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Protein

Pannexin-1

Gene

PANX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Structural component of the gap junctions and the hemichannels. May play a role as a Ca2+-leak channel to regulate ER Ca2+ homeostasis.2 Publications

GO - Molecular functioni

  • actin filament binding Source: Ensembl
  • calcium channel activity Source: UniProtKB
  • gap junction hemi-channel activity Source: UniProtKB
  • ion channel binding Source: Ensembl
  • leak channel activity Source: UniProtKB
  • protease binding Source: Ensembl
  • protein heterodimerization activity Source: Ensembl
  • scaffold protein binding Source: Ensembl
  • signaling receptor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionCalcium channel, Ion channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Enzyme and pathway databases

ReactomeiR-HSA-112303 Electric Transmission Across Gap Junctions
R-HSA-844456 The NLRP3 inflammasome

Protein family/group databases

TCDBi1.A.25.2.1 the gap junction-forming innexin (innexin) family

Names & Taxonomyi

Protein namesi
Recommended name:
Pannexin-1
Gene namesi
Name:PANX1
Synonyms:MRS1
ORF Names:UNQ2529/PRO6028
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000110218.8
HGNCiHGNC:8599 PANX1
MIMi608420 gene
neXtProtiNX_Q96RD7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 40CytoplasmicSequence analysisAdd BLAST40
Transmembranei41 – 61HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini62 – 106ExtracellularSequence analysisAdd BLAST45
Transmembranei107 – 127HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini128 – 217CytoplasmicSequence analysisAdd BLAST90
Transmembranei218 – 238HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini239 – 266ExtracellularSequence analysisAdd BLAST28
Transmembranei267 – 287HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini288 – 426CytoplasmicSequence analysisAdd BLAST139

Keywords - Cellular componenti

Cell junction, Cell membrane, Endoplasmic reticulum, Gap junction, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi255N → Q: Impairs glycosylation. 1 Publication1
Mutagenesisi347C → S: Leaky hemichannel conductive at resting potential. 1 Publication1

Organism-specific databases

DisGeNETi24145
OpenTargetsiENSG00000110218
PharmGKBiPA32929

Chemistry databases

ChEMBLiCHEMBL3779756
DrugBankiDB01032 Probenecid

Polymorphism and mutation databases

BioMutaiPANX1
DMDMi317373551

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002084841 – 426Pannexin-1Add BLAST426

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei40S-nitrosocysteineBy similarity1
Glycosylationi255N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei347S-nitrosocysteineBy similarity1

Post-translational modificationi

S-nitrosylation inhibits channel currents and ATP release.By similarity

Keywords - PTMi

Glycoprotein, S-nitrosylation

Proteomic databases

EPDiQ96RD7
MaxQBiQ96RD7
PaxDbiQ96RD7
PeptideAtlasiQ96RD7
PRIDEiQ96RD7
ProteomicsDBi77946
77947 [Q96RD7-2]

PTM databases

iPTMnetiQ96RD7
PhosphoSitePlusiQ96RD7

Expressioni

Gene expression databases

BgeeiENSG00000110218 Expressed in 175 organ(s), highest expression level in left coronary artery
CleanExiHS_PANX1
ExpressionAtlasiQ96RD7 baseline and differential
GenevisibleiQ96RD7 HS

Organism-specific databases

HPAiHPA016930

Interactioni

Subunit structurei

Homohexamer. Forms homomeric or PANX1/PANX2-heteromeric intercellular channels on coexpression in paired Xenopus oocytes (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117295, 12 interactors
DIPiDIP-43936N
IntActiQ96RD7, 19 interactors
MINTiQ96RD7
STRINGi9606.ENSP00000227638

Chemistry databases

BindingDBiQ96RD7

Structurei

3D structure databases

ProteinModelPortaliQ96RD7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pannexin family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II5X Eukaryota
ENOG410YA5H LUCA
GeneTreeiENSGT00390000009703
HOVERGENiHBG053497
InParanoidiQ96RD7
KOiK03443
OMAiDRFQCKL
OrthoDBiEOG091G086D
PhylomeDBiQ96RD7
TreeFamiTF333142

Family and domain databases

InterProiView protein in InterPro
IPR000990 Innexin
IPR039099 Pannexin
PANTHERiPTHR15759 PTHR15759, 1 hit
PfamiView protein in Pfam
PF00876 Innexin, 1 hit
PROSITEiView protein in PROSITE
PS51013 PANNEXIN, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q96RD7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAIAQLATEY VFSDFLLKEP TEPKFKGLRL ELAVDKMVTC IAVGLPLLLI
60 70 80 90 100
SLAFAQEISI GTQISCFSPS SFSWRQAAFV DSYCWAAVQQ KNSLQSESGN
110 120 130 140 150
LPLWLHKFFP YILLLFAILL YLPPLFWRFA AAPHICSDLK FIMEELDKVY
160 170 180 190 200
NRAIKAAKSA RDLDMRDGAC SVPGVTENLG QSLWEVSESH FKYPIVEQYL
210 220 230 240 250
KTKKNSNNLI IKYISCRLLT LIIILLACIY LGYYFSLSSL SDEFVCSIKS
260 270 280 290 300
GILRNDSTVP DQFQCKLIAV GIFQLLSVIN LVVYVLLAPV VVYTLFVPFR
310 320 330 340 350
QKTDVLKVYE ILPTFDVLHF KSEGYNDLSL YNLFLEENIS EVKSYKCLKV
360 370 380 390 400
LENIKSSGQG IDPMLLLTNL GMIKMDVVDG KTPMSAEMRE EQGNQTAELQ
410 420
GMNIDSETKA NNGEKNARQR LLDSSC
Length:426
Mass (Da):48,050
Last modified:January 11, 2011 - v4
Checksum:i368B48E0709424FB
GO
Isoform 2 (identifier: Q96RD7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     401-404: Missing.

Show »
Length:422
Mass (Da):47,635
Checksum:i91800555C528DED0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti182 – 185Missing in AAK73361 (Ref. 7) Curated4
Sequence conflicti316D → V in AAK73361 (Ref. 7) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0160985Q → H4 PublicationsCorresponds to variant dbSNP:rs1138800Ensembl.1
Natural variantiVAR_031225272I → V. Corresponds to variant dbSNP:rs12793348Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011476401 – 404Missing in isoform 2. 2 Publications4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093239 mRNA Translation: AAC61779.1
AF398509 mRNA Translation: AAK91714.1
AF398508, AF398506, AF398507 Genomic DNA Translation: AAK91713.1
AY048509 Genomic DNA Translation: AAL06604.1
AY359023 mRNA Translation: AAQ89382.1
AK074897 mRNA Translation: BAC11276.1
AP003966 Genomic DNA No translation available.
BC016931 mRNA Translation: AAH16931.1
AH010945 Genomic DNA Translation: AAK73361.1
CCDSiCCDS8296.1 [Q96RD7-1]
RefSeqiNP_056183.2, NM_015368.3 [Q96RD7-1]
UniGeneiHs.591976

Genome annotation databases

EnsembliENST00000227638; ENSP00000227638; ENSG00000110218 [Q96RD7-1]
ENST00000436171; ENSP00000411461; ENSG00000110218 [Q96RD7-2]
GeneIDi24145
KEGGihsa:24145
UCSCiuc001peq.4 human [Q96RD7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Pannexin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093239 mRNA Translation: AAC61779.1
AF398509 mRNA Translation: AAK91714.1
AF398508, AF398506, AF398507 Genomic DNA Translation: AAK91713.1
AY048509 Genomic DNA Translation: AAL06604.1
AY359023 mRNA Translation: AAQ89382.1
AK074897 mRNA Translation: BAC11276.1
AP003966 Genomic DNA No translation available.
BC016931 mRNA Translation: AAH16931.1
AH010945 Genomic DNA Translation: AAK73361.1
CCDSiCCDS8296.1 [Q96RD7-1]
RefSeqiNP_056183.2, NM_015368.3 [Q96RD7-1]
UniGeneiHs.591976

3D structure databases

ProteinModelPortaliQ96RD7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117295, 12 interactors
DIPiDIP-43936N
IntActiQ96RD7, 19 interactors
MINTiQ96RD7
STRINGi9606.ENSP00000227638

Chemistry databases

BindingDBiQ96RD7
ChEMBLiCHEMBL3779756
DrugBankiDB01032 Probenecid

Protein family/group databases

TCDBi1.A.25.2.1 the gap junction-forming innexin (innexin) family

PTM databases

iPTMnetiQ96RD7
PhosphoSitePlusiQ96RD7

Polymorphism and mutation databases

BioMutaiPANX1
DMDMi317373551

Proteomic databases

EPDiQ96RD7
MaxQBiQ96RD7
PaxDbiQ96RD7
PeptideAtlasiQ96RD7
PRIDEiQ96RD7
ProteomicsDBi77946
77947 [Q96RD7-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000227638; ENSP00000227638; ENSG00000110218 [Q96RD7-1]
ENST00000436171; ENSP00000411461; ENSG00000110218 [Q96RD7-2]
GeneIDi24145
KEGGihsa:24145
UCSCiuc001peq.4 human [Q96RD7-1]

Organism-specific databases

CTDi24145
DisGeNETi24145
EuPathDBiHostDB:ENSG00000110218.8
GeneCardsiPANX1
H-InvDBiHIX0010028
HGNCiHGNC:8599 PANX1
HPAiHPA016930
MIMi608420 gene
neXtProtiNX_Q96RD7
OpenTargetsiENSG00000110218
PharmGKBiPA32929
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II5X Eukaryota
ENOG410YA5H LUCA
GeneTreeiENSGT00390000009703
HOVERGENiHBG053497
InParanoidiQ96RD7
KOiK03443
OMAiDRFQCKL
OrthoDBiEOG091G086D
PhylomeDBiQ96RD7
TreeFamiTF333142

Enzyme and pathway databases

ReactomeiR-HSA-112303 Electric Transmission Across Gap Junctions
R-HSA-844456 The NLRP3 inflammasome

Miscellaneous databases

ChiTaRSiPANX1 human
GeneWikiiPANX1
GenomeRNAii24145
PROiPR:Q96RD7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000110218 Expressed in 175 organ(s), highest expression level in left coronary artery
CleanExiHS_PANX1
ExpressionAtlasiQ96RD7 baseline and differential
GenevisibleiQ96RD7 HS

Family and domain databases

InterProiView protein in InterPro
IPR000990 Innexin
IPR039099 Pannexin
PANTHERiPTHR15759 PTHR15759, 1 hit
PfamiView protein in Pfam
PF00876 Innexin, 1 hit
PROSITEiView protein in PROSITE
PS51013 PANNEXIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPANX1_HUMAN
AccessioniPrimary (citable) accession number: Q96RD7
Secondary accession number(s): O75968
, Q543A0, Q6UW26, Q96AM9, Q96L77, Q96RS5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 11, 2011
Last modified: November 7, 2018
This is version 147 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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