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UniProtKB - Q96RD9 (FCRL5_HUMAN)
Protein
Fc receptor-like protein 5
Gene
FCRL5
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells.
1 PublicationGO - Molecular functioni
- transmembrane signaling receptor activity Source: GO_Central
GO - Biological processi
- cell surface receptor signaling pathway Source: GO_Central
Keywordsi
Molecular function | Receptor |
Enzyme and pathway databases
PathwayCommonsi | Q96RD9 |
SignaLinki | Q96RD9 |
Names & Taxonomyi
Protein namesi | Recommended name: Fc receptor-like protein 5Short name: FcR-like protein 5 Short name: FcRL5 Alternative name(s): BXMAS1 Fc receptor homolog 5 Short name: FcRH5 Immune receptor translocation-associated protein 2 CD_antigen: CD307e |
Gene namesi | Name:FCRL5 Synonyms:FCRH5, IRTA2 ORF Names:UNQ503/PRO820 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18508, FCRL5 |
MIMi | 605877, gene |
neXtProti | NX_Q96RD9 |
VEuPathDBi | HostDB:ENSG00000143297 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Other locations
- cell surface Source: UniProtKB
- receptor complex Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 16 – 851 | ExtracellularSequence analysisAdd BLAST | 836 | |
Transmembranei | 852 – 872 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 873 – 977 | CytoplasmicSequence analysisAdd BLAST | 105 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Involvement in diseasei
A chromosomal aberration involving FCRL5 has been found in cell lines with 1q21 abnormalities derived from Burkitt lymphoma. Duplication dup(1)(q21q32).1 Publication
Organism-specific databases
DisGeNETi | 83416 |
OpenTargetsi | ENSG00000143297 |
PharmGKBi | PA142671769 |
Miscellaneous databases
Pharosi | Q96RD9, Tbio |
Genetic variation databases
BioMutai | FCRL5 |
DMDMi | 296439341 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 15 | Sequence analysisAdd BLAST | 15 | |
ChainiPRO_0000225622 | 16 – 977 | Fc receptor-like protein 5Add BLAST | 962 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 44 ↔ 85 | PROSITE-ProRule annotation | ||
Disulfide bondi | 211 ↔ 260 | PROSITE-ProRule annotation | ||
Disulfide bondi | 308 ↔ 355 | PROSITE-ProRule annotation | ||
Glycosylationi | 383 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 401 ↔ 448 | PROSITE-ProRule annotation | ||
Disulfide bondi | 494 ↔ 541 | PROSITE-ProRule annotation | ||
Disulfide bondi | 587 ↔ 634 | PROSITE-ProRule annotation | ||
Disulfide bondi | 680 ↔ 727 | PROSITE-ProRule annotation | ||
Disulfide bondi | 773 ↔ 819 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
jPOSTi | Q96RD9 |
MassIVEi | Q96RD9 |
PaxDbi | Q96RD9 |
PeptideAtlasi | Q96RD9 |
PRIDEi | Q96RD9 |
ProteomicsDBi | 77948 [Q96RD9-1] 77949 [Q96RD9-2] 77950 [Q96RD9-3] 77951 [Q96RD9-4] 77952 [Q96RD9-5] |
PTM databases
GlyGeni | Q96RD9, 4 sites |
iPTMneti | Q96RD9 |
PhosphoSitePlusi | Q96RD9 |
Expressioni
Tissue specificityi
Expressed in marginal zone B-cells, immunoblasts, tonsillar germinal center centrocytes and in the intraepithelial and interfollicular regions of the tonsil. Expressed in many lymphoma cell lines and on hairy cell leukemia cells. Isoform 1, isoform 3, isoform 4 and isoform 5 are detected in lymph node, spleen, bone marrow, and small intestine with preponderance of isoform 3. Expressed in mature and memory B-cells and down-regulated in germinal center cells (at protein level).3 Publications
Gene expression databases
Bgeei | ENSG00000143297, Expressed in tonsil and 119 other tissues |
Genevisiblei | Q96RD9, HS |
Organism-specific databases
HPAi | ENSG00000143297, Tissue enriched (lymphoid) |
Interactioni
Binary interactionsi
Q96RD9
With | #Exp. | IntAct |
---|---|---|
AMOTL2 [Q9Y2J4] | 3 | EBI-12091825,EBI-746752 |
CAGE1 - isoform 4 [Q8TC20-4] | 3 | EBI-12091825,EBI-11522698 |
USHBP1 [Q8N6Y0] | 3 | EBI-12091825,EBI-739895 |
Protein-protein interaction databases
BioGRIDi | 123640, 15 interactors |
IntActi | Q96RD9, 9 interactors |
STRINGi | 9606.ENSP00000354691 |
Miscellaneous databases
RNActi | Q96RD9, protein |
Structurei
3D structure databases
AlphaFoldDBi | Q96RD9 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 23 – 101 | Ig-like C2-type 1Add BLAST | 79 | |
Domaini | 188 – 271 | Ig-like C2-type 2Add BLAST | 84 | |
Domaini | 287 – 374 | Ig-like C2-type 3Add BLAST | 88 | |
Domaini | 380 – 463 | Ig-like C2-type 4Add BLAST | 84 | |
Domaini | 473 – 556 | Ig-like C2-type 5Add BLAST | 84 | |
Domaini | 566 – 651 | Ig-like C2-type 6Add BLAST | 86 | |
Domaini | 659 – 744 | Ig-like C2-type 7Add BLAST | 86 | |
Domaini | 752 – 834 | Ig-like C2-type 8Add BLAST | 83 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 879 – 898 | DisorderedSequence analysisAdd BLAST | 20 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 897 – 902 | ITIM motif 1 | 6 | |
Motifi | 910 – 915 | ITIM motif 2 | 6 | |
Motifi | 922 – 927 | ITIM motif 3 | 6 | |
Motifi | 952 – 957 | ITIM motif 4 | 6 |
Domaini
Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM).By similarity
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S65W, Eukaryota |
GeneTreei | ENSGT01040000240447 |
HOGENOMi | CLU_325948_0_0_1 |
InParanoidi | Q96RD9 |
OMAi | RFYHDDV |
OrthoDBi | 53940at2759 |
PhylomeDBi | Q96RD9 |
TreeFami | TF351107 |
Family and domain databases
Gene3Di | 2.60.40.10, 9 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR003598, Ig_sub2 |
Pfami | View protein in Pfam PF13895, Ig_2, 7 hits |
SMARTi | View protein in SMART SM00409, IG, 9 hits SM00408, IGc2, 8 hits |
SUPFAMi | SSF48726, SSF48726, 9 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 8 hits |
s (5)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q96RD9-1) [UniParc]FASTAAdd to basket
Also known as: IRTA2c
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLLWVILLVL APVSGQFART PRPIIFLQPP WTTVFQGERV TLTCKGFRFY
60 70 80 90 100
SPQKTKWYHR YLGKEILRET PDNILEVQES GEYRCQAQGS PLSSPVHLDF
110 120 130 140 150
SSASLILQAP LSVFEGDSVV LRCRAKAEVT LNNTIYKNDN VLAFLNKRTD
160 170 180 190 200
FHIPHACLKD NGAYRCTGYK ESCCPVSSNT VKIQVQEPFT RPVLRASSFQ
210 220 230 240 250
PISGNPVTLT CETQLSLERS DVPLRFRFFR DDQTLGLGWS LSPNFQITAM
260 270 280 290 300
WSKDSGFYWC KAATMPYSVI SDSPRSWIQV QIPASHPVLT LSPEKALNFE
310 320 330 340 350
GTKVTLHCET QEDSLRTLYR FYHEGVPLRH KSVRCERGAS ISFSLTTENS
360 370 380 390 400
GNYYCTADNG LGAKPSKAVS LSVTVPVSHP VLNLSSPEDL IFEGAKVTLH
410 420 430 440 450
CEAQRGSLPI LYQFHHEGAA LERRSANSAG GVAISFSLTA EHSGNYYCTA
460 470 480 490 500
DNGFGPQRSK AVSLSVTVPV SHPVLTLSSA EALTFEGATV TLHCEVQRGS
510 520 530 540 550
PQILYQFYHE DMPLWSSSTP SVGRVSFSFS LTEGHSGNYY CTADNGFGPQ
560 570 580 590 600
RSEVVSLFVT VPVSRPILTL RVPRAQAVVG DLLELHCEAP RGSPPILYWF
610 620 630 640 650
YHEDVTLGSS SAPSGGEASF NLSLTAEHSG NYSCEANNGL VAQHSDTISL
660 670 680 690 700
SVIVPVSRPI LTFRAPRAQA VVGDLLELHC EALRGSSPIL YWFYHEDVTL
710 720 730 740 750
GKISAPSGGG ASFNLSLTTE HSGIYSCEAD NGLEAQRSEM VTLKVAVPVS
760 770 780 790 800
RPVLTLRAPG THAAVGDLLE LHCEALRGSP LILYRFFHED VTLGNRSSPS
810 820 830 840 850
GGASLNLSLT AEHSGNYSCE ADNGLGAQRS ETVTLYITGL TANRSGPFAT
860 870 880 890 900
GVAGGLLSIA GLAAGALLLY CWLSRKAGRK PASDPARSPS DSDSQEPTYH
910 920 930 940 950
NVPAWEELQP VYTNANPRGE NVVYSEVRII QEKKKHAVAS DPRHLRNKGS
960 970
PIIYSEVKVA STPVSGSLFL ASSAPHR
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 733 | L → P in AAK50059 (PubMed:11453668).Curated | 1 | |
Sequence conflicti | 890 | S → P in AAK50059 (PubMed:11453668).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_025447 | 267 | Y → H4 PublicationsCorresponds to variant dbSNP:rs6679793Ensembl. | 1 | |
Natural variantiVAR_025448 | 269 | V → I2 PublicationsCorresponds to variant dbSNP:rs12036228Ensembl. | 1 | |
Natural variantiVAR_025449 | 418 | G → D5 PublicationsCorresponds to variant dbSNP:rs2012199Ensembl. | 1 | |
Natural variantiVAR_056044 | 427 | N → K. Corresponds to variant dbSNP:rs16838748EnsemblClinVar. | 1 | |
Natural variantiVAR_056045 | 457 | Q → R. Corresponds to variant dbSNP:rs34868810EnsemblClinVar. | 1 | |
Natural variantiVAR_025450 | 466 | V → I5 PublicationsCorresponds to variant dbSNP:rs6427384Ensembl. | 1 | |
Natural variantiVAR_035514 | 687 | S → C in a breast cancer sample; somatic mutation. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_017379 | 103 – 124 | ASLIL…VLRCR → EMGFPHAAQANVELLGSSDL LT in isoform 2. 2 PublicationsAdd BLAST | 22 | |
Alternative sequenceiVSP_017380 | 125 – 977 | Missing in isoform 2. 2 PublicationsAdd BLAST | 853 | |
Alternative sequenceiVSP_017381 | 152 | H → Q in isoform 5. 1 Publication | 1 | |
Alternative sequenceiVSP_017382 | 153 – 977 | Missing in isoform 5. 1 PublicationAdd BLAST | 825 | |
Alternative sequenceiVSP_017383 | 561 – 592 | VPVSR…EAPRG → GKCWVLASHPPLAEFSLTHS FKNLFALSSFLP in isoform 4. 1 PublicationAdd BLAST | 32 | |
Alternative sequenceiVSP_017384 | 593 – 977 | Missing in isoform 4. 1 PublicationAdd BLAST | 385 | |
Alternative sequenceiVSP_017385 | 747 – 759 | VPVSR…TLRAP → GEWALPTSSTSEN in isoform 3. 1 PublicationAdd BLAST | 13 | |
Alternative sequenceiVSP_017386 | 760 – 977 | Missing in isoform 3. 1 PublicationAdd BLAST | 218 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF369794 mRNA Translation: AAK50059.2 AF343662 mRNA Translation: AAK31325.1 AF343663 mRNA Translation: AAK31326.1 AF343664 mRNA Translation: AAK31327.1 AF343665 mRNA Translation: AAK31328.1 AF397453 mRNA Translation: AAK93971.1 AY358085 mRNA Translation: AAQ88452.1 AL834187 mRNA Translation: CAH56486.1 EF064730 Genomic DNA Translation: ABK41913.1 AL135929 Genomic DNA No translation available. AL353899 Genomic DNA No translation available. BC101066 mRNA Translation: AAI01067.1 BC101067 mRNA Translation: AAI01068.1 BC101069 mRNA Translation: AAI01070.1 |
CCDSi | CCDS1165.1 [Q96RD9-1] |
RefSeqi | NP_001182317.1, NM_001195388.1 NP_112571.2, NM_031281.2 [Q96RD9-1] |
Genome annotation databases
Ensembli | ENST00000361835.8; ENSP00000354691.3; ENSG00000143297.19 ENST00000368189.3; ENSP00000357172.3; ENSG00000143297.19 [Q96RD9-4] ENST00000368190.7; ENSP00000357173.3; ENSG00000143297.19 [Q96RD9-3] |
GeneIDi | 83416 |
KEGGi | hsa:83416 |
MANE-Selecti | ENST00000361835.8; ENSP00000354691.3; NM_031281.3; NP_112571.2 |
UCSCi | uc001fqu.3, human [Q96RD9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF369794 mRNA Translation: AAK50059.2 AF343662 mRNA Translation: AAK31325.1 AF343663 mRNA Translation: AAK31326.1 AF343664 mRNA Translation: AAK31327.1 AF343665 mRNA Translation: AAK31328.1 AF397453 mRNA Translation: AAK93971.1 AY358085 mRNA Translation: AAQ88452.1 AL834187 mRNA Translation: CAH56486.1 EF064730 Genomic DNA Translation: ABK41913.1 AL135929 Genomic DNA No translation available. AL353899 Genomic DNA No translation available. BC101066 mRNA Translation: AAI01067.1 BC101067 mRNA Translation: AAI01068.1 BC101069 mRNA Translation: AAI01070.1 |
CCDSi | CCDS1165.1 [Q96RD9-1] |
RefSeqi | NP_001182317.1, NM_001195388.1 NP_112571.2, NM_031281.2 [Q96RD9-1] |
3D structure databases
AlphaFoldDBi | Q96RD9 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 123640, 15 interactors |
IntActi | Q96RD9, 9 interactors |
STRINGi | 9606.ENSP00000354691 |
PTM databases
GlyGeni | Q96RD9, 4 sites |
iPTMneti | Q96RD9 |
PhosphoSitePlusi | Q96RD9 |
Genetic variation databases
BioMutai | FCRL5 |
DMDMi | 296439341 |
Proteomic databases
jPOSTi | Q96RD9 |
MassIVEi | Q96RD9 |
PaxDbi | Q96RD9 |
PeptideAtlasi | Q96RD9 |
PRIDEi | Q96RD9 |
ProteomicsDBi | 77948 [Q96RD9-1] 77949 [Q96RD9-2] 77950 [Q96RD9-3] 77951 [Q96RD9-4] 77952 [Q96RD9-5] |
Protocols and materials databases
ABCDi | Q96RD9, 76 sequenced antibodies |
Antibodypediai | 47044, 276 antibodies from 30 providers |
DNASUi | 83416 |
Genome annotation databases
Ensembli | ENST00000361835.8; ENSP00000354691.3; ENSG00000143297.19 ENST00000368189.3; ENSP00000357172.3; ENSG00000143297.19 [Q96RD9-4] ENST00000368190.7; ENSP00000357173.3; ENSG00000143297.19 [Q96RD9-3] |
GeneIDi | 83416 |
KEGGi | hsa:83416 |
MANE-Selecti | ENST00000361835.8; ENSP00000354691.3; NM_031281.3; NP_112571.2 |
UCSCi | uc001fqu.3, human [Q96RD9-1] |
Organism-specific databases
CTDi | 83416 |
DisGeNETi | 83416 |
GeneCardsi | FCRL5 |
HGNCi | HGNC:18508, FCRL5 |
HPAi | ENSG00000143297, Tissue enriched (lymphoid) |
MIMi | 605877, gene |
neXtProti | NX_Q96RD9 |
OpenTargetsi | ENSG00000143297 |
PharmGKBi | PA142671769 |
VEuPathDBi | HostDB:ENSG00000143297 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S65W, Eukaryota |
GeneTreei | ENSGT01040000240447 |
HOGENOMi | CLU_325948_0_0_1 |
InParanoidi | Q96RD9 |
OMAi | RFYHDDV |
OrthoDBi | 53940at2759 |
PhylomeDBi | Q96RD9 |
TreeFami | TF351107 |
Enzyme and pathway databases
PathwayCommonsi | Q96RD9 |
SignaLinki | Q96RD9 |
Miscellaneous databases
BioGRID-ORCSi | 83416, 6 hits in 1061 CRISPR screens |
ChiTaRSi | FCRL5, human |
GeneWikii | FCRL5 |
GenomeRNAii | 83416 |
Pharosi | Q96RD9, Tbio |
PROi | PR:Q96RD9 |
RNActi | Q96RD9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000143297, Expressed in tonsil and 119 other tissues |
Genevisiblei | Q96RD9, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 9 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR003598, Ig_sub2 |
Pfami | View protein in Pfam PF13895, Ig_2, 7 hits |
SMARTi | View protein in SMART SM00409, IG, 9 hits SM00408, IGc2, 8 hits |
SUPFAMi | SSF48726, SSF48726, 9 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 8 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | FCRL5_HUMAN | |
Accessioni | Q96RD9Primary (citable) accession number: Q96RD9 Secondary accession number(s): A0N0M2 Q6UY46 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 7, 2006 |
Last sequence update: | May 18, 2010 | |
Last modified: | May 25, 2022 | |
This is version 174 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot