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Entry version 154 (13 Feb 2019)
Sequence version 2 (25 Nov 2008)
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Protein

Sorting nexin-18

Gene

SNX18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Stimulates the GTPase activity of DNM2. Promotes DNM2 location at the plasma membrane.4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei312Phosphatidylinositol 4,5-bisphosphateBy similarity1
Binding sitei314Phosphatidylinositol 4,5-bisphosphateBy similarity1
Binding sitei338Phosphatidylinositol 4,5-bisphosphateBy similarity1
Binding sitei352Phosphatidylinositol 4,5-bisphosphateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • phosphatidylinositol-4,5-bisphosphate binding Source: FlyBase

GO - Biological processi

  • cleavage furrow formation Source: UniProtKB
  • endocytosis Source: UniProtKB
  • endosomal transport Source: UniProtKB
  • mitotic cytokinesis Source: UniProtKB
  • positive regulation of GTPase activity Source: UniProtKB
  • protein transport Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Endocytosis, Mitosis, Protein transport, Transport
LigandLipid-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8856828 Clathrin-mediated endocytosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sorting nexin-18
Alternative name(s):
SH3 and PX domain-containing protein 3B
Sorting nexin-associated Golgi protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SNX18
Synonyms:SH3PXD3B, SNAG1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000178996.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19245 SNX18

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96RF0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
112574

Open Targets

More...
OpenTargetsi
ENSG00000178996

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162404304

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SNX18

Domain mapping of disease mutations (DMDM)

More...
DMDMi
215273942

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002138661 – 628Sorting nexin-18Add BLAST628

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96RF0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96RF0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96RF0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96RF0

PeptideAtlas

More...
PeptideAtlasi
Q96RF0

PRoteomics IDEntifications database

More...
PRIDEi
Q96RF0

ProteomicsDB human proteome resource

More...
ProteomicsDBi
77957
77958 [Q96RF0-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96RF0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96RF0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000178996 Expressed in 210 organ(s), highest expression level in epithelial cell of pancreas

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96RF0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA037800

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer with SNX9. Interacts with ITCH. Interacts with dynamin, SYNJ1 and WASL. Interacts with the AP-1 complex. Interacts with FCHSD1 (via the F-BAR domain) (By similarity).By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
RAB11FIP5Q9BXF63EBI-298169,EBI-1387068

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
125193, 25 interactors

Protein interaction database and analysis system

More...
IntActi
Q96RF0, 27 interactors

Molecular INTeraction database

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MINTi
Q96RF0

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000317332

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q96RF0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96RF0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 61SH3PROSITE-ProRule annotationAdd BLAST61
Domaini276 – 386PXPROSITE-ProRule annotationAdd BLAST111
Domaini421 – 628BARAdd BLAST208

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PX domain mediates interaction with membranes enriched in phosphatidylinositol 4,5-bisphosphate.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sorting nexin family.Curated

Keywords - Domaini

SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2528 Eukaryota
ENOG410XPHZ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157724

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000261633

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG009996

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96RF0

KEGG Orthology (KO)

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KOi
K17923

Identification of Orthologs from Complete Genome Data

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OMAi
AFEMDQQ

Database of Orthologous Groups

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OrthoDBi
811995at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q96RF0

TreeFam database of animal gene trees

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TreeFami
TF314082

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07286 PX_SNX18, 1 hit
cd11897 SH3_SNX18, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1270.60, 1 hit
3.30.1520.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR001683 Phox
IPR036871 PX_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR035703 SNX18_PX
IPR035557 SNX18_SH3
IPR014536 Snx9_fam
IPR039358 Sorting_nexin-like
IPR019497 Sorting_nexin_WASP-bd-dom

The PANTHER Classification System

More...
PANTHERi
PTHR10555 PTHR10555, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10456 BAR_3_WASP_bdg, 1 hit
PF00787 PX, 1 hit
PF14604 SH3_9, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF027744 Snx9, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00312 PX, 1 hit
SM00326 SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50044 SSF50044, 1 hit
SSF64268 SSF64268, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50195 PX, 1 hit
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q96RF0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALRARALYD FRSENPGEIS LREHEVLSLC SEQDIEGWLE GVNSRGDRGL
60 70 80 90 100
FPASYVQVIR APEPGPAGDG GPGAPARYAN VPPGGFEPLP VAPPASFKPP
110 120 130 140 150
PDAFQALLQP QQAPPPSTFQ PPGAGFPYGG GALQPSPQQL YGGYQASQGS
160 170 180 190 200
DDDWDDEWDD SSTVADEPGA LGSGAYPDLD GSSSAGVGAA GRYRLSTRSD
210 220 230 240 250
LSLGSRGGSV PPQHHPSGPK SSATVSRNLN RFSTFVKSGG EAFVLGEASG
260 270 280 290 300
FVKDGDKLCV VLGPYGPEWQ ENPYPFQCTI DDPTKQTKFK GMKSYISYKL
310 320 330 340 350
VPTHTQVPVH RRYKHFDWLY ARLAEKFPVI SVPHLPEKQA TGRFEEDFIS
360 370 380 390 400
KRRKGLIWWM NHMASHPVLA QCDVFQHFLT CPSSTDEKAW KQGKRKAEKD
410 420 430 440 450
EMVGANFFLT LSTPPAAALD LQEVESKIDG FKCFTKKMDD SALQLNHTAN
460 470 480 490 500
EFARKQVTGF KKEYQKVGQS FRGLSQAFEL DQQAFSVGLN QAIAFTGDAY
510 520 530 540 550
DAIGELFAEQ PRQDLDPVMD LLALYQGHLA NFPDIIHVQK GKAWPLEQVI
560 570 580 590 600
WSVLCRLKGA TLTAVPLWVS ESYSTGEEAS RDVDAWVFSL ECKLDCSTGS
610 620
FLLEYLALGN EYSFSKVQRV PLMTVLSF
Length:628
Mass (Da):68,894
Last modified:November 25, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBE7B16835BA80F9C
GO
Isoform 2 (identifier: Q96RF0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     542-628: KAWPLEQVIW...RVPLMTVLSF → ALTKVKESRR...EEALHKYDSV

Show »
Length:624
Mass (Da):69,006
Checksum:iA348EFB754F465E9
GO
Isoform 3 (identifier: Q96RF0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     592-628: Missing.

Note: No experimental confirmation available.
Show »
Length:591
Mass (Da):64,752
Checksum:i43574BCAEBF15EDD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti32E → G in BAG65075 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052480571E → D2 PublicationsCorresponds to variant dbSNP:rs2548612Ensembl.1
Natural variantiVAR_052481593K → T1 PublicationCorresponds to variant dbSNP:rs13162502Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_035839542 – 628KAWPL…TVLSF → ALTKVKESRRHVEEGKMEVQ KADGIQDRCNTISFATLAEI HHFHQIRVRDFKSQMQHFLQ QQIIFFQKVTQKLEEALHKY DSV in isoform 2. 1 PublicationAdd BLAST87
Alternative sequenceiVSP_045476592 – 628Missing in isoform 3. 1 PublicationAdd BLAST37

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF395536 mRNA Translation: AAK82415.1
AK304195 mRNA Translation: BAG65075.1
AC091888 Genomic DNA No translation available.
CH471123 Genomic DNA Translation: EAW54894.1
BC060791 mRNA Translation: AAH60791.1
BC067860 mRNA Translation: AAH67860.1
BC117218 mRNA Translation: AAI17219.1
BC117220 mRNA Translation: AAI17221.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3962.1 [Q96RF0-1]
CCDS43317.1 [Q96RF0-2]
CCDS54851.1 [Q96RF0-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001096045.1, NM_001102575.1 [Q96RF0-2]
NP_001138899.1, NM_001145427.1 [Q96RF0-3]
NP_443102.2, NM_052870.2 [Q96RF0-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.432755
Hs.606166

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000326277; ENSP00000317332; ENSG00000178996 [Q96RF0-3]
ENST00000343017; ENSP00000342276; ENSG00000178996 [Q96RF0-1]
ENST00000381410; ENSP00000370817; ENSG00000178996 [Q96RF0-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
112574

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:112574

UCSC genome browser

More...
UCSCi
uc003jpi.5 human [Q96RF0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF395536 mRNA Translation: AAK82415.1
AK304195 mRNA Translation: BAG65075.1
AC091888 Genomic DNA No translation available.
CH471123 Genomic DNA Translation: EAW54894.1
BC060791 mRNA Translation: AAH60791.1
BC067860 mRNA Translation: AAH67860.1
BC117218 mRNA Translation: AAI17219.1
BC117220 mRNA Translation: AAI17221.1
CCDSiCCDS3962.1 [Q96RF0-1]
CCDS43317.1 [Q96RF0-2]
CCDS54851.1 [Q96RF0-3]
RefSeqiNP_001096045.1, NM_001102575.1 [Q96RF0-2]
NP_001138899.1, NM_001145427.1 [Q96RF0-3]
NP_443102.2, NM_052870.2 [Q96RF0-1]
UniGeneiHs.432755
Hs.606166

3D structure databases

ProteinModelPortaliQ96RF0
SMRiQ96RF0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125193, 25 interactors
IntActiQ96RF0, 27 interactors
MINTiQ96RF0
STRINGi9606.ENSP00000317332

PTM databases

iPTMnetiQ96RF0
PhosphoSitePlusiQ96RF0

Polymorphism and mutation databases

BioMutaiSNX18
DMDMi215273942

Proteomic databases

EPDiQ96RF0
jPOSTiQ96RF0
MaxQBiQ96RF0
PaxDbiQ96RF0
PeptideAtlasiQ96RF0
PRIDEiQ96RF0
ProteomicsDBi77957
77958 [Q96RF0-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326277; ENSP00000317332; ENSG00000178996 [Q96RF0-3]
ENST00000343017; ENSP00000342276; ENSG00000178996 [Q96RF0-1]
ENST00000381410; ENSP00000370817; ENSG00000178996 [Q96RF0-2]
GeneIDi112574
KEGGihsa:112574
UCSCiuc003jpi.5 human [Q96RF0-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
112574
DisGeNETi112574
EuPathDBiHostDB:ENSG00000178996.12

GeneCards: human genes, protein and diseases

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GeneCardsi
SNX18

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0174367
HGNCiHGNC:19245 SNX18
HPAiHPA037800
neXtProtiNX_Q96RF0
OpenTargetsiENSG00000178996
PharmGKBiPA162404304

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2528 Eukaryota
ENOG410XPHZ LUCA
GeneTreeiENSGT00940000157724
HOGENOMiHOG000261633
HOVERGENiHBG009996
InParanoidiQ96RF0
KOiK17923
OMAiAFEMDQQ
OrthoDBi811995at2759
PhylomeDBiQ96RF0
TreeFamiTF314082

Enzyme and pathway databases

ReactomeiR-HSA-8856828 Clathrin-mediated endocytosis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SNX18 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SNAG1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
112574

Protein Ontology

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PROi
PR:Q96RF0

Gene expression databases

BgeeiENSG00000178996 Expressed in 210 organ(s), highest expression level in epithelial cell of pancreas
GenevisibleiQ96RF0 HS

Family and domain databases

CDDicd07286 PX_SNX18, 1 hit
cd11897 SH3_SNX18, 1 hit
Gene3Di1.20.1270.60, 1 hit
3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR001683 Phox
IPR036871 PX_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR035703 SNX18_PX
IPR035557 SNX18_SH3
IPR014536 Snx9_fam
IPR039358 Sorting_nexin-like
IPR019497 Sorting_nexin_WASP-bd-dom
PANTHERiPTHR10555 PTHR10555, 1 hit
PfamiView protein in Pfam
PF10456 BAR_3_WASP_bdg, 1 hit
PF00787 PX, 1 hit
PF14604 SH3_9, 1 hit
PIRSFiPIRSF027744 Snx9, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSNX18_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96RF0
Secondary accession number(s): B4E2B3
, H7BXX3, Q05BB3, Q0VG02
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 25, 2008
Last modified: February 13, 2019
This is version 154 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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