PANX1

Functionⁱ

Structural component of the gap junctions and the hemichannels. May play a role as a Ca²⁺-leak channel to regulate ER Ca²⁺ homeostasis.2 Publications

GO - Molecular functionⁱ

actin filament binding Source: Ensembl
calcium channel activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16908669
gap junction hemi-channel activity
Source: UniProtKB
Inferred from direct assayⁱ
- 17715132
ion channel binding Source: Ensembl
leak channel activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16908669
protease binding Source: Ensembl
protein heterodimerization activity Source: Ensembl
scaffold protein binding Source: Ensembl
signaling receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 17036048

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

calcium ion transport
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16908669
cation transport
Source: BHF-UCL
Inferred from direct assayⁱ
- 17036048
cell-cell signaling
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of interleukin-1 alpha secretion Source: Ensembl
positive regulation of interleukin-1 beta secretion
Source: BHF-UCL
Inferred from direct assayⁱ
- 17036048
protein hexamerization
Source: UniProtKB
Inferred from direct assayⁱ
- 17715132
response to ATP Source: Ensembl
response to ischemia Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Calcium channel, Ion channel
Biological process	Calcium transport, Ion transport, Transport
Ligand	Calcium

Enzyme and pathway databases

Reactomeⁱ	R-HSA-112303 Electric Transmission Across Gap Junctions R-HSA-844456 The NLRP3 inflammasome

Reactomeⁱ

R-HSA-112303 Electric Transmission Across Gap Junctions
R-HSA-844456 The NLRP3 inflammasome

Protein family/group databases

TCDBⁱ	1.A.25.2.1 the gap junction-forming innexin (innexin) family

TCDBⁱ

1.A.25.2.1 the gap junction-forming innexin (innexin) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Pannexin-1
Gene namesⁱ	Name:PANX1 Synonyms:MRS1 ORF Names:UNQ2529/PRO6028
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000110218.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8599 PANX1
MIMⁱ	608420 gene
neXtProtⁱ	NX_Q96RD7

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 40	CytoplasmicSequence analysisAdd BLAST	40
Transmembraneⁱ	41 – 61	HelicalPROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	62 – 106	ExtracellularSequence analysisAdd BLAST	45
Transmembraneⁱ	107 – 127	HelicalPROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	128 – 217	CytoplasmicSequence analysisAdd BLAST	90
Transmembraneⁱ	218 – 238	HelicalPROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	239 – 266	ExtracellularSequence analysisAdd BLAST	28
Transmembraneⁱ	267 – 287	HelicalPROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	288 – 426	CytoplasmicSequence analysisAdd BLAST	139

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Endoplasmic reticulum, Gap junction, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	255	N → Q: Impairs glycosylation. 1 Publication		1
Mutagenesisⁱ	347	C → S: Leaky hemichannel conductive at resting potential. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	24145
Open Targets More...OpenTargetsⁱ	ENSG00000110218
PharmGKBⁱ	PA32929

Chemistry databases

ChEMBLⁱ	CHEMBL3779756
Drug and drug target database More...DrugBankⁱ	DB01032 Probenecid

Polymorphism and mutation databases

BioMutaⁱ	PANX1
DMDMⁱ	317373551

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000208484	1 – 426	Pannexin-1Add BLAST		426

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	40	S-nitrosocysteineBy similarity	1
Glycosylationⁱ	255	N-linked (GlcNAc...) asparagine1 Publication	1
Modified residueⁱ	347	S-nitrosocysteineBy similarity	1

Post-translational modificationⁱ

S-nitrosylation inhibits channel currents and ATP release.By similarity

Keywords - PTMⁱ

Glycoprotein, S-nitrosylation

Proteomic databases

EPDⁱ	Q96RD7
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96RD7
PaxDbⁱ	Q96RD7
PeptideAtlas More...PeptideAtlasⁱ	Q96RD7
PRIDEⁱ	Q96RD7
ProteomicsDBⁱ	77946 77947 [Q96RD7-2]

