UniProtKB - Q96RK1 (CITE4_HUMAN)
Protein
Cbp/p300-interacting transactivator 4
Gene
CITED4
Organism
Homo sapiens (Human)
Status
Functioni
Acts as transcriptional coactivator for TFAP2/AP-2. Enhances estrogen-dependent transactivation mediated by estrogen receptors. May function as an inhibitor of transactivation by HIF1A by disrupting HIF1A interaction with CREBBP. May be involved in regulation of gene expression during development and differentiation of blood cells, endothelial cells and mammary epithelial cells.2 Publications
GO - Molecular functioni
- transcription coactivator activity Source: UniProtKB
GO - Biological processi
- positive regulation of transcription by RNA polymerase II Source: Reactome
- response to estrogen Source: UniProtKB
Keywordsi
Molecular function | Activator |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q96RK1 |
Reactomei | R-HSA-8866907, Activation of the TFAP2 (AP-2) family of transcription factors |
Names & Taxonomyi
Protein namesi | Recommended name: Cbp/p300-interacting transactivator 4Alternative name(s): MSG1-related protein 2 Short name: MRG-2 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18696, CITED4 |
MIMi | 606815, gene |
neXtProti | NX_Q96RK1 |
VEuPathDBi | HostDB:ENSG00000179862.6 |
Subcellular locationi
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: GO_Central
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 163732 |
OpenTargetsi | ENSG00000179862 |
PharmGKBi | PA38643 |
Miscellaneous databases
Pharosi | Q96RK1, Tbio |
Genetic variation databases
BioMutai | CITED4 |
DMDMi | 74732696 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000233309 | 1 – 184 | Cbp/p300-interacting transactivator 4Add BLAST | 184 |
Proteomic databases
EPDi | Q96RK1 |
MassIVEi | Q96RK1 |
MaxQBi | Q96RK1 |
PaxDbi | Q96RK1 |
PeptideAtlasi | Q96RK1 |
PRIDEi | Q96RK1 |
ProteomicsDBi | 77974 |
TopDownProteomicsi | Q96RK1 |
Expressioni
Tissue specificityi
Expressed in most tissues examined with highest levels of expression in heart, liver, skeletal muscle and pancreas. Also expressed in bladder cell line ECV-304 and in various breast cancer cell lines. Also detected in both in situ and invasive breast tumors where its expression is down-regulated and mostly restricted to the cytoplasm of malignant epithelium. Down-regulation of expression is associated with elevated levels of HIF1A and increased tumor growth and angiogenesis.2 Publications
Gene expression databases
Bgeei | ENSG00000179862, Expressed in muscle tissue and 164 other tissues |
Genevisiblei | Q96RK1, HS |
Organism-specific databases
HPAi | ENSG00000179862, Low tissue specificity |
Interactioni
Subunit structurei
Interacts via its C-terminal region with the CH1 domain of CREBBP and EP300.
Interacts with all TFAP2/AP-2 isoforms.
1 PublicationProtein-protein interaction databases
BioGRIDi | 127875, 5 interactors |
STRINGi | 9606.ENSP00000361721 |
Miscellaneous databases
RNActi | Q96RK1, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 17 – 125 | Pro-richSequence analysisAdd BLAST | 109 |
Sequence similaritiesi
Belongs to the CITED family.Sequence analysis
Phylogenomic databases
eggNOGi | ENOG502QQEE, Eukaryota |
GeneTreei | ENSGT00530000063624 |
HOGENOMi | CLU_128809_0_0_1 |
InParanoidi | Q96RK1 |
OMAi | FGPPFSF |
OrthoDBi | 1378769at2759 |
PhylomeDBi | Q96RK1 |
TreeFami | TF331915 |
Family and domain databases
InterProi | View protein in InterPro IPR007576, CITED |
PANTHERi | PTHR17045, PTHR17045, 1 hit |
Pfami | View protein in Pfam PF04487, CITED, 1 hit |
i Sequence
Sequence statusi: Complete.
Q96RK1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MADHLMLAEG YRLVQRPPSA AAAHGPHALR TLPPYAGPGL DSGLRPRGAP
60 70 80 90 100
LGPPPPRQPG ALAYGAFGPP SSFQPFPAVP PPAAGIAHLQ PVATPYPGRA
110 120 130 140 150
AAPPNAPGGP PGPQPAPSAA APPPPAHALG GMDAELIDEE ALTSLELELG
160 170 180
LHRVRELPEL FLGQSEFDCF SDLGSAPPAG SVSC
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF362074 Genomic DNA Translation: AAK64235.1 AF466291 Genomic DNA Translation: AAL73989.1 BC052559 mRNA Translation: AAH52559.1 BC035496 mRNA Translation: AAH35496.1 |
CCDSi | CCDS458.1 |
RefSeqi | NP_597724.1, NM_133467.2 |
Genome annotation databases
Ensembli | ENST00000372638; ENSP00000361721; ENSG00000179862 |
GeneIDi | 163732 |
KEGGi | hsa:163732 |
UCSCi | uc001cgj.4, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF362074 Genomic DNA Translation: AAK64235.1 AF466291 Genomic DNA Translation: AAL73989.1 BC052559 mRNA Translation: AAH52559.1 BC035496 mRNA Translation: AAH35496.1 |
CCDSi | CCDS458.1 |
RefSeqi | NP_597724.1, NM_133467.2 |
3D structure databases
SMRi | Q96RK1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 127875, 5 interactors |
STRINGi | 9606.ENSP00000361721 |
Genetic variation databases
BioMutai | CITED4 |
DMDMi | 74732696 |
Proteomic databases
EPDi | Q96RK1 |
MassIVEi | Q96RK1 |
MaxQBi | Q96RK1 |
PaxDbi | Q96RK1 |
PeptideAtlasi | Q96RK1 |
PRIDEi | Q96RK1 |
ProteomicsDBi | 77974 |
TopDownProteomicsi | Q96RK1 |
Protocols and materials databases
Antibodypediai | 32148, 142 antibodies |
Genome annotation databases
Ensembli | ENST00000372638; ENSP00000361721; ENSG00000179862 |
GeneIDi | 163732 |
KEGGi | hsa:163732 |
UCSCi | uc001cgj.4, human |
Organism-specific databases
CTDi | 163732 |
DisGeNETi | 163732 |
GeneCardsi | CITED4 |
HGNCi | HGNC:18696, CITED4 |
HPAi | ENSG00000179862, Low tissue specificity |
MIMi | 606815, gene |
neXtProti | NX_Q96RK1 |
OpenTargetsi | ENSG00000179862 |
PharmGKBi | PA38643 |
VEuPathDBi | HostDB:ENSG00000179862.6 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQEE, Eukaryota |
GeneTreei | ENSGT00530000063624 |
HOGENOMi | CLU_128809_0_0_1 |
InParanoidi | Q96RK1 |
OMAi | FGPPFSF |
OrthoDBi | 1378769at2759 |
PhylomeDBi | Q96RK1 |
TreeFami | TF331915 |
Enzyme and pathway databases
PathwayCommonsi | Q96RK1 |
Reactomei | R-HSA-8866907, Activation of the TFAP2 (AP-2) family of transcription factors |
Miscellaneous databases
BioGRID-ORCSi | 163732, 11 hits in 987 CRISPR screens |
ChiTaRSi | CITED4, human |
GenomeRNAii | 163732 |
Pharosi | Q96RK1, Tbio |
PROi | PR:Q96RK1 |
RNActi | Q96RK1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000179862, Expressed in muscle tissue and 164 other tissues |
Genevisiblei | Q96RK1, HS |
Family and domain databases
InterProi | View protein in InterPro IPR007576, CITED |
PANTHERi | PTHR17045, PTHR17045, 1 hit |
Pfami | View protein in Pfam PF04487, CITED, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CITE4_HUMAN | |
Accessioni | Q96RK1Primary (citable) accession number: Q96RK1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 2, 2006 |
Last sequence update: | December 1, 2001 | |
Last modified: | April 7, 2021 | |
This is version 131 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families