Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sialic acid-binding Ig-like lectin 11

Gene

SIGLEC11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.

Caution

It is uncertain whether Met-1 or Met-13 is the initiator.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei132Sialic acidBy similarity1

GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB-KW
  • phosphatase binding Source: UniProtKB
  • sialic acid binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processCell adhesion
LigandLectin

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Names & Taxonomyi

Protein namesi
Recommended name:
Sialic acid-binding Ig-like lectin 11
Short name:
Sialic acid-binding lectin 11
Short name:
Siglec-11
Gene namesi
ORF Names:UNQ9222/PRO28718
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000161640.15
HGNCiHGNC:15622 SIGLEC11
MIMi607157 gene
neXtProtiNX_Q96RL6

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini28 – 561ExtracellularSequence analysisAdd BLAST534
Transmembranei562 – 584HelicalSequence analysisAdd BLAST23
Topological domaini585 – 698CytoplasmicSequence analysisAdd BLAST114

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000161640
PharmGKBiPA38005

Polymorphism and mutation databases

BioMutaiSIGLEC11
DMDMi294862467

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000001495128 – 698Sialic acid-binding Ig-like lectin 11Add BLAST671

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 186PROSITE-ProRule annotation
Disulfide bondi54 ↔ 114PROSITE-ProRule annotation
Glycosylationi55N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi90N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi177 ↔ 228PROSITE-ProRule annotation
Glycosylationi262N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi287 ↔ 334PROSITE-ProRule annotation
Glycosylationi366N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi375N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi391 ↔ 436PROSITE-ProRule annotation
Glycosylationi497N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi515N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei668PhosphotyrosineBy similarity1

Post-translational modificationi

Phosphorylated on tyrosine residues.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ96RL6
PaxDbiQ96RL6
PeptideAtlasiQ96RL6
PRIDEiQ96RL6
ProteomicsDBi77982
77983 [Q96RL6-2]

PTM databases

iPTMnetiQ96RL6
PhosphoSitePlusiQ96RL6

Expressioni

Tissue specificityi

Expressed by macrophages in various tissues including Kupffer cells. Also found in brain microglia.

Gene expression databases

BgeeiENSG00000161640 Expressed in 85 organ(s), highest expression level in right ovary
CleanExiHS_SIGLEC11
ExpressionAtlasiQ96RL6 baseline and differential
GenevisibleiQ96RL6 HS

Organism-specific databases

HPAiHPA060278

Interactioni

Subunit structurei

Interacts with PTPN6/SHP-1 and PTPN11/SHP-2 upon phosphorylation.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi125285, 3 interactors
IntActiQ96RL6, 8 interactors
STRINGi9606.ENSP00000412361

Structurei

3D structure databases

ProteinModelPortaliQ96RL6
SMRiQ96RL6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 134Ig-like V-typeAdd BLAST104
Domaini159 – 244Ig-like C2-type 1Add BLAST86
Domaini251 – 350Ig-like C2-type 2Add BLAST100
Domaini355 – 452Ig-like C2-type 3Add BLAST98

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi642 – 647ITIM motif6

Domaini

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJT6 Eukaryota
ENOG410YKZU LUCA
GeneTreeiENSGT00760000119139
HOGENOMiHOG000236324
HOVERGENiHBG036161
InParanoidiQ96RL6
KOiK06750
OMAiHECSAGS
OrthoDBiEOG091G0BMG
PhylomeDBiQ96RL6
TreeFamiTF332441

Family and domain databases

Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 4 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 5 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS00290 IG_MHC, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96RL6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVPGQAQPQS PEMLLLPLLL PVLGAGSLNK DPSYSLQVQR QVPVPEGLCV
60 70 80 90 100
IVSCNLSYPR DGWDESTAAY GYWFKGRTSP KTGAPVATNN QSREVEMSTR
110 120 130 140 150
DRFQLTGDPG KGSCSLVIRD AQREDEAWYF FRVERGSRVR HSFLSNAFFL
160 170 180 190 200
KVTALTKKPD VYIPETLEPG QPVTVICVFN WAFKKCPAPS FSWTGAALSP
210 220 230 240 250
RRTRPSTSHF SVLSFTPSPQ DHDTDLTCHV DFSRKGVSAQ RTVRLRVAYA
260 270 280 290 300
PKDLIISISH DNTSALELQG NVIYLEVQKG QFLRLLCAAD SQPPATLSWV
310 320 330 340 350
LQDRVLSSSH PWGPRTLGLE LRGVRAGDSG RYTCRAENRL GSQQQALDLS
360 370 380 390 400
VQYPPENLRV MVSQANRTVL ENLGNGTSLP VLEGQSLRLV CVTHSSPPAR
410 420 430 440 450
LSWTRWGQTV GPSQPSDPGV LELPPIQMEH EGEFTCHAQH PLGSQHVSLS
460 470 480 490 500
LSVHYPPQLL GPSCSWEAEG LHCSCSSQAS PAPSLRWWLG EELLEGNSSQ
510 520 530 540 550
GSFEVTPSSA GPWANSSLSL HGGLSSGLRL RCKAWNVHGA QSGSVFQLLP
560 570 580 590 600
GKLEHGGGLG LGAALGAGVA ALLAFCSCLV VFRVKICRKE ARKRAAAEQD
610 620 630 640 650
VPSTLGPISQ GHQHECSAGS SQDHPPPGAA TYTPGKGEEQ ELHYASLSFQ
660 670 680 690
GLRLWEPADQ EAPSTTEYSE IKIHTGQPLR GPGFGLQLER EMSGMVPK
Length:698
Mass (Da):75,795
Last modified:April 20, 2010 - v2
Checksum:i61CF0F530DCDD62F
GO
Isoform 2 (identifier: Q96RL6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     455-551: YPPQLLGPSC...SGSVFQLLPG → W

Show »
Length:602
Mass (Da):65,818
Checksum:i648623DDB469EA95
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C2S0H7C2S0_HUMAN
Sialic acid-binding Ig-like lectin ...
SIGLEC11
60Annotation score:

Sequence cautioni

The sequence AAK72907 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAQ88502 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti96E → A in AAQ88502 (PubMed:12975309).Curated1
Sequence conflicti365A → G in AAQ88502 (PubMed:12975309).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008764455 – 551YPPQL…QLLPG → W in isoform 2. CuratedAdd BLAST97

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF337818 mRNA Translation: AAK72907.1 Different initiation.
AC011452 Genomic DNA No translation available.
AY358135 mRNA Translation: AAQ88502.1 Different initiation.
CCDSiCCDS12790.2 [Q96RL6-1]
CCDS46150.1 [Q96RL6-2]
RefSeqiNP_001128635.1, NM_001135163.1 [Q96RL6-2]
NP_443116.2, NM_052884.2 [Q96RL6-1]
UniGeneiHs.661852

Genome annotation databases

EnsembliENST00000426971; ENSP00000398891; ENSG00000161640 [Q96RL6-2]
ENST00000447370; ENSP00000412361; ENSG00000161640 [Q96RL6-1]
GeneIDi114132
KEGGihsa:114132
UCSCiuc010ybh.3 human [Q96RL6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF337818 mRNA Translation: AAK72907.1 Different initiation.
AC011452 Genomic DNA No translation available.
AY358135 mRNA Translation: AAQ88502.1 Different initiation.
CCDSiCCDS12790.2 [Q96RL6-1]
CCDS46150.1 [Q96RL6-2]
RefSeqiNP_001128635.1, NM_001135163.1 [Q96RL6-2]
NP_443116.2, NM_052884.2 [Q96RL6-1]
UniGeneiHs.661852

3D structure databases

ProteinModelPortaliQ96RL6
SMRiQ96RL6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125285, 3 interactors
IntActiQ96RL6, 8 interactors
STRINGi9606.ENSP00000412361

PTM databases

iPTMnetiQ96RL6
PhosphoSitePlusiQ96RL6

Polymorphism and mutation databases

BioMutaiSIGLEC11
DMDMi294862467

Proteomic databases

EPDiQ96RL6
PaxDbiQ96RL6
PeptideAtlasiQ96RL6
PRIDEiQ96RL6
ProteomicsDBi77982
77983 [Q96RL6-2]

Protocols and materials databases

DNASUi114132
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000426971; ENSP00000398891; ENSG00000161640 [Q96RL6-2]
ENST00000447370; ENSP00000412361; ENSG00000161640 [Q96RL6-1]
GeneIDi114132
KEGGihsa:114132
UCSCiuc010ybh.3 human [Q96RL6-1]

Organism-specific databases

CTDi114132
EuPathDBiHostDB:ENSG00000161640.15
GeneCardsiSIGLEC11
HGNCiHGNC:15622 SIGLEC11
HPAiHPA060278
MIMi607157 gene
neXtProtiNX_Q96RL6
OpenTargetsiENSG00000161640
PharmGKBiPA38005
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJT6 Eukaryota
ENOG410YKZU LUCA
GeneTreeiENSGT00760000119139
HOGENOMiHOG000236324
HOVERGENiHBG036161
InParanoidiQ96RL6
KOiK06750
OMAiHECSAGS
OrthoDBiEOG091G0BMG
PhylomeDBiQ96RL6
TreeFamiTF332441

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Miscellaneous databases

GenomeRNAii114132
PROiPR:Q96RL6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000161640 Expressed in 85 organ(s), highest expression level in right ovary
CleanExiHS_SIGLEC11
ExpressionAtlasiQ96RL6 baseline and differential
GenevisibleiQ96RL6 HS

Family and domain databases

Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 4 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 5 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS00290 IG_MHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSIG11_HUMAN
AccessioniPrimary (citable) accession number: Q96RL6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: April 20, 2010
Last modified: September 12, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again