PTM databases

iPTMnetⁱ	Q96RD7
PhosphoSitePlusⁱ	Q96RD7

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000110218 Expressed in 175 organ(s), highest expression level in left coronary artery
CleanExⁱ	HS_PANX1
ExpressionAtlasⁱ	Q96RD7 baseline and differential
Genevisibleⁱ	Q96RD7 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA016930

HPAⁱ

HPA016930

Interactionⁱ

Subunit structureⁱ

Homohexamer. Forms homomeric or PANX1/PANX2-heteromeric intercellular channels on coexpression in paired Xenopus oocytes (By similarity).By similarity

GO - Molecular functionⁱ

actin filament binding Source: Ensembl
ion channel binding Source: Ensembl
protease binding Source: Ensembl
protein heterodimerization activity Source: Ensembl
scaffold protein binding Source: Ensembl
signaling receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 17036048

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	117295, 12 interactors
Database of interacting proteins More...DIPⁱ	DIP-43936N
IntActⁱ	Q96RD7, 19 interactors
Molecular INTeraction database More...MINTⁱ	Q96RD7
STRINGⁱ	9606.ENSP00000227638

Chemistry databases

BindingDBⁱ

Q96RD7

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96RD7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the pannexin family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410II5X Eukaryota ENOG410YA5H LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000009703
HOVERGENⁱ	HBG053497
InParanoidⁱ	Q96RD7
KEGG Orthology (KO) More...KOⁱ	K03443
OMAⁱ	DRFQCKL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G086D
PhylomeDBⁱ	Q96RD7
TreeFamⁱ	TF333142

Family and domain databases

InterProⁱ	View protein in InterPro IPR000990 Innexin IPR039099 Pannexin
PANTHERⁱ	PTHR15759 PTHR15759, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00876 Innexin, 1 hit
PROSITEⁱ	View protein in PROSITE PS51013 PANNEXIN, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q96RD7-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAIAQLATEY VFSDFLLKEP TEPKFKGLRL ELAVDKMVTC IAVGLPLLLI 
        60         70         80         90        100
SLAFAQEISI GTQISCFSPS SFSWRQAAFV DSYCWAAVQQ KNSLQSESGN 
       110        120        130        140        150
LPLWLHKFFP YILLLFAILL YLPPLFWRFA AAPHICSDLK FIMEELDKVY 
       160        170        180        190        200
NRAIKAAKSA RDLDMRDGAC SVPGVTENLG QSLWEVSESH FKYPIVEQYL 
       210        220        230        240        250
KTKKNSNNLI IKYISCRLLT LIIILLACIY LGYYFSLSSL SDEFVCSIKS 
       260        270        280        290        300
GILRNDSTVP DQFQCKLIAV GIFQLLSVIN LVVYVLLAPV VVYTLFVPFR 
       310        320        330        340        350
QKTDVLKVYE ILPTFDVLHF KSEGYNDLSL YNLFLEENIS EVKSYKCLKV 
       360        370        380        390        400
LENIKSSGQG IDPMLLLTNL GMIKMDVVDG KTPMSAEMRE EQGNQTAELQ 
       410        420 
GMNIDSETKA NNGEKNARQR LLDSSC

Length:426

Mass (Da):48,050

Last modified:January 11, 2011 - v4

Checksum:ⁱ368B48E0709424FB

GO

Isoform 2 (identifier: Q96RD7-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
401-404: Missing.

« Hide

        10         20         30         40         50
MAIAQLATEY VFSDFLLKEP TEPKFKGLRL ELAVDKMVTC IAVGLPLLLI 
        60         70         80         90        100
SLAFAQEISI GTQISCFSPS SFSWRQAAFV DSYCWAAVQQ KNSLQSESGN 
       110        120        130        140        150
LPLWLHKFFP YILLLFAILL YLPPLFWRFA AAPHICSDLK FIMEELDKVY 
       160        170        180        190        200
NRAIKAAKSA RDLDMRDGAC SVPGVTENLG QSLWEVSESH FKYPIVEQYL 
       210        220        230        240        250
KTKKNSNNLI IKYISCRLLT LIIILLACIY LGYYFSLSSL SDEFVCSIKS 
       260        270        280        290        300
GILRNDSTVP DQFQCKLIAV GIFQLLSVIN LVVYVLLAPV VVYTLFVPFR 
       310        320        330        340        350
QKTDVLKVYE ILPTFDVLHF KSEGYNDLSL YNLFLEENIS EVKSYKCLKV 
       360        370        380        390        400
LENIKSSGQG IDPMLLLTNL GMIKMDVVDG KTPMSAEMRE EQGNQTAELQ 
       410        420 
DSETKANNGE KNARQRLLDS SC

Show »

Length:422

Mass (Da):47,635

Checksum:ⁱ91800555C528DED0

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	182 – 185	Missing in AAK73361 (Ref. 7) Curated		4
Sequence conflictⁱ	316	D → V in AAK73361 (Ref. 7) Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_016098	5	Q → H4 PublicationsCorresponds to variant dbSNP:rs1138800Ensembl.		1
Natural variantⁱVAR_031225	272	I → V. Corresponds to variant dbSNP:rs12793348Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_011476	401 – 404	Missing in isoform 2. 2 Publications		4

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF093239 mRNA Translation: AAC61779.1 AF398509 mRNA Translation: AAK91714.1 AF398508, AF398506, AF398507 Genomic DNA Translation: AAK91713.1 AY048509 Genomic DNA Translation: AAL06604.1 AY359023 mRNA Translation: AAQ89382.1 AK074897 mRNA Translation: BAC11276.1 AP003966 Genomic DNA No translation available. BC016931 mRNA Translation: AAH16931.1 AH010945 Genomic DNA Translation: AAK73361.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8296.1 [Q96RD7-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_056183.2, NM_015368.3 [Q96RD7-1]
UniGeneⁱ	Hs.591976

Genome annotation databases

Ensemblⁱ	ENST00000227638; ENSP00000227638; ENSG00000110218 [Q96RD7-1] ENST00000436171; ENSP00000411461; ENSG00000110218 [Q96RD7-2]
GeneIDⁱ	24145
KEGGⁱ	hsa:24145
UCSC genome browser More...UCSCⁱ	uc001peq.4 human [Q96RD7-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96RD7	Pannexin		HUMAN		426	UniRef100_Q96RD7
UPI000387CD7C		HUMAN		284

Protein	Similar proteins		Species	Score	Length	Source
Q96RD7	Pannexin-1		PONAB		426	UniRef90_Q96RD7
Pannexin		HUMAN		426
Pannexin		PROCO		427
Pannexin		HETGA		427
Pannexin		CAVPO		427
+44

Protein	Similar proteins		Species	Score	Length	Source
Q96RD7	Pannexin-1		PONAB		426	UniRef50_Q96RD7
Pannexin		HUMAN		426
Pannexin		SAIBB		427
Pannexin		CALJA		427
Pannexin		OTOGA		427
+226

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

Pannexin entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF093239 mRNA Translation: AAC61779.1 AF398509 mRNA Translation: AAK91714.1 AF398508, AF398506, AF398507 Genomic DNA Translation: AAK91713.1 AY048509 Genomic DNA Translation: AAL06604.1 AY359023 mRNA Translation: AAQ89382.1 AK074897 mRNA Translation: BAC11276.1 AP003966 Genomic DNA No translation available. BC016931 mRNA Translation: AAH16931.1 AH010945 Genomic DNA Translation: AAK73361.1
CCDSⁱ	CCDS8296.1 [Q96RD7-1]
RefSeqⁱ	NP_056183.2, NM_015368.3 [Q96RD7-1]
UniGeneⁱ	Hs.591976

3D structure databases

ProteinModelPortalⁱ	Q96RD7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117295, 12 interactors
DIPⁱ	DIP-43936N
IntActⁱ	Q96RD7, 19 interactors
MINTⁱ	Q96RD7
STRINGⁱ	9606.ENSP00000227638

Chemistry databases

BindingDBⁱ	Q96RD7
ChEMBLⁱ	CHEMBL3779756
DrugBankⁱ	DB01032 Probenecid

Protein family/group databases

TCDBⁱ	1.A.25.2.1 the gap junction-forming innexin (innexin) family

TCDBⁱ

1.A.25.2.1 the gap junction-forming innexin (innexin) family

PTM databases

iPTMnetⁱ	Q96RD7
PhosphoSitePlusⁱ	Q96RD7

Polymorphism and mutation databases

BioMutaⁱ	PANX1
DMDMⁱ	317373551

Proteomic databases

EPDⁱ	Q96RD7
MaxQBⁱ	Q96RD7
PaxDbⁱ	Q96RD7
PeptideAtlasⁱ	Q96RD7
PRIDEⁱ	Q96RD7
ProteomicsDBⁱ	77946 77947 [Q96RD7-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000227638; ENSP00000227638; ENSG00000110218 [Q96RD7-1] ENST00000436171; ENSP00000411461; ENSG00000110218 [Q96RD7-2]
GeneIDⁱ	24145
KEGGⁱ	hsa:24145
UCSCⁱ	uc001peq.4 human [Q96RD7-1]

Organism-specific databases

CTDⁱ	24145
DisGeNETⁱ	24145
EuPathDBⁱ	HostDB:ENSG00000110218.8
GeneCardsⁱ	PANX1
H-InvDBⁱ	HIX0010028
HGNCⁱ	HGNC:8599 PANX1
HPAⁱ	HPA016930
MIMⁱ	608420 gene
neXtProtⁱ	NX_Q96RD7
OpenTargetsⁱ	ENSG00000110218
PharmGKBⁱ	PA32929
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410II5X Eukaryota ENOG410YA5H LUCA
GeneTreeⁱ	ENSGT00390000009703
HOVERGENⁱ	HBG053497
InParanoidⁱ	Q96RD7
KOⁱ	K03443
OMAⁱ	DRFQCKL
OrthoDBⁱ	EOG091G086D
PhylomeDBⁱ	Q96RD7
TreeFamⁱ	TF333142

Enzyme and pathway databases

Reactomeⁱ	R-HSA-112303 Electric Transmission Across Gap Junctions R-HSA-844456 The NLRP3 inflammasome

Reactomeⁱ

R-HSA-112303 Electric Transmission Across Gap Junctions
R-HSA-844456 The NLRP3 inflammasome

Miscellaneous databases

ChiTaRSⁱ	PANX1 human
GeneWikiⁱ	PANX1
GenomeRNAiⁱ	24145
Protein Ontology More...PROⁱ	PR:Q96RD7
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000110218 Expressed in 175 organ(s), highest expression level in left coronary artery
CleanExⁱ	HS_PANX1
ExpressionAtlasⁱ	Q96RD7 baseline and differential
Genevisibleⁱ	Q96RD7 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000990 Innexin IPR039099 Pannexin
PANTHERⁱ	PTHR15759 PTHR15759, 1 hit
Pfamⁱ	View protein in Pfam PF00876 Innexin, 1 hit
PROSITEⁱ	View protein in PROSITE PS51013 PANNEXIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PANX1_HUMAN
Accessionⁱ	Q96RD7Primary (citable) accession number: Q96RD7 Secondary accession number(s): O75968 , Q543A0, Q6UW26, Q96AM9, Q96L77, Q96RS5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
	Last sequence update:	January 11, 2011
	Last modified:	November 7, 2018
	This is version 147 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM

UniProtKB

UniParc

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UniRef

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Annotation systems

Supporting data

UniProtKB - Q96RD7 (PANX1_HUMAN)

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Pannexin-1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Plasma membrane

Other locations

Endoplasmic reticulum

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