UniProtKB - Q96RQ9 (OXLA_HUMAN)

BLAST

>sp|Q96RQ9|OXLA_HUMAN L-amino-acid oxidase OS=Homo sapiens OX=9606 GN=IL4I1 PE=1 SV=1
MAPLALHLLVLVPILLSLVASQDWKAERSQDPFEKCMQDPDYEQLLKVVTWGLNRTLKPQ
RVIVVGAGVAGLVAAKVLSDAGHKVTILEADNRIGGRIFTYRDQNTGWIGELGAMRMPSS
HRILHKLCQGLGLNLTKFTQYDKNTWTEVHEVKLRNYVVEKVPEKLGYALRPQEKGHSPE
DIYQMALNQALKDLKALGCRKAMKKFERHTLLEYLLGEGNLSRPAVQLLGDVMSEDGFFY
LSFAEALRAHSCLSDRLQYSRIVGGWDLLPRALLSSLSGLVLLNAPVVAMTQGPHDVHVQ
IETSPPARNLKVLKADVVLLTASGPAVKRITFSPPLPRHMQEALRRLHYVPATKVFLSFR
RPFWREEHIEGGHSNTDRPSRMIFYPPPREGALLLASYTWSDAAAAFAGLSREEALRLAL
DDVAALHGPVVRQLWDGTGVVKRWAEDQHSQGGFVVQPPALWQTEKDDWTVPYGRIYFAG
EHTAYPHGWVETAVKSALRAAIKINSRKGPASDTASPEGHASDMEGQGHVHGVASSPSHD
LAKEEGSHPPVQGQLSLQNTTHTRTSH

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History
Entry version 146 (07 Nov 2018)
Sequence version 1 (01 Dec 2001)
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Protein

L-amino-acid oxidase

Gene

IL4I1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Lysosomal L-amino-acid oxidase with highest specific activity with phenylalanine. May play a role in lysosomal antigen processing and presentation (By similarity).By similarity

Catalytic activityⁱ

An L-amino acid + H₂O + O₂ = a 2-oxo acid + NH₃ + H₂O₂.

Cofactorⁱ

FADBy similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	89	FADBy similarity	1
Binding siteⁱ	97	FADBy similarity	1
Binding siteⁱ	116	SubstrateBy similarity	1
Binding siteⁱ	287	FAD; via amide nitrogen and carbonyl oxygenBy similarity	1
Binding siteⁱ	398	SubstrateBy similarity	1
Binding siteⁱ	481	FADBy similarity	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	115 – 116	FADBy similarity		2
Nucleotide bindingⁱ	490 – 493	FADBy similarity		4

GO - Molecular functionⁱ

L-amino-acid oxidase activity
Source: Reactome
Inferred from experimentⁱ
- 17356132
oxidoreductase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular amino acid catabolic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
L-phenylalanine catabolic process Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase
Ligand	FAD, Flavoprotein

Enzyme and pathway databases

Reactomeⁱ	R-HSA-71182 Phenylalanine and tyrosine catabolism

Reactomeⁱ

R-HSA-71182 Phenylalanine and tyrosine catabolism

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: L-amino-acid oxidase (EC:1.4.3.2) Short name: LAAO Short name: LAO Alternative name(s): Interleukin-4-induced protein 1 Short name: IL4-induced protein 1 Protein Fig-1 Short name: hFIG1
Gene namesⁱ	Name:IL4I1 Synonyms:FIG1 ORF Names:UNQ636/PRO1265
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000104951.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:19094 IL4I1
MIMⁱ	609742 gene
neXtProtⁱ	NX_Q96RQ9

Keywords - Cellular componentⁱ

Lysosome

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	259307
Open Targets More...OpenTargetsⁱ	ENSG00000104951
PharmGKBⁱ	PA38795

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB04166 2-Aminobenzoic Acid DB04272 Citric Acid DB03147 Flavin adenine dinucleotide DB03214 Vinylglycine

DrugBankⁱ

DB04166 2-Aminobenzoic Acid
DB04272 Citric Acid
DB03147 Flavin adenine dinucleotide
DB03214 Vinylglycine

Polymorphism and mutation databases

BioMutaⁱ	IL4I1
DMDMⁱ	20138284

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 21	1 PublicationAdd BLAST		21
ChainⁱPRO_0000001710	22 – 567	L-amino-acid oxidaseAdd BLAST		546

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	36 ↔ 199	By similarity
Glycosylationⁱ	54	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	134	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	220	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	559	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96RQ9
PaxDbⁱ	Q96RQ9
PeptideAtlas More...PeptideAtlasⁱ	Q96RQ9
PRIDEⁱ	Q96RQ9
ProteomicsDBⁱ	78004 78005 [Q96RQ9-2]

PTM databases

GlyConnectⁱ	1446
iPTMnetⁱ	Q96RQ9
PhosphoSitePlusⁱ	Q96RQ9

Expressionⁱ

Tissue specificityⁱ

Isoform 1 is primarily found in immune tissues.1 Publication

Inductionⁱ

By IL4/interleukin-4.

Gene expression databases

Bgeeⁱ	ENSG00000104951 Expressed in 101 organ(s), highest expression level in testis
ExpressionAtlasⁱ	Q96RQ9 baseline and differential
Genevisibleⁱ	Q96RQ9 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA045598

HPAⁱ

HPA045598

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000342557

STRINGⁱ

9606.ENSP00000342557

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96RQ9
SMRⁱ	Q96RQ9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the flavin monoamine oxidase family. FIG1 subfamily.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IEXX Eukaryota COG1231 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000110942
HOGENOMⁱ	HOG000088141
HOVERGENⁱ	HBG005729
InParanoidⁱ	Q96RQ9
KEGG Orthology (KO) More...KOⁱ	K03334
OMAⁱ	VGWHRVP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0412
PhylomeDBⁱ	Q96RQ9
TreeFamⁱ	TF313314

Family and domain databases

Gene3Dⁱ	3.50.50.60, 1 hit
InterProⁱ	View protein in InterPro IPR002937 Amino_oxidase IPR036188 FAD/NAD-bd_sf IPR001613 Flavin_amine_oxidase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01593 Amino_oxidase, 1 hit
PRINTSⁱ	PR00757 AMINEOXDASEF
SUPFAMⁱ	SSF51905 SSF51905, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative promoter usage and alternative splicing. Align Add to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q96RQ9-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPLALHLLV LVPILLSLVA SQDWKAERSQ DPFEKCMQDP DYEQLLKVVT 
        60         70         80         90        100
WGLNRTLKPQ RVIVVGAGVA GLVAAKVLSD AGHKVTILEA DNRIGGRIFT 
       110        120        130        140        150
YRDQNTGWIG ELGAMRMPSS HRILHKLCQG LGLNLTKFTQ YDKNTWTEVH 
       160        170        180        190        200
EVKLRNYVVE KVPEKLGYAL RPQEKGHSPE DIYQMALNQA LKDLKALGCR 
       210        220        230        240        250
KAMKKFERHT LLEYLLGEGN LSRPAVQLLG DVMSEDGFFY LSFAEALRAH 
       260        270        280        290        300
SCLSDRLQYS RIVGGWDLLP RALLSSLSGL VLLNAPVVAM TQGPHDVHVQ 
       310        320        330        340        350
IETSPPARNL KVLKADVVLL TASGPAVKRI TFSPPLPRHM QEALRRLHYV 
       360        370        380        390        400
PATKVFLSFR RPFWREEHIE GGHSNTDRPS RMIFYPPPRE GALLLASYTW 
       410        420        430        440        450
SDAAAAFAGL SREEALRLAL DDVAALHGPV VRQLWDGTGV VKRWAEDQHS 
       460        470        480        490        500
QGGFVVQPPA LWQTEKDDWT VPYGRIYFAG EHTAYPHGWV ETAVKSALRA 
       510        520        530        540        550
AIKINSRKGP ASDTASPEGH ASDMEGQGHV HGVASSPSHD LAKEEGSHPP 
       560 
VQGQLSLQNT THTRTSH

Length:567

Mass (Da):62,881

Last modified:December 1, 2001 - v1

Checksum:ⁱFFF953CB28D22F19

Isoform 2 (identifier: Q96RQ9-2) [UniParc]FASTA Add to basket

Also known as: IL4I1_2

The sequence of this isoform differs from the canonical sequence as follows:
1-5: MAPLA → MPNDDFCPGLTIKAMGAERAPQRQPCT

« Hide

        10         20         30         40         50
MPNDDFCPGL TIKAMGAERA PQRQPCTLHL LVLVPILLSL VASQDWKAER 
        60         70         80         90        100
SQDPFEKCMQ DPDYEQLLKV VTWGLNRTLK PQRVIVVGAG VAGLVAAKVL 
       110        120        130        140        150
SDAGHKVTIL EADNRIGGRI FTYRDQNTGW IGELGAMRMP SSHRILHKLC 
       160        170        180        190        200
QGLGLNLTKF TQYDKNTWTE VHEVKLRNYV VEKVPEKLGY ALRPQEKGHS 
       210        220        230        240        250
PEDIYQMALN QALKDLKALG CRKAMKKFER HTLLEYLLGE GNLSRPAVQL 
       260        270        280        290        300
LGDVMSEDGF FYLSFAEALR AHSCLSDRLQ YSRIVGGWDL LPRALLSSLS 
       310        320        330        340        350
GLVLLNAPVV AMTQGPHDVH VQIETSPPAR NLKVLKADVV LLTASGPAVK 
       360        370        380        390        400
RITFSPPLPR HMQEALRRLH YVPATKVFLS FRRPFWREEH IEGGHSNTDR 
       410        420        430        440        450
PSRMIFYPPP REGALLLASY TWSDAAAAFA GLSREEALRL ALDDVAALHG 
       460        470        480        490        500
PVVRQLWDGT GVVKRWAEDQ HSQGGFVVQP PALWQTEKDD WTVPYGRIYF 
       510        520        530        540        550
AGEHTAYPHG WVETAVKSAL RAAIKINSRK GPASDTASPE GHASDMEGQG 
       560        570        580 
HVHGVASSPS HDLAKEEGSH PPVQGQLSLQ NTTHTRTSH

Note: Uses the promoter of the upstream NUP62 gene and shares the first 2 non-coding exons with NUP62.

Show »

Length:589

Mass (Da):65,328

Checksum:ⁱ61FEFA634DF56B49

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

M0QYW8	M0QYW8_HUMAN	L-amino-acid oxidase L-amino-acid oxidase	IL4I1	150	Annotation score:
M0QYH9	M0QYH9_HUMAN	L-amino-acid oxidase L-amino-acid oxidase	IL4I1	71	Annotation score:
M0R1L1	M0R1L1_HUMAN	L-amino-acid oxidase L-amino-acid oxidase	IL4I1	106	Annotation score:
M0R2S9	M0R2S9_HUMAN	L-amino-acid oxidase L-amino-acid oxidase	IL4I1	32	Annotation score:
M0QXY7	M0QXY7_HUMAN	L-amino-acid oxidase L-amino-acid oxidase	IL4I1	82	Annotation score:

Sequence cautionⁱ

The sequence BAB84923 differs from that shown. Reason: Erroneous initiation.Curated

The sequence CAI54291 differs from that shown. Reason: Erroneous initiation.Curated

The sequence CAI54292 differs from that shown. Reason: Erroneous initiation.Curated

The sequence CAI54293 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	24	W → R in AAH64378 (PubMed:15489334).Curated	1
Sequence conflictⁱ	114	A → T in CAI54291 (PubMed:16029492).Curated	1
Sequence conflictⁱ	114	A → T in CAI54293 (PubMed:16029492).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_048260	501	A → S. Corresponds to variant dbSNP:rs2290772Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_017173	1 – 5	MAPLA → MPNDDFCPGLTIKAMGAERA PQRQPCT in isoform 2. 2 Publications		5

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF293462 mRNA Translation: AAK73362.1 AF293463 Genomic DNA Translation: AAK73363.1 AJ880386 mRNA Translation: CAI54291.1 Different initiation. AJ880387 mRNA Translation: CAI54292.1 Different initiation. AJ880388 mRNA Translation: CAI54293.1 Different initiation. DQ079587 mRNA Translation: AAZ32711.1 DQ079588 mRNA Translation: AAZ32712.1 DQ079589 mRNA Translation: AAZ32713.1 AK074097 mRNA Translation: BAB84923.1 Different initiation. AY358933 mRNA Translation: AAQ89292.1 CH471177 Genomic DNA Translation: EAW52575.1 BC064378 mRNA Translation: AAH64378.2 BC090852 mRNA Translation: AAH90852.2
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12786.1 [Q96RQ9-2] CCDS12787.1 [Q96RQ9-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001244946.1, NM_001258017.1 [Q96RQ9-2] NP_001244947.1, NM_001258018.1 [Q96RQ9-2] NP_690863.1, NM_152899.1 [Q96RQ9-1] NP_758962.1, NM_172374.2 [Q96RQ9-2]
UniGeneⁱ	Hs.574492 Hs.741750

Genome annotation databases

Ensemblⁱ	ENST00000341114; ENSP00000342557; ENSG00000104951 [Q96RQ9-2] ENST00000391826; ENSP00000375702; ENSG00000104951 [Q96RQ9-1] ENST00000595948; ENSP00000472474; ENSG00000104951 [Q96RQ9-2]
GeneIDⁱ	259307
KEGGⁱ	hsa:259307
UCSC genome browser More...UCSCⁱ	uc002pqt.2 human [Q96RQ9-1]

Keywords - Coding sequence diversityⁱ

Alternative promoter usage, Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96RQ9	L-amino-acid oxidase (Fragment)		HUMAN		32	UniRef100_Q96RQ9
L-amino-acid oxidase (Fragment)		HUMAN		71

Protein	Similar proteins		Species	Score	Length	Source
Q96RQ9	L-amino-acid oxidase (Fragment)		HUMAN		32	UniRef90_Q96RQ9
Amine oxidase		PANTR		589
Amine oxidase		PANPA		589
Amine oxidase		GORGO		589
Amine oxidase (Fragment)		PONAB		589
+45

Protein	Similar proteins		Species	Score	Length	Source
Q96RQ9	L-amino-acid oxidase (Fragment)		HUMAN		32	UniRef50_Q96RQ9
Amine oxidase		PAPAN		589
Amine oxidase		CERAT		589
Amine oxidase		MACNE		589
Amine oxidase		MACFA		589
+131

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF293462 mRNA Translation: AAK73362.1 AF293463 Genomic DNA Translation: AAK73363.1 AJ880386 mRNA Translation: CAI54291.1 Different initiation. AJ880387 mRNA Translation: CAI54292.1 Different initiation. AJ880388 mRNA Translation: CAI54293.1 Different initiation. DQ079587 mRNA Translation: AAZ32711.1 DQ079588 mRNA Translation: AAZ32712.1 DQ079589 mRNA Translation: AAZ32713.1 AK074097 mRNA Translation: BAB84923.1 Different initiation. AY358933 mRNA Translation: AAQ89292.1 CH471177 Genomic DNA Translation: EAW52575.1 BC064378 mRNA Translation: AAH64378.2 BC090852 mRNA Translation: AAH90852.2
CCDSⁱ	CCDS12786.1 [Q96RQ9-2] CCDS12787.1 [Q96RQ9-1]
RefSeqⁱ	NP_001244946.1, NM_001258017.1 [Q96RQ9-2] NP_001244947.1, NM_001258018.1 [Q96RQ9-2] NP_690863.1, NM_152899.1 [Q96RQ9-1] NP_758962.1, NM_172374.2 [Q96RQ9-2]
UniGeneⁱ	Hs.574492 Hs.741750

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2I8H	model	-	@	30-504	[»]
ProteinModelPortalⁱ	Q96RQ9
SMRⁱ	Q96RQ9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000342557

STRINGⁱ

9606.ENSP00000342557

Chemistry databases

DrugBankⁱ	DB04166 2-Aminobenzoic Acid DB04272 Citric Acid DB03147 Flavin adenine dinucleotide DB03214 Vinylglycine

DrugBankⁱ

DB04166 2-Aminobenzoic Acid
DB04272 Citric Acid
DB03147 Flavin adenine dinucleotide
DB03214 Vinylglycine

PTM databases

GlyConnectⁱ	1446
iPTMnetⁱ	Q96RQ9
PhosphoSitePlusⁱ	Q96RQ9

Polymorphism and mutation databases

BioMutaⁱ	IL4I1
DMDMⁱ	20138284

Proteomic databases

MaxQBⁱ	Q96RQ9
PaxDbⁱ	Q96RQ9
PeptideAtlasⁱ	Q96RQ9
PRIDEⁱ	Q96RQ9
ProteomicsDBⁱ	78004 78005 [Q96RQ9-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000341114; ENSP00000342557; ENSG00000104951 [Q96RQ9-2] ENST00000391826; ENSP00000375702; ENSG00000104951 [Q96RQ9-1] ENST00000595948; ENSP00000472474; ENSG00000104951 [Q96RQ9-2]
GeneIDⁱ	259307
KEGGⁱ	hsa:259307
UCSCⁱ	uc002pqt.2 human [Q96RQ9-1]

Organism-specific databases

CTDⁱ	259307
DisGeNETⁱ	259307
EuPathDBⁱ	HostDB:ENSG00000104951.15
GeneCardsⁱ	IL4I1
HGNCⁱ	HGNC:19094 IL4I1
HPAⁱ	HPA045598
MIMⁱ	609742 gene
neXtProtⁱ	NX_Q96RQ9
OpenTargetsⁱ	ENSG00000104951
PharmGKBⁱ	PA38795
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IEXX Eukaryota COG1231 LUCA
GeneTreeⁱ	ENSGT00730000110942
HOGENOMⁱ	HOG000088141
HOVERGENⁱ	HBG005729
InParanoidⁱ	Q96RQ9
KOⁱ	K03334
OMAⁱ	VGWHRVP
OrthoDBⁱ	EOG091G0412
PhylomeDBⁱ	Q96RQ9
TreeFamⁱ	TF313314

Enzyme and pathway databases

Reactomeⁱ	R-HSA-71182 Phenylalanine and tyrosine catabolism

Reactomeⁱ

R-HSA-71182 Phenylalanine and tyrosine catabolism

Miscellaneous databases

ChiTaRSⁱ	IL4I1 human
GenomeRNAiⁱ	259307
Protein Ontology More...PROⁱ	PR:Q96RQ9
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000104951 Expressed in 101 organ(s), highest expression level in testis
ExpressionAtlasⁱ	Q96RQ9 baseline and differential
Genevisibleⁱ	Q96RQ9 HS

Family and domain databases

Gene3Dⁱ	3.50.50.60, 1 hit
InterProⁱ	View protein in InterPro IPR002937 Amino_oxidase IPR036188 FAD/NAD-bd_sf IPR001613 Flavin_amine_oxidase
Pfamⁱ	View protein in Pfam PF01593 Amino_oxidase, 1 hit
PRINTSⁱ	PR00757 AMINEOXDASEF
SUPFAMⁱ	SSF51905 SSF51905, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	OXLA_HUMAN
Accessionⁱ	Q96RQ9Primary (citable) accession number: Q96RQ9 Secondary accession number(s): Q1WMJ3 , Q4GZN1, Q4GZN2, Q6P2Q3, Q8TEM5, Q96RQ8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 27, 2002
	Last sequence update:	December 1, 2001
	Last modified:	November 7, 2018
	This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q96RQ9 (OXLA_HUMAN)

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L-amino-acid oxidase

IL4I1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Lysosome

Lysosome

Extracellular region or secreted

Lysosome

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