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Protein

Zinc finger protein 300

Gene

ZNF300

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has a transcriptional repressor activity.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri269 – 291C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri297 – 319C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri325 – 347C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri353 – 375C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri381 – 403C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri409 – 431C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri437 – 459C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri465 – 487C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri493 – 515C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri521 – 543C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri549 – 571C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri577 – 599C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 300
Gene namesi
Name:ZNF300
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000145908.12
HGNCiHGNC:13091 ZNF300
MIMi612429 gene
neXtProtiNX_Q96RE9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi91975
OpenTargetsiENSG00000145908
PharmGKBiPA37666

Polymorphism and mutation databases

BioMutaiZNF300
DMDMi20141015

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475211 – 604Zinc finger protein 300Add BLAST604

Proteomic databases

MaxQBiQ96RE9
PaxDbiQ96RE9
PeptideAtlasiQ96RE9
PRIDEiQ96RE9
ProteomicsDBi77954
77955 [Q96RE9-2]
77956 [Q96RE9-3]

PTM databases

iPTMnetiQ96RE9
PhosphoSitePlusiQ96RE9

Expressioni

Tissue specificityi

Expressed mostly in heart, skeletal muscle and brain. Isoform 1 and isoform 2 are highly expressed in testis.2 Publications

Gene expression databases

BgeeiENSG00000145908 Expressed in 135 organ(s), highest expression level in cerebral cortex
CleanExiHS_ZNF300
ExpressionAtlasiQ96RE9 baseline and differential
GenevisibleiQ96RE9 HS

Organism-specific databases

HPAiHPA028975
HPA051777

Interactioni

Subunit structurei

Interacts (via the KRAB domain) with TRIM28 (via the RBCC domain).1 Publication

Protein-protein interaction databases

BioGridi124898, 2 interactors
IntActiQ96RE9, 3 interactors
MINTiQ96RE9
STRINGi9606.ENSP00000397178

Structurei

3D structure databases

ProteinModelPortaliQ96RE9
SMRiQ96RE9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 79KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri269 – 291C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri297 – 319C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri325 – 347C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri353 – 375C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri381 – 403C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri409 – 431C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri437 – 459C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri465 – 487C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri493 – 515C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri521 – 543C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri549 – 571C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri577 – 599C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150946
HOVERGENiHBG018163
InParanoidiQ96RE9
KOiK09228
OMAiKEKTCVC
OrthoDBiEOG091G02KC
PhylomeDBiQ96RE9

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 12 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 12 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 12 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96RE9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMKSQGLVSF KDVAVDFTQE EWQQLDPSQR TLYRDVMLEN YSHLVSMGYP
60 70 80 90 100
VSKPDVISKL EQGEEPWIIK GDISNWIYPD EYQADGRQDR KSNLHNSQSC
110 120 130 140 150
ILGTVSFHHK ILKGVTRDGS LCSILKVCQG DGQLQRFLEN QDKLFRQVTF
160 170 180 190 200
VNSKTVTEAS GHKYNPLGKI FQECIETDIS IQRFHKYDAF KKNLKPNIDL
210 220 230 240 250
PSCYKSNSRK KPDQSFGGGK SSSQSEPNSN LEKIHNGVIP FDDNQCGNVF
260 270 280 290 300
RNTQSLIQYQ NVETKEKSCV CVTCGKAFAK KSQLIVHQRI HTGKKPYDCG
310 320 330 340 350
ACGKAFSEKF HLVVHQRTHT GEKPYDCSEC GKAFSQKSSL IIHQRVHTGE
360 370 380 390 400
KPYECSECGK AFSQKSPLII HQRIHTGEKP YECRECGKAF SQKSQLIIHH
410 420 430 440 450
RAHTGEKPYE CTECGKAFCE KSHLIIHKRI HTGEKPYKCA QCEEAFSRKT
460 470 480 490 500
ELITHQLVHT GEKPYECTEC GKTFSRKSQL IIHQRTHTGE KPYKCSECGK
510 520 530 540 550
AFCQKSHLIG HQRIHTGEKP YICTECGKAF SQKSHLPGHQ RIHTGEKPYI
560 570 580 590 600
CAECGKAFSQ KSDLVLHQRI HTGERPYQCA ICGKAFIQKS QLTVHQRIHT

VVKS
Length:604
Mass (Da):68,743
Last modified:December 1, 2001 - v1
Checksum:iEABCF821E9FAC441
GO
Isoform 2 (identifier: Q96RE9-2) [UniParc]FASTAAdd to basket
Also known as: Zinc finger protein 300-B, ZNF300B

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MVPAETSSSGLLEEQK

Show »
Length:619
Mass (Da):70,300
Checksum:iB21C77AF8C8BFBB3
GO
Isoform 3 (identifier: Q96RE9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MVPAETSSSGLLEEQKM

Note: No experimental confirmation available.
Show »
Length:620
Mass (Da):70,431
Checksum:i45E71F07512FCA5E
GO
Isoform 4 (identifier: Q96RE9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: Missing.

Note: No experimental confirmation available.
Show »
Length:568
Mass (Da):64,484
Checksum:i093ED8AC23D7E6D4
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MS50A0A0A0MS50_HUMAN
Zinc finger protein 300
ZNF300
604Annotation score:
F8WE31F8WE31_HUMAN
Zinc finger protein 300
ZNF300
90Annotation score:

Sequence cautioni

The sequence EAW61702 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti253T → I in CAI46270 (PubMed:17974005).Curated1
Sequence conflicti535H → Q in CAI46270 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_012355336Q → H. Corresponds to variant dbSNP:rs1988688Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0475061 – 36Missing in isoform 4. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_0368301M → MVPAETSSSGLLEEQK in isoform 2. 1 Publication1
Alternative sequenceiVSP_0368311M → MVPAETSSSGLLEEQKM in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF395541 mRNA Translation: AAK83888.1
DQ908918 mRNA Translation: ABI81769.1
AK096465 mRNA Translation: BAG53297.1
AK300528 mRNA Translation: BAG62240.1
DB094933 mRNA No translation available.
AC010441 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61702.1 Sequence problems.
BC117248 mRNA Translation: AAI17249.1
CR933727 mRNA Translation: CAI46270.1
CCDSiCCDS4311.2 [Q96RE9-1]
CCDS54939.1 [Q96RE9-4]
CCDS54940.1 [Q96RE9-3]
RefSeqiNP_001166302.1, NM_001172831.1 [Q96RE9-3]
NP_001166303.1, NM_001172832.1 [Q96RE9-4]
NP_443092.1, NM_052860.2 [Q96RE9-1]
UniGeneiHs.134885

Genome annotation databases

EnsembliENST00000274599; ENSP00000274599; ENSG00000145908 [Q96RE9-1]
ENST00000418587; ENSP00000392593; ENSG00000145908 [Q96RE9-4]
ENST00000446148; ENSP00000397178; ENSG00000145908 [Q96RE9-3]
GeneIDi91975
KEGGihsa:91975
UCSCiuc021yfx.1 human [Q96RE9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF395541 mRNA Translation: AAK83888.1
DQ908918 mRNA Translation: ABI81769.1
AK096465 mRNA Translation: BAG53297.1
AK300528 mRNA Translation: BAG62240.1
DB094933 mRNA No translation available.
AC010441 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61702.1 Sequence problems.
BC117248 mRNA Translation: AAI17249.1
CR933727 mRNA Translation: CAI46270.1
CCDSiCCDS4311.2 [Q96RE9-1]
CCDS54939.1 [Q96RE9-4]
CCDS54940.1 [Q96RE9-3]
RefSeqiNP_001166302.1, NM_001172831.1 [Q96RE9-3]
NP_001166303.1, NM_001172832.1 [Q96RE9-4]
NP_443092.1, NM_052860.2 [Q96RE9-1]
UniGeneiHs.134885

3D structure databases

ProteinModelPortaliQ96RE9
SMRiQ96RE9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124898, 2 interactors
IntActiQ96RE9, 3 interactors
MINTiQ96RE9
STRINGi9606.ENSP00000397178

PTM databases

iPTMnetiQ96RE9
PhosphoSitePlusiQ96RE9

Polymorphism and mutation databases

BioMutaiZNF300
DMDMi20141015

Proteomic databases

MaxQBiQ96RE9
PaxDbiQ96RE9
PeptideAtlasiQ96RE9
PRIDEiQ96RE9
ProteomicsDBi77954
77955 [Q96RE9-2]
77956 [Q96RE9-3]

Protocols and materials databases

DNASUi91975
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274599; ENSP00000274599; ENSG00000145908 [Q96RE9-1]
ENST00000418587; ENSP00000392593; ENSG00000145908 [Q96RE9-4]
ENST00000446148; ENSP00000397178; ENSG00000145908 [Q96RE9-3]
GeneIDi91975
KEGGihsa:91975
UCSCiuc021yfx.1 human [Q96RE9-1]

Organism-specific databases

CTDi91975
DisGeNETi91975
EuPathDBiHostDB:ENSG00000145908.12
GeneCardsiZNF300
HGNCiHGNC:13091 ZNF300
HPAiHPA028975
HPA051777
MIMi612429 gene
neXtProtiNX_Q96RE9
OpenTargetsiENSG00000145908
PharmGKBiPA37666
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150946
HOVERGENiHBG018163
InParanoidiQ96RE9
KOiK09228
OMAiKEKTCVC
OrthoDBiEOG091G02KC
PhylomeDBiQ96RE9

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

GeneWikiiZNF300
GenomeRNAii91975
PROiPR:Q96RE9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000145908 Expressed in 135 organ(s), highest expression level in cerebral cortex
CleanExiHS_ZNF300
ExpressionAtlasiQ96RE9 baseline and differential
GenevisibleiQ96RE9 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 12 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 12 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 12 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN300_HUMAN
AccessioniPrimary (citable) accession number: Q96RE9
Secondary accession number(s): A8MY91
, B3KU35, B4DU78, F5GWS1, Q06DQ3, Q17RP3, Q5H9N5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 160 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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