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UniProtKB - Q96RQ9 (OXLA_HUMAN)

Entry version 162 (10 Feb 2021)
Sequence version 1 (01 Dec 2001)
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Protein

L-amino-acid oxidase

Gene

IL4I1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Secreted L-amino-acid oxidase that acts as a key immunoregulator (PubMed:17356132, PubMed:32818467, PubMed:32866000). Has preference for L-aromatic amino acids: converts phenylalanine (Phe), tyrosine (Tyr) and tryptophan (Trp) to phenylpyruvic acid (PP), hydroxyphenylpyruvic acid (HPP), and indole-3-pyruvic acid (I3P), respectively (PubMed:17356132, PubMed:32818467, PubMed:32866000). Also has weak L-arginine oxidase activity (PubMed:26673964). Acts as a negative regulator of anti-tumor immunity by mediating Trp degradation via an indole pyruvate pathway that activates the transcription factor AHR (PubMed:32818467, PubMed:32866000). IL4I1-mediated Trp catabolism generates I3P, giving rise to indole metabolites (indole-3-acetic acid (IAA) and indole-3-aldehyde (I3A)) and kynurenic acid, which act as ligands for AHR, a ligand-activated transcription factor that plays important roles in immunity and cancer (PubMed:32818467, PubMed:32866000). AHR activation by indoles following IL4I1-mediated Trp degradation enhances tumor progression by promoting cancer cell motility and suppressing adaptive immunity (PubMed:32818467). Also has an immunoregulatory function in some immune cells, probably by mediating Trp degradation and promoting downstream AHR activation: inhibits T-cell activation and proliferation, promotes the differentiation of naive CD4+ T-cells into FOXP3+ regulatory T-cells (Treg) and regulates the development and function of B-cells (PubMed:17356132, PubMed:25446972, PubMed:25778793, PubMed:28891065). Also regulates M2 macrophage polarization by inhibiting T-cell activation (By similarity). Also has antibacterial properties by inhibiting growth of Gram negative and Gram positive bacteria through the production of NH4+ and H2O2 (PubMed:23355881).By similarity8 Publications

Caution

According to a report, acts as a negative regulator of T-cell activation independently of its enzymatic activity (PubMed:28891065). However, authors of this study only tested enzyme activity via phenylalanine (Phe) deprivation and not via tryptophan (Trp). As IL4I1 immunoregulator activity is mediated via Trp degradation and subsequent activation of the transcription factor AHR, additional experiments are required to confirm this statement (PubMed:32818467, PubMed:32866000).Curated3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FADBy similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

L-amino-acid oxidase activity toward phenylalanine (Phe) is specfically inhibited by a number of Phe derivatives, such as Cp3 (ethyl 3-(2,6-dichlorophenyl)-2-(piperidin-1-yl)propanoate) or Cp2-SO4 (PubMed:31812258). Cp3 is a very potent inhibitor for activity toward phenylalanine but is toxic (PubMed:31812258). In contrast, Cp2-SO4 is less efficient but not toxic and is able to reverse immunosuppressive action of IL4I1 in vitro (PubMed:31812258).1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1.48 mM for L-phenylalanine1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-tryptophan degradation via pyruvate pathway

    This protein is involved in the pathway L-tryptophan degradation via pyruvate pathway, which is part of Amino-acid degradation.2 Publications
    View all proteins of this organism that are known to be involved in the pathway L-tryptophan degradation via pyruvate pathway and in Amino-acid degradation.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei97FADBy similarity1
    Binding sitei116SubstrateBy similarity1
    Binding sitei287FAD; via amide nitrogen and carbonyl oxygenBy similarity1
    Binding sitei398SubstrateBy similarity1
    Binding sitei481FAD1 Publication1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi69 – 70FADBy similarity2
    Nucleotide bindingi89 – 90FADBy similarity2
    Nucleotide bindingi113 – 116FADBy similarity4
    Nucleotide bindingi488 – 493FADBy similarity6

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    GO - Biological processi

    Complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionOxidoreductase
    Biological processAdaptive immunity, Immunity
    LigandFAD, Flavoprotein

    Enzyme and pathway databases

    Pathway Commons web resource for biological pathway data

    More...    PathwayCommonsi    		Q96RQ9

    Reactome - a knowledgebase of biological pathways and processes

    More...    Reactomei    		R-HSA-8964208, Phenylalanine metabolism

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...    UniPathwayi    		UPA00332

