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Protein

Sorting nexin-18

Gene

SNX18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Stimulates the GTPase activity of DNM2. Promotes DNM2 location at the plasma membrane.4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei312Phosphatidylinositol 4,5-bisphosphateBy similarity1
Binding sitei314Phosphatidylinositol 4,5-bisphosphateBy similarity1
Binding sitei338Phosphatidylinositol 4,5-bisphosphateBy similarity1
Binding sitei352Phosphatidylinositol 4,5-bisphosphateBy similarity1

GO - Molecular functioni

  • phosphatidylinositol-4,5-bisphosphate binding Source: FlyBase

GO - Biological processi

  • cleavage furrow formation Source: UniProtKB
  • endocytosis Source: UniProtKB
  • endosomal transport Source: UniProtKB
  • mitotic cytokinesis Source: UniProtKB
  • positive regulation of GTPase activity Source: UniProtKB
  • protein transport Source: UniProtKB-KW

Keywordsi

Biological processCell cycle, Cell division, Endocytosis, Mitosis, Protein transport, Transport
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-HSA-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-18
Alternative name(s):
SH3 and PX domain-containing protein 3B
Sorting nexin-associated Golgi protein 1
Gene namesi
Name:SNX18
Synonyms:SH3PXD3B, SNAG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000178996.12
HGNCiHGNC:19245 SNX18
neXtProtiNX_Q96RF0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi112574
OpenTargetsiENSG00000178996
PharmGKBiPA162404304

Polymorphism and mutation databases

BioMutaiSNX18
DMDMi215273942

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002138661 – 628Sorting nexin-18Add BLAST628

Proteomic databases

EPDiQ96RF0
MaxQBiQ96RF0
PaxDbiQ96RF0
PeptideAtlasiQ96RF0
PRIDEiQ96RF0
ProteomicsDBi77957
77958 [Q96RF0-2]

PTM databases

iPTMnetiQ96RF0
PhosphoSitePlusiQ96RF0

Expressioni

Gene expression databases

BgeeiENSG00000178996
CleanExiHS_SNX18
GenevisibleiQ96RF0 HS

Organism-specific databases

HPAiHPA037800

Interactioni

Subunit structurei

Heterodimer with SNX9. Interacts with ITCH. Interacts with dynamin, SYNJ1 and WASL. Interacts with the AP-1 complex.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
RAB11FIP5Q9BXF63EBI-298169,EBI-1387068

Protein-protein interaction databases

BioGridi125193, 24 interactors
IntActiQ96RF0, 26 interactors
MINTiQ96RF0
STRINGi9606.ENSP00000317332

Structurei

3D structure databases

ProteinModelPortaliQ96RF0
SMRiQ96RF0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 61SH3PROSITE-ProRule annotationAdd BLAST61
Domaini276 – 386PXPROSITE-ProRule annotationAdd BLAST111
Domaini421 – 628BARAdd BLAST208

Domaini

The PX domain mediates interaction with membranes enriched in phosphatidylinositol 4,5-bisphosphate.

Sequence similaritiesi

Belongs to the sorting nexin family.Curated

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiKOG2528 Eukaryota
ENOG410XPHZ LUCA
GeneTreeiENSGT00510000046469
HOGENOMiHOG000261633
HOVERGENiHBG009996
InParanoidiQ96RF0
KOiK17923
OMAiAEIHHFH
OrthoDBiEOG091G07IM
PhylomeDBiQ96RF0
TreeFamiTF314082

Family and domain databases

CDDicd07286 PX_SNX18, 1 hit
cd11897 SH3_SNX18, 1 hit
Gene3Di1.20.1270.60, 1 hit
3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR001683 Phox
IPR036871 PX_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR035703 SNX18_PX
IPR035557 SNX18_SH3
IPR014536 Snx9_fam
IPR019497 Sorting_nexin_WASP-bd-dom
PfamiView protein in Pfam
PF10456 BAR_3_WASP_bdg, 1 hit
PF00787 PX, 1 hit
PF14604 SH3_9, 1 hit
PIRSFiPIRSF027744 Snx9, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit
PS50002 SH3, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96RF0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALRARALYD FRSENPGEIS LREHEVLSLC SEQDIEGWLE GVNSRGDRGL
60 70 80 90 100
FPASYVQVIR APEPGPAGDG GPGAPARYAN VPPGGFEPLP VAPPASFKPP
110 120 130 140 150
PDAFQALLQP QQAPPPSTFQ PPGAGFPYGG GALQPSPQQL YGGYQASQGS
160 170 180 190 200
DDDWDDEWDD SSTVADEPGA LGSGAYPDLD GSSSAGVGAA GRYRLSTRSD
210 220 230 240 250
LSLGSRGGSV PPQHHPSGPK SSATVSRNLN RFSTFVKSGG EAFVLGEASG
260 270 280 290 300
FVKDGDKLCV VLGPYGPEWQ ENPYPFQCTI DDPTKQTKFK GMKSYISYKL
310 320 330 340 350
VPTHTQVPVH RRYKHFDWLY ARLAEKFPVI SVPHLPEKQA TGRFEEDFIS
360 370 380 390 400
KRRKGLIWWM NHMASHPVLA QCDVFQHFLT CPSSTDEKAW KQGKRKAEKD
410 420 430 440 450
EMVGANFFLT LSTPPAAALD LQEVESKIDG FKCFTKKMDD SALQLNHTAN
460 470 480 490 500
EFARKQVTGF KKEYQKVGQS FRGLSQAFEL DQQAFSVGLN QAIAFTGDAY
510 520 530 540 550
DAIGELFAEQ PRQDLDPVMD LLALYQGHLA NFPDIIHVQK GKAWPLEQVI
560 570 580 590 600
WSVLCRLKGA TLTAVPLWVS ESYSTGEEAS RDVDAWVFSL ECKLDCSTGS
610 620
FLLEYLALGN EYSFSKVQRV PLMTVLSF
Length:628
Mass (Da):68,894
Last modified:November 25, 2008 - v2
Checksum:iBE7B16835BA80F9C
GO
Isoform 2 (identifier: Q96RF0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     542-628: KAWPLEQVIW...RVPLMTVLSF → ALTKVKESRR...EEALHKYDSV

Show »
Length:624
Mass (Da):69,006
Checksum:iA348EFB754F465E9
GO
Isoform 3 (identifier: Q96RF0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     592-628: Missing.

Note: No experimental confirmation available.
Show »
Length:591
Mass (Da):64,752
Checksum:i43574BCAEBF15EDD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32E → G in BAG65075 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052480571E → D2 PublicationsCorresponds to variant dbSNP:rs2548612Ensembl.1
Natural variantiVAR_052481593K → T1 PublicationCorresponds to variant dbSNP:rs13162502Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_035839542 – 628KAWPL…TVLSF → ALTKVKESRRHVEEGKMEVQ KADGIQDRCNTISFATLAEI HHFHQIRVRDFKSQMQHFLQ QQIIFFQKVTQKLEEALHKY DSV in isoform 2. 1 PublicationAdd BLAST87
Alternative sequenceiVSP_045476592 – 628Missing in isoform 3. 1 PublicationAdd BLAST37

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF395536 mRNA Translation: AAK82415.1
AK304195 mRNA Translation: BAG65075.1
AC091888 Genomic DNA No translation available.
CH471123 Genomic DNA Translation: EAW54894.1
BC060791 mRNA Translation: AAH60791.1
BC067860 mRNA Translation: AAH67860.1
BC117218 mRNA Translation: AAI17219.1
BC117220 mRNA Translation: AAI17221.1
CCDSiCCDS3962.1 [Q96RF0-1]
CCDS43317.1 [Q96RF0-2]
CCDS54851.1 [Q96RF0-3]
RefSeqiNP_001096045.1, NM_001102575.1 [Q96RF0-2]
NP_001138899.1, NM_001145427.1 [Q96RF0-3]
NP_443102.2, NM_052870.2 [Q96RF0-1]
UniGeneiHs.432755
Hs.606166

Genome annotation databases

EnsembliENST00000326277; ENSP00000317332; ENSG00000178996 [Q96RF0-3]
ENST00000343017; ENSP00000342276; ENSG00000178996 [Q96RF0-1]
ENST00000381410; ENSP00000370817; ENSG00000178996 [Q96RF0-2]
GeneIDi112574
KEGGihsa:112574
UCSCiuc003jpi.5 human [Q96RF0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSNX18_HUMAN
AccessioniPrimary (citable) accession number: Q96RF0
Secondary accession number(s): B4E2B3
, H7BXX3, Q05BB3, Q0VG02
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 25, 2008
Last modified: June 20, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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