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Entry version 81 (31 Jul 2019)
Sequence version 1 (01 Dec 2001)
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Protein
Submitted name:

Insulin receptor substrate 2 insertion mutant

Gene

IRS2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptorImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Insulin receptor substrate 2 insertion mutantImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IRS2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96RG5

PeptideAtlas

More...
PeptideAtlasi
Q96RG5

PRoteomics IDEntifications database

More...
PRIDEi
Q96RG5

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini32 – 146PHInterPro annotationAdd BLAST115
Domaini196 – 300IRS-type PTBInterPro annotationAdd BLAST105

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 33DisorderedSequence analysisAdd BLAST33
Regioni52 – 74DisorderedSequence analysisAdd BLAST23
Regioni305 – 413DisorderedSequence analysisAdd BLAST109
Regioni430 – 539DisorderedSequence analysisAdd BLAST110
Regioni705 – 741DisorderedSequence analysisAdd BLAST37
Regioni842 – 1103DisorderedSequence analysisAdd BLAST262
Regioni1123 – 1292DisorderedSequence analysisAdd BLAST170

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi16 – 33PolarSequence analysisAdd BLAST18
Compositional biasi444 – 459PolarSequence analysisAdd BLAST16
Compositional biasi460 – 477Pro-richSequence analysisAdd BLAST18
Compositional biasi482 – 496PolarSequence analysisAdd BLAST15
Compositional biasi941 – 985PolarSequence analysisAdd BLAST45
Compositional biasi1013 – 1044Pro-richSequence analysisAdd BLAST32
Compositional biasi1056 – 1072PolarSequence analysisAdd BLAST17
Compositional biasi1134 – 1148PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1149 – 1185PolarSequence analysisAdd BLAST37
Compositional biasi1206 – 1221Pro-richSequence analysisAdd BLAST16
Compositional biasi1265 – 1281Pro-richSequence analysisAdd BLAST17

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IXEK Eukaryota
ENOG410Z9EP LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113103

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01204 PTB_IRS, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039011 IRS
IPR002404 IRS_PTB
IPR011993 PH-like_dom_sf
IPR001849 PH_domain

The PANTHER Classification System

More...
PANTHERi
PTHR10614 PTHR10614, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02174 IRS, 1 hit
PF00169 PH, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00628 INSULINRSI

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233 PH, 1 hit
SM00310 PTBI, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51064 IRS_PTB, 1 hit
PS50003 PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q96RG5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASPPRHGPP GPASGDGPNL NNNNNNNNNN HSVRKCGYLR KQKHGHKRFF
60 70 80 90 100
VLRGPGAGGD EATAGGGSAP QPPRLEYYES EKKWRSKAGA PKRVIALDCC
110 120 130 140 150
LNINKRADAK HKYLIALYTK DEYFAVAAEN EQEQEGWYRA LTDLVSEGRA
160 170 180 190 200
AAGDAPPAAA PAASCSASLP GALGGSAGAA GAEDSYGLVA PATAAYREVW
210 220 230 240 250
QVNLKPKGLG QSKNLTGVYR LCLSARTIGF VKLNCEQPSV TLQLMNIRRC
260 270 280 290 300
GHSDSFFFIE VGRSAVTGPG ELWMQADDSV VAQNIHETIL EAMKALKELF
310 320 330 340 350
EFRPRSKSQS SGSSATHPIS VPGARRHHHL VNLPPSQTGL VRRSRTDSLA
360 370 380 390 400
ATPPAAKCSS CRVRTASEGD GGAAAGAAAA GARPVSVAGS PLSPGPVRAP
410 420 430 440 450
LSRSHTLSGG CGGRGSKVAL LPAGGALQHS RSMSMPVAHS PPAATSPGSL
460 470 480 490 500
SSSSGHGSGS YPPPPGPHPP LPHPLHHGPG QRPSSGSASA SGSPSDPGFM
510 520 530 540 550
SLDEYGSSPG DLRAFCSHRS NTPESIAETP PARDGGGGGE FYGYMTMDRP
560 570 580 590 600
LSHCGRSYRR VSGDAAQDLD RGLRKRTYSL TTPARQRPVP QPSSASLDEY
610 620 630 640 650
TLMRATFSGS AGRLCPSCPA SSPKVAYHPY PEDYGDIEIG SHRSSSSNLG
660 670 680 690 700
ADDGYMPMTP GAALAGSGSG SCRSDDYMPM SPASVSAPKQ ILQPRAAAAA
710 720 730 740 750
AAAVPSAGPA GPAPTSAAGR TFPASGGGYK ASSPAESSPE DSGYMRMWCG
760 770 780 790 800
SKLSMEHADG KLLPNGDYLN VSPSDAVTTG TPPDFFSAAL HPGGEPLRGV
810 820 830 840 850
PGCCYSSLPR SYKAPYTCGG DSDQYVLMSS PVGRILEEER LEPQATPGPS
860 870 880 890 900
QAASAFGAGP TQPPHPVVPS PVRPSGGRPE GFLGQRGRAV RPTRLSLEGL
910 920 930 940 950
PSLPSMHEYP LPPEPKSPGE YINIDFGEPG ARLSPPAPPL LASAASSSSL
960 970 980 990 1000
LSASSPASSL GSGTPGTSSD SRQRSPLSDY MNLDFSSPKS PKPGAPSGHP
1010 1020 1030 1040 1050
VGSLDGLLSP EASSPYPPLP PRPSASPSSS LQPPPPPPAP GELYRLPPAS
1060 1070 1080 1090 1100
AVATAQGPGA ASSLSSDTGD NGDYTEMAFG VAATPPQPIA APPKPEAARV
1110 1120 1130 1140 1150
ASPTSGVKRL SLMEQVSGVE AFLQASQPPD PHRGAKVIRA DPQGGRRRHS
1160 1170 1180 1190 1200
SETFSSTTTV TPVSPSFAHN PKRHNSASVE NVSLRKSSEG GVGVGPGGGD
1210 1220 1230 1240 1250
EPPTSPRQLQ PAPPLAPQGR PWTPGQPGGL VGCPGSGGSP MRRETSAGFQ
1260 1270 1280 1290 1300
NGLNYIAIDV REEPGLPPQP QPPPPPLPQP GDKSSWGRTR SLGGLISAVG
1310 1320 1330
VGSTGGGCGG PGPGALPPAN TYASIDFLSH HLKEATIVK
Length:1,339
Mass (Da):137,433
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBC3C060E0F5ABE1A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1339Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF385932 Genomic DNA Translation: AAK66750.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF385932 Genomic DNA Translation: AAK66750.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

MaxQBiQ96RG5
PeptideAtlasiQ96RG5
PRIDEiQ96RG5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IXEK Eukaryota
ENOG410Z9EP LUCA
HOGENOMiHOG000113103

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
IRS2 human

Family and domain databases

CDDicd01204 PTB_IRS, 1 hit
Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR039011 IRS
IPR002404 IRS_PTB
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR10614 PTHR10614, 1 hit
PfamiView protein in Pfam
PF02174 IRS, 1 hit
PF00169 PH, 1 hit
PRINTSiPR00628 INSULINRSI
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00310 PTBI, 1 hit
PROSITEiView protein in PROSITE
PS51064 IRS_PTB, 1 hit
PS50003 PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ96RG5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96RG5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: July 31, 2019
This is version 81 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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