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    L-amino-acid oxidaseCurated (EC:1.4.3.26 Publications, EC:1.4.3.251 Publication)
    Short name:
    LAAOCurated
    Short name:
    LAOCurated
    Alternative name(s):
    Interleukin-4-induced protein 11 Publication
    Short name:
    IL4-induced protein 11 Publication
    Short name:
    hIL4I11 Publication
    Protein Fig-11 Publication
    Short name:
    hFIG11 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:IL4I11 Publication
    Synonyms:FIG11 Publication
    ORF Names:UNQ636/PRO12651 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

    Organism-specific databases

    Human Gene Nomenclature Database

    More...    HGNCi    		HGNC:19094, IL4I1

    Online Mendelian Inheritance in Man (OMIM)

    More...    MIMi    		609742, gene

    neXtProt; the human protein knowledge platform

    More...    neXtProti    		NX_Q96RQ9

    Eukaryotic Pathogen, Vector and Host Database Resources

    More...    VEuPathDBi    		HostDB:ENSG00000104951.15

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Lysosome, Secreted

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi481E → A: Abolished L-amino-acid oxidase activity. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...    DisGeNETi    		259307

    Open Targets

    More...    OpenTargetsi    		ENSG00000104951

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...    PharmGKBi    		PA38795

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...    Pharosi    		Q96RQ9, Tbio

    Chemistry databases

    Drug and drug target database

    More...    DrugBanki    		DB04166, Anthranilic acid
    DB04272, Citric acid
    DB03147, Flavin adenine dinucleotide
    DB03214, Vinylglycine

    Genetic variation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...    BioMutai    		IL4I1

    Domain mapping of disease mutations (DMDM)

    More...    DMDMi    		20138284

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 211 PublicationAdd BLAST21
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000171022 – 567L-amino-acid oxidaseAdd BLAST546

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi36 ↔ 199By similarity
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi54N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi220N-linked (GlcNAc...) asparagine1 Publication1
    Glycosylationi559N-linked (GlcNAc...) asparagineSequence analysis1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    N-glycosylated.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    jPOST - Japan Proteome Standard Repository/Database

    More...    jPOSTi    		Q96RQ9

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...    MassIVEi    		Q96RQ9

    MaxQB - The MaxQuant DataBase

    More...    MaxQBi    		Q96RQ9

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		Q96RQ9

    PeptideAtlas

    More...    PeptideAtlasi    		Q96RQ9

    PRoteomics IDEntifications database

    More...    PRIDEi    		Q96RQ9

    ProteomicsDB: a multi-organism proteome resource

    More...    ProteomicsDBi    		78004 [Q96RQ9-1]
    78005 [Q96RQ9-2]

    PTM databases

    GlyConnect protein glycosylation platform

    More...    GlyConnecti    		1446, 2 N-Linked glycans (2 sites)

    GlyGen: Computational and Informatics Resources for Glycoscience

    More...    GlyGeni    		Q96RQ9, 5 sites

    iPTMnet integrated resource for PTMs in systems biology context

    More...    iPTMneti    		Q96RQ9

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...    PhosphoSitePlusi    		Q96RQ9

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Primarily found in immune tissues, with the highest expression in lymph nodes and spleen (PubMed:12031486, PubMed:12446450). Present in germinal center macrophages and inflammatory myeloid cells and antigen-presenting cells (at protein level) (PubMed:17356132). Also present in spermatozoa (at protein level) (PubMed:25767141). Highly expressed in primary mediastinal large B-cell lymphoma, a specific subtype of diffuse large B-cell lymphoma (PubMed:12446450). Expressed by neoplastic cells of several B-cell lymphomas and by tumor-associated macrophages (PubMed:19436310).5 Publications

    <p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    By IL4/interleukin-4 (PubMed:12031486). Expression is up-regulated in numerous cancer and metastasis: expression is induced by immune checkpoint blockade (PubMed:32818467).2 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...    Bgeei    		ENSG00000104951, Expressed in testis and 128 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...    ExpressionAtlasi    		Q96RQ9, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...    Genevisiblei    		Q96RQ9, HS

    Organism-specific databases

    Human Protein Atlas

    More...    HPAi    		ENSG00000104951, Tissue enhanced (blood, testis)

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Hide details

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...    BioGRIDi    		129252, 1 interactor

    Protein interaction database and analysis system

    More...    IntActi    		Q96RQ9, 4 interactors

    STRING: functional protein association networks

    More...    STRINGi    		9606.ENSP00000472474

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...    RNActi    		Q96RQ9, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...    SMRi    		Q96RQ9

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    Protein Data Bank in Europe - Knowledge Base

    More...    PDBe-KBi    		Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni488 – 489Substrate bindingBy similarity2

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the flavin monoamine oxidase family. FIG1 subfamily.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		KOG0029, Eukaryota

    Ensembl GeneTree

    More...    GeneTreei    		ENSGT00940000162082

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...    HOGENOMi    		CLU_004498_8_3_1

    InParanoid: Eukaryotic Ortholog Groups

    More...    InParanoidi    		Q96RQ9

    Identification of Orthologs from Complete Genome Data

    More...    OMAi    		VGWHRVP

    Database of Orthologous Groups

    More...    OrthoDBi    		367611at2759

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		Q96RQ9

    TreeFam database of animal gene trees

    More...    TreeFami    		TF313314

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...    Gene3Di    		3.50.50.60, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR002937, Amino_oxidase
    IPR036188, FAD/NAD-bd_sf
    IPR001613, Flavin_amine_oxidase

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF01593, Amino_oxidase, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...    PRINTSi    		PR00757, AMINEOXDASEF

    Superfamily database of structural and functional annotation

    More...    SUPFAMi    		SSF51905, SSF51905, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q96RQ9-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MAPLALHLLV LVPILLSLVA SQDWKAERSQ DPFEKCMQDP DYEQLLKVVT 
            60         70         80         90        100
    WGLNRTLKPQ RVIVVGAGVA GLVAAKVLSD AGHKVTILEA DNRIGGRIFT 
           110        120        130        140        150
    YRDQNTGWIG ELGAMRMPSS HRILHKLCQG LGLNLTKFTQ YDKNTWTEVH 
           160        170        180        190        200
    EVKLRNYVVE KVPEKLGYAL RPQEKGHSPE DIYQMALNQA LKDLKALGCR 
           210        220        230        240        250
    KAMKKFERHT LLEYLLGEGN LSRPAVQLLG DVMSEDGFFY LSFAEALRAH 
           260        270        280        290        300
    SCLSDRLQYS RIVGGWDLLP RALLSSLSGL VLLNAPVVAM TQGPHDVHVQ 
           310        320        330        340        350
    IETSPPARNL KVLKADVVLL TASGPAVKRI TFSPPLPRHM QEALRRLHYV 
           360        370        380        390        400
    PATKVFLSFR RPFWREEHIE GGHSNTDRPS RMIFYPPPRE GALLLASYTW 
           410        420        430        440        450
    SDAAAAFAGL SREEALRLAL DDVAALHGPV VRQLWDGTGV VKRWAEDQHS 
           460        470        480        490        500
    QGGFVVQPPA LWQTEKDDWT VPYGRIYFAG EHTAYPHGWV ETAVKSALRA 
           510        520        530        540        550
    AIKINSRKGP ASDTASPEGH ASDMEGQGHV HGVASSPSHD LAKEEGSHPP 
           560 
    VQGQLSLQNT THTRTSH
    Length:567
    Mass (Da):62,881
    Last modified:December 1, 2001 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFFF953CB28D22F19
    GO
    Isoform 2 (identifier: Q96RQ9-2) [UniParc]FASTAAdd to basket
    Also known as: IL4I1_21 Publication

    The sequence of this isoform differs from the canonical sequence as follows:
         1-5: MAPLA → MPNDDFCPGLTIKAMGAERAPQRQPCT

