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Protein

Olfactory receptor 2A14

Gene

OR2A14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2A14
Alternative name(s):
OST182
Olfactory receptor 2A6
Olfactory receptor OR7-12
Gene namesi
Name:OR2A14
Synonyms:OR2A14P, OR2A6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000221938.3
HGNCiHGNC:15084 OR2A14
neXtProtiNX_Q96R47

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24ExtracellularSequence analysisAdd BLAST24
Transmembranei25 – 48Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini49 – 56CytoplasmicSequence analysis8
Transmembranei57 – 78Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini79 – 99ExtracellularSequence analysisAdd BLAST21
Transmembranei100 – 119Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini120 – 138CytoplasmicSequence analysisAdd BLAST19
Transmembranei139 – 157Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini158 – 194ExtracellularSequence analysisAdd BLAST37
Transmembranei195 – 218Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini219 – 235CytoplasmicSequence analysisAdd BLAST17
Transmembranei236 – 258Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 291Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini292 – 310CytoplasmicSequence analysisAdd BLAST19

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32106

Polymorphism and mutation databases

BioMutaiOR2A14
DMDMi296439489

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504581 – 310Olfactory receptor 2A14Add BLAST310

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi96 ↔ 188PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96R47
PRIDEiQ96R47
ProteomicsDBi77929

PTM databases

iPTMnetiQ96R47
PhosphoSitePlusiQ96R47

Expressioni

Gene expression databases

BgeeiENSG00000221938
CleanExiHS_OR2A14
ExpressionAtlasiQ96R47 differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000386137

Structurei

3D structure databases

ProteinModelPortaliQ96R47
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHHV Eukaryota
ENOG410Z9E8 LUCA
GeneTreeiENSGT00820000127003
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ96R47
KOiK04257
OrthoDBiEOG091G0CU6
PhylomeDBiQ96R47
TreeFamiTF337251

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q96R47-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGNKTWITD ITLPRFQVGP ALEILLCGLF SAFYTLTLLG NGVIFGIICL
60 70 80 90 100
DCKLHTPMYF FLSHLAIVDI SYASNYVPKM LTNLMNQEST ISFFPCIMQT
110 120 130 140 150
FLYLAFAHVE CLILVVMSYD RYADICHPLR YNSLMSWRVC TVLAVASWVF
160 170 180 190 200
SFLLALVPLV LILSLPFCGP HEINHFFCEI LSVLKLACAD TWLNQVVIFA
210 220 230 240 250
ACVFILVGPL CLVLVSYLRI LAAILRIQSG EGRRKAFSTC SSHLCVVGLF
260 270 280 290 300
FGSAIVTYMA PKSRHPEEQQ KVLSLFYSLF NPMLNPLIYS LRNAEVKGAL
310
RRALRKERLT
Length:310
Mass (Da):34,993
Last modified:May 18, 2010 - v4
Checksum:i79C30FF4D573BEC8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti177Missing in ALI87723 (PubMed:25977809).Curated1
Sequence conflicti177Missing in AAK95081 (PubMed:12213199).Curated1
Sequence conflicti177Missing in EAL23799 (PubMed:12690205).Curated1
Sequence conflicti177Missing in AAI36890 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060477133S → I5 PublicationsCorresponds to variant dbSNP:rs2961160Ensembl.1
Natural variantiVAR_060478164S → R2 PublicationsCorresponds to variant dbSNP:rs2961161Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065693 Genomic DNA Translation: BAC05916.1
AF399596 Genomic DNA Translation: AAK95081.1
KP290564 Genomic DNA Translation: ALI87723.1
AC091768 Genomic DNA No translation available.
CH236959 Genomic DNA Translation: EAL23799.1
CH878732 Genomic DNA Translation: EAW55633.1
BC136889 mRNA Translation: AAI36890.1
BK004421 Genomic DNA Translation: DAA04819.1
CCDSiCCDS43672.1
RefSeqiNP_001001659.1, NM_001001659.1
UniGeneiHs.534547

Genome annotation databases

EnsembliENST00000408899; ENSP00000386137; ENSG00000221938
ENST00000641068; ENSP00000493353; ENSG00000221938
GeneIDi135941
KEGGihsa:135941
UCSCiuc011kua.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiO2A14_HUMAN
AccessioniPrimary (citable) accession number: Q96R47
Secondary accession number(s): A4D2G5, Q6IF41, Q8NGT8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 18, 2010
Last modified: June 20, 2018
This is version 129 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

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