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UniProtKB - Q96RN1 (S26A8_HUMAN)

Entry version 158 (29 Sep 2021)
Sequence version 1 (01 Dec 2001)
Previous versions | rss
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Protein

Testis anion transporter 1

Gene

SLC26A8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence male fertility. May form a molecular complex involved in the regulation of chloride and bicarbonate ions fluxes during sperm capacitation.

3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activity is inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of several anion channels and transporters), gluconate, and by thiosulfate.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processAnion exchange, Differentiation, Ion transport, Meiosis, Spermatogenesis, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96RN1

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.53.2.14, the sulfate permease (sulp) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Testis anion transporter 1
Alternative name(s):
Anion exchange transporter
Solute carrier family 26 member 8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC26A8Imported
Synonyms:TAT11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:14468, SLC26A8

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		608480, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96RN1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000112053

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 95CytoplasmicSequence analysisAdd BLAST95
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei96 – 116HelicalSequence analysisAdd BLAST21
Topological domaini117 – 119ExtracellularSequence analysis3
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21
Topological domaini141 – 146CytoplasmicSequence analysis6
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Topological domaini168 – 202ExtracellularSequence analysisAdd BLAST35
Transmembranei203 – 223HelicalSequence analysisAdd BLAST21
Topological domaini224 – 232CytoplasmicSequence analysis9
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21
Topological domaini254 – 270ExtracellularSequence analysisAdd BLAST17
Transmembranei271 – 291HelicalSequence analysisAdd BLAST21
Topological domaini292 – 307CytoplasmicSequence analysisAdd BLAST16
Transmembranei308 – 328HelicalSequence analysisAdd BLAST21
Topological domaini329 – 355ExtracellularSequence analysisAdd BLAST27
Transmembranei356 – 376HelicalSequence analysisAdd BLAST21
Topological domaini377 – 392CytoplasmicSequence analysisAdd BLAST16
Transmembranei393 – 413HelicalSequence analysisAdd BLAST21
Topological domaini414 – 429ExtracellularSequence analysisAdd BLAST16
Transmembranei430 – 450HelicalSequence analysisAdd BLAST21
Topological domaini451 – 452CytoplasmicSequence analysis2
Transmembranei453 – 473HelicalSequence analysisAdd BLAST21
Topological domaini474 – 497ExtracellularSequence analysisAdd BLAST24
Transmembranei498 – 518HelicalSequence analysisAdd BLAST21
Topological domaini519 – 970CytoplasmicSequence analysisAdd BLAST452

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Spermatogenic failure 3 (SPGF3)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disorder characterized by primary infertility, sperm morphologic abnormalities, and moderate to severe asthenozoospermia, condition in which the percentage of progressively motile sperm is abnormally low.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07005887R → Q in SPGF3; there is a reduced interactions with CFTR and complete failure to activate CFTR-dependent anion transport. 1 PublicationCorresponds to variant dbSNP:rs140210148EnsemblClinVar.1
Natural variantiVAR_070059812E → K in SPGF3; there is a reduced interactions with CFTR and complete failure to activate CFTR-dependent anion transport. 1 PublicationCorresponds to variant dbSNP:rs142724470EnsemblClinVar.1
Natural variantiVAR_070060954R → C in SPGF3; there is a reduced interactions with CFTR and complete failure to activate CFTR-dependent anion transport. 1 PublicationCorresponds to variant dbSNP:rs398123027EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi914P → S: Not a cause of male infertility. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		116369

MalaCards human disease database

More...MalaCardsi		SLC26A8
MIMi606766, phenotype

Open Targets

More...OpenTargetsi		ENSG00000112053

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		276234, Non-syndromic male infertility due to sperm motility disorder

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37885

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96RN1, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SLC26A8

Domain mapping of disease mutations (DMDM)

More...DMDMi		74761075

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003225861 – 970Testis anion transporter 1Add BLAST970

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi192N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96RN1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96RN1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96RN1

PeptideAtlas

More...PeptideAtlasi		Q96RN1

PRoteomics IDEntifications database

More...PRIDEi		Q96RN1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		77989 [Q96RN1-1]
77990 [Q96RN1-2]
77991 [Q96RN1-3]
77992 [Q96RN1-4]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q96RN1, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96RN1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96RN1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expression observed exclusively in testis, restricted to the meiotic phase of the germ cell. Abundant expression located in the seminiferous tubules, concentrated on the luminal side of the tubuli harboring the spermatocytes and spermatids. Expressed in spermatozoa.2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Repressed by tunicamycin, an inhibitor of N-glycosylation.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000112053, Expressed in testis and 111 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96RN1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96RN1, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000112053, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RACGAP1.