    Note: Uses the promoter of the upstream NUP62 gene and shares the first 2 non-coding exons with NUP62.1 Publication
    Show »
    Length:589
    Mass (Da):65,328
    Checksum:i61FEFA634DF56B49
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    		Gene namesLengthAnnotation
    M0QYW8M0QYW8_HUMAN
    L-amino-acid oxidase
    IL4I1
    		150Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    M0QYH9M0QYH9_HUMAN
    L-amino-acid oxidase
    IL4I1
    		71Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    M0R1L1M0R1L1_HUMAN
    L-amino-acid oxidase
    IL4I1
    		106Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    M0R2S9M0R2S9_HUMAN
    L-amino-acid oxidase
    IL4I1
    		32Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    M0QXY7M0QXY7_HUMAN
    L-amino-acid oxidase
    IL4I1
    		82Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence BAB84923 differs from that shown. Reason: Erroneous initiation.Curated
    The sequence CAI54291 differs from that shown. Reason: Erroneous initiation.Curated
    The sequence CAI54292 differs from that shown. Reason: Erroneous initiation.Curated
    The sequence CAI54293 differs from that shown. Reason: Erroneous initiation.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti24W → R in AAH64378 (PubMed:15489334).Curated1
    Sequence conflicti114A → T in CAI54291 (PubMed:16029492).Curated1
    Sequence conflicti114A → T in CAI54293 (PubMed:16029492).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08394192N → D Increased L-amino-acid oxidase activity. 1 Publication1
    Natural variantiVAR_083942102R → G in an ovarian cancer; decreased L-amino-acid oxidase activity. 1 Publication1
    Natural variantiVAR_048260501A → S. Corresponds to variant dbSNP:rs2290772Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0171731 – 5MAPLA → MPNDDFCPGLTIKAMGAERA PQRQPCT in isoform 2. 2 Publications5

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		AF293462 mRNA Translation: AAK73362.1
    AF293463 Genomic DNA Translation: AAK73363.1
    AJ880386 mRNA Translation: CAI54291.1 Different initiation.
    AJ880387 mRNA Translation: CAI54292.1 Different initiation.
    AJ880388 mRNA Translation: CAI54293.1 Different initiation.
    DQ079587 mRNA Translation: AAZ32711.1
    DQ079588 mRNA Translation: AAZ32712.1
    DQ079589 mRNA Translation: AAZ32713.1
    AK074097 mRNA Translation: BAB84923.1 Different initiation.
    AY358933 mRNA Translation: AAQ89292.1
    CH471177 Genomic DNA Translation: EAW52575.1
    BC064378 mRNA Translation: AAH64378.2
    BC090852 mRNA Translation: AAH90852.2

    The Consensus CDS (CCDS) project

    More...    CCDSi    		CCDS12786.1 [Q96RQ9-2]
    CCDS12787.1 [Q96RQ9-1]

    NCBI Reference Sequences

    More...    RefSeqi    		NP_001244946.1, NM_001258017.1 [Q96RQ9-2]
    NP_001244947.1, NM_001258018.1 [Q96RQ9-2]
    NP_690863.1, NM_152899.1 [Q96RQ9-1]
    NP_758962.1, NM_172374.2 [Q96RQ9-2]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...    Ensembli    		ENST00000341114; ENSP00000342557; ENSG00000104951 [Q96RQ9-2]
    ENST00000391826; ENSP00000375702; ENSG00000104951 [Q96RQ9-1]
    ENST00000595948; ENSP00000472474; ENSG00000104951 [Q96RQ9-2]

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		259307

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		hsa:259307

    UCSC genome browser

    More...    UCSCi    		uc002pqt.2, human [Q96RQ9-1]

    Keywords - Coding sequence diversityi

    Alternative promoter usage, Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		AF293462 mRNA Translation: AAK73362.1
    AF293463 Genomic DNA Translation: AAK73363.1
    AJ880386 mRNA Translation: CAI54291.1 Different initiation.
    AJ880387 mRNA Translation: CAI54292.1 Different initiation.
    AJ880388 mRNA Translation: CAI54293.1 Different initiation.
    DQ079587 mRNA Translation: AAZ32711.1
    DQ079588 mRNA Translation: AAZ32712.1
    DQ079589 mRNA Translation: AAZ32713.1
    AK074097 mRNA Translation: BAB84923.1 Different initiation.
    AY358933 mRNA Translation: AAQ89292.1
    CH471177 Genomic DNA Translation: EAW52575.1
    BC064378 mRNA Translation: AAH64378.2
    BC090852 mRNA Translation: AAH90852.2
    CCDSiCCDS12786.1 [Q96RQ9-2]
    CCDS12787.1 [Q96RQ9-1]
    RefSeqiNP_001244946.1, NM_001258017.1 [Q96RQ9-2]
    NP_001244947.1, NM_001258018.1 [Q96RQ9-2]
    NP_690863.1, NM_152899.1 [Q96RQ9-1]
    NP_758962.1, NM_172374.2 [Q96RQ9-2]

