UniProtKB - Q96RQ9 (OXLA_HUMAN)
Protein
L-amino-acid oxidase
Gene
IL4I1
Organism
Homo sapiens (Human)
Status
Functioni
Secreted L-amino-acid oxidase that acts as a key immunoregulator (PubMed:17356132, PubMed:32818467, PubMed:32866000). Has preference for L-aromatic amino acids: converts phenylalanine (Phe), tyrosine (Tyr) and tryptophan (Trp) to phenylpyruvic acid (PP), hydroxyphenylpyruvic acid (HPP), and indole-3-pyruvic acid (I3P), respectively (PubMed:17356132, PubMed:32818467, PubMed:32866000). Also has weak L-arginine oxidase activity (PubMed:26673964). Acts as a negative regulator of anti-tumor immunity by mediating Trp degradation via an indole pyruvate pathway that activates the transcription factor AHR (PubMed:32818467, PubMed:32866000). IL4I1-mediated Trp catabolism generates I3P, giving rise to indole metabolites (indole-3-acetic acid (IAA) and indole-3-aldehyde (I3A)) and kynurenic acid, which act as ligands for AHR, a ligand-activated transcription factor that plays important roles in immunity and cancer (PubMed:32818467, PubMed:32866000). AHR activation by indoles following IL4I1-mediated Trp degradation enhances tumor progression by promoting cancer cell motility and suppressing adaptive immunity (PubMed:32818467). Also has an immunoregulatory function in some immune cells, probably by mediating Trp degradation and promoting downstream AHR activation: inhibits T-cell activation and proliferation, promotes the differentiation of naive CD4+ T-cells into FOXP3+ regulatory T-cells (Treg) and regulates the development and function of B-cells (PubMed:17356132, PubMed:25446972, PubMed:25778793, PubMed:28891065). Also regulates M2 macrophage polarization by inhibiting T-cell activation (By similarity). Also has antibacterial properties by inhibiting growth of Gram negative and Gram positive bacteria through the production of NH4+ and H2O2 (PubMed:23355881).By similarity8 Publications
Caution
According to a report, acts as a negative regulator of T-cell activation independently of its enzymatic activity (PubMed:28891065). However, authors of this study only tested enzyme activity via phenylalanine (Phe) deprivation and not via tryptophan (Trp). As IL4I1 immunoregulator activity is mediated via Trp degradation and subsequent activation of the transcription factor AHR, additional experiments are required to confirm this statement (PubMed:32818467, PubMed:32866000).Curated3 Publications
Catalytic activityi
- EC:1.4.3.25 PublicationsThis reaction proceeds in the forward5 Publications direction.
- This reaction proceeds in the forward4 Publications direction.
- This reaction proceeds in the forward5 Publications direction.
- This reaction proceeds in the forward2 Publications direction.
- EC:1.4.3.251 PublicationThis reaction proceeds in the forward1 Publication direction.
