392, AF321393, AF321394, AF321395, AF321396, AF321397, AF321398, AF321399, AF321400, AF321575, AF321576, AF321577, AF321578 Genomic DNA Translation: AAK91829.1
AF140507 mRNA Translation: AAD31507.1
AB081336 mRNA Translation: BAC19840.1
AB018330 mRNA Translation: BAA34507.2 Different initiation.
AK292072 mRNA Translation: BAF84761.1
AC069209 Genomic DNA No translation available.
BC000318 mRNA Translation: AAH00318.2
BC026060 mRNA Translation: AAH26060.1
AF101264 mRNA Translation: AAD04566.1
AL834322 mRNA Translation: CAD38990.1 Sequence problems.
AF091074 mRNA Translation: AAC72943.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS44999.1 [Q96RR4-2]
CCDS53837.1 [Q96RR4-6]
CCDS58283.1 [Q96RR4-7]
CCDS9216.1 [Q96RR4-1]
CCDS9217.1 [Q96RR4-4]
CCDS9218.1 [Q96RR4-3]
CCDS9219.1 [Q96RR4-5]

Protein sequence database of the Protein Information Resource

More...PIRi		JE0191

NCBI Reference Sequences

More...RefSeqi		NP_001257414.1, NM_001270485.1 [Q96RR4-1]
NP_001257415.1, NM_001270486.1 [Q96RR4-7]
NP_006540.3, NM_006549.3 [Q96RR4-1]
NP_705719.2, NM_153499.2 [Q96RR4-3]
NP_705720.1, NM_153500.1 [Q96RR4-5]
NP_757363.1, NM_172214.2 [Q96RR4-2]
NP_757364.1, NM_172215.2 [Q96RR4-6]
NP_757365.1, NM_172216.1 [Q96RR4-4]
NP_757380.1, NM_172226.2 [Q96RR4-3]
XP_005253880.1, XM_005253823.1 [Q96RR4-2]
XP_005253881.1, XM_005253824.3 [Q96RR4-5]
XP_011536065.1, XM_011537763.1 [Q96RR4-7]
XP_016874187.1, XM_017018698.1
XP_016874190.1, XM_017018701.1
XP_016874191.1, XM_017018702.1 [Q96RR4-7]
XP_016874193.1, XM_017018704.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000324774; ENSP00000312741; ENSG00000110931 [Q96RR4-1]
ENST00000337174; ENSP00000336634; ENSG00000110931 [Q96RR4-3]
ENST00000347034; ENSP00000321230; ENSG00000110931 [Q96RR4-4]
ENST00000392473; ENSP00000376265; ENSG00000110931 [Q96RR4-2]
ENST00000392474; ENSP00000376266; ENSG00000110931 [Q96RR4-7]
ENST00000402834; ENSP00000384591; ENSG00000110931 [Q96RR4-1]
ENST00000404169; ENSP00000384600; ENSG00000110931 [Q96RR4-1]
ENST00000412367; ENSP00000388368; ENSG00000110931 [Q96RR4-3]
ENST00000446440; ENSP00000388273; ENSG00000110931 [Q96RR4-6]
ENST00000538733; ENSP00000445944; ENSG00000110931 [Q96RR4-5]
ENST00000652382; ENSP00000498824; ENSG00000110931 [Q96RR4-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10645

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10645

UCSC genome browser

More...UCSCi		uc001tzt.4 human [Q96RR4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB081337 mRNA Translation: BAC19841.1
AF287630 mRNA Translation: AAK64600.1
AF287631 mRNA Translation: AAK64601.1
AF321385 mRNA Translation: AAL37215.1
AF321386 mRNA Translation: AAL37216.1
AF321387 mRNA Translation: AAL37217.1
AF321388 mRNA Translation: AAL37218.1
AF321401
, AF321390, AF321391, AF321392, AF321393, AF321394, AF321395, AF321396, AF321397, AF321398, AF321399, AF321400, AF321575, AF321576, AF321577, AF321578 Genomic DNA Translation: AAK91830.1
AF321402
, AF321390, AF321391, AF321392, AF321393, AF321394, AF321395, AF321396, AF321397, AF321398, AF321399, AF321400, AF321575, AF321576, AF321577, AF321578 Genomic DNA Translation: AAK91829.1
AF140507 mRNA Translation: AAD31507.1
AB081336 mRNA Translation: BAC19840.1
AB018330 mRNA Translation: BAA34507.2 Different initiation.
AK292072 mRNA Translation: BAF84761.1
AC069209 Genomic DNA No translation available.
BC000318 mRNA Translation: AAH00318.2
BC026060 mRNA Translation: AAH26060.1
AF101264 mRNA Translation: AAD04566.1
AL834322 mRNA Translation: CAD38990.1 Sequence problems.
AF091074 mRNA Translation: AAC72943.1 Different initiation.
CCDSiCCDS44999.1 [Q96RR4-2]
CCDS53837.1 [Q96RR4-6]
CCDS58283.1 [Q96RR4-7]
CCDS9216.1 [Q96RR4-1]
CCDS9217.1 [Q96RR4-4]
CCDS9218.1 [Q96RR4-3]
CCDS9219.1 [Q96RR4-5]
PIRiJE0191
RefSeqiNP_001257414.1, NM_001270485.1 [Q96RR4-1]
NP_001257415.1, NM_001270486.1 [Q96RR4-7]
NP_006540.3, NM_006549.3 [Q96RR4-1]
NP_705719.2, NM_153499.2 [Q96RR4-3]
NP_705720.1, NM_153500.1 [Q96RR4-5]
NP_757363.1, NM_172214.2 [Q96RR4-2]
NP_757364.1, NM_172215.2 [Q96RR4-6]
NP_757365.1, NM_172216.1 [Q96RR4-4]
NP_757380.1, NM_172226.2 [Q96RR4-3]
XP_005253880.1, XM_005253823.1 [Q96RR4-2]
XP_005253881.1, XM_005253824.3 [Q96RR4-5]
XP_011536065.1, XM_011537763.1 [Q96RR4-7]
XP_016874187.1, XM_017018698.1
XP_016874190.1, XM_017018701.1
XP_016874191.1, XM_017018702.1 [Q96RR4-7]
XP_016874193.1, XM_017018704.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ZV2X-ray2.40A158-448[»]
5UY6X-ray1.70A161-449[»]
5UYJX-ray1.60A161-449[»]
5VT1X-ray1.90A161-449[»]
5YV8X-ray1.93A158-448[»]
5YV9X-ray2.53A158-448[»]
5YVAX-ray2.57A158-448[»]
5YVBX-ray2.02A158-448[»]
5YVCX-ray2.02A158-448[»]
6BKUX-ray2.00A162-449[»]
6BLEX-ray1.90A161-449[»]
6BQLX-ray2.00A161-449[»]
6BQPX-ray1.95A161-449[»]
6BQQX-ray1.80A161-449[»]
6BRCX-ray2.20A/B161-449[»]
6CMJX-ray2.40A/B149-465[»]
6EWWX-ray2.68E/F/G/H97-104[»]
6FELX-ray2.84E/F/G/H508-515[»]
SMRiQ96RR4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115889, 31 interactors
IntActiQ96RR4, 20 interactors
STRINGi9606.ENSP00000312741

