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UniProtKB - Q96RN5 (MED15_HUMAN)

Entry version 174 (05 Jun 2019)
Sequence version 2 (10 Jan 2003)
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Protein

Mediator of RNA polymerase II transcription subunit 15

Gene

MED15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1989781 PPARA activates gene expression
R-HSA-212436 Generic Transcription Pathway
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 15
Alternative name(s):
Activator-recruited cofactor 105 kDa component
Short name:
ARC105
CTG repeat protein 7a
Mediator complex subunit 15
Positive cofactor 2 glutamine/Q-rich-associated protein
Short name:
PC2 glutamine/Q-rich-associated protein
TPA-inducible gene 1 protein
Short name:
TIG-1
Trinucleotide repeat-containing gene 7 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MED15
Synonyms:ARC105, CTG7A, PCQAP, TIG1, TNRC7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:14248 MED15

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607372 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96RN5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi42E → A: Abrogates interaction with SREBF1. 1 Publication1
Mutagenesisi58L → D: Abrogates interaction with SREBF1. 1 Publication1
Mutagenesisi60A → D: Abrogates interaction with SREBF1. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		51586

Open Targets

More...OpenTargetsi		ENSG00000099917

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33088

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MED15

Domain mapping of disease mutations (DMDM)

More...DMDMi		27734440

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000582641 – 788Mediator of RNA polymerase II transcription subunit 15Add BLAST788

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei349Asymmetric dimethylarginineBy similarity1
Modified residuei603PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated by TRIM11, leading to proteasomal degradation.1 Publication

Keywords - PTMi

Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96RN5

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96RN5

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96RN5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96RN5

PeptideAtlas

More...PeptideAtlasi		Q96RN5

PRoteomics IDEntifications database

More...PRIDEi		Q96RN5

ProteomicsDB human proteome resource

More...ProteomicsDBi		77993
77994 [Q96RN5-2]
77995 [Q96RN5-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96RN5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96RN5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in all tissues examined, including heart, brain, lung, spleen, thymus, pancreas, blood leukocyte and placenta. However, the level of expression varied, with highest expression in the placenta and peripheral blood and lowest in the pancreas and kidney.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By 12-O-tetradecanoylphorbol-13-acetate (TPA).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000099917 Expressed in 214 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96RN5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96RN5 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA003179

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.

Interacts with SMAD2, SMAD3, SREBF1 and SREBF2.

Interacts with WWTR1.

Interacts with TRIM11.

7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		119623, 88 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-3227 Core mediator complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q96RN5

Database of interacting proteins

More...DIPi		DIP-32908N

Protein interaction database and analysis system

More...IntActi		Q96RN5, 37 interactors

Molecular INTeraction database

More...MINTi		Q96RN5

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000263205

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1788
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96RN5

Database of comparative protein structure models

More...ModBasei		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q96RN5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni9 – 73Interaction with SREBF11 PublicationAdd BLAST65

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi547 – 564Nuclear localization signalSequence analysisAdd BLAST18

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi161 – 174Poly-GlnAdd BLAST14
Compositional biasi178 – 193Poly-GlnAdd BLAST16
Compositional biasi205 – 218Poly-GlnAdd BLAST14
Compositional biasi226 – 239Poly-GlnAdd BLAST14
Compositional biasi243 – 262Poly-GlnAdd BLAST20
Compositional biasi266 – 515Pro-richAdd BLAST250
Compositional biasi360 – 367Poly-Gln8
Compositional biasi449 – 456Poly-Pro8
Compositional biasi602 – 611Poly-Pro10

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Mediator complex subunit 15 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4274 Eukaryota
ENOG410YKAW LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00730000111140

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96RN5

KEGG Orthology (KO)

More...KOi		K15157

Identification of Orthologs from Complete Genome Data

More...OMAi		ICCLDDK

Database of Orthologous Groups

More...OrthoDBi		1424577at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96RN5

TreeFam database of animal gene trees

More...TreeFami		TF324988

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR019087 Med15

Pfam protein domain database

More...Pfami		View protein in Pfam
PF09606 Med15, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 15 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96RN5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDVSGQETDW RSTAFRQKLV SQIEDAMRKA GVAHSKSSKD MESHVFLKAK 
        60         70         80         90        100
TRDEYLSLVA RLIIHFRDIH NKKSQASVSD PMNALQSLTG GPAAGAAGIG 
       110        120        130        140        150
MPPRGPGQSL GGMGSLGAMG QPMSLSGQPP PGTSGMAPHS MAVVSTATPQ 
       160        170        180        190        200
TQLQLQQVAL QQQQQQQQFQ QQQQAALQQQ QQQQQQQQFQ AQQSAMQQQF 
       210        220        230        240        250
QAVVQQQQQL QQQQQQQQHL IKLHHQNQQQ IQQQQQQLQR IAQLQLQQQQ 
       260        270        280        290        300
QQQQQQQQQQ QQALQAQPPI QQPPMQQPQP PPSQALPQQL QQMHHTQHHQ 
       310        320        330        340        350
PPPQPQQPPV AQNQPSQLPP QSQTQPLVSQ AQALPGQMLY TQPPLKFVRA 
       360        370        380        390        400
PMVVQQPPVQ PQVQQQQTAV QTAQAAQMVA PGVQMITEAL AQGGMHIRAR 
       410        420        430        440        450
FPPTTAVSAI PSSSIPLGRQ PMAQVSQSSL PMLSSPSPGQ QVQTPQSMPP 
       460        470        480        490        500
PPQPSPQPGQ PSSQPNSNVS SGPAPSPSSF LPSPSPQPSQ SPVTARTPQN 
       510        520        530        540        550
FSVPSPGPLN TPVNPSSVMS PAGSSQAEEQ QYLDKLKQLS KYIEPLRRMI 
       560        570        580        590        600
NKIDKNEDRK KDLSKMKSLL DILTDPSKRC PLKTLQKCEI ALEKLKNDMA 
       610        620        630        640        650
VPTPPPPPVP PTKQQYLCQP LLDAVLANIR SPVFNHSLYR TFVPAMTAIH 
       660        670        680        690        700
GPPITAPVVC TRKRRLEDDE RQSIPSVLQG EVARLDPKFL VNLDPSHCSN 
       710        720        730        740        750
NGTVHLICKL DDKDLPSVPP LELSVPADYP AQSPLWIDRQ WQYDANPFLQ 
       760        770        780 
SVHRCMTSRL LQLPDKHSVT ALLNTWAQSV HQACLSAA
Length:788
Mass (Da):86,753
Last modified:January 10, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBB6AC6C63ED2F97E
GO
Isoform 2 (identifier: Q96RN5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     385-424: Missing.

Show »
Length:748
Mass (Da):82,581
Checksum:i436AD762713DCC63
GO
Isoform 3 (identifier: Q96RN5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     80-151: DPMNALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTATPQT → A
     385-424: Missing.

Note: No experimental confirmation available.
Show »
Length:677
Mass (Da):75,927
Checksum:iC5DBE759F22901CB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 15 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V1P5G3V1P5_HUMAN
Mediator of RNA polymerase II trans...
MED15 PCQAP, hCG_41277
722Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JGN2C9JGN2_HUMAN
Mediator of RNA polymerase II trans...
MED15
124Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JZV5C9JZV5_HUMAN
Mediator of RNA polymerase II trans...
MED15
120Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J1I1C9J1I1_HUMAN
Mediator of RNA polymerase II trans...
MED15
141Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JM58C9JM58_HUMAN
Mediator of RNA polymerase II trans...
MED15
105Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JJ12C9JJ12_HUMAN
Mediator of RNA polymerase II trans...
MED15
160Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JCQ3C9JCQ3_HUMAN
Mediator of RNA polymerase II trans...
MED15
165Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z2B7F2Z2B7_HUMAN
Mediator of RNA polymerase II trans...
MED15
55Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JLN7C9JLN7_HUMAN
Mediator of RNA polymerase II trans...
MED15
105Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JWK5C9JWK5_HUMAN
Mediator of RNA polymerase II trans...
MED15
82Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC12944 differs from that shown. Reason: Frameshift at positions 13, 600 and 749.Curated
The sequence BAB85034 differs from that shown. Several sequencing errors.Curated
The sequence BAC03446 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti12S → R in AAC12944 (PubMed:11024300).Curated1
Sequence conflicti116L → F in AAC12944 (PubMed:11024300).Curated1
Sequence conflicti154Q → H in BAC03446 (PubMed:14702039).Curated1
Sequence conflicti161Q → R in BAB85034 (PubMed:14702039).Curated1
Sequence conflicti185 – 186QQ → EL in AAB91443 (PubMed:9225980).Curated2
Sequence conflicti186 – 187Missing in CAG30423 (PubMed:15461802).Curated2
Sequence conflicti218Missing in CAG30423 (PubMed:15461802).Curated1
Sequence conflicti232 – 287Missing in BAB85034 (PubMed:14702039).CuratedAdd BLAST56
Sequence conflicti265Q → E in AAC12944 (PubMed:11024300).Curated1
Sequence conflicti265Q → E in AAB91443 (PubMed:9225980).Curated1
Sequence conflicti572 – 573IL → GI in AAB91443 (PubMed:9225980).Curated2
Sequence conflicti685L → V in BAB85034 (PubMed:14702039).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

The poly-Gln region from amino acids 235-262 of PCQAP is polymorphic. There are from 15 to 18 repeats in the Italian population.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_013136261 – 262Missing . 2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01302480 – 151DPMNA…ATPQT → A in isoform 3. 1 PublicationAdd BLAST72
Alternative sequenceiVSP_003922385 – 424Missing in isoform 2 and isoform 3. 6 PublicationsAdd BLAST40