Cofactori
FADBy similarity
Activity regulationi
L-amino-acid oxidase activity toward phenylalanine (Phe) is specfically inhibited by a number of Phe derivatives, such as Cp3 (ethyl 3-(2,6-dichlorophenyl)-2-(piperidin-1-yl)propanoate) or Cp2-SO4 (PubMed:31812258). Cp3 is a very potent inhibitor for activity toward phenylalanine but is toxic (PubMed:31812258). In contrast, Cp2-SO4 is less efficient but not toxic and is able to reverse immunosuppressive action of IL4I1 in vitro (PubMed:31812258).1 Publication
Kineticsi
- KM=1.48 mM for L-phenylalanine1 Publication
: L-tryptophan degradation via pyruvate pathway Pathwayi
This protein is involved in the pathway L-tryptophan degradation via pyruvate pathway, which is part of Amino-acid degradation.2 PublicationsView all proteins of this organism that are known to be involved in the pathway L-tryptophan degradation via pyruvate pathway and in Amino-acid degradation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 97 | FADBy similarity | 1 | |
Binding sitei | 116 | SubstrateBy similarity | 1 | |
Binding sitei | 287 | FAD; via amide nitrogen and carbonyl oxygenBy similarity | 1 | |
Binding sitei | 398 | SubstrateBy similarity | 1 | |
Binding sitei | 481 | FAD1 Publication | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 69 – 70 | FADBy similarity | 2 | |
Nucleotide bindingi | 89 – 90 | FADBy similarity | 2 | |
Nucleotide bindingi | 113 – 116 | FADBy similarity | 4 | |
Nucleotide bindingi | 488 – 493 | FADBy similarity | 6 |
GO - Molecular functioni
- L-amino-acid oxidase activity Source: GO_Central
- oxidoreductase activity Source: GO_Central
- polyamine oxidase activity Source: GO_Central
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- cellular amino acid catabolic process Source: GO_Central
- L-phenylalanine catabolic process Source: Reactome
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Adaptive immunity, Immunity |
Ligand | FAD, Flavoprotein |
Enzyme and pathway databases
PathwayCommonsi | Q96RQ9 |
Reactomei | R-HSA-8964208, Phenylalanine metabolism |
UniPathwayi | UPA00332 |
Names & Taxonomyi
Protein namesi | Recommended name: L-amino-acid oxidaseCurated (EC:1.4.3.26 Publications, EC:1.4.3.251 Publication)Short name: LAAOCurated Short name: LAOCurated Alternative name(s): Interleukin-4-induced protein 11 Publication Short name: IL4-induced protein 11 Publication Short name: hIL4I11 Publication Protein Fig-11 Publication Short name: hFIG11 Publication |
Gene namesi | ORF Names:UNQ636/PRO12651 Publication |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19094, IL4I1 |
MIMi | 609742, gene |
neXtProti | NX_Q96RQ9 |
VEuPathDBi | HostDB:ENSG00000104951.15 |
Subcellular locationi
Extracellular region or secreted
- extracellular region Source: Reactome
Lysosome
- lysosome Source: UniProtKB-SubCell
Other locations
- acrosomal vesicle Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasmic vesicle, Lysosome, SecretedPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 481 | E → A: Abolished L-amino-acid oxidase activity. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 259307 |
OpenTargetsi | ENSG00000104951 |
PharmGKBi | PA38795 |
Miscellaneous databases
Pharosi | Q96RQ9, Tbio |
Chemistry databases
DrugBanki | DB04166, Anthranilic acid DB04272, Citric acid DB03147, Flavin adenine dinucleotide DB03214, Vinylglycine |
Genetic variation databases
BioMutai | IL4I1 |
DMDMi | 20138284 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | 1 PublicationAdd BLAST | 21 | |
ChainiPRO_0000001710 | 22 – 567 | L-amino-acid oxidaseAdd BLAST | 546 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 36 ↔ 199 | By similarity | ||
Glycosylationi | 54 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 134 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 220 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 559 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
N-glycosylated.1 Publication
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
jPOSTi | Q96RQ9 |
MassIVEi | Q96RQ9 |
MaxQBi | Q96RQ9 |
PaxDbi | Q96RQ9 |
PeptideAtlasi | Q96RQ9 |
PRIDEi | Q96RQ9 |
ProteomicsDBi | 78004 [Q96RQ9-1] 78005 [Q96RQ9-2] |
PTM databases
GlyConnecti | 1446, 2 N-Linked glycans (2 sites) |
GlyGeni | Q96RQ9, 5 sites |
iPTMneti | Q96RQ9 |
PhosphoSitePlusi | Q96RQ9 |
Expressioni
Tissue specificityi
Primarily found in immune tissues, with the highest expression in lymph nodes and spleen (PubMed:12031486, PubMed:12446450). Present in germinal center macrophages and inflammatory myeloid cells and antigen-presenting cells (at protein level) (PubMed:17356132). Also present in spermatozoa (at protein level) (PubMed:25767141). Highly expressed in primary mediastinal large B-cell lymphoma, a specific subtype of diffuse large B-cell lymphoma (PubMed:12446450). Expressed by neoplastic cells of several B-cell lymphomas and by tumor-associated macrophages (PubMed:19436310).5 Publications
Inductioni
By IL4/interleukin-4 (PubMed:12031486). Expression is up-regulated in numerous cancer and metastasis: expression is induced by immune checkpoint blockade (PubMed:32818467).2 Publications
Gene expression databases
Bgeei | ENSG00000104951, Expressed in testis and 128 other tissues |
ExpressionAtlasi | Q96RQ9, baseline and differential |
Genevisiblei | Q96RQ9, HS |
Organism-specific databases
HPAi | ENSG00000104951, Tissue enhanced (blood, testis) |
Interactioni
Binary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 129252, 1 interactor |
IntActi | Q96RQ9, 4 interactors |
STRINGi | 9606.ENSP00000472474 |
Miscellaneous databases
RNActi | Q96RQ9, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 488 – 489 | Substrate bindingBy similarity | 2 |
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG0029, Eukaryota |
GeneTreei | ENSGT00940000162082 |
HOGENOMi | CLU_004498_8_3_1 |
InParanoidi | Q96RQ9 |
OMAi | VGWHRVP |
OrthoDBi | 367611at2759 |
PhylomeDBi | Q96RQ9 |
TreeFami | TF313314 |
Family and domain databases
Gene3Di | 3.50.50.60, 1 hit |
InterProi | View protein in InterPro IPR002937, Amino_oxidase IPR036188, FAD/NAD-bd_sf IPR001613, Flavin_amine_oxidase |
Pfami | View protein in Pfam PF01593, Amino_oxidase, 1 hit |
PRINTSi | PR00757, AMINEOXDASEF |
SUPFAMi | SSF51905, SSF51905, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative promoter usage and alternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q96RQ9-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAPLALHLLV LVPILLSLVA SQDWKAERSQ DPFEKCMQDP DYEQLLKVVT
60 70 80 90 100
WGLNRTLKPQ RVIVVGAGVA GLVAAKVLSD AGHKVTILEA DNRIGGRIFT
110 120 130 140 150
YRDQNTGWIG ELGAMRMPSS HRILHKLCQG LGLNLTKFTQ YDKNTWTEVH
160 170 180 190 200
EVKLRNYVVE KVPEKLGYAL RPQEKGHSPE DIYQMALNQA LKDLKALGCR
210 220 230 240 250
KAMKKFERHT LLEYLLGEGN LSRPAVQLLG DVMSEDGFFY LSFAEALRAH
260 270 280 290 300
SCLSDRLQYS RIVGGWDLLP RALLSSLSGL VLLNAPVVAM TQGPHDVHVQ
310 320 330 340 350
IETSPPARNL KVLKADVVLL TASGPAVKRI TFSPPLPRHM QEALRRLHYV
360 370 380 390 400
PATKVFLSFR RPFWREEHIE GGHSNTDRPS RMIFYPPPRE GALLLASYTW
410 420 430 440 450
SDAAAAFAGL SREEALRLAL DDVAALHGPV VRQLWDGTGV VKRWAEDQHS
460 470 480 490 500
QGGFVVQPPA LWQTEKDDWT VPYGRIYFAG EHTAYPHGWV ETAVKSALRA
510 520 530 540 550
AIKINSRKGP ASDTASPEGH ASDMEGQGHV HGVASSPSHD LAKEEGSHPP
560
VQGQLSLQNT THTRTSH
Isoform 2 (identifier: Q96RQ9-2) [UniParc]FASTAAdd to basket
Also known as: IL4I1_21 Publication
The sequence of this isoform differs from the canonical sequence as follows:
1-5: MAPLA → MPNDDFCPGLTIKAMGAERAPQRQPCT
Note: Uses the promoter of the upstream NUP62 gene and shares the first 2 non-coding exons with NUP62.1 Publication
Show »Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0QYW8 | M0QYW8_HUMAN | L-amino-acid oxidase | IL4I1 | 150 | Annotation score: | ||
M0QYH9 | M0QYH9_HUMAN | L-amino-acid oxidase | IL4I1 | 71 | Annotation score: | ||
M0R1L1 | M0R1L1_HUMAN | L-amino-acid oxidase | IL4I1 | 106 | Annotation score: | ||
M0R2S9 | M0R2S9_HUMAN | L-amino-acid oxidase | IL4I1 | 32 | Annotation score: | ||
M0QXY7 | M0QXY7_HUMAN | L-amino-acid oxidase | IL4I1 | 82 | Annotation score: |
Sequence cautioni
The sequence BAB84923 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI54291 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI54292 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI54293 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 24 | W → R in AAH64378 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 114 | A → T in CAI54291 (PubMed:16029492).Curated | 1 | |
Sequence conflicti | 114 | A → T in CAI54293 (PubMed:16029492).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_083941 | 92 | N → D Increased L-amino-acid oxidase activity. 1 Publication | 1 | |
Natural variantiVAR_083942 | 102 | R → G in an ovarian cancer; decreased L-amino-acid oxidase activity. 1 Publication | 1 | |
Natural variantiVAR_048260 | 501 | A → S. Corresponds to variant dbSNP:rs2290772Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_017173 | 1 – 5 | MAPLA → MPNDDFCPGLTIKAMGAERA PQRQPCT in isoform 2. 2 Publications | 5 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF293462 mRNA Translation: AAK73362.1 AF293463 Genomic DNA Translation: AAK73363.1 AJ880386 mRNA Translation: CAI54291.1 Different initiation. AJ880387 mRNA Translation: CAI54292.1 Different initiation. AJ880388 mRNA Translation: CAI54293.1 Different initiation. DQ079587 mRNA Translation: AAZ32711.1 DQ079588 mRNA Translation: AAZ32712.1 DQ079589 mRNA Translation: AAZ32713.1 AK074097 mRNA Translation: BAB84923.1 Different initiation. AY358933 mRNA Translation: AAQ89292.1 CH471177 Genomic DNA Translation: EAW52575.1 BC064378 mRNA Translation: AAH64378.2 BC090852 mRNA Translation: AAH90852.2 |
CCDSi | CCDS12786.1 [Q96RQ9-2] CCDS12787.1 [Q96RQ9-1] |
RefSeqi | NP_001244946.1, NM_001258017.1 [Q96RQ9-2] NP_001244947.1, NM_001258018.1 [Q96RQ9-2] NP_690863.1, NM_152899.1 [Q96RQ9-1] NP_758962.1, NM_172374.2 [Q96RQ9-2] |
Genome annotation databases
Ensembli | ENST00000341114; ENSP00000342557; ENSG00000104951 [Q96RQ9-2] ENST00000391826; ENSP00000375702; ENSG00000104951 [Q96RQ9-1] ENST00000595948; ENSP00000472474; ENSG00000104951 [Q96RQ9-2] |
GeneIDi | 259307 |
KEGGi | hsa:259307 |
UCSCi | uc002pqt.2, human [Q96RQ9-1] |
Keywords - Coding sequence diversityi
