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UniProtKB - Q96RQ9 (OXLA_HUMAN)

Entry version 167 (25 May 2022)
Sequence version 1 (01 Dec 2001)
Previous versions | rss
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Protein

L-amino-acid oxidase

Gene

IL4I1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Secreted L-amino-acid oxidase that acts as a key immunoregulator (PubMed:17356132, PubMed:32818467, PubMed:32866000).

Has preference for L-aromatic amino acids: converts phenylalanine (Phe), tyrosine (Tyr) and tryptophan (Trp) to phenylpyruvic acid (PP), hydroxyphenylpyruvic acid (HPP), and indole-3-pyruvic acid (I3P), respectively (PubMed:17356132, PubMed:32818467, PubMed:32866000).

Also has weak L-arginine oxidase activity (PubMed:26673964).

Acts as a negative regulator of anti-tumor immunity by mediating Trp degradation via an indole pyruvate pathway that activates the transcription factor AHR (PubMed:32818467, PubMed:32866000).

IL4I1-mediated Trp catabolism generates I3P, giving rise to indole metabolites (indole-3-acetic acid (IAA) and indole-3-aldehyde (I3A)) and kynurenic acid, which act as ligands for AHR, a ligand-activated transcription factor that plays important roles in immunity and cancer (PubMed:32818467, PubMed:32866000).

AHR activation by indoles following IL4I1-mediated Trp degradation enhances tumor progression by promoting cancer cell motility and suppressing adaptive immunity (PubMed:32818467).

Also has an immunoregulatory function in some immune cells, probably by mediating Trp degradation and promoting downstream AHR activation: inhibits T-cell activation and proliferation, promotes the differentiation of naive CD4+ T-cells into FOXP3+ regulatory T-cells (Treg) and regulates the development and function of B-cells (PubMed:17356132, PubMed:25446972, PubMed:25778793, PubMed:28891065).

Also regulates M2 macrophage polarization by inhibiting T-cell activation (By similarity).

Also has antibacterial properties by inhibiting growth of Gram negative and Gram positive bacteria through the production of NH4+ and H2O2 (PubMed:23355881).

By similarity8 Publications

Caution

According to a report, acts as a negative regulator of T-cell activation independently of its enzymatic activity (PubMed:28891065). However, authors of this study only tested enzyme activity via phenylalanine (Phe) deprivation and not via tryptophan (Trp). As IL4I1 immunoregulator activity is mediated via Trp degradation and subsequent activation of the transcription factor AHR, additional experiments are required to confirm this statement (PubMed:32818467, PubMed:32866000).Curated3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FADBy similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

L-amino-acid oxidase activity toward phenylalanine (Phe) is specfically inhibited by a number of Phe derivatives, such as Cp3 (ethyl 3-(2,6-dichlorophenyl)-2-(piperidin-1-yl)propanoate) or Cp2-SO4 (PubMed:31812258). Cp3 is a very potent inhibitor for activity toward phenylalanine but is toxic (PubMed:31812258). In contrast, Cp2-SO4 is less efficient but not toxic and is able to reverse immunosuppressive action of IL4I1 in vitro (PubMed:31812258).1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1.48 mM for L-phenylalanine1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-tryptophan degradation via pyruvate pathway

This protein is involved in the pathway L-tryptophan degradation via pyruvate pathway, which is part of Amino-acid degradation.2 Publications
View all proteins of this organism that are known to be involved in the pathway L-tryptophan degradation via pyruvate pathway and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei97FADBy similarity1
Binding sitei116SubstrateBy similarity1
Binding sitei287FAD; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei398SubstrateBy similarity1
Binding sitei481FAD1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi69 – 70FADBy similarity2
Nucleotide bindingi89 – 90FADBy similarity2
Nucleotide bindingi113 – 116FADBy similarity4
Nucleotide bindingi488 – 493FADBy similarity6

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processAdaptive immunity, Immunity
LigandFAD, Flavoprotein

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96RQ9

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-8964208, Phenylalanine metabolism

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q96RQ9

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00332

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
L-amino-acid oxidaseCurated (EC:1.4.3.26 Publications, EC:1.4.3.251 Publication)
Short name:
LAAOCurated
Short name:
LAOCurated
Alternative name(s):
Interleukin-4-induced protein 11 Publication
Short name:
IL4-induced protein 11 Publication
Short name:
hIL4I11 Publication
Protein Fig-11 Publication
Short name:
hFIG11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IL4I11 Publication
Synonyms:FIG11 Publication
ORF Names:UNQ636/PRO12651 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:19094, IL4I1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609742, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96RQ9

