UniProtKB - Q96R05 (RET7_HUMAN)
Protein
Retinoid-binding protein 7
Gene
RBP7
Organism
Homo sapiens (Human)
Status
Functioni
Intracellular transport of retinol.1 Publication
GO - Molecular functioni
- retinal binding Source: UniProtKB-KW
- retinol binding Source: UniProtKB-KW
Keywordsi
Biological process | Transport |
Ligand | Retinol-binding, Vitamin A |
Enzyme and pathway databases
PathwayCommonsi | Q96R05 |
Names & Taxonomyi
Protein namesi | Recommended name: Retinoid-binding protein 7Alternative name(s): Cellular retinoic acid-binding protein 4 Short name: CRABP4 Short name: CRBP4 Cellular retinoic acid-binding protein IV Short name: CRABP-IV |
Gene namesi | Name:RBP7 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30316, RBP7 |
MIMi | 608604, gene |
neXtProti | NX_Q96R05 |
VEuPathDBi | HostDB:ENSG00000162444.11 |
Subcellular locationi
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 116362 |
OpenTargetsi | ENSG00000162444 |
PharmGKBi | PA134988307 |
Miscellaneous databases
Pharosi | Q96R05, Tbio |
Chemistry databases
DrugBanki | DB00162, Vitamin A |
DrugCentrali | Q96R05 |
Genetic variation databases
BioMutai | RBP7 |
DMDMi | 20139582 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000067403 | 1 – 134 | Retinoid-binding protein 7Add BLAST | 134 |
Proteomic databases
EPDi | Q96R05 |
jPOSTi | Q96R05 |
MassIVEi | Q96R05 |
MaxQBi | Q96R05 |
PaxDbi | Q96R05 |
PeptideAtlasi | Q96R05 |
PRIDEi | Q96R05 |
ProteomicsDBi | 77921 |
Expressioni
Tissue specificityi
Expressed primarily in kidney, heart and transverse colon. Detected in adult lymph node, appendix, ascending colon, and in fetal heart and spleen.1 Publication
Gene expression databases
Bgeei | ENSG00000162444, Expressed in omental fat pad and 205 other tissues |
ExpressionAtlasi | Q96R05, baseline and differential |
Genevisiblei | Q96R05, HS |
Organism-specific databases
HPAi | ENSG00000162444, Tissue enhanced (adipose tissue, breast) |
Interactioni
Binary interactionsi
Hide detailsQ96R05
With | #Exp. | IntAct |
---|---|---|
NCKIPSD - isoform 3 [Q9NZQ3-3] | 3 | EBI-2856326,EBI-10963850 |
PIK3R3 [Q92569] | 3 | EBI-2856326,EBI-79893 |
SOCS4 [Q8WXH5] | 3 | EBI-2856326,EBI-3942425 |
Protein-protein interaction databases
BioGRIDi | 125500, 7 interactors |
IntActi | Q96R05, 8 interactors |
STRINGi | 9606.ENSP00000294435 |
Miscellaneous databases
RNActi | Q96R05, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q96R05 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q96R05 |
Family & Domainsi
Domaini
Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4015, Eukaryota |
GeneTreei | ENSGT00940000162218 |
HOGENOMi | CLU_113772_5_1_1 |
InParanoidi | Q96R05 |
OMAi | DFSGTWN |
OrthoDBi | 1417203at2759 |
PhylomeDBi | Q96R05 |
TreeFami | TF316894 |
Family and domain databases
Gene3Di | 2.40.128.20, 1 hit |
InterProi | View protein in InterPro IPR012674, Calycin IPR000463, Fatty_acid-bd IPR031259, ILBP IPR000566, Lipocln_cytosolic_FA-bd_dom |
PANTHERi | PTHR11955, PTHR11955, 1 hit |
Pfami | View protein in Pfam PF00061, Lipocalin, 1 hit |
PRINTSi | PR00178, FATTYACIDBP |
SUPFAMi | SSF50814, SSF50814, 1 hit |
PROSITEi | View protein in PROSITE PS00214, FABP, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q96R05-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPADLSGTWT LLSSDNFEGY MLALGIDFAT RKIAKLLKPQ KVIEQNGDSF
60 70 80 90 100
TIHTNSSLRN YFVKFKVGEE FDEDNRGLDN RKCKSLVIWD NDRLTCIQKG
110 120 130