Interacts with CFTR.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		125501, 2 interactors

Protein interaction database and analysis system

More...IntActi		Q96RN1, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000417638

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96RN1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini543 – 795STASPROSITE-ProRule annotationAdd BLAST253

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni664 – 970Interaction with RACGAP11 PublicationAdd BLAST307
Regioni858 – 970DisorderedSequence analysisAdd BLAST113

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi858 – 872Acidic residuesSequence analysisAdd BLAST15
Compositional biasi873 – 916Basic and acidic residuesSequence analysisAdd BLAST44
Compositional biasi932 – 947Polar residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. [View classification]Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0236, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01030000234512

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_003182_9_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96RN1

Identification of Orthologs from Complete Genome Data

More...OMAi		TFQQEHR

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96RN1

TreeFam database of animal gene trees

More...TreeFami		TF313784

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011547, SLC26A/SulP_dom
IPR001902, SLC26A/SulP_fam
IPR030303, SLC26A8
IPR002645, STAS_dom
IPR036513, STAS_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR11814, PTHR11814, 1 hit
PTHR11814:SF11, PTHR11814:SF11, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01740, STAS, 1 hit
PF00916, Sulfate_transp, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52091, SSF52091, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50801, STAS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 13 Publications (identifier: Q96RN1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQLERSAIS GFSSKSRRNS FAYDVKREVY NEETFQQEHK RKASSSGNMN 
        60         70         80         90        100
INITTFRHHV QCRCSWHRFL RCVLTIFPFL EWMCMYRLKD WLLGDLLAGI 
       110        120        130        140        150
SVGLVQVPQG LTLSLLARQL IPPLNIAYAA FCSSVIYVIF GSCHQMSIGS 
       160        170        180        190        200
FFLVSALLIN VLKVSPFNNG QLVMGSFVKN EFSAPSYLMG YNKSLSVVAT 
       210        220        230        240        250
TTFLTGIIQL IMGVLGLGFI ATYLPESAMS AYLAAVALHI MLSQLTFIFG 
       260        270        280        290        300
IMISFHAGPI SFFYDIINYC VALPKANSTS ILVFLTVVVA LRINKCIRIS 
       310        320        330        340        350
FNQYPIEFPM ELFLIIGFTV IANKISMATE TSQTLIDMIP YSFLLPVTPD 
       360        370        380        390        400
FSLLPKIILQ AFSLSLVSSF LLIFLGKKIA SLHNYSVNSN QDLIAIGLCN 
       410        420        430        440        450
VVSSFFRSCV FTGAIARTII QDKSGGRQQF ASLVGAGVML LLMVKMGHFF 
       460        470        480        490        500
YTLPNAVLAG IILSNVIPYL ETISNLPSLW RQDQYDCALW MMTFSSSIFL 
       510        520        530        540        550
GLDIGLIISV VSAFFITTVR SHRAKILLLG QIPNTNIYRS INDYREIITI 
       560        570        580        590        600
PGVKIFQCCS SITFVNVYYL KHKLLKEVDM VKVPLKEEEI FSLFNSSDTN 
       610        620        630        640        650
LQGGKICRCF CNCDDLEPLP RILYTERFEN KLDPEASSIN LIHCSHFESM 
       660        670        680        690        700
NTSQTASEDQ VPYTVSSVSQ KNQGQQYEEV EEVWLPNNSS RNSSPGLPDV 
       710        720        730        740        750
AESQGRRSLI PYSDASLLPS VHTIILDFSM VHYVDSRGLV VLRQICNAFQ 
       760        770        780        790        800
NANILILIAG CHSSIVRAFE RNDFFDAGIT KTQLFLSVHD AVLFALSRKV 
       810        820        830        840        850
IGSSELSIDE SETVIRETYS ETDKNDNSRY KMSSSFLGSQ KNVSPGFIKI 
       860        870        880        890        900
QQPVEEESEL DLELESEQEA GLGLDLDLDR ELEPEMEPKA ETETKTQTEM 
       910        920        930        940        950
EPQPETEPEM EPNPKSRPRA HTFPQQRYWP MYHPSMASTQ SQTQTRTWSV 
       960        970
ERRRHPMDSY SPEGNSNEDV
Length:970
Mass (Da):109,006
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7F932A9CFE3A9EC4
GO
Isoform 21 Publication (identifier: Q96RN1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     210-314: Missing.

