UniProtKB - Q96RP8 (KCNA7_HUMAN)
Protein
Potassium voltage-gated channel subfamily A member 7
Gene
KCNA7
Organism
Homo sapiens (Human)
Status
Functioni
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (By similarity).By similarity
GO - Molecular functioni
- delayed rectifier potassium channel activity Source: GO_Central
- voltage-gated potassium channel activity Source: GO_Central
GO - Biological processi
- potassium ion transmembrane transport Source: GO_Central
- protein homooligomerization Source: InterPro
- regulation of ion transmembrane transport Source: UniProtKB-KW
Keywordsi
Molecular function | Ion channel, Potassium channel, Voltage-gated channel |
Biological process | Ion transport, Potassium transport, Transport |
Ligand | Potassium |
Enzyme and pathway databases
PathwayCommonsi | Q96RP8 |
Reactomei | R-HSA-1296072, Voltage gated Potassium channels |
Names & Taxonomyi
Protein namesi | Recommended name: Potassium voltage-gated channel subfamily A member 7Alternative name(s): Voltage-gated potassium channel subunit Kv1.7 |
Gene namesi | Name:KCNA7 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000104848.1 |
HGNCi | HGNC:6226, KCNA7 |
MIMi | 176268, gene |
neXtProti | NX_Q96RP8 |
Subcellular locationi
Other locations
- Membrane By similarity; Multi-pass membrane protein By similarity
Plasma Membrane
- plasma membrane Source: Reactome
- voltage-gated potassium channel complex Source: GO_Central
Other locations
- integral component of membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 144 – 164 | Helical; Name=Segment S1Sequence analysisAdd BLAST | 21 | |
Transmembranei | 209 – 229 | Helical; Name=Segment S2Sequence analysisAdd BLAST | 21 | |
Transmembranei | 241 – 261 | Helical; Name=Segment S3Sequence analysisAdd BLAST | 21 | |
Transmembranei | 276 – 295 | Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST | 20 | |
Transmembranei | 312 – 332 | Helical; Name=Segment S5Sequence analysisAdd BLAST | 21 | |
Transmembranei | 373 – 393 | Helical; Name=Segment S6Sequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 3743 |
OpenTargetsi | ENSG00000104848 |
PharmGKBi | PA30023 |
Miscellaneous databases
Pharosi | Q96RP8, Tclin |
Chemistry databases
ChEMBLi | CHEMBL2773 |
DrugBanki | DB06637, Dalfampridine |
DrugCentrali | Q96RP8 |
GuidetoPHARMACOLOGYi | 544 |
Polymorphism and mutation databases
BioMutai | KCNA7 |
DMDMi | 74752109 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000308273 | 1 – 456 | Potassium voltage-gated channel subfamily A member 7Add BLAST | 456 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 191 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Lipidationi | 231 | S-palmitoyl cysteineSequence analysis | 1 |
Keywords - PTMi
Glycoprotein, Lipoprotein, PalmitateProteomic databases
PaxDbi | Q96RP8 |
PeptideAtlasi | Q96RP8 |
PRIDEi | Q96RP8 |
ProteomicsDBi | 77999 |
PTM databases
GlyGeni | Q96RP8, 1 site |
iPTMneti | Q96RP8 |
PhosphoSitePlusi | Q96RP8 |
Expressioni
Tissue specificityi
Highly expressed in skeletal muscle, heart and kidney.2 Publications
Gene expression databases
Bgeei | ENSG00000104848, Expressed in skeletal muscle tissue and 35 other tissues |
Genevisiblei | Q96RP8, HS |
Organism-specific databases
HPAi | ENSG00000104848, Tissue enriched (skeletal) |
Interactioni
Subunit structurei
Heterotetramer of potassium channel proteins.
By similarityProtein-protein interaction databases
STRINGi | 9606.ENSP00000221444 |
Miscellaneous databases
RNActi | Q96RP8, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 358 – 363 | Selectivity filterBy similarity | 6 |
Domaini
The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.By similarity
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.By similarity
Sequence similaritiesi
Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.7/KCNA7 sub-subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1545, Eukaryota |
GeneTreei | ENSGT00940000162339 |
HOGENOMi | CLU_011722_4_1_1 |
InParanoidi | Q96RP8 |
OMAi | RAMEPRC |
OrthoDBi | 818306at2759 |
PhylomeDBi | Q96RP8 |
TreeFami | TF313103 |
Family and domain databases
Gene3Di | 1.20.120.350, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR005821, Ion_trans_dom IPR003968, K_chnl_volt-dep_Kv IPR003972, K_chnl_volt-dep_Kv1 IPR011333, SKP1/BTB/POZ_sf IPR003131, T1-type_BTB IPR028325, VG_K_chnl IPR027359, Volt_channel_dom_sf |
PANTHERi | PTHR11537, PTHR11537, 1 hit |
Pfami | View protein in Pfam PF02214, BTB_2, 1 hit PF00520, Ion_trans, 1 hit |
PRINTSi | PR01491, KVCHANNEL PR01496, SHAKERCHANEL |
SMARTi | View protein in SMART SM00225, BTB, 1 hit |
SUPFAMi | SSF54695, SSF54695, 1 hit |
i Sequence
Sequence statusi: Complete.