Chemistry databases

BindingDBiQ96RR4
ChEMBLiCHEMBL5284
GuidetoPHARMACOLOGYi1957

PTM databases

iPTMnetiQ96RR4
PhosphoSitePlusiQ96RR4

Polymorphism and mutation databases

BioMutaiCAMKK2
DMDMi317373374

Proteomic databases

EPDiQ96RR4
jPOSTiQ96RR4
MaxQBiQ96RR4
PaxDbiQ96RR4
PeptideAtlasiQ96RR4
PRIDEiQ96RR4
ProteomicsDBi78009
78010 [Q96RR4-2]
78011 [Q96RR4-3]
78012 [Q96RR4-4]
78013 [Q96RR4-5]
78014 [Q96RR4-6]
78015 [Q96RR4-7]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		10645
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324774; ENSP00000312741; ENSG00000110931 [Q96RR4-1]
ENST00000337174; ENSP00000336634; ENSG00000110931 [Q96RR4-3]
ENST00000347034; ENSP00000321230; ENSG00000110931 [Q96RR4-4]
ENST00000392473; ENSP00000376265; ENSG00000110931 [Q96RR4-2]
ENST00000392474; ENSP00000376266; ENSG00000110931 [Q96RR4-7]
ENST00000402834; ENSP00000384591; ENSG00000110931 [Q96RR4-1]
ENST00000404169; ENSP00000384600; ENSG00000110931 [Q96RR4-1]
ENST00000412367; ENSP00000388368; ENSG00000110931 [Q96RR4-3]
ENST00000446440; ENSP00000388273; ENSG00000110931 [Q96RR4-6]
ENST00000538733; ENSP00000445944; ENSG00000110931 [Q96RR4-5]
ENST00000652382; ENSP00000498824; ENSG00000110931 [Q96RR4-1]
GeneIDi10645
KEGGihsa:10645
UCSCiuc001tzt.4 human [Q96RR4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10645
DisGeNETi10645

GeneCards: human genes, protein and diseases

More...GeneCardsi		CAMKK2

H-Invitational Database, human transcriptome db

More...H-InvDBi		HIX0011079
HIX0171630
HIX0171665
HGNCiHGNC:1470 CAMKK2
HPAiHPA017389
MIMi615002 gene
neXtProtiNX_Q96RR4
OpenTargetsiENSG00000110931
PharmGKBiPA26052

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0585 Eukaryota
ENOG410YHHF LUCA
GeneTreeiENSGT00940000161828
InParanoidiQ96RR4
KOiK07359
OMAiSEGQKPC
OrthoDBi856506at2759
PhylomeDBiQ96RR4
TreeFamiTF313013

Enzyme and pathway databases

BRENDAi2.7.11.17 2681
ReactomeiR-HSA-111932 CaMK IV-mediated phosphorylation of CREB
R-HSA-442729 CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
R-HSA-9619229 Activation of RAC1 downstream of NMDARs
R-HSA-9619483 Activation of AMPK downstream of NMDARs
SignaLinkiQ96RR4
SIGNORiQ96RR4

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CAMKK2 human
EvolutionaryTraceiQ96RR4

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CAMKK2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10645

Protein Ontology

More...PROi		PR:Q96RR4

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000110931 Expressed in 232 organ(s), highest expression level in cerebellum
ExpressionAtlasiQ96RR4 baseline and differential
GenevisibleiQ96RR4 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKKCC2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96RR4
Secondary accession number(s): A8K7Q7
, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: January 11, 2011
Last modified: June 5, 2019
This is version 167 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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