Show »
Length:865
Mass (Da):97,353
Checksum:i95925D014048905D
GO
Isoform 31 Publication (identifier: Q96RN1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-419: Missing.
     420-428: IQDKSGGRQ → VSLQLALSP

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Length:552
Mass (Da):62,455
Checksum:iFBB6C75D929BB281
GO
Isoform 41 Publication (identifier: Q96RN1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     745-768: ICNAFQNANILILIAGCHSSIVRA → VSTEEALAGALIPLLPSQPHPDPD
     769-970: Missing.

Show »
Length:768
Mass (Da):85,680
Checksum:i2A3BD6BC6188401F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C4T4H7C4T4_HUMAN
Testis anion transporter 1
SLC26A8
320Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JMV8C9JMV8_HUMAN
Testis anion transporter 1
SLC26A8
190Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C5E6H7C5E6_HUMAN
Testis anion transporter 1
SLC26A8
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAO26699 differs from that shown. Incorrectly indicated as originating from mouse.Curated
The sequence BAB71408 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti168N → D in AAL26868 (Ref. 3) Curated1
Sequence conflicti168N → D in AAO26699 (Ref. 3) Curated1
Sequence conflicti560S → C in AAL26868 (Ref. 3) Curated1
Sequence conflicti560S → C in AAO26699 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03946473V → M Not a cause of male infertility. 4 PublicationsCorresponds to variant dbSNP:rs743923Ensembl.1
Natural variantiVAR_07005887R → Q in SPGF3; there is a reduced interactions with CFTR and complete failure to activate CFTR-dependent anion transport. 1 PublicationCorresponds to variant dbSNP:rs140210148EnsemblClinVar.1
Natural variantiVAR_039465148I → V Not a cause of male infertility. 2 PublicationsCorresponds to variant dbSNP:rs17713154Ensembl.1
Natural variantiVAR_039466230S → N Not a cause of male infertility. 2 PublicationsCorresponds to variant dbSNP:rs17707331Ensembl.1
Natural variantiVAR_039467639I → V Not a cause of male infertility. 4 PublicationsCorresponds to variant dbSNP:rs2295852Ensembl.1
Natural variantiVAR_070059812E → K in SPGF3; there is a reduced interactions with CFTR and complete failure to activate CFTR-dependent anion transport. 1 PublicationCorresponds to variant dbSNP:rs142724470EnsemblClinVar.1
Natural variantiVAR_070060954R → C in SPGF3; there is a reduced interactions with CFTR and complete failure to activate CFTR-dependent anion transport. 1 PublicationCorresponds to variant dbSNP:rs398123027EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0527042 – 419Missing in isoform 3. 1 PublicationAdd BLAST418
Alternative sequenceiVSP_052705210 – 314Missing in isoform 2. 1 PublicationAdd BLAST105
Alternative sequenceiVSP_052706420 – 428IQDKSGGRQ → VSLQLALSP in isoform 3. 1 Publication9
Alternative sequenceiVSP_052707745 – 768ICNAF…SIVRA → VSTEEALAGALIPLLPSQPH PDPD in isoform 4. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_052708769 – 970Missing in isoform 4. 1 PublicationAdd BLAST202

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF331522 mRNA Translation: AAK95666.1
AF314959 mRNA Translation: AAL26868.1
AF403499 mRNA Translation: AAO26699.1 Sequence problems.
AL133507 Genomic DNA No translation available.
Z95152 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03862.1
BC025408 mRNA Translation: AAH25408.1
AK057276 mRNA Translation: BAB71408.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4813.1 [Q96RN1-1]
CCDS4814.1 [Q96RN1-2]

NCBI Reference Sequences

More...RefSeqi		NP_001180405.1, NM_001193476.1 [Q96RN1-1]
NP_443193.1, NM_052961.3 [Q96RN1-1]
NP_619732.2, NM_138718.2 [Q96RN1-2]
XP_016865724.1, XM_017010235.1 [Q96RN1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000355574; ENSP00000347778; ENSG00000112053 [Q96RN1-1]
ENST00000394602; ENSP00000378100; ENSG00000112053 [Q96RN1-2]
ENST00000490799; ENSP00000417638; ENSG00000112053 [Q96RN1-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		116369

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:116369

UCSC genome browser

More...UCSCi		uc003oll.4, human [Q96RN1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF331522 mRNA Translation: AAK95666.1
AF314959 mRNA Translation: AAL26868.1
AF403499 mRNA Translation: AAO26699.1 Sequence problems.
AL133507 Genomic DNA No translation available.
Z95152 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03862.1
BC025408 mRNA Translation: AAH25408.1
AK057276 mRNA Translation: BAB71408.1 Different initiation.
CCDSiCCDS4813.1 [Q96RN1-1]
CCDS4814.1 [Q96RN1-2]
RefSeqiNP_001180405.1, NM_001193476.1 [Q96RN1-1]
NP_443193.1, NM_052961.3 [Q96RN1-1]
NP_619732.2, NM_138718.2 [Q96RN1-2]
XP_016865724.1, XM_017010235.1 [Q96RN1-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi125501, 2 interactors
IntActiQ96RN1, 2 interactors
STRINGi9606.ENSP00000417638

Protein family/group databases

TCDBi2.A.53.2.14, the sulfate permease (sulp) family

PTM databases

GlyGeniQ96RN1, 1 site
iPTMnetiQ96RN1
PhosphoSitePlusiQ96RN1

Genetic variation databases

BioMutaiSLC26A8
DMDMi74761075

Proteomic databases

EPDiQ96RN1
MassIVEiQ96RN1
PaxDbiQ96RN1
PeptideAtlasiQ96RN1
PRIDEiQ96RN1
ProteomicsDBi77989 [Q96RN1-1]
77990 [Q96RN1-2]
77991 [Q96RN1-3]
77992 [Q96RN1-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		29584, 102 antibodies

The DNASU plasmid repository

More...DNASUi		116369

Genome annotation databases

EnsembliENST00000355574; ENSP00000347778; ENSG00000112053 [Q96RN1-1]
ENST00000394602; ENSP00000378100; ENSG00000112053 [Q96RN1-2]
ENST00000490799; ENSP00000417638; ENSG00000112053 [Q96RN1-1]
GeneIDi116369
KEGGihsa:116369
UCSCiuc003oll.4, human [Q96RN1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		116369
DisGeNETi116369

GeneCards: human genes, protein and diseases

More...GeneCardsi		SLC26A8
HGNCiHGNC:14468, SLC26A8
HPAiENSG00000112053, Tissue enriched (testis)
MalaCardsiSLC26A8
MIMi606766, phenotype
608480, gene
neXtProtiNX_Q96RN1
OpenTargetsiENSG00000112053
Orphaneti276234, Non-syndromic male infertility due to sperm motility disorder
PharmGKBiPA37885
VEuPathDBiHostDB:ENSG00000112053

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0236, Eukaryota
GeneTreeiENSGT01030000234512
HOGENOMiCLU_003182_9_3_1
InParanoidiQ96RN1
OMAiTFQQEHR
PhylomeDBiQ96RN1
TreeFamiTF313784

Enzyme and pathway databases

PathwayCommonsiQ96RN1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		116369, 12 hits in 1003 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SLC26A8, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SLC26A8

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		116369
PharosiQ96RN1, Tbio

Protein Ontology

More...PROi		PR:Q96RN1
RNActiQ96RN1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000112053, Expressed in testis and 111 other tissues
ExpressionAtlasiQ96RN1, baseline and differential
GenevisibleiQ96RN1, HS

Family and domain databases

InterProiView protein in InterPro
IPR011547, SLC26A/SulP_dom
IPR001902, SLC26A/SulP_fam
IPR030303, SLC26A8
IPR002645, STAS_dom
IPR036513, STAS_dom_sf
PANTHERiPTHR11814, PTHR11814, 1 hit
PTHR11814:SF11, PTHR11814:SF11, 1 hit
PfamiView protein in Pfam
PF01740, STAS, 1 hit
PF00916, Sulfate_transp, 1 hit
SUPFAMiSSF52091, SSF52091, 1 hit
PROSITEiView protein in PROSITE
PS50801, STAS, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS26A8_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96RN1
Secondary accession number(s): Q5JVR5
, Q812C7, Q8TC65, Q96MA0, Q96PK8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: December 1, 2001
Last modified: September 29, 2021
This is version 158 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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