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000104951

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasmic vesicle, Lysosome, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi481E → A: Abolished L-amino-acid oxidase activity. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		259307

MalaCards human disease database

More...MalaCardsi		IL4I1

Open Targets

More...OpenTargetsi		ENSG00000104951

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38795

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96RQ9, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB04166, Anthranilic acid
DB04272, Citric acid
DB03147, Flavin adenine dinucleotide
DB03214, Vinylglycine

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		IL4I1

Domain mapping of disease mutations (DMDM)

More...DMDMi		20138284

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 211 PublicationAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000171022 – 567L-amino-acid oxidaseAdd BLAST546

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi36 ↔ 199By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi54N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi220N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi559N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96RQ9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96RQ9

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96RQ9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96RQ9

PeptideAtlas

More...PeptideAtlasi		Q96RQ9

PRoteomics IDEntifications database

More...PRIDEi		Q96RQ9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		78004 [Q96RQ9-1]
78005 [Q96RQ9-2]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1446, 2 N-Linked glycans (2 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q96RQ9, 5 sites, 2 N-linked glycans (2 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96RQ9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96RQ9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Primarily found in immune tissues, with the highest expression in lymph nodes and spleen (PubMed:12031486, PubMed:12446450). Present in germinal center macrophages and inflammatory myeloid cells and antigen-presenting cells (at protein level) (PubMed:17356132). Also present in spermatozoa (at protein level) (PubMed:25767141). Highly expressed in primary mediastinal large B-cell lymphoma, a specific subtype of diffuse large B-cell lymphoma (PubMed:12446450). Expressed by neoplastic cells of several B-cell lymphomas and by tumor-associated macrophages (PubMed:19436310).5 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By IL4/interleukin-4 (PubMed:12031486). Expression is up-regulated in numerous cancer and metastasis: expression is induced by immune checkpoint blockade (PubMed:32818467).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000104951, Expressed in testis and 128 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96RQ9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96RQ9, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000104951, Group enriched (lymphoid tissue, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		129252, 4 interactors

Protein interaction database and analysis system

More...IntActi		Q96RQ9, 4 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000472474

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96RQ9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q96RQ9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96RQ9

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni488 – 489Substrate bindingBy similarity2
Regioni506 – 567DisorderedSequence analysisAdd BLAST62

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi551 – 567Polar residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the flavin monoamine oxidase family. FIG1 subfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0029, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162082

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004498_8_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96RQ9

Identification of Orthologs from Complete Genome Data

More...OMAi		YTHAWIA

Database of Orthologous Groups

More...OrthoDBi		367611at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96RQ9

TreeFam database of animal gene trees

More...TreeFami		TF313314

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.50.50.60, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002937, Amino_oxidase
IPR036188, FAD/NAD-bd_sf
IPR001613, Flavin_amine_oxidase

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01593, Amino_oxidase, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00757, AMINEOXDASEF

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51905, SSF51905, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96RQ9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPLALHLLV LVPILLSLVA SQDWKAERSQ DPFEKCMQDP DYEQLLKVVT 
        60         70         80         90        100
WGLNRTLKPQ RVIVVGAGVA GLVAAKVLSD AGHKVTILEA DNRIGGRIFT 
       110        120        130        140        150
YRDQNTGWIG ELGAMRMPSS HRILHKLCQG LGLNLTKFTQ YDKNTWTEVH 
       160        170        180        190        200
EVKLRNYVVE KVPEKLGYAL RPQEKGHSPE DIYQMALNQA LKDLKALGCR 
       210        220        230        240        250
KAMKKFERHT LLEYLLGEGN LSRPAVQLLG DVMSEDGFFY LSFAEALRAH 
       260        270        280        290        300
SCLSDRLQYS RIVGGWDLLP RALLSSLSGL VLLNAPVVAM TQGPHDVHVQ 
       310        320        330        340        350
IETSPPARNL KVLKADVVLL TASGPAVKRI TFSPPLPRHM QEALRRLHYV 
       360        370        380        390        400
PATKVFLSFR RPFWREEHIE GGHSNTDRPS RMIFYPPPRE GALLLASYTW 
       410        420        430        440        450
SDAAAAFAGL SREEALRLAL DDVAALHGPV VRQLWDGTGV VKRWAEDQHS 
       460        470        480        490        500
QGGFVVQPPA LWQTEKDDWT VPYGRIYFAG EHTAYPHGWV ETAVKSALRA 
       510        520        530        540        550
AIKINSRKGP ASDTASPEGH ASDMEGQGHV HGVASSPSHD LAKEEGSHPP 
       560 
VQGQLSLQNT THTRTSH
Length:567
Mass (Da):62,881
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFFF953CB28D22F19
GO
Isoform 2 (identifier: Q96RQ9-2) [UniParc]FASTAAdd to basket
Also known as: IL4I1_21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-5: MAPLA → MPNDDFCPGLTIKAMGAERAPQRQPCT

Note: Uses the promoter of the upstream NUP62 gene and shares the first 2 non-coding exons with NUP62.1 Publication
Show »
Length:589
Mass (Da):65,328
Checksum:i61FEFA634DF56B49
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QYW8M0QYW8_HUMAN
L-amino-acid oxidase
IL4I1
150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QYH9M0QYH9_HUMAN
L-amino-acid oxidase
IL4I1
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R1L1M0R1L1_HUMAN
L-amino-acid oxidase
IL4I1
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R2S9M0R2S9_HUMAN
L-amino-acid oxidase
IL4I1
32Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QXY7M0QXY7_HUMAN
L-amino-acid oxidase
IL4I1
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB84923 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI54291 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI54292 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI54293 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti24W → R in AAH64378 (PubMed:15489334).Curated1
Sequence conflicti114A → T in CAI54291 (PubMed:16029492).Curated1
Sequence conflicti114A → T in CAI54293 (PubMed:16029492).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08394192N → D Increased L-amino-acid oxidase activity. 1 PublicationCorresponds to variant dbSNP:rs111772144Ensembl.1
Natural variantiVAR_083942102R → G in an ovarian cancer; decreased L-amino-acid oxidase activity. 1 Publication1
Natural variantiVAR_048260501A → S. Corresponds to variant dbSNP:rs2290772Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0171731 – 5MAPLA → MPNDDFCPGLTIKAMGAERA PQRQPCT in isoform 2. 2 Publications5

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF293462 mRNA Translation: AAK73362.1
AF293463 Genomic DNA Translation: AAK73363.1
AJ880386 mRNA Translation: CAI54291.1 Different initiation.
AJ880387 mRNA Translation: CAI54292.1 Different initiation.
AJ880388 mRNA Translation: CAI54293.1 Different initiation.
DQ079587 mRNA Translation: AAZ32711.1
DQ079588 mRNA Translation: AAZ32712.1
DQ079589 mRNA Translation: AAZ32713.1
AK074097 mRNA Translation: BAB84923.1 Different initiation.
AY358933 mRNA Translation: AAQ89292.1
CH471177 Genomic DNA Translation: EAW52575.1
BC064378 mRNA Translation: AAH64378.2
BC090852 mRNA Translation: AAH90852.2

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12786.1 [Q96RQ9-2]
CCDS12787.1 [Q96RQ9-1]

NCBI Reference Sequences

More...RefSeqi		NP_001244946.1, NM_001258017.1 [Q96RQ9-2]
NP_001244947.1, NM_001258018.1 [Q96RQ9-2]
NP_690863.1, NM_152899.1 [Q96RQ9-1]
NP_758962.1, NM_172374.2 [Q96RQ9-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000341114.7; ENSP00000342557.2; ENSG00000104951.16 [Q96RQ9-2]
ENST00000391826.7; ENSP00000375702.1; ENSG00000104951.16
ENST00000595948.5; ENSP00000472474.1; ENSG00000104951.16 [Q96RQ9-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		259307

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:259307

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000391826.7; ENSP00000375702.1; NM_152899.2; NP_690863.1

UCSC genome browser

More...UCSCi		uc002pqt.2, human [Q96RQ9-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF293462 mRNA Translation: AAK73362.1
AF293463 Genomic DNA Translation: AAK73363.1
AJ880386 mRNA Translation: CAI54291.1 Different initiation.
AJ880387 mRNA Translation: CAI54292.1 Different initiation.
AJ880388 mRNA Translation: CAI54293.1 Different initiation.
DQ079587 mRNA Translation: AAZ32711.1
DQ079588 mRNA Translation: AAZ32712.1
DQ079589 mRNA Translation: AAZ32713.1
AK074097 mRNA Translation: BAB84923.1 Different initiation.
AY358933 mRNA Translation: AAQ89292.1
CH471177 Genomic DNA Translation: EAW52575.1
BC064378 mRNA Translation: AAH64378.2
BC090852 mRNA Translation: AAH90852.2
CCDSiCCDS12786.1 [Q96RQ9-2]
CCDS12787.1 [Q96RQ9-1]
RefSeqiNP_001244946.1, NM_001258017.1 [Q96RQ9-2]
NP_001244947.1, NM_001258018.1 [Q96RQ9-2]
NP_690863.1, NM_152899.1 [Q96RQ9-1]
NP_758962.1, NM_172374.2 [Q96RQ9-2]

3D structure databases

AlphaFoldDBiQ96RQ9
SMRiQ96RQ9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi129252, 4 interactors
IntActiQ96RQ9, 4 interactors
STRINGi9606.ENSP00000472474

Chemistry databases

DrugBankiDB04166, Anthranilic acid
DB04272, Citric acid
DB03147, Flavin adenine dinucleotide
DB03214, Vinylglycine

PTM databases

GlyConnecti1446, 2 N-Linked glycans (2 sites)
GlyGeniQ96RQ9, 5 sites, 2 N-linked glycans (2 sites)
iPTMnetiQ96RQ9
PhosphoSitePlusiQ96RQ9

Genetic variation databases

BioMutaiIL4I1
DMDMi20138284

Proteomic databases

jPOSTiQ96RQ9
MassIVEiQ96RQ9
MaxQBiQ96RQ9
PaxDbiQ96RQ9
PeptideAtlasiQ96RQ9
PRIDEiQ96RQ9
ProteomicsDBi78004 [Q96RQ9-1]
78005 [Q96RQ9-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		32207, 151 antibodies from 24 providers

The DNASU plasmid repository

More...DNASUi		259307

Genome annotation databases

EnsembliENST00000341114.7; ENSP00000342557.2; ENSG00000104951.16 [Q96RQ9-2]
ENST00000391826.7; ENSP00000375702.1; ENSG00000104951.16
ENST00000595948.5; ENSP00000472474.1; ENSG00000104951.16 [Q96RQ9-2]
GeneIDi259307
KEGGihsa:259307
MANE-SelectiENST00000391826.7; ENSP00000375702.1; NM_152899.2; NP_690863.1
UCSCiuc002pqt.2, human [Q96RQ9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		259307
DisGeNETi259307

GeneCards: human genes, protein and diseases

More...GeneCardsi		IL4I1
HGNCiHGNC:19094, IL4I1
HPAiENSG00000104951, Group enriched (lymphoid tissue, testis)
MalaCardsiIL4I1
MIMi609742, gene
neXtProtiNX_Q96RQ9
OpenTargetsiENSG00000104951
PharmGKBiPA38795
VEuPathDBiHostDB:ENSG00000104951

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0029, Eukaryota
GeneTreeiENSGT00940000162082
HOGENOMiCLU_004498_8_3_1
InParanoidiQ96RQ9
OMAiYTHAWIA
OrthoDBi367611at2759
PhylomeDBiQ96RQ9
TreeFamiTF313314

Enzyme and pathway databases

UniPathwayiUPA00332
PathwayCommonsiQ96RQ9
ReactomeiR-HSA-8964208, Phenylalanine metabolism
SignaLinkiQ96RQ9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		259307, 17 hits in 1075 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		IL4I1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		259307
PharosiQ96RQ9, Tbio

Protein Ontology

More...PROi		PR:Q96RQ9
RNActiQ96RQ9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000104951, Expressed in testis and 128 other tissues
ExpressionAtlasiQ96RQ9, baseline and differential
GenevisibleiQ96RQ9, HS

Family and domain databases

Gene3Di3.50.50.60, 1 hit
InterProiView protein in InterPro
IPR002937, Amino_oxidase
IPR036188, FAD/NAD-bd_sf
IPR001613, Flavin_amine_oxidase
PfamiView protein in Pfam
PF01593, Amino_oxidase, 1 hit
PRINTSiPR00757, AMINEOXDASEF
SUPFAMiSSF51905, SSF51905, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOXLA_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96RQ9
Secondary accession number(s): Q1WMJ3
, Q4GZN1, Q4GZN2, Q6P2Q3, Q8TEM5, Q96RQ8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: December 1, 2001
Last modified: May 25, 2022
This is version 167 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families
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