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...    PDBei

    Protein Data Bank RCSB

    More...    RCSB PDBi

    Protein Data Bank Japan

    More...    PDBji
    Links Updated
    		PDB entryMethodResolution (Å)ChainPositionsPDBsum
    2I8Hmodel-@30-504[»]
    SMRiQ96RQ9
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi129252, 1 interactor
    IntActiQ96RQ9, 4 interactors
    STRINGi9606.ENSP00000472474

    Chemistry databases

    DrugBankiDB04166, Anthranilic acid
    DB04272, Citric acid
    DB03147, Flavin adenine dinucleotide
    DB03214, Vinylglycine

    PTM databases

    GlyConnecti1446, 2 N-Linked glycans (2 sites)
    GlyGeniQ96RQ9, 5 sites
    iPTMnetiQ96RQ9
    PhosphoSitePlusiQ96RQ9

    Genetic variation databases

    BioMutaiIL4I1
    DMDMi20138284

    Proteomic databases

    jPOSTiQ96RQ9
    MassIVEiQ96RQ9
    MaxQBiQ96RQ9
    PaxDbiQ96RQ9
    PeptideAtlasiQ96RQ9
    PRIDEiQ96RQ9
    ProteomicsDBi78004 [Q96RQ9-1]
    78005 [Q96RQ9-2]

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...    Antibodypediai    		32207, 128 antibodies

    Genome annotation databases

    EnsembliENST00000341114; ENSP00000342557; ENSG00000104951 [Q96RQ9-2]
    ENST00000391826; ENSP00000375702; ENSG00000104951 [Q96RQ9-1]
    ENST00000595948; ENSP00000472474; ENSG00000104951 [Q96RQ9-2]
    GeneIDi259307
    KEGGihsa:259307
    UCSCiuc002pqt.2, human [Q96RQ9-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...    CTDi    		259307
    DisGeNETi259307

    GeneCards: human genes, protein and diseases

    More...    GeneCardsi    		IL4I1
    HGNCiHGNC:19094, IL4I1
    HPAiENSG00000104951, Tissue enhanced (blood, testis)
    MIMi609742, gene
    neXtProtiNX_Q96RQ9
    OpenTargetsiENSG00000104951
    PharmGKBiPA38795
    VEuPathDBiHostDB:ENSG00000104951.15

    GenAtlas: human gene database

    More...    GenAtlasi    		Search...

    Phylogenomic databases

    eggNOGiKOG0029, Eukaryota
    GeneTreeiENSGT00940000162082
    HOGENOMiCLU_004498_8_3_1
    InParanoidiQ96RQ9
    OMAiVGWHRVP
    OrthoDBi367611at2759
    PhylomeDBiQ96RQ9
    TreeFamiTF313314

    Enzyme and pathway databases

    UniPathwayiUPA00332
    PathwayCommonsiQ96RQ9
    ReactomeiR-HSA-8964208, Phenylalanine metabolism

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...    BioGRID-ORCSi    		259307, 7 hits in 876 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...    ChiTaRSi    		IL4I1, human

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...    GenomeRNAii    		259307
    PharosiQ96RQ9, Tbio

    Protein Ontology

    More...    PROi    		PR:Q96RQ9
    RNActiQ96RQ9, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...    SOURCEi    		Search...

    Gene expression databases

    BgeeiENSG00000104951, Expressed in testis and 128 other tissues
    ExpressionAtlasiQ96RQ9, baseline and differential
    GenevisibleiQ96RQ9, HS

    Family and domain databases

    Gene3Di3.50.50.60, 1 hit
    InterProiView protein in InterPro
    IPR002937, Amino_oxidase
    IPR036188, FAD/NAD-bd_sf
    IPR001613, Flavin_amine_oxidase
    PfamiView protein in Pfam
    PF01593, Amino_oxidase, 1 hit
    PRINTSiPR00757, AMINEOXDASEF
    SUPFAMiSSF51905, SSF51905, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOXLA_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96RQ9
    Secondary accession number(s): Q1WMJ3
    , Q4GZN1, Q4GZN2, Q6P2Q3, Q8TEM5, Q96RQ8
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
    Last sequence update: December 1, 2001
    Last modified: February 10, 2021
    This is version 162 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with genetic variants
      List of human entries with genetic variants
    3. Human variants curated from literature reports
      Index of human variants curated from literature reports
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families
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