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Protein

L-amino-acid oxidase

Gene

IL4I1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Lysosomal L-amino-acid oxidase with highest specific activity with phenylalanine. May play a role in lysosomal antigen processing and presentation (By similarity).By similarity

Catalytic activityi

An L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + H2O2.

Cofactori

FADBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei89FADBy similarity1
Binding sitei97FADBy similarity1
Binding sitei116SubstrateBy similarity1
Binding sitei287FAD; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei398SubstrateBy similarity1
Binding sitei481FADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi115 – 116FADBy similarity2
Nucleotide bindingi490 – 493FADBy similarity4

GO - Molecular functioni

  • L-amino-acid oxidase activity Source: Reactome
  • oxidoreductase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein

Enzyme and pathway databases

ReactomeiR-HSA-71182 Phenylalanine and tyrosine catabolism

Names & Taxonomyi

Protein namesi
Recommended name:
L-amino-acid oxidase (EC:1.4.3.2)
Short name:
LAAO
Short name:
LAO
Alternative name(s):
Interleukin-4-induced protein 1
Short name:
IL4-induced protein 1
Protein Fig-1
Short name:
hFIG1
Gene namesi
Name:IL4I1
Synonyms:FIG1
ORF Names:UNQ636/PRO1265
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000104951.15
HGNCiHGNC:19094 IL4I1
MIMi609742 gene
neXtProtiNX_Q96RQ9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi259307
OpenTargetsiENSG00000104951
PharmGKBiPA38795

Chemistry databases

DrugBankiDB04166 2-Aminobenzoic Acid
DB04272 Citric Acid
DB03147 Flavin adenine dinucleotide
DB03214 Vinylglycine

Polymorphism and mutation databases

BioMutaiIL4I1
DMDMi20138284

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000000171022 – 567L-amino-acid oxidaseAdd BLAST546

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 199By similarity
Glycosylationi54N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi220N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi559N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ96RQ9
PaxDbiQ96RQ9
PeptideAtlasiQ96RQ9
PRIDEiQ96RQ9
ProteomicsDBi78004
78005 [Q96RQ9-2]

PTM databases

GlyConnecti1446
iPTMnetiQ96RQ9
PhosphoSitePlusiQ96RQ9

Expressioni

Tissue specificityi

Isoform 1 is primarily found in immune tissues.1 Publication

Inductioni

By IL4/interleukin-4.

Gene expression databases

BgeeiENSG00000104951 Expressed in 101 organ(s), highest expression level in testis
ExpressionAtlasiQ96RQ9 baseline and differential
GenevisibleiQ96RQ9 HS

Organism-specific databases

HPAiHPA045598

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000342557

Structurei

3D structure databases

ProteinModelPortaliQ96RQ9
SMRiQ96RQ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IEXX Eukaryota
COG1231 LUCA
GeneTreeiENSGT00730000110942
HOGENOMiHOG000088141
HOVERGENiHBG005729
InParanoidiQ96RQ9
KOiK03334
OMAiVGWHRVP
OrthoDBiEOG091G0412
PhylomeDBiQ96RQ9
TreeFamiTF313314

Family and domain databases

Gene3Di3.50.50.60, 1 hit
InterProiView protein in InterPro
IPR002937 Amino_oxidase
IPR036188 FAD/NAD-bd_sf
IPR001613 Flavin_amine_oxidase
PfamiView protein in Pfam
PF01593 Amino_oxidase, 1 hit
PRINTSiPR00757 AMINEOXDASEF
SUPFAMiSSF51905 SSF51905, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96RQ9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPLALHLLV LVPILLSLVA SQDWKAERSQ DPFEKCMQDP DYEQLLKVVT
60 70 80 90 100
WGLNRTLKPQ RVIVVGAGVA GLVAAKVLSD AGHKVTILEA DNRIGGRIFT
110 120 130 140 150
YRDQNTGWIG ELGAMRMPSS HRILHKLCQG LGLNLTKFTQ YDKNTWTEVH
160 170 180 190 200
EVKLRNYVVE KVPEKLGYAL RPQEKGHSPE DIYQMALNQA LKDLKALGCR
210 220 230 240 250
KAMKKFERHT LLEYLLGEGN LSRPAVQLLG DVMSEDGFFY LSFAEALRAH
260 270 280 290 300
SCLSDRLQYS RIVGGWDLLP RALLSSLSGL VLLNAPVVAM TQGPHDVHVQ
310 320 330 340 350
IETSPPARNL KVLKADVVLL TASGPAVKRI TFSPPLPRHM QEALRRLHYV
360 370 380 390 400
PATKVFLSFR RPFWREEHIE GGHSNTDRPS RMIFYPPPRE GALLLASYTW
410 420 430 440 450
SDAAAAFAGL SREEALRLAL DDVAALHGPV VRQLWDGTGV VKRWAEDQHS
460 470 480 490 500
QGGFVVQPPA LWQTEKDDWT VPYGRIYFAG EHTAYPHGWV ETAVKSALRA
510 520 530 540 550
AIKINSRKGP ASDTASPEGH ASDMEGQGHV HGVASSPSHD LAKEEGSHPP
560
VQGQLSLQNT THTRTSH
Length:567
Mass (Da):62,881
Last modified:December 1, 2001 - v1
Checksum:iFFF953CB28D22F19
GO
Isoform 2 (identifier: Q96RQ9-2) [UniParc]FASTAAdd to basket
Also known as: IL4I1_2

The sequence of this isoform differs from the canonical sequence as follows:
     1-5: MAPLA → MPNDDFCPGLTIKAMGAERAPQRQPCT

Note: Uses the promoter of the upstream NUP62 gene and shares the first 2 non-coding exons with NUP62.
Show »
Length:589
Mass (Da):65,328
Checksum:i61FEFA634DF56B49
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QYW8M0QYW8_HUMAN
L-amino-acid oxidase
IL4I1
150Annotation score:
M0QYH9M0QYH9_HUMAN
L-amino-acid oxidase
IL4I1
71Annotation score:
M0R1L1M0R1L1_HUMAN
L-amino-acid oxidase
IL4I1
106Annotation score:
M0R2S9M0R2S9_HUMAN
L-amino-acid oxidase
IL4I1
32Annotation score:
M0QXY7M0QXY7_HUMAN
L-amino-acid oxidase
IL4I1
82Annotation score:

Sequence cautioni

The sequence BAB84923 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI54291 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI54292 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI54293 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24W → R in AAH64378 (PubMed:15489334).Curated1
Sequence conflicti114A → T in CAI54291 (PubMed:16029492).Curated1
Sequence conflicti114A → T in CAI54293 (PubMed:16029492).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048260501A → S. Corresponds to variant dbSNP:rs2290772Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0171731 – 5MAPLA → MPNDDFCPGLTIKAMGAERA PQRQPCT in isoform 2. 2 Publications5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF293462 mRNA Translation: AAK73362.1
AF293463 Genomic DNA Translation: AAK73363.1
AJ880386 mRNA Translation: CAI54291.1 Different initiation.
AJ880387 mRNA Translation: CAI54292.1 Different initiation.
AJ880388 mRNA Translation: CAI54293.1 Different initiation.
DQ079587 mRNA Translation: AAZ32711.1
DQ079588 mRNA Translation: AAZ32712.1
DQ079589 mRNA Translation: AAZ32713.1
AK074097 mRNA Translation: BAB84923.1 Different initiation.
AY358933 mRNA Translation: AAQ89292.1
CH471177 Genomic DNA Translation: EAW52575.1
BC064378 mRNA Translation: AAH64378.2
BC090852 mRNA Translation: AAH90852.2
CCDSiCCDS12786.1 [Q96RQ9-2]
CCDS12787.1 [Q96RQ9-1]
RefSeqiNP_001244946.1, NM_001258017.1 [Q96RQ9-2]
NP_001244947.1, NM_001258018.1 [Q96RQ9-2]
NP_690863.1, NM_152899.1 [Q96RQ9-1]
NP_758962.1, NM_172374.2 [Q96RQ9-2]
UniGeneiHs.574492
Hs.741750

Genome annotation databases

EnsembliENST00000341114; ENSP00000342557; ENSG00000104951 [Q96RQ9-2]
ENST00000391826; ENSP00000375702; ENSG00000104951 [Q96RQ9-1]
ENST00000595948; ENSP00000472474; ENSG00000104951 [Q96RQ9-2]
GeneIDi259307
KEGGihsa:259307
UCSCiuc002pqt.2 human [Q96RQ9-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF293462 mRNA Translation: AAK73362.1
AF293463 Genomic DNA Translation: AAK73363.1
AJ880386 mRNA Translation: CAI54291.1 Different initiation.
AJ880387 mRNA Translation: CAI54292.1 Different initiation.
AJ880388 mRNA Translation: CAI54293.1 Different initiation.
DQ079587 mRNA Translation: AAZ32711.1
DQ079588 mRNA Translation: AAZ32712.1
DQ079589 mRNA Translation: AAZ32713.1
AK074097 mRNA Translation: BAB84923.1 Different initiation.
AY358933 mRNA Translation: AAQ89292.1
CH471177 Genomic DNA Translation: EAW52575.1
BC064378 mRNA Translation: AAH64378.2
BC090852 mRNA Translation: AAH90852.2
CCDSiCCDS12786.1 [Q96RQ9-2]
CCDS12787.1 [Q96RQ9-1]
RefSeqiNP_001244946.1, NM_001258017.1 [Q96RQ9-2]
NP_001244947.1, NM_001258018.1 [Q96RQ9-2]
NP_690863.1, NM_152899.1 [Q96RQ9-1]
NP_758962.1, NM_172374.2 [Q96RQ9-2]
UniGeneiHs.574492
Hs.741750

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2I8Hmodel-@30-504[»]
ProteinModelPortaliQ96RQ9
SMRiQ96RQ9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000342557

Chemistry databases

DrugBankiDB04166 2-Aminobenzoic Acid
DB04272 Citric Acid
DB03147 Flavin adenine dinucleotide
DB03214 Vinylglycine

PTM databases

GlyConnecti1446
iPTMnetiQ96RQ9
PhosphoSitePlusiQ96RQ9

Polymorphism and mutation databases

BioMutaiIL4I1
DMDMi20138284

Proteomic databases

MaxQBiQ96RQ9
PaxDbiQ96RQ9
PeptideAtlasiQ96RQ9
PRIDEiQ96RQ9
ProteomicsDBi78004
78005 [Q96RQ9-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341114; ENSP00000342557; ENSG00000104951 [Q96RQ9-2]
ENST00000391826; ENSP00000375702; ENSG00000104951 [Q96RQ9-1]
ENST00000595948; ENSP00000472474; ENSG00000104951 [Q96RQ9-2]
GeneIDi259307
KEGGihsa:259307
UCSCiuc002pqt.2 human [Q96RQ9-1]

Organism-specific databases

CTDi259307
DisGeNETi259307
EuPathDBiHostDB:ENSG00000104951.15
GeneCardsiIL4I1
HGNCiHGNC:19094 IL4I1
HPAiHPA045598
MIMi609742 gene
neXtProtiNX_Q96RQ9
OpenTargetsiENSG00000104951
PharmGKBiPA38795
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEXX Eukaryota
COG1231 LUCA
GeneTreeiENSGT00730000110942
HOGENOMiHOG000088141
HOVERGENiHBG005729
InParanoidiQ96RQ9
KOiK03334
OMAiVGWHRVP
OrthoDBiEOG091G0412
PhylomeDBiQ96RQ9
TreeFamiTF313314

Enzyme and pathway databases

ReactomeiR-HSA-71182 Phenylalanine and tyrosine catabolism

Miscellaneous databases

ChiTaRSiIL4I1 human
GenomeRNAii259307
PROiPR:Q96RQ9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000104951 Expressed in 101 organ(s), highest expression level in testis
ExpressionAtlasiQ96RQ9 baseline and differential
GenevisibleiQ96RQ9 HS

Family and domain databases

Gene3Di3.50.50.60, 1 hit
InterProiView protein in InterPro
IPR002937 Amino_oxidase
IPR036188 FAD/NAD-bd_sf
IPR001613 Flavin_amine_oxidase
PfamiView protein in Pfam
PF01593 Amino_oxidase, 1 hit
PRINTSiPR00757 AMINEOXDASEF
SUPFAMiSSF51905 SSF51905, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOXLA_HUMAN
AccessioniPrimary (citable) accession number: Q96RQ9
Secondary accession number(s): Q1WMJ3
, Q4GZN1, Q4GZN2, Q6P2Q3, Q8TEM5, Q96RQ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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