Alternative promoter usage, Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF293462 mRNA Translation: AAK73362.1 AF293463 Genomic DNA Translation: AAK73363.1 AJ880386 mRNA Translation: CAI54291.1 Different initiation. AJ880387 mRNA Translation: CAI54292.1 Different initiation. AJ880388 mRNA Translation: CAI54293.1 Different initiation. DQ079587 mRNA Translation: AAZ32711.1 DQ079588 mRNA Translation: AAZ32712.1 DQ079589 mRNA Translation: AAZ32713.1 AK074097 mRNA Translation: BAB84923.1 Different initiation. AY358933 mRNA Translation: AAQ89292.1 CH471177 Genomic DNA Translation: EAW52575.1 BC064378 mRNA Translation: AAH64378.2 BC090852 mRNA Translation: AAH90852.2 |
CCDSi | CCDS12786.1 [Q96RQ9-2] CCDS12787.1 [Q96RQ9-1] |
RefSeqi | NP_001244946.1, NM_001258017.1 [Q96RQ9-2] NP_001244947.1, NM_001258018.1 [Q96RQ9-2] NP_690863.1, NM_152899.1 [Q96RQ9-1] NP_758962.1, NM_172374.2 [Q96RQ9-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2I8H | model | - | @ | 30-504 | [»] | |
SMRi | Q96RQ9 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 129252, 1 interactor |
IntActi | Q96RQ9, 4 interactors |
STRINGi | 9606.ENSP00000472474 |
Chemistry databases
DrugBanki | DB04166, Anthranilic acid DB04272, Citric acid DB03147, Flavin adenine dinucleotide DB03214, Vinylglycine |
PTM databases
GlyConnecti | 1446, 2 N-Linked glycans (2 sites) |
GlyGeni | Q96RQ9, 5 sites |
iPTMneti | Q96RQ9 |
PhosphoSitePlusi | Q96RQ9 |
Genetic variation databases
BioMutai | IL4I1 |
DMDMi | 20138284 |
Proteomic databases
jPOSTi | Q96RQ9 |
MassIVEi | Q96RQ9 |
MaxQBi | Q96RQ9 |
PaxDbi | Q96RQ9 |
PeptideAtlasi | Q96RQ9 |
PRIDEi | Q96RQ9 |
ProteomicsDBi | 78004 [Q96RQ9-1] 78005 [Q96RQ9-2] |
Protocols and materials databases
Antibodypediai | 32207, 128 antibodies |
Genome annotation databases
Ensembli | ENST00000341114; ENSP00000342557; ENSG00000104951 [Q96RQ9-2] ENST00000391826; ENSP00000375702; ENSG00000104951 [Q96RQ9-1] ENST00000595948; ENSP00000472474; ENSG00000104951 [Q96RQ9-2] |
GeneIDi | 259307 |
KEGGi | hsa:259307 |
UCSCi | uc002pqt.2, human [Q96RQ9-1] |
Organism-specific databases
CTDi | 259307 |
DisGeNETi | 259307 |
GeneCardsi | IL4I1 |
HGNCi | HGNC:19094, IL4I1 |
HPAi | ENSG00000104951, Tissue enhanced (blood, testis) |
MIMi | 609742, gene |
neXtProti | NX_Q96RQ9 |
OpenTargetsi | ENSG00000104951 |
PharmGKBi | PA38795 |
VEuPathDBi | HostDB:ENSG00000104951.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0029, Eukaryota |
GeneTreei | ENSGT00940000162082 |
HOGENOMi | CLU_004498_8_3_1 |
InParanoidi | Q96RQ9 |
OMAi | VGWHRVP |
OrthoDBi | 367611at2759 |
PhylomeDBi | Q96RQ9 |
TreeFami | TF313314 |
Enzyme and pathway databases
UniPathwayi | UPA00332 |
PathwayCommonsi | Q96RQ9 |
Reactomei | R-HSA-8964208, Phenylalanine metabolism |
Miscellaneous databases
BioGRID-ORCSi | 259307, 7 hits in 876 CRISPR screens |
ChiTaRSi | IL4I1, human |
GenomeRNAii | 259307 |
Pharosi | Q96RQ9, Tbio |
PROi | PR:Q96RQ9 |
RNActi | Q96RQ9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000104951, Expressed in testis and 128 other tissues |
ExpressionAtlasi | Q96RQ9, baseline and differential |
Genevisiblei | Q96RQ9, HS |
Family and domain databases
Gene3Di | 3.50.50.60, 1 hit |
InterProi | View protein in InterPro IPR002937, Amino_oxidase IPR036188, FAD/NAD-bd_sf IPR001613, Flavin_amine_oxidase |
Pfami | View protein in Pfam PF01593, Amino_oxidase, 1 hit |
PRINTSi | PR00757, AMINEOXDASEF |
SUPFAMi | SSF51905, SSF51905, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | OXLA_HUMAN | |
Accessioni | Q96RQ9Primary (citable) accession number: Q96RQ9 Secondary accession number(s): Q1WMJ3 Q96RQ8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 27, 2002 |
Last sequence update: | December 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 162 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families