EKKNRGWTHW IEGDKLHLEM FCEGQVCKQT FQRA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketB1AQ60 | B1AQ60_HUMAN | Retinoid-binding protein 7 | RBP7 hCG_1820860 | 59 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY145438 mRNA Translation: AAN61071.1 AF399927 mRNA Translation: AAK85409.1 AK312027 mRNA Translation: BAG34964.1 AL603962 Genomic DNA No translation available. AL590639 Genomic DNA No translation available. CH471130 Genomic DNA Translation: EAW71638.1 BC063013 mRNA Translation: AAH63013.1 |
CCDSi | CCDS109.1 |
RefSeqi | NP_443192.1, NM_052960.2 |
Genome annotation databases
Ensembli | ENST00000294435; ENSP00000294435; ENSG00000162444 |
GeneIDi | 116362 |
KEGGi | hsa:116362 |
UCSCi | uc001aqq.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY145438 mRNA Translation: AAN61071.1 AF399927 mRNA Translation: AAK85409.1 AK312027 mRNA Translation: BAG34964.1 AL603962 Genomic DNA No translation available. AL590639 Genomic DNA No translation available. CH471130 Genomic DNA Translation: EAW71638.1 BC063013 mRNA Translation: AAH63013.1 |
CCDSi | CCDS109.1 |
RefSeqi | NP_443192.1, NM_052960.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1LPJ | X-ray | 2.00 | A | 2-134 | [»] | |
6AT8 | X-ray | 1.10 | A | 2-134 | [»] | |
6E6K | X-ray | 1.30 | A | 2-134 | [»] | |
SMRi | Q96R05 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 125500, 7 interactors |
IntActi | Q96R05, 8 interactors |
STRINGi | 9606.ENSP00000294435 |
Chemistry databases
DrugBanki | DB00162, Vitamin A |
DrugCentrali | Q96R05 |
Genetic variation databases
BioMutai | RBP7 |
DMDMi | 20139582 |
Proteomic databases
EPDi | Q96R05 |
jPOSTi | Q96R05 |
MassIVEi | Q96R05 |
MaxQBi | Q96R05 |
PaxDbi | Q96R05 |
PeptideAtlasi | Q96R05 |
PRIDEi | Q96R05 |
ProteomicsDBi | 77921 |
Protocols and materials databases
Antibodypediai | 27796, 122 antibodies |
DNASUi | 116362 |
Genome annotation databases
Ensembli | ENST00000294435; ENSP00000294435; ENSG00000162444 |
GeneIDi | 116362 |
KEGGi | hsa:116362 |
UCSCi | uc001aqq.4, human |
Organism-specific databases
CTDi | 116362 |
DisGeNETi | 116362 |
GeneCardsi | RBP7 |
HGNCi | HGNC:30316, RBP7 |
HPAi | ENSG00000162444, Tissue enhanced (adipose tissue, breast) |
MIMi | 608604, gene |
neXtProti | NX_Q96R05 |
OpenTargetsi | ENSG00000162444 |
PharmGKBi | PA134988307 |
VEuPathDBi | HostDB:ENSG00000162444.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4015, Eukaryota |
GeneTreei | ENSGT00940000162218 |
HOGENOMi | CLU_113772_5_1_1 |
InParanoidi | Q96R05 |
OMAi | DFSGTWN |
OrthoDBi | 1417203at2759 |
PhylomeDBi | Q96R05 |
TreeFami | TF316894 |
Enzyme and pathway databases
PathwayCommonsi | Q96R05 |
Miscellaneous databases
BioGRID-ORCSi | 116362, 6 hits in 870 CRISPR screens |
ChiTaRSi | RBP7, human |
EvolutionaryTracei | Q96R05 |
GenomeRNAii | 116362 |
Pharosi | Q96R05, Tbio |
PROi | PR:Q96R05 |
RNActi | Q96R05, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000162444, Expressed in omental fat pad and 205 other tissues |
ExpressionAtlasi | Q96R05, baseline and differential |
Genevisiblei | Q96R05, HS |
Family and domain databases
Gene3Di | 2.40.128.20, 1 hit |
InterProi | View protein in InterPro IPR012674, Calycin IPR000463, Fatty_acid-bd IPR031259, ILBP IPR000566, Lipocln_cytosolic_FA-bd_dom |
PANTHERi | PTHR11955, PTHR11955, 1 hit |
Pfami | View protein in Pfam PF00061, Lipocalin, 1 hit |
PRINTSi | PR00178, FATTYACIDBP |
SUPFAMi | SSF50814, SSF50814, 1 hit |
PROSITEi | View protein in PROSITE PS00214, FABP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RET7_HUMAN | |
Accessioni | Q96R05Primary (citable) accession number: Q96R05 Secondary accession number(s): B2R517, Q5SWJ4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 3, 2002 |
Last sequence update: | December 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 155 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families