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Protein

Urocortin-2

Gene

UCN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.

GO - Molecular functioni

  • corticotropin-releasing hormone receptor 2 binding Source: InterPro
  • corticotropin-releasing hormone receptor binding Source: UniProtKB
  • G-protein coupled receptor binding Source: GO_Central
  • hormone activity Source: UniProtKB-KW
  • hormone binding Source: UniProtKB

GO - Biological processi

  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: UniProtKB
  • cellular response to nutrient levels Source: GO_Central
  • digestion Source: UniProtKB
  • hormone-mediated signaling pathway Source: UniProtKB
  • response to stress Source: InterPro

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-HSA-373080 Class B/2 (Secretin family receptors)

Names & Taxonomyi

Protein namesi
Recommended name:
Urocortin-2
Alternative name(s):
Stresscopin-related peptide
Urocortin II
Short name:
Ucn II
Urocortin-related peptide
Gene namesi
Name:UCN2
Synonyms:SRP, URP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000145040.3
HGNCiHGNC:18414 UCN2
MIMi605902 gene
neXtProtiNX_Q96RP3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi90226
OpenTargetsiENSG00000145040
PharmGKBiPA133787055

Polymorphism and mutation databases

BioMutaiUCN2
DMDMi20532289

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
PropeptideiPRO_000000623923 – 70By similarityAdd BLAST48
ChainiPRO_000000624072 – 112Urocortin-2Add BLAST41

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ96RP3
PRIDEiQ96RP3
ProteomicsDBi77996

Expressioni

Gene expression databases

BgeeiENSG00000145040
CleanExiHS_UCN2
GenevisibleiQ96RP3 HS

Organism-specific databases

HPAiHPA066841

Interactioni

Subunit structurei

Binds with high affinity to CRF receptors 2-alpha and 2-beta.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi124679, 2 interactors
STRINGi9606.ENSP00000273610

Structurei

Secondary structure

1112
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi80 – 88Combined sources9
Helixi95 – 108Combined sources14

3D structure databases

ProteinModelPortaliQ96RP3
SMRiQ96RP3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96RP3

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J5CP Eukaryota
ENOG4111C21 LUCA
GeneTreeiENSGT00390000004650
HOGENOMiHOG000154768
HOVERGENiHBG036242
InParanoidiQ96RP3
KOiK05257
OMAiQNSPQTT
PhylomeDBiQ96RP3
TreeFamiTF330723

Family and domain databases

InterProiView protein in InterPro
IPR000187 CRF
IPR024273 Urocortin_II
IPR024270 Urocortin_II/III
PANTHERiPTHR17575 PTHR17575, 1 hit
PTHR17575:SF0 PTHR17575:SF0, 1 hit
PfamiView protein in Pfam
PF00473 CRF, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD455741 PD455741, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96RP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRCALLLLM VLMLGRVLVV PVTPIPTFQL RPQNSPQTTP RPAASESPSA
60 70 80 90 100
APTWPWAAQS HCSPTRHPGS RIVLSLDVPI GLLQILLEQA RARAAREQAT
110
TNARILARVG HC
Length:112
Mass (Da):12,146
Last modified:December 1, 2001 - v1
Checksum:i0EFF29A3463723D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF320560 mRNA Translation: AAK52672.1
BC002647 mRNA Translation: AAH02647.2
BC022096 mRNA Translation: AAH22096.1
CCDSiCCDS2772.1
RefSeqiNP_149976.1, NM_033199.3
UniGeneiHs.631914

Genome annotation databases

EnsembliENST00000273610; ENSP00000273610; ENSG00000145040
GeneIDi90226
KEGGihsa:90226
UCSCiuc003cty.2 human

Similar proteinsi

Entry informationi

Entry nameiUCN2_HUMAN
AccessioniPrimary (citable) accession number: Q96RP3
Secondary accession number(s): Q9BUG0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: December 1, 2001
Last modified: June 20, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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