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF056191 mRNA Translation: AAC12944.1 Frameshift.
AF328769 mRNA Translation: AAK58423.1
AK074268 mRNA Translation: BAB85034.1 Sequence problems.
AK090465 mRNA Translation: BAC03446.1 Different initiation.
CR456537 mRNA Translation: CAG30423.1
CH471176 Genomic DNA Translation: EAX02951.1
CH471176 Genomic DNA Translation: EAX02952.1
CH471176 Genomic DNA Translation: EAX02954.1
CH471176 Genomic DNA Translation: EAX02956.1
BC007529 mRNA Translation: AAH07529.1
BC013985 mRNA Translation: AAH13985.1
U80745 mRNA Translation: AAB91443.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13781.1 [Q96RN5-2]
CCDS33602.1 [Q96RN5-1]
CCDS74824.1 [Q96RN5-3]

NCBI Reference Sequences

More...RefSeqi		NP_001003891.1, NM_001003891.2 [Q96RN5-1]
NP_001280164.1, NM_001293235.1
NP_001280165.1, NM_001293236.1 [Q96RN5-3]
NP_056973.2, NM_015889.4 [Q96RN5-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000263205; ENSP00000263205; ENSG00000099917 [Q96RN5-1]
ENST00000292733; ENSP00000292733; ENSG00000099917 [Q96RN5-2]
ENST00000382974; ENSP00000372434; ENSG00000099917 [Q96RN5-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		51586

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:51586

UCSC genome browser

More...UCSCi		uc002zsp.4 human [Q96RN5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism, Triplet repeat expansion

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF056191 mRNA Translation: AAC12944.1 Frameshift.
AF328769 mRNA Translation: AAK58423.1
AK074268 mRNA Translation: BAB85034.1 Sequence problems.
AK090465 mRNA Translation: BAC03446.1 Different initiation.
CR456537 mRNA Translation: CAG30423.1
CH471176 Genomic DNA Translation: EAX02951.1
CH471176 Genomic DNA Translation: EAX02952.1
CH471176 Genomic DNA Translation: EAX02954.1
CH471176 Genomic DNA Translation: EAX02956.1
BC007529 mRNA Translation: AAH07529.1
BC013985 mRNA Translation: AAH13985.1
U80745 mRNA Translation: AAB91443.1
CCDSiCCDS13781.1 [Q96RN5-2]
CCDS33602.1 [Q96RN5-1]
CCDS74824.1 [Q96RN5-3]
RefSeqiNP_001003891.1, NM_001003891.2 [Q96RN5-1]
NP_001280164.1, NM_001293235.1
NP_001280165.1, NM_001293236.1 [Q96RN5-3]
NP_056973.2, NM_015889.4 [Q96RN5-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GUTNMR-A5-78[»]
SMRiQ96RN5
ModBaseiSearch...

Protein-protein interaction databases

BioGridi119623, 88 interactors
ComplexPortaliCPX-3227 Core mediator complex
CORUMiQ96RN5
DIPiDIP-32908N
IntActiQ96RN5, 37 interactors
MINTiQ96RN5
STRINGi9606.ENSP00000263205

PTM databases

iPTMnetiQ96RN5
PhosphoSitePlusiQ96RN5

Polymorphism and mutation databases

BioMutaiMED15
DMDMi27734440

Proteomic databases

EPDiQ96RN5
jPOSTiQ96RN5
MaxQBiQ96RN5
PaxDbiQ96RN5
PeptideAtlasiQ96RN5
PRIDEiQ96RN5
ProteomicsDBi77993
77994 [Q96RN5-2]
77995 [Q96RN5-3]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		51586
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263205; ENSP00000263205; ENSG00000099917 [Q96RN5-1]
ENST00000292733; ENSP00000292733; ENSG00000099917 [Q96RN5-2]
ENST00000382974; ENSP00000372434; ENSG00000099917 [Q96RN5-3]
GeneIDi51586
KEGGihsa:51586
UCSCiuc002zsp.4 human [Q96RN5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		51586
DisGeNETi51586

GeneCards: human genes, protein and diseases

More...GeneCardsi		MED15
HGNCiHGNC:14248 MED15
HPAiHPA003179
MIMi607372 gene
neXtProtiNX_Q96RN5
OpenTargetsiENSG00000099917
PharmGKBiPA33088

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4274 Eukaryota
ENOG410YKAW LUCA
GeneTreeiENSGT00730000111140
InParanoidiQ96RN5
KOiK15157
OMAiICCLDDK
OrthoDBi1424577at2759
PhylomeDBiQ96RN5
TreeFamiTF324988

Enzyme and pathway databases

ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-212436 Generic Transcription Pathway
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MED15 human
EvolutionaryTraceiQ96RN5

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		MED15

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		51586

Protein Ontology

More...PROi		PR:Q96RN5

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000099917 Expressed in 214 organ(s), highest expression level in blood
ExpressionAtlasiQ96RN5 baseline and differential
GenevisibleiQ96RN5 HS

Family and domain databases

InterProiView protein in InterPro
IPR019087 Med15
PfamiView protein in Pfam
PF09606 Med15, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMED15_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96RN5
Secondary accession number(s): D3DX31
, D3DX32, O15413, Q6IC31, Q8NF16, Q96CT0, Q96IH7, Q9P1T3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: January 10, 2003
Last modified: June 5, 2019
This is version 174 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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