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Protein

PAS domain-containing serine/threonine-protein kinase

Gene

PASK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate to respiratory regulation.6 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Protein kinase activity is inhibited by the first PAS domain: binding of an unidentified ligand desinhibits the protein kinase activity. May be activated by autophosphorylation on Thr-1161 and Thr-1165 (PubMed:11459942). The activating role of autophosphorylation at Thr-1161 is unclear: according to a report, autophosphorylation at Thr-1161 does not play a major role in activation (PubMed:20943661). Autophosphorylation is enhanced upon phosphatidylinositol monophosphate (phosphatidylinositol 4-phosphate) binding and inhibited upon phosphatidylinositol bi- and tri-phosphate binding. In contrast, phosphorylation of target proteins is inhibited upon all phosphatidylinositol-binding (phosphatidylinositol mono- bi- and tri-phosphate).3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1028ATP1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1128Proton acceptor1
Binding sitei1146ATP1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1005 – 1013ATP9
Nucleotide bindingi1082 – 1089ATP8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Lipid-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q96RG2

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q96RG2

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...
MoonDBi
Q96RG2 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PAS domain-containing serine/threonine-protein kinase (EC:2.7.11.1)
Short name:
PAS-kinase
Short name:
PASKIN
Short name:
hPASK
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PASK
Synonyms:KIAA0135
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000115687.13

Human Gene Nomenclature Database

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HGNCi
HGNC:17270 PASK

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607505 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96RG2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1028K → R: Loss of autophosphorylating activity. 2 Publications1
Mutagenesisi1058R → A: Induces lower protein kinase activity. 1 Publication1
Mutagenesisi1058R → K: Does not affect protein kinase activity. 1 Publication1
Mutagenesisi1151A → K: Induces lower protein kinase activity and ability to autophosphorylate. 1 Publication1
Mutagenesisi1152Y → F: Induces lower protein kinase activity. 1 Publication1
Mutagenesisi1161T → A: Loss of catalytic activity (PubMed:11459942). According to another report, does not affect the protein kinase activity (PubMed:20943661). Does not affect protein translation. 3 Publications1
Mutagenesisi1165T → A: Loss of catalytic activity. Does not affect protein translation. 2 Publications1

Organism-specific databases

DisGeNET

More...
DisGeNETi
23178

Open Targets

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OpenTargetsi
ENSG00000115687

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA32953

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL6054

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PASK

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116242701

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000864801 – 1323PAS domain-containing serine/threonine-protein kinaseAdd BLAST1323

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei19PhosphoserineBy similarity1
Modified residuei34PhosphothreonineBy similarity1
Modified residuei582PhosphoserineCombined sources1
Modified residuei939PhosphoserineCombined sources1
Modified residuei1161Phosphothreonine; by autocatalysis1 Publication1
Modified residuei1165Phosphothreonine; by autocatalysis1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylated on Thr-1161 and Thr-1165. Autophosphorylation is activated by phospholipids.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q96RG2

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96RG2

MaxQB - The MaxQuant DataBase

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MaxQBi
Q96RG2

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96RG2

PeptideAtlas

More...
PeptideAtlasi
Q96RG2

PRoteomics IDEntifications database

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PRIDEi
Q96RG2

ProteomicsDB human proteome resource

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ProteomicsDBi
77959
77960 [Q96RG2-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q96RG2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q96RG2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed, with slightly higher expression in brain, prostate and testis. Reduced expression was found in placenta. Present in germ cells of testis and in the midpiece of sperm tails (at protein level).

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000115687 Expressed in 149 organ(s), highest expression level in small intestine Peyer's patch

CleanEx database of gene expression profiles

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CleanExi
HS_PASK

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96RG2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96RG2 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA016450
HPA021079

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116790, 71 interactors

Protein interaction database and analysis system

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IntActi
Q96RG2, 59 interactors

Molecular INTeraction database

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MINTi
Q96RG2

STRING: functional protein association networks

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STRINGi
9606.ENSP00000234040

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q96RG2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11323
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LL8NMR-A131-237[»]
3DLSX-ray2.30A/B/C/D/E/F977-1300[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q96RG2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96RG2

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q96RG2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini119 – 190PAS 1PROSITE-ProRule annotationAdd BLAST72
Domaini335 – 402PAS 2PROSITE-ProRule annotationAdd BLAST68
Domaini999 – 1251Protein kinasePROSITE-ProRule annotationAdd BLAST253

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The protein kinase domain mediates binding to phosphatidylinositol.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1152 Eukaryota
COG0515 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000159035

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000115456

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG047936

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96RG2

KEGG Orthology (KO)

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KOi
K08801

Identification of Orthologs from Complete Genome Data

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OMAi
WSSYCLS

Database of Orthologous Groups

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OrthoDBi
297397at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q96RG2

TreeFam database of animal gene trees

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TreeFami
TF323242

Family and domain databases

Conserved Domains Database

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CDDi
cd00130 PAS, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS

Pfam protein domain database

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Pfami
View protein in Pfam
PF13426 PAS_9, 2 hits
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00091 PAS, 2 hits
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF55785 SSF55785, 1 hit
SSF56112 SSF56112, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR00229 sensory_box, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50112 PAS, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96RG2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEDGGLTAFE EDQRCLSQSL PLPVSAEGPA AQTTAEPSRS FSSAHRHLSR
60 70 80 90 100
RNGLSRLCQS RTALSEDRWS SYCLSSLAAQ NICTSKLHCP AAPEHTDPSE
110 120 130 140 150
PRGSVSCCSL LRGLSSGWSS PLLPAPVCNP NKAIFTVDAK TTEILVANDK
160 170 180 190 200
ACGLLGYSSQ DLIGQKLTQF FLRSDSDVVE ALSEEHMEAD GHAAVVFGTV
210 220 230 240 250
VDIISRSGEK IPVSVWMKRM RQERRLCCVV VLEPVERVST WVAFQSDGTV
260 270 280 290 300
TSCDSLFAHL HGYVSGEDVA GQHITDLIPS VQLPPSGQHI PKNLKIQRSV
310 320 330 340 350
GRARDGTTFP LSLKLKSQPS SEEATTGEAA PVSGYRASVW VFCTISGLIT
360 370 380 390 400
LLPDGTIHGI NHSFALTLFG YGKTELLGKN ITFLIPGFYS YMDLAYNSSL
410 420 430 440 450
QLPDLASCLD VGNESGCGER TLDPWQGQDP AEGGQDPRIN VVLAGGHVVP
460 470 480 490 500
RDEIRKLMES QDIFTGTQTE LIAGGQLLSC LSPQPAPGVD NVPEGSLPVH
510 520 530 540 550
GEQALPKDQQ ITALGREEPV AIESPGQDLL GESRSEPVDV KPFASCEDSE
560 570 580 590 600
APVPAEDGGS DAGMCGLCQK AQLERMGVSG PSGSDLWAGA AVAKPQAKGQ
610 620 630 640 650
LAGGSLLMHC PCYGSEWGLW WRSQDLAPSP SGMAGLSFGT PTLDEPWLGV
660 670 680 690 700
ENDREELQTC LIKEQLSQLS LAGALDVPHA ELVPTECQAV TAPVSSCDLG
710 720 730 740 750
GRDLCGGCTG SSSACYALAT DLPGGLEAVE AQEVDVNSFS WNLKELFFSD
760 770 780 790 800
QTDQTSSNCS CATSELRETP SSLAVGSDPD VGSLQEQGSC VLDDRELLLL
810 820 830 840 850
TGTCVDLGQG RRFRESCVGH DPTEPLEVCL VSSEHYAASD RESPGHVPST
860 870 880 890 900
LDAGPEDTCP SAEEPRLNVQ VTSTPVIVMR GAAGLQREIQ EGAYSGSCYH
910 920 930 940 950
RDGLRLSIQF EVRRVELQGP TPLFCCWLVK DLLHSQRDSA ARTRLFLASL
960 970 980 990 1000
PGSTHSTAAE LTGPSLVEVL RARPWFEEPP KAVELEGLAA CEGEYSQKYS
1010 1020 1030 1040 1050
TMSPLGSGAF GFVWTAVDKE KNKEVVVKFI KKEKVLEDCW IEDPKLGKVT
1060 1070 1080 1090 1100
LEIAILSRVE HANIIKVLDI FENQGFFQLV MEKHGSGLDL FAFIDRHPRL
1110 1120 1130 1140 1150
DEPLASYIFR QLVSAVGYLR LKDIIHRDIK DENIVIAEDF TIKLIDFGSA
1160 1170 1180 1190 1200
AYLERGKLFY TFCGTIEYCA PEVLMGNPYR GPELEMWSLG VTLYTLVFEE
1210 1220 1230 1240 1250
NPFCELEETV EAAIHPPYLV SKELMSLVSG LLQPVPERRT TLEKLVTDPW
1260 1270 1280 1290 1300
VTQPVNLADY TWEEVFRVNK PESGVLSAAS LEMGNRSLSD VAQAQELCGG
1310 1320
PVPGEAPNGQ GCLHPGDPRL LTS
Length:1,323
Mass (Da):142,929
Last modified:October 17, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF8A3633CC6F6C8CD
GO
Isoform 2 (identifier: Q96RG2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1111-1111: Q → QVRAGQSR

Note: No experimental confirmation available.
Show »
Length:1,330
Mass (Da):143,684
Checksum:i8177593F181C6914
GO
Isoform 3 (identifier: Q96RG2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1112-1143: LVSAVGYLRLKDIIHRDIKDENIVIAEDFTIK → VRAGQSRVSVNAGLGAWVRWLQRSVIHTRFSL
     1144-1323: Missing.

Note: No experimental confirmation available.
Show »
Length:1,143
Mass (Da):123,048
Checksum:i535BFCA305C18419
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J1Z3C9J1Z3_HUMAN
PAS domain-containing serine/threon...
PASK
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J4R3C9J4R3_HUMAN
PAS domain-containing serine/threon...
PASK
125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0L7H7C0L7_HUMAN
PAS domain-containing serine/threon...
PASK
193Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WEB4F8WEB4_HUMAN
PAS domain-containing serine/threon...
PASK
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA09484 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti205S → T in BAA09484 (PubMed:8590280).Curated1
Sequence conflicti407S → C in CAH18087 (PubMed:17974005).Curated1
Sequence conflicti623S → R in BAA09484 (PubMed:8590280).Curated1
Sequence conflicti741W → R in CAH18087 (PubMed:17974005).Curated1
Sequence conflicti850T → M in BAA09484 (PubMed:8590280).Curated1
Sequence conflicti899Y → H in AAK69752 (PubMed:11459942).Curated1
Sequence conflicti1048K → E in CAH18087 (PubMed:17974005).Curated1
Sequence conflicti1062A → S in AAH50565 (PubMed:15489334).Curated1
Sequence conflicti1129I → F in AAB50198 (PubMed:9110174).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04098611E → K in a metastatic melanoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1277219458Ensembl.1
Natural variantiVAR_028293250V → I2 PublicationsCorresponds to variant dbSNP:rs1470414Ensembl.1
Natural variantiVAR_040987426Q → R1 PublicationCorresponds to variant dbSNP:rs35187712Ensembl.1
Natural variantiVAR_040988512T → A1 PublicationCorresponds to variant dbSNP:rs56033464Ensembl.1
Natural variantiVAR_028294514L → S1 PublicationCorresponds to variant dbSNP:rs2240543Ensembl.1
Natural variantiVAR_040989684P → R1 PublicationCorresponds to variant dbSNP:rs56372985Ensembl.1
Natural variantiVAR_028295694V → M1 PublicationCorresponds to variant dbSNP:rs6727226Ensembl.1
Natural variantiVAR_028296725G → D1 PublicationCorresponds to variant dbSNP:rs2005771Ensembl.1
Natural variantiVAR_040990796E → K1 PublicationCorresponds to variant dbSNP:rs35129131Ensembl.1
Natural variantiVAR_040991844P → Q1 PublicationCorresponds to variant dbSNP:rs36082918Ensembl.1
Natural variantiVAR_040992937R → H1 PublicationCorresponds to variant dbSNP:rs56139954Ensembl.1
Natural variantiVAR_0282971210V → M1 PublicationCorresponds to variant dbSNP:rs10167000Ensembl.1
Natural variantiVAR_0282981266F → C3 PublicationsCorresponds to variant dbSNP:rs1131293Ensembl.1
Natural variantiVAR_0409931301P → S1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0093021111Q → QVRAGQSR in isoform 2. 1 Publication1
Alternative sequenceiVSP_0455431112 – 1143LVSAV…DFTIK → VRAGQSRVSVNAGLGAWVRW LQRSVIHTRFSL in isoform 3. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_0455441144 – 1323Missing in isoform 3. 1 PublicationAdd BLAST180

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF387103 mRNA Translation: AAK69752.1
D50925 mRNA Translation: BAA09484.2 Different initiation.
CR749231 mRNA Translation: CAH18087.1
AC005237 Genomic DNA No translation available.
CH471063 Genomic DNA Translation: EAW71238.1
BC043495 mRNA Translation: AAH43495.1
BC050565 mRNA Translation: AAH50565.1
BC063585 mRNA Translation: AAH63585.1
U79240 mRNA Translation: AAB50198.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2545.1 [Q96RG2-1]
CCDS58758.1 [Q96RG2-4]
CCDS58759.1 [Q96RG2-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
T17211

NCBI Reference Sequences

More...
RefSeqi
NP_001239048.1, NM_001252119.1 [Q96RG2-2]
NP_001239049.1, NM_001252120.1 [Q96RG2-1]
NP_001239051.1, NM_001252122.1
NP_001239053.1, NM_001252124.1 [Q96RG2-4]
NP_055963.2, NM_015148.3 [Q96RG2-1]
XP_011509130.1, XM_011510828.1 [Q96RG2-2]
XP_011509131.1, XM_011510829.1 [Q96RG2-2]
XP_011509132.1, XM_011510830.1 [Q96RG2-2]
XP_016859124.1, XM_017003635.1 [Q96RG2-1]
XP_016859125.1, XM_017003636.1 [Q96RG2-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.397891

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000234040; ENSP00000234040; ENSG00000115687 [Q96RG2-1]
ENST00000358649; ENSP00000351475; ENSG00000115687 [Q96RG2-2]
ENST00000403638; ENSP00000384438; ENSG00000115687 [Q96RG2-4]
ENST00000405260; ENSP00000384016; ENSG00000115687 [Q96RG2-1]
ENST00000544142; ENSP00000441374; ENSG00000115687 [Q96RG2-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23178

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23178

UCSC genome browser

More...
UCSCi
uc002wao.2 human [Q96RG2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF387103 mRNA Translation: AAK69752.1
D50925 mRNA Translation: BAA09484.2 Different initiation.
CR749231 mRNA Translation: CAH18087.1
AC005237 Genomic DNA No translation available.
CH471063 Genomic DNA Translation: EAW71238.1
BC043495 mRNA Translation: AAH43495.1
BC050565 mRNA Translation: AAH50565.1
BC063585 mRNA Translation: AAH63585.1
U79240 mRNA Translation: AAB50198.1
CCDSiCCDS2545.1 [Q96RG2-1]
CCDS58758.1 [Q96RG2-4]
CCDS58759.1 [Q96RG2-2]
PIRiT17211
RefSeqiNP_001239048.1, NM_001252119.1 [Q96RG2-2]
NP_001239049.1, NM_001252120.1 [Q96RG2-1]
NP_001239051.1, NM_001252122.1
NP_001239053.1, NM_001252124.1 [Q96RG2-4]
NP_055963.2, NM_015148.3 [Q96RG2-1]
XP_011509130.1, XM_011510828.1 [Q96RG2-2]
XP_011509131.1, XM_011510829.1 [Q96RG2-2]
XP_011509132.1, XM_011510830.1 [Q96RG2-2]
XP_016859124.1, XM_017003635.1 [Q96RG2-1]
XP_016859125.1, XM_017003636.1 [Q96RG2-1]
UniGeneiHs.397891

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LL8NMR-A131-237[»]
3DLSX-ray2.30A/B/C/D/E/F977-1300[»]
ProteinModelPortaliQ96RG2
SMRiQ96RG2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116790, 71 interactors
IntActiQ96RG2, 59 interactors
MINTiQ96RG2
STRINGi9606.ENSP00000234040

Chemistry databases

BindingDBiQ96RG2
ChEMBLiCHEMBL6054

Protein family/group databases

MoonDBiQ96RG2 Predicted

PTM databases

iPTMnetiQ96RG2
PhosphoSitePlusiQ96RG2

Polymorphism and mutation databases

BioMutaiPASK
DMDMi116242701

Proteomic databases

EPDiQ96RG2
jPOSTiQ96RG2
MaxQBiQ96RG2
PaxDbiQ96RG2
PeptideAtlasiQ96RG2
PRIDEiQ96RG2
ProteomicsDBi77959
77960 [Q96RG2-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
23178
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000234040; ENSP00000234040; ENSG00000115687 [Q96RG2-1]
ENST00000358649; ENSP00000351475; ENSG00000115687 [Q96RG2-2]
ENST00000403638; ENSP00000384438; ENSG00000115687 [Q96RG2-4]
ENST00000405260; ENSP00000384016; ENSG00000115687 [Q96RG2-1]
ENST00000544142; ENSP00000441374; ENSG00000115687 [Q96RG2-1]
GeneIDi23178
KEGGihsa:23178
UCSCiuc002wao.2 human [Q96RG2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23178
DisGeNETi23178
EuPathDBiHostDB:ENSG00000115687.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PASK
HGNCiHGNC:17270 PASK
HPAiHPA016450
HPA021079
MIMi607505 gene
neXtProtiNX_Q96RG2
OpenTargetsiENSG00000115687
PharmGKBiPA32953

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1152 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00940000159035
HOGENOMiHOG000115456
HOVERGENiHBG047936
InParanoidiQ96RG2
KOiK08801
OMAiWSSYCLS
OrthoDBi297397at2759
PhylomeDBiQ96RG2
TreeFamiTF323242

Enzyme and pathway databases

SignaLinkiQ96RG2
SIGNORiQ96RG2

Miscellaneous databases

EvolutionaryTraceiQ96RG2

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PASK

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23178

Protein Ontology

More...
PROi
PR:Q96RG2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000115687 Expressed in 149 organ(s), highest expression level in small intestine Peyer's patch
CleanExiHS_PASK
ExpressionAtlasiQ96RG2 baseline and differential
GenevisibleiQ96RG2 HS

Family and domain databases

CDDicd00130 PAS, 2 hits
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF13426 PAS_9, 2 hits
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00091 PAS, 2 hits
SM00220 S_TKc, 1 hit
SUPFAMiSSF55785 SSF55785, 1 hit
SSF56112 SSF56112, 1 hit
TIGRFAMsiTIGR00229 sensory_box, 1 hit
PROSITEiView protein in PROSITE
PS50112 PAS, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPASK_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96RG2
Secondary accession number(s): G5E9F1
, Q05BE4, Q68DY3, Q6GSJ5, Q86XH6, Q99763, Q9UFR7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 17, 2006
Last modified: January 16, 2019
This is version 182 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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