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Protein

Retinoid-binding protein 7

Gene

RBP7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Intracellular transport of retinol.1 Publication

GO - Molecular functioni

Keywordsi

Biological processTransport
LigandRetinol-binding, Vitamin A

Names & Taxonomyi

Protein namesi
Recommended name:
Retinoid-binding protein 7
Alternative name(s):
Cellular retinoic acid-binding protein 4
Short name:
CRABP4
Short name:
CRBP4
Cellular retinoic acid-binding protein IV
Short name:
CRABP-IV
Gene namesi
Name:RBP7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162444.11
HGNCiHGNC:30316 RBP7
MIMi608604 gene
neXtProtiNX_Q96R05

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi116362
OpenTargetsiENSG00000162444
PharmGKBiPA134988307

Chemistry databases

DrugBankiDB00162 Vitamin A

Polymorphism and mutation databases

BioMutaiRBP7
DMDMi20139582

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000674031 – 134Retinoid-binding protein 7Add BLAST134

Proteomic databases

EPDiQ96R05
MaxQBiQ96R05
PaxDbiQ96R05
PeptideAtlasiQ96R05
PRIDEiQ96R05
ProteomicsDBi77921

Expressioni

Tissue specificityi

Expressed primarily in kidney, heart and transverse colon. Detected in adult lymph node, appendix, ascending colon, and in fetal heart and spleen.1 Publication

Gene expression databases

BgeeiENSG00000162444 Expressed in 189 organ(s), highest expression level in omental fat pad
CleanExiHS_RBP7
ExpressionAtlasiQ96R05 baseline and differential
GenevisibleiQ96R05 HS

Organism-specific databases

HPAiHPA034749

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi125500, 6 interactors
IntActiQ96R05, 9 interactors
STRINGi9606.ENSP00000294435

Structurei

Secondary structure

1134
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ96R05
SMRiQ96R05
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96R05

Family & Domainsi

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015 Eukaryota
ENOG4111US8 LUCA
GeneTreeiENSGT00760000118898
HOGENOMiHOG000004831
HOVERGENiHBG005633
InParanoidiQ96R05
OMAiVTKGMDN
OrthoDBiEOG091G0QSV
PhylomeDBiQ96R05
TreeFamiTF316894

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR000463 Fatty_acid-bd
IPR031259 ILBP
IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERiPTHR11955 PTHR11955, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR00178 FATTYACIDBP
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00214 FABP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q96R05-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPADLSGTWT LLSSDNFEGY MLALGIDFAT RKIAKLLKPQ KVIEQNGDSF
60 70 80 90 100
TIHTNSSLRN YFVKFKVGEE FDEDNRGLDN RKCKSLVIWD NDRLTCIQKG
110 120 130
EKKNRGWTHW IEGDKLHLEM FCEGQVCKQT FQRA
Length:134
Mass (Da):15,536
Last modified:December 1, 2001 - v1
Checksum:iB152C8B3D95B20BD
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AQ60B1AQ60_HUMAN
Retinoid-binding protein 7
RBP7 hCG_1820860
59Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY145438 mRNA Translation: AAN61071.1
AF399927 mRNA Translation: AAK85409.1
AK312027 mRNA Translation: BAG34964.1
AL603962 Genomic DNA No translation available.
AL590639 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71638.1
BC063013 mRNA Translation: AAH63013.1
CCDSiCCDS109.1
RefSeqiNP_443192.1, NM_052960.2
UniGeneiHs.422688

Genome annotation databases

EnsembliENST00000294435; ENSP00000294435; ENSG00000162444
GeneIDi116362
KEGGihsa:116362
UCSCiuc001aqq.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY145438 mRNA Translation: AAN61071.1
AF399927 mRNA Translation: AAK85409.1
AK312027 mRNA Translation: BAG34964.1
AL603962 Genomic DNA No translation available.
AL590639 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71638.1
BC063013 mRNA Translation: AAH63013.1
CCDSiCCDS109.1
RefSeqiNP_443192.1, NM_052960.2
UniGeneiHs.422688

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LPJX-ray2.00A2-134[»]
6AT8X-ray1.10A2-134[»]
ProteinModelPortaliQ96R05
SMRiQ96R05
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125500, 6 interactors
IntActiQ96R05, 9 interactors
STRINGi9606.ENSP00000294435

Chemistry databases

DrugBankiDB00162 Vitamin A

Polymorphism and mutation databases

BioMutaiRBP7
DMDMi20139582

Proteomic databases

EPDiQ96R05
MaxQBiQ96R05
PaxDbiQ96R05
PeptideAtlasiQ96R05
PRIDEiQ96R05
ProteomicsDBi77921

Protocols and materials databases

DNASUi116362
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294435; ENSP00000294435; ENSG00000162444
GeneIDi116362
KEGGihsa:116362
UCSCiuc001aqq.4 human

Organism-specific databases

CTDi116362
DisGeNETi116362
EuPathDBiHostDB:ENSG00000162444.11
GeneCardsiRBP7
HGNCiHGNC:30316 RBP7
HPAiHPA034749
MIMi608604 gene
neXtProtiNX_Q96R05
OpenTargetsiENSG00000162444
PharmGKBiPA134988307
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4015 Eukaryota
ENOG4111US8 LUCA
GeneTreeiENSGT00760000118898
HOGENOMiHOG000004831
HOVERGENiHBG005633
InParanoidiQ96R05
OMAiVTKGMDN
OrthoDBiEOG091G0QSV
PhylomeDBiQ96R05
TreeFamiTF316894

Miscellaneous databases

ChiTaRSiRBP7 human
EvolutionaryTraceiQ96R05
GenomeRNAii116362
PROiPR:Q96R05
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162444 Expressed in 189 organ(s), highest expression level in omental fat pad
CleanExiHS_RBP7
ExpressionAtlasiQ96R05 baseline and differential
GenevisibleiQ96R05 HS

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR000463 Fatty_acid-bd
IPR031259 ILBP
IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERiPTHR11955 PTHR11955, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR00178 FATTYACIDBP
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00214 FABP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRET7_HUMAN
AccessioniPrimary (citable) accession number: Q96R05
Secondary accession number(s): B2R517, Q5SWJ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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