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Protein

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

Gene

MAGI1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi103 – 110ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • alpha-actinin binding Source: UniProtKB
  • ATP binding Source: UniProtKB-KW
  • protein-containing complex scaffold activity Source: InterPro
  • protein C-terminus binding Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q96QZ7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
Alternative name(s):
Atrophin-1-interacting protein 3
Short name:
AIP-3
BAI1-associated protein 1
Short name:
BAP-1
Membrane-associated guanylate kinase inverted 1
Short name:
MAGI-1
Trinucleotide repeat-containing gene 19 protein
WW domain-containing protein 3
Short name:
WWP3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MAGI1
Synonyms:AIP3, BAIAP1, BAP1, TNRC19
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000151276.23

Human Gene Nomenclature Database

More...
HGNCi
HGNC:946 MAGI1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
602625 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96QZ7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9223

Open Targets

More...
OpenTargetsi
ENSG00000151276

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164742006

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MAGI1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
281185501

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000945891 – 1491Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1Add BLAST1491

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei357PhosphoserineCombined sources1
Modified residuei730PhosphoserineCombined sources1
Modified residuei741PhosphoserineCombined sources1
Modified residuei800PhosphoserineBy similarity1
Modified residuei1071PhosphoserineCombined sources1
Modified residuei1361PhosphoserineCombined sources1
Modified residuei1412PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96QZ7

MaxQB - The MaxQuant DataBase

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MaxQBi
Q96QZ7

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96QZ7

PeptideAtlas

More...
PeptideAtlasi
Q96QZ7

PRoteomics IDEntifications database

More...
PRIDEi
Q96QZ7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
77914
77915 [Q96QZ7-2]
77916 [Q96QZ7-3]
77917 [Q96QZ7-4]
77918 [Q96QZ7-5]
77919 [Q96QZ7-6]
77920 [Q96QZ7-7]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96QZ7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96QZ7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed with the exception of skeletal muscle. Isoform 1, isoform 2 and isoform 6 are highly expressed in colon, kidney, lung, liver, and pancreas. Isoform 5 is predominantly expressed in brain and heart. Isoform 3 and isoform 4 are highly expressed in pancreas and brain.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000151276 Expressed in 224 organ(s), highest expression level in corpus callosum

CleanEx database of gene expression profiles

More...
CleanExi
HS_BAP1
HS_MAGI1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96QZ7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96QZ7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA031851
HPA031852
HPA031853

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts through its WW 2 domain with SYNPO and through its PDZ 5 domain with ACTN4 (PubMed:12042308). Interacts with cytoplasmic domain of ADGRB1 (PubMed:9647739). Interacts via its WW domains with DRPLA (PubMed:9647693). Interacts with ESAM, LRP2 and CXADR (By similarity). May interact with CTNNB1 (By similarity). Interacts through its PDZ 1 domain with NET1 (By similarity). Interacts with ASIC3 and AMOT (PubMed:15317815, PubMed:16043488). Interacts with FCHSD2 (PubMed:14627983). Interacts with IGSF5/JAM4 and through its PDZ 2 and 3 domains with NPHS1 forming a tripartite complex (By similarity) (PubMed:12773569). Interacts with DDN (PubMed:16751601). Isoform 3 (via PDZ domain) interacts with RAPGEF2 (PubMed:11168587). Interacts with DLL1 (By similarity). Interacts with KCNJ10 and possibly with KCNJ10/KCNJ16 heterodimer; this interaction may facilitate KCNJ10/KCNJ16 potassium channel expression at the basolateral membrane in kidney tubular cells.By similarity9 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
114655, 91 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q96QZ7

Protein interaction database and analysis system

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IntActi
Q96QZ7, 26 interactors

Molecular INTeraction database

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MINTi
Q96QZ7

STRING: functional protein association networks

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STRINGi
9606.ENSP00000385450

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11491
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q96QZ7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96QZ7

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q96QZ7

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini17 – 105PDZ 1PROSITE-ProRule annotationAdd BLAST89
Domaini96 – 287Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST192
Domaini300 – 333WW 1PROSITE-ProRule annotationAdd BLAST34
Domaini359 – 392WW 2PROSITE-ProRule annotationAdd BLAST34
Domaini472 – 554PDZ 2PROSITE-ProRule annotationAdd BLAST83
Domaini643 – 721PDZ 3PROSITE-ProRule annotationAdd BLAST79
Domaini813 – 895PDZ 4PROSITE-ProRule annotationAdd BLAST83
Domaini970 – 1066PDZ 5PROSITE-ProRule annotationAdd BLAST97
Domaini1124 – 1206PDZ 6PROSITE-ProRule annotationAdd BLAST83

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni970 – 1066Interaction with FCHSD21 PublicationAdd BLAST97

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi402 – 421Poly-GlnAdd BLAST20
Compositional biasi662 – 665Poly-Gly4
Compositional biasi978 – 988Poly-GlyAdd BLAST11
Compositional biasi1341 – 1344Poly-Ala4
Compositional biasi1398 – 1401Poly-Arg4

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3209 Eukaryota
COG5021 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155820

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000113463

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG007091

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96QZ7

KEGG Orthology (KO)

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KOi
K05631

Identification of Orthologs from Complete Genome Data

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OMAi
ERMVTNG

Database of Orthologous Groups

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OrthoDBi
EOG091G0NSY

Database for complete collections of gene phylogenies

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PhylomeDBi
Q96QZ7

TreeFam database of animal gene trees

More...
TreeFami
TF316816

Family and domain databases

Conserved Domains Database

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CDDi
cd00201 WW, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR020590 Guanylate_kinase_CS
IPR030033 MAGI1
IPR027417 P-loop_NTPase
IPR001478 PDZ
IPR036034 PDZ_sf
IPR001202 WW_dom
IPR036020 WW_dom_sf

The PANTHER Classification System

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PANTHERi
PTHR10316:SF12 PTHR10316:SF12, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00625 Guanylate_kin, 1 hit
PF00595 PDZ, 5 hits
PF00397 WW, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00072 GuKc, 1 hit
SM00228 PDZ, 6 hits
SM00456 WW, 2 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50156 SSF50156, 6 hits
SSF51045 SSF51045, 2 hits
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00856 GUANYLATE_KINASE_1, 1 hit
PS50052 GUANYLATE_KINASE_2, 1 hit
PS50106 PDZ, 6 hits
PS01159 WW_DOMAIN_1, 2 hits
PS50020 WW_DOMAIN_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 7 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96QZ7-1) [UniParc]FASTAAdd to basket
Also known as: MAGI-1C-alpha-beta1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSKVIQKKNH WTSRVHECTV KRGPQGELGV TVLGGAEHGE FPYVGAVAAV
60 70 80 90 100
EAAGLPGGGE GPRLGEGELL LEVQGVRVSG LPRYDVLGVI DSCKEAVTFK
110 120 130 140 150
AVRQGGRLNK DLRHFLNQRF QKGSPDHELQ QTIRDNLYRH AVPCTTRSPR
160 170 180 190 200
EGEVPGVDYN FLTVKEFLDL EQSGTLLEVG TYEGNYYGTP KPPSQPVSGK
210 220 230 240 250
VITTDALHSL QSGSKQSTPK RTKSYNDMQN AGIVHAENEE EDDVPEMNSS
260 270 280 290 300
FTADSGEQEE HTLQETALPP VNSSIIAAPI TDPSQKFPQY LPLSAEDNLG
310 320 330 340 350
PLPENWEMAY TENGEVYFID HNTKTTSWLD PRCLNKQQKP LEECEDDEGV
360 370 380 390 400
HTEELDSELE LPAGWEKIED PVYGIYYVDH INRKTQYENP VLEAKRKKQL
410 420 430 440 450
EQQQQQQQQQ QQQQQQQQQQ QTEEWTEDHS ALVPPVIPNH PPSNPEPARE
460 470 480 490 500
VPLQGKPFFT RNPSELKGKF IHTKLRKSSR GFGFTVVGGD EPDEFLQIKS
510 520 530 540 550
LVLDGPAALD GKMETGDVIV SVNDTCVLGH THAQVVKIFQ SIPIGASVDL
560 570 580 590 600
ELCRGYPLPF DPDDPNTSLV TSVAILDKEP IIVNGQETYD SPASHSSKTG
610 620 630 640 650
KVNGMKDARP SSPADVASNS SHGYPNDTVS LASSIATQPE LITVHIVKGP
660 670 680 690 700
MGFGFTIADS PGGGGQRVKQ IVDSPRCRGL KEGDLIVEVN KKNVQALTHN
710 720 730 740 750
QVVDMLVECP KGSEVTLLVQ RGGLPVPKKS PKSQPLERKD SQNSSQHSVS
760 770 780 790 800
SHRSLHTASP SHSTQVLPEF PPAEAQAPDQ TDSSGQKKPD PFKIWAQSRS
810 820 830 840 850
MYENRPMSPS PASGLSKGER EREINSTNFG ECPIPDYQEQ DIFLWRKETG
860 870 880 890 900
FGFRILGGNE PGEPIYIGHI VPLGAADTDG RLRSGDELIC VDGTPVIGKS
910 920 930 940 950
HQLVVQLMQQ AAKQGHVNLT VRRKVVFAVP KTENEVPSPA SSHHSSNQPA
960 970 980 990 1000
SLTEEKRTPQ GSQNSLNTVS SGSGSTSGIG SGGGGGSGVV STVVQPYDVE
1010 1020 1030 1040 1050
IRRGENEGFG FVIVSSVSRP EAGTTFAGNA CVAMPHKIGR IIEGSPADRC
1060 1070 1080 1090 1100
GKLKVGDRIL AVNGCSITNK SHSDIVNLIK EAGNTVTLRI IPGDESSNAT
1110 1120 1130 1140 1150
LLTNAEKIAT ITTTHTPSQQ GTQETRNTTK PKQESQFEFK APQATQEQDF
1160 1170 1180 1190 1200
YTVELERGAK GFGFSLRGGR EYNMDLYVLR LAEDGPAERC GKMRIGDEIL
1210 1220 1230 1240 1250
EINGETTKNM KHSRAIELIK NGGRRVRLFL KRGDGSVPEY DPSSDRHGPA
1260 1270 1280 1290 1300
TGPQGVPEVR AGPDRRQHPS LESSYPPDLH KSSPHGEKRA HARDPKGSRE
1310 1320 1330 1340 1350
YSRQPNEHHT WNGTSRKPDS GACRPKDRAP EGRRDAQAER AAAANGPKRR
1360 1370 1380 1390 1400
SPEKRREGTR SADNTLERRE KHEKRRDVSP ERRRERSPTR RRDGSPSRRR
1410 1420 1430 1440 1450
RSLERLLEQR RSPERRRGGS PERRAKSTDR RRARSPERRR ERSLDKRNRE
1460 1470 1480 1490
DRASHREREE ANLKQDAGRS SRHPPEQRRR PYKECSTDLS I
Note: No experimental confirmation available.
Length:1,491
Mass (Da):164,581
Last modified:December 15, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4B2EE05243A6FA65
GO
Isoform 2 (identifier: Q96QZ7-2) [UniParc]FASTAAdd to basket
Also known as: MAGI-1C-beta

The sequence of this isoform differs from the canonical sequence as follows:
     806-834: PMSPSPASGLSKGEREREINSTNFGECPI → L
     1027-1027: Missing.

Show »
Length:1,462
Mass (Da):161,550
Checksum:i09C49DDDEB792655
GO
Isoform 3 (identifier: Q96QZ7-3) [UniParc]FASTAAdd to basket
Also known as: MAGI-1A-alpha-beta1

The sequence of this isoform differs from the canonical sequence as follows:
     1241-1256: DPSSDRHGPATGPQGV → GGSNYENIPSFPGMTP
     1257-1288: Missing.
     1289-1491: Missing.

Show »
Length:1,256
Mass (Da):136,921
Checksum:i1D906FFCE0F8F6CE
GO
Isoform 4 (identifier: Q96QZ7-4) [UniParc]FASTAAdd to basket
Also known as: MAGI-1A-alpha

The sequence of this isoform differs from the canonical sequence as follows:
     806-834: PMSