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Entry version 150 (13 Feb 2019)
Sequence version 4 (11 Jan 2011)
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Protein

Pannexin-1

Gene

PANX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Structural component of the gap junctions and the hemichannels. May play a role as a Ca2+-leak channel to regulate ER Ca2+ homeostasis.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin filament binding Source: Ensembl
  • calcium channel activity Source: UniProtKB
  • gap junction hemi-channel activity Source: UniProtKB
  • ion channel binding Source: Ensembl
  • leak channel activity Source: UniProtKB
  • protease binding Source: Ensembl
  • protein heterodimerization activity Source: Ensembl
  • scaffold protein binding Source: Ensembl
  • signaling receptor binding Source: UniProtKB
  • wide pore channel activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channel, Ion channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-112303 Electric Transmission Across Gap Junctions
R-HSA-844456 The NLRP3 inflammasome

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.25.2.1 the gap junction-forming innexin (innexin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pannexin-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PANX1
Synonyms:MRS1
ORF Names:UNQ2529/PRO6028
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000110218.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:8599 PANX1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608420 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96RD7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 40CytoplasmicSequence analysisAdd BLAST40
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei41 – 61HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini62 – 106ExtracellularSequence analysisAdd BLAST45
Transmembranei107 – 127HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini128 – 217CytoplasmicSequence analysisAdd BLAST90
Transmembranei218 – 238HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini239 – 266ExtracellularSequence analysisAdd BLAST28
Transmembranei267 – 287HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini288 – 426CytoplasmicSequence analysisAdd BLAST139

Keywords - Cellular componenti

Cell junction, Cell membrane, Endoplasmic reticulum, Gap junction, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi255N → Q: Impairs glycosylation. 1 Publication1
Mutagenesisi347C → S: Leaky hemichannel conductive at resting potential. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
24145

Open Targets

More...
OpenTargetsi
ENSG00000110218

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA32929

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3779756

Drug and drug target database

More...
DrugBanki
DB01032 Probenecid

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PANX1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373551

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002084841 – 426Pannexin-1Add BLAST426

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei40S-nitrosocysteineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi255N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei347S-nitrosocysteineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

S-nitrosylation inhibits channel currents and ATP release.By similarity

Keywords - PTMi

Glycoprotein, S-nitrosylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96RD7

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96RD7

MaxQB - The MaxQuant DataBase

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MaxQBi
Q96RD7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96RD7

PeptideAtlas

More...
PeptideAtlasi
Q96RD7

PRoteomics IDEntifications database

More...
PRIDEi
Q96RD7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
77946
77947 [Q96RD7-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96RD7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96RD7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000110218 Expressed in 175 organ(s), highest expression level in left coronary artery

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96RD7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96RD7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA016930

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homohexamer. Forms homomeric or PANX1/PANX2-heteromeric intercellular channels on coexpression in paired Xenopus oocytes (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117295, 12 interactors

Database of interacting proteins

More...
DIPi
DIP-43936N

Protein interaction database and analysis system

More...
IntActi
Q96RD7, 20 interactors

Molecular INTeraction database

More...
MINTi
Q96RD7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000227638

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q96RD7

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q96RD7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the pannexin family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410II5X Eukaryota
ENOG410YA5H LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153972

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG053497

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96RD7

KEGG Orthology (KO)

More...
KOi
K03443

Identification of Orthologs from Complete Genome Data

More...
OMAi
DRFQCKL

Database of Orthologous Groups

More...
OrthoDBi
623546at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96RD7

TreeFam database of animal gene trees

More...
TreeFami
TF333142

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000990 Innexin
IPR039099 Pannexin

The PANTHER Classification System

More...
PANTHERi
PTHR15759 PTHR15759, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00876 Innexin, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51013 PANNEXIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q96RD7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAIAQLATEY VFSDFLLKEP TEPKFKGLRL ELAVDKMVTC IAVGLPLLLI
60 70 80 90 100
SLAFAQEISI GTQISCFSPS SFSWRQAAFV DSYCWAAVQQ KNSLQSESGN
110 120 130 140 150
LPLWLHKFFP YILLLFAILL YLPPLFWRFA AAPHICSDLK FIMEELDKVY
160 170 180 190 200
NRAIKAAKSA RDLDMRDGAC SVPGVTENLG QSLWEVSESH FKYPIVEQYL
210 220 230 240 250
KTKKNSNNLI IKYISCRLLT LIIILLACIY LGYYFSLSSL SDEFVCSIKS
260 270 280 290 300
GILRNDSTVP DQFQCKLIAV GIFQLLSVIN LVVYVLLAPV VVYTLFVPFR
310 320 330 340 350
QKTDVLKVYE ILPTFDVLHF KSEGYNDLSL YNLFLEENIS EVKSYKCLKV
360 370 380 390 400
LENIKSSGQG IDPMLLLTNL GMIKMDVVDG KTPMSAEMRE EQGNQTAELQ
410 420
GMNIDSETKA NNGEKNARQR LLDSSC
Length:426
Mass (Da):48,050
Last modified:January 11, 2011 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i368B48E0709424FB
GO
Isoform 2 (identifier: Q96RD7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     401-404: Missing.

Show »
Length:422
Mass (Da):47,635
Checksum:i91800555C528DED0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti182 – 185Missing in AAK73361 (Ref. 7) Curated4
Sequence conflicti316D → V in AAK73361 (Ref. 7) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0160985Q → H4 PublicationsCorresponds to variant dbSNP:rs1138800Ensembl.1
Natural variantiVAR_031225272I → V. Corresponds to variant dbSNP:rs12793348Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_011476401 – 404Missing in isoform 2. 2 Publications4

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF093239 mRNA Translation: AAC61779.1
AF398509 mRNA Translation: AAK91714.1
AF398508, AF398506, AF398507 Genomic DNA Translation: AAK91713.1
AY048509 Genomic DNA Translation: AAL06604.1
AY359023 mRNA Translation: AAQ89382.1
AK074897 mRNA Translation: BAC11276.1
AP003966 Genomic DNA No translation available.
BC016931 mRNA Translation: AAH16931.1
AH010945 Genomic DNA Translation: AAK73361.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8296.1 [Q96RD7-1]

NCBI Reference Sequences

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RefSeqi
NP_056183.2, NM_015368.3 [Q96RD7-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.591976

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000227638; ENSP00000227638; ENSG00000110218 [Q96RD7-1]
ENST00000436171; ENSP00000411461; ENSG00000110218 [Q96RD7-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
24145

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:24145

UCSC genome browser

More...
UCSCi
uc001peq.4 human [Q96RD7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Pannexin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093239 mRNA Translation: AAC61779.1
AF398509 mRNA Translation: AAK91714.1
AF398508, AF398506, AF398507 Genomic DNA Translation: AAK91713.1
AY048509 Genomic DNA Translation: AAL06604.1
AY359023 mRNA Translation: AAQ89382.1
AK074897 mRNA Translation: BAC11276.1
AP003966 Genomic DNA No translation available.
BC016931 mRNA Translation: AAH16931.1
AH010945 Genomic DNA Translation: AAK73361.1
CCDSiCCDS8296.1 [Q96RD7-1]
RefSeqiNP_056183.2, NM_015368.3 [Q96RD7-1]
UniGeneiHs.591976

3D structure databases

ProteinModelPortaliQ96RD7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117295, 12 interactors
DIPiDIP-43936N
IntActiQ96RD7, 20 interactors
MINTiQ96RD7
STRINGi9606.ENSP00000227638

Chemistry databases

BindingDBiQ96RD7
ChEMBLiCHEMBL3779756
DrugBankiDB01032 Probenecid

Protein family/group databases

TCDBi1.A.25.2.1 the gap junction-forming innexin (innexin) family

PTM databases

iPTMnetiQ96RD7
PhosphoSitePlusiQ96RD7

Polymorphism and mutation databases

BioMutaiPANX1
DMDMi317373551

Proteomic databases

EPDiQ96RD7
jPOSTiQ96RD7
MaxQBiQ96RD7
PaxDbiQ96RD7
PeptideAtlasiQ96RD7
PRIDEiQ96RD7
ProteomicsDBi77946
77947 [Q96RD7-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000227638; ENSP00000227638; ENSG00000110218 [Q96RD7-1]
ENST00000436171; ENSP00000411461; ENSG00000110218 [Q96RD7-2]
GeneIDi24145
KEGGihsa:24145
UCSCiuc001peq.4 human [Q96RD7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
24145
DisGeNETi24145
EuPathDBiHostDB:ENSG00000110218.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PANX1

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0010028
HGNCiHGNC:8599 PANX1
HPAiHPA016930
MIMi608420 gene
neXtProtiNX_Q96RD7
OpenTargetsiENSG00000110218
PharmGKBiPA32929

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410II5X Eukaryota
ENOG410YA5H LUCA
GeneTreeiENSGT00940000153972
HOVERGENiHBG053497
InParanoidiQ96RD7
KOiK03443
OMAiDRFQCKL
OrthoDBi623546at2759
PhylomeDBiQ96RD7
TreeFamiTF333142

Enzyme and pathway databases

ReactomeiR-HSA-112303 Electric Transmission Across Gap Junctions
R-HSA-844456 The NLRP3 inflammasome

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PANX1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PANX1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
24145

Protein Ontology

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PROi
PR:Q96RD7

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000110218 Expressed in 175 organ(s), highest expression level in left coronary artery
ExpressionAtlasiQ96RD7 baseline and differential
GenevisibleiQ96RD7 HS

Family and domain databases

InterProiView protein in InterPro
IPR000990 Innexin
IPR039099 Pannexin
PANTHERiPTHR15759 PTHR15759, 1 hit
PfamiView protein in Pfam
PF00876 Innexin, 1 hit
PROSITEiView protein in PROSITE
PS51013 PANNEXIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPANX1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96RD7
Secondary accession number(s): O75968
, Q543A0, Q6UW26, Q96AM9, Q96L77, Q96RS5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 11, 2011
Last modified: February 13, 2019
This is version 150 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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