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Entry version 152 (16 Oct 2019)
Sequence version 2 (10 May 2004)
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Protein

Sperm-associated antigen 5

Gene

SPAG5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457).1 Publication8 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • microtubule binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q96R06

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sperm-associated antigen 5
Alternative name(s):
Astrin
Deepest
Mitotic spindle-associated protein p126
Short name:
MAP126
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPAG5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13452 SPAG5

Online Mendelian Inheritance in Man (OMIM)

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MIMi
615562 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96R06

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi111T → A: Decreased phosphorylation by GSK3-beta. Partial loss of spindle association; when associated with A-937, A974 and A-978. 1 Publication1
Mutagenesisi937T → A: Decreased phosphorylation by GSK3-beta. Partial loss of spindle association; when associated with A-111, A974 and A-978. 1 Publication1
Mutagenesisi974S → A: Decreased phosphorylation by GSK3-beta; when associated with A-978. Partial loss of spindle association; when associated with A-111, A937 and A-978. 1 Publication1
Mutagenesisi978T → A: Decreased phosphorylation by GSK3-beta; when associated with A-97A. Partial loss of spindle association; when associated with A-111, A-937 and A-974. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
10615

Open Targets

More...
OpenTargetsi
ENSG00000076382

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134868542

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96R06

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SPAG5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
47117278

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000720931 – 1193Sperm-associated antigen 5Add BLAST1193

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei12PhosphoserineBy similarity1
Modified residuei14PhosphoserineBy similarity1
Modified residuei43PhosphoserineCombined sources1
Modified residuei62PhosphoserineCombined sources1
Modified residuei66PhosphoserineCombined sources1
Modified residuei111Phosphothreonine; by GSK3-beta1 Publication1
Modified residuei135PhosphoserineCombined sources1
Modified residuei159PhosphoserineCombined sources1
Modified residuei334PhosphoserineCombined sources1
Modified residuei336PhosphothreonineCombined sources1
Modified residuei341PhosphoserineCombined sources1
Modified residuei353PhosphoserineCombined sources1
Modified residuei362PhosphoserineCombined sources1
Modified residuei937Phosphothreonine; by GSK3-beta1 Publication1
Modified residuei974Phosphoserine; by GSK3-beta1 Publication1
Modified residuei978Phosphothreonine; by GSK3-beta1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by AURKA.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96R06

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96R06

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q96R06

MaxQB - The MaxQuant DataBase

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MaxQBi
Q96R06

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96R06

PeptideAtlas

More...
PeptideAtlasi
Q96R06

PRoteomics IDEntifications database

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PRIDEi
Q96R06

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
77922

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96R06

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96R06

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in testis. Detected at low levels in placenta, liver, pancreas, thymus and colon.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is cell cycle-regulated, with an increase from prophase to cytokinesis and return to basal levels at the next G1 phase.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000076382 Expressed in 154 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96R06 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96R06 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA022008
HPA022479

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer, with a globular head domain and a long stalk. Homooligomer; the globular head domains associate, resulting in aster-like structures. Binds to microtubules in the mitotic spindle (PubMed:27462074).

Interacts with DCLRE1B/Apollo.

Part of an astrin (SPAG5)-kinastrin (SKAP) complex containing KNSTRN, SPAG5, PLK1, DYNLL1 and SGO2.

Interacts with KNSTRN.

Interacts with RPTOR; this interaction competes with RPTOR binding to MTOR, resulting in decreased mTORC1 formation.

Interacts with G3BP1. The complex formed with G3BP1 AND RPTOR is increased by oxidative stress.

Interacts with OSBPL8, PCM1 and CDK5RAP2 (PubMed:24424245, PubMed:26297806).

Interacts (via C-terminus) with NUMA1 (via C-terminus); this interaction promotes the recruitment of SPAG5 to the microtubules at spindle poles in a dynein-dynactin-dependent manner (PubMed:27462074).

9 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
115861, 103 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q96R06

Database of interacting proteins

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DIPi
DIP-30998N

Protein interaction database and analysis system

More...
IntActi
Q96R06, 114 interactors

Molecular INTeraction database

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MINTi
Q96R06

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000323300

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96R06

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni482 – 850Interaction with KNSTRN1 PublicationAdd BLAST369

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili545 – 608Sequence analysisAdd BLAST64
Coiled coili759 – 868Sequence analysisAdd BLAST110
Coiled coili979 – 1174Sequence analysisAdd BLAST196

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi617 – 789Gln-richAdd BLAST173

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IIA9 Eukaryota
ENOG410YG9P LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00400000022377

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000049113

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96R06

KEGG Orthology (KO)

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KOi
K21764

Identification of Orthologs from Complete Genome Data

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OMAi
PWMSPLA

Database of Orthologous Groups

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OrthoDBi
257437at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q96R06

TreeFam database of animal gene trees

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TreeFami
TF336280

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR028728 Astrin

The PANTHER Classification System

More...
PANTHERi
PTHR15347 PTHR15347, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

Q96R06-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWRVKKLSLS LSPSPQTGKP SMRTPLRELT LQPGALTNSG KRSPACSSLT
60 70 80 90 100
PSLCKLGLQE GSNNSSPVDF VNNKRTDLSS EHFSHSSKWL ETCQHESDEQ
110 120 130 140 150
PLDPIPQISS TPKTSEEAVD PLGNYMVKTI VLVPSPLGQQ QDMIFEARLD
160 170 180 190 200
TMAETNSISL NGPLRTDDLV REEVAPCMGD RFSEVAAVSE KPIFQESPSH
210 220 230 240 250
LLEESPPNPC SEQLHCSKES LSSRTEAVRE DLVPSESNAF LPSSVLWLSP
260 270 280 290 300
STALAADFRV NHVDPEEEIV EHGAMEEREM RFPTHPKESE TEDQALVSSV
310 320 330 340 350
EDILSTCLTP NLVEMESQEA PGPAVEDVGR ILGSDTESWM SPLAWLEKGV
360 370 380 390 400
NTSVMLENLR QSLSLPSMLR DAAIGTTPFS TCSVGTWFTP SAPQEKSTNT
410 420 430 440 450
SQTGLVGTKH STSETEQLLC GRPPDLTALS RHDLEDNLLS SLVILEVLSR
460 470 480 490 500
QLRDWKSQLA VPHPETQDSS TQTDTSHSGI TNKLQHLKES HEMGQALQQA
510 520 530 540 550
RNVMQSWVLI SKELISLLHL SLLHLEEDKT TVSQESRRAE TLVCCCFDLL
560 570 580 590 600
KKLRAKLQSL KAEREEARHR EEMALRGKDA AEIVLEAFCA HASQRISQLE
610 620 630 640 650
QDLASMREFR GLLKDAQTQL VGLHAKQEEL VQQTVSLTST LQQDWRSMQL
660 670 680 690 700
DYTTWTALLS RSRQLTEKLT VKSQQALQER DVAIEEKQEV SRVLEQVSAQ
710 720 730 740 750
LEECKGQTEQ LELENSRLAT DLRAQLQILA NMDSQLKELQ SQHTHCAQDL
760 770 780 790 800
AMKDELLCQL TQSNEEQAAQ WQKEEMALKH MQAELQQQQA VLAKEVRDLK
810 820 830 840 850
ETLEFADQEN QVAHLELGQV ECQLKTTLEV LRERSLQCEN LKDTVENLTA
860 870 880 890 900
KLASTIADNQ EQDLEKTRQY SQKLGLLTEQ LQSLTLFLQT KLKEKTEQET
910 920 930 940 950
LLLSTACPPT QEHPLPNDRT FLGSILTAVA DEEPESTPVP LLGSDKSAFT
960 970 980 990 1000
RVASMVSLQP AETPGMEESL AEMSIMTTEL QSLCSLLQES KEEAIRTLQR
1010 1020 1030 1040 1050
KICELQARLQ AQEEQHQEVQ KAKEADIEKL NQALCLRYKN EKELQEVIQQ
1060 1070 1080 1090 1100
QNEKILEQID KSGELISLRE EVTHLTRSLR RAETETKVLQ EALAGQLDSN
1110 1120 1130 1140 1150
CQPMATNWIQ EKVWLSQEVD KLRVMFLEMK NEKEKLMIKF QSHRNILEEN
1160 1170 1180 1190
LRRSDKELEK LDDIVQHIYK TLLSIPEVVR GCKELQGLLE FLS
Length:1,193
Mass (Da):134,422
Last modified:May 10, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA846DB3FE624519C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KTQ0J3KTQ0_HUMAN
Sperm-associated antigen 5
SPAG5
238Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GZT2F5GZT2_HUMAN
Sperm-associated antigen 5
SPAG5
272Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KSV2J3KSV2_HUMAN
Sperm-associated antigen 5
SPAG5
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QRV8J3QRV8_HUMAN
Sperm-associated antigen 5
SPAG5
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ELC8K7ELC8_HUMAN
Sperm-associated antigen 5
SPAG5
186Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ELG0K7ELG0_HUMAN
Sperm-associated antigen 5
SPAG5
185Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QS12J3QS12_HUMAN
Sperm-associated antigen 5
SPAG5
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QRL6J3QRL6_HUMAN
Sperm-associated antigen 5
SPAG5
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD02813 differs from that shown. Reason: Frameshift.Curated
The sequence AAL06396 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti38N → T in AAK91712 (PubMed:11724960).Curated1
Sequence conflicti38N → T in AAL06396 (PubMed:11549262).Curated1
Sequence conflicti38N → T in AAD02813 (Ref. 3) Curated1
Sequence conflicti445 – 447LEV → VEF in AAK91712 (PubMed:11724960).Curated3
Sequence conflicti445 – 447LEV → VEF in AAL06396 (PubMed:11549262).Curated3
Sequence conflicti445 – 447LEV → VEF in AAD02813 (Ref. 3) Curated3
Sequence conflicti533S → N in AAK91712 (PubMed:11724960).Curated1
Sequence conflicti533S → N in AAL06396 (PubMed:11549262).Curated1
Sequence conflicti533S → N in AAD02813 (Ref. 3) Curated1
Sequence conflicti716S → I in AAK91712 (PubMed:11724960).Curated1
Sequence conflicti716S → I in AAL06396 (PubMed:11549262).Curated1
Sequence conflicti716S → I in AAD02813 (Ref. 3) Curated1
Sequence conflicti771 – 772WQ → CV in AAK91712 (PubMed:11724960).Curated2
Sequence conflicti771 – 772WQ → CV in AAL06396 (PubMed:11549262).Curated2
Sequence conflicti771 – 772WQ → CV in AAD02813 (Ref. 3) Curated2
Sequence conflicti1051Missing in AAL06396 (PubMed:11549262).Curated1
Sequence conflicti1051Missing in AAD02813 (Ref. 3) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF399910 mRNA Translation: AAK91712.1
AF345347 mRNA Translation: AAL06396.2 Frameshift.
AF063308 mRNA Translation: AAD02813.1 Frameshift.
BC000322 mRNA Translation: AAH00322.1
AL122116 mRNA Translation: CAB59275.1
AL137585 mRNA Translation: CAB70827.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS32594.1

Protein sequence database of the Protein Information Resource

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PIRi
JC7765
T34542
T46296

NCBI Reference Sequences

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RefSeqi
NP_006452.3, NM_006461.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000321765; ENSP00000323300; ENSG00000076382

Database of genes from NCBI RefSeq genomes

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GeneIDi
10615

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10615

UCSC genome browser

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UCSCi
uc002hbq.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF399910 mRNA Translation: AAK91712.1
AF345347 mRNA Translation: AAL06396.2 Frameshift.
AF063308 mRNA Translation: AAD02813.1 Frameshift.
BC000322 mRNA Translation: AAH00322.1
AL122116 mRNA Translation: CAB59275.1
AL137585 mRNA Translation: CAB70827.1
CCDSiCCDS32594.1
PIRiJC7765
T34542
T46296
RefSeqiNP_006452.3, NM_006461.3

3D structure databases

SMRiQ96R06
ModBaseiSearch...

Protein-protein interaction databases

BioGridi115861, 103 interactors
CORUMiQ96R06
DIPiDIP-30998N
IntActiQ96R06, 114 interactors
MINTiQ96R06
STRINGi9606.ENSP00000323300

PTM databases

iPTMnetiQ96R06
PhosphoSitePlusiQ96R06

Polymorphism and mutation databases

BioMutaiSPAG5
DMDMi47117278

Proteomic databases

EPDiQ96R06
jPOSTiQ96R06
MassIVEiQ96R06
MaxQBiQ96R06
PaxDbiQ96R06
PeptideAtlasiQ96R06
PRIDEiQ96R06
ProteomicsDBi77922

Genome annotation databases

EnsembliENST00000321765; ENSP00000323300; ENSG00000076382
GeneIDi10615
KEGGihsa:10615
UCSCiuc002hbq.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10615
DisGeNETi10615

GeneCards: human genes, protein and diseases

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GeneCardsi
SPAG5
HGNCiHGNC:13452 SPAG5
HPAiHPA022008
HPA022479
MIMi615562 gene
neXtProtiNX_Q96R06
OpenTargetsiENSG00000076382
PharmGKBiPA134868542

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IIA9 Eukaryota
ENOG410YG9P LUCA
GeneTreeiENSGT00400000022377
HOGENOMiHOG000049113
InParanoidiQ96R06
KOiK21764
OMAiPWMSPLA
OrthoDBi257437at2759
PhylomeDBiQ96R06
TreeFamiTF336280

Enzyme and pathway databases

SIGNORiQ96R06

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SPAG5 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Sperm_associated_antigen_5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10615
PharosiQ96R06

Protein Ontology

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PROi
PR:Q96R06

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000076382 Expressed in 154 organ(s), highest expression level in testis
ExpressionAtlasiQ96R06 baseline and differential
GenevisibleiQ96R06 HS

Family and domain databases

InterProiView protein in InterPro
IPR028728 Astrin
PANTHERiPTHR15347 PTHR15347, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPAG5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96R06
Secondary accession number(s): O95213
, Q9BWE8, Q9NT17, Q9UFE6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: October 16, 2019
This is version 152 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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