Q96RP8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEPRCPPPCG CCERLVLNVA GLRFETRART LGRFPDTLLG DPARRGRFYD
60 70 80 90 100
DARREYFFDR HRPSFDAVLY YYQSGGRLRR PAHVPLDVFL EEVAFYGLGA
110 120 130 140 150
AALARLREDE GCPVPPERPL PRRAFARQLW LLFEFPESSQ AARVLAVVSV
160 170 180 190 200
LVILVSIVVF CLETLPDFRD DRDGTGLAAA AAAGPFPAPL NGSSQMPGNP
210 220 230 240 250
PRLPFNDPFF VVETLCICWF SFELLVRLLV CPSKAIFFKN VMNLIDFVAI
260 270 280 290 300
LPYFVALGTE LARQRGVGQQ AMSLAILRVI RLVRVFRIFK LSRHSKGLQI
310 320 330 340 350
LGQTLRASMR ELGLLIFFLF IGVVLFSSAV YFAEVDRVDS HFTSIPESFW
360 370 380 390 400
WAVVTMTTVG YGDMAPVTVG GKIVGSLCAI AGVLTISLPV PVIVSNFSYF
410 420 430 440 450
YHRETEGEEA GMFSHVDMQP CGPLEGKANG GLVDGEVPEL PPPLWAPPGK
HLVTEV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 71 | Y → H in AAX11186 (Ref. 3) Curated | 1 | |
Sequence conflicti | 180 | A → V in AAX11186 (Ref. 3) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_036776 | 189 | P → R2 PublicationsCorresponds to variant dbSNP:rs1611775Ensembl. | 1 | |
Natural variantiVAR_036777 | 418 | M → T2 PublicationsCorresponds to variant dbSNP:rs1017219Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ310479 mRNA Translation: CAC29065.1 AF315818 mRNA Translation: AAK63002.1 AY779768 mRNA Translation: AAX11186.1 |
CCDSi | CCDS12755.1 |
RefSeqi | NP_114092.2, NM_031886.2 |
Genome annotation databases
Ensembli | ENST00000221444; ENSP00000221444; ENSG00000104848 |
GeneIDi | 3743 |
KEGGi | hsa:3743 |
UCSCi | uc002pmg.3, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ310479 mRNA Translation: CAC29065.1 AF315818 mRNA Translation: AAK63002.1 AY779768 mRNA Translation: AAX11186.1 |
CCDSi | CCDS12755.1 |
RefSeqi | NP_114092.2, NM_031886.2 |
3D structure databases
SMRi | Q96RP8 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000221444 |
Chemistry databases
ChEMBLi | CHEMBL2773 |
DrugBanki | DB06637, Dalfampridine |
DrugCentrali | Q96RP8 |
GuidetoPHARMACOLOGYi | 544 |
PTM databases
GlyGeni | Q96RP8, 1 site |
iPTMneti | Q96RP8 |
PhosphoSitePlusi | Q96RP8 |
Polymorphism and mutation databases
BioMutai | KCNA7 |
DMDMi | 74752109 |
Proteomic databases
PaxDbi | Q96RP8 |
PeptideAtlasi | Q96RP8 |
PRIDEi | Q96RP8 |
ProteomicsDBi | 77999 |
Protocols and materials databases
Antibodypediai | 18500, 71 antibodies |
Genome annotation databases
Ensembli | ENST00000221444; ENSP00000221444; ENSG00000104848 |
GeneIDi | 3743 |
KEGGi | hsa:3743 |
UCSCi | uc002pmg.3, human |
Organism-specific databases
CTDi | 3743 |
DisGeNETi | 3743 |
EuPathDBi | HostDB:ENSG00000104848.1 |
GeneCardsi | KCNA7 |
HGNCi | HGNC:6226, KCNA7 |
HPAi | ENSG00000104848, Tissue enriched (skeletal) |
MIMi | 176268, gene |
neXtProti | NX_Q96RP8 |
OpenTargetsi | ENSG00000104848 |
PharmGKBi | PA30023 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1545, Eukaryota |
GeneTreei | ENSGT00940000162339 |
HOGENOMi | CLU_011722_4_1_1 |
InParanoidi | Q96RP8 |
OMAi | RAMEPRC |
OrthoDBi | 818306at2759 |
PhylomeDBi | Q96RP8 |
TreeFami | TF313103 |
Enzyme and pathway databases
PathwayCommonsi | Q96RP8 |
Reactomei | R-HSA-1296072, Voltage gated Potassium channels |
Miscellaneous databases
BioGRID-ORCSi | 3743, 5 hits in 838 CRISPR screens |
GeneWikii | KCNA7 |
GenomeRNAii | 3743 |
Pharosi | Q96RP8, Tclin |
PROi | PR:Q96RP8 |
RNActi | Q96RP8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000104848, Expressed in skeletal muscle tissue and 35 other tissues |
Genevisiblei | Q96RP8, HS |
Family and domain databases
Gene3Di | 1.20.120.350, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR005821, Ion_trans_dom IPR003968, K_chnl_volt-dep_Kv IPR003972, K_chnl_volt-dep_Kv1 IPR011333, SKP1/BTB/POZ_sf IPR003131, T1-type_BTB IPR028325, VG_K_chnl IPR027359, Volt_channel_dom_sf |
PANTHERi | PTHR11537, PTHR11537, 1 hit |
Pfami | View protein in Pfam PF02214, BTB_2, 1 hit PF00520, Ion_trans, 1 hit |
PRINTSi | PR01491, KVCHANNEL PR01496, SHAKERCHANEL |
SMARTi | View protein in SMART SM00225, BTB, 1 hit |
SUPFAMi | SSF54695, SSF54695, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KCNA7_HUMAN | |
Accessioni | Q96RP8Primary (citable) accession number: Q96RP8 Secondary accession number(s): A1KYX7, Q9BYS4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 23, 2007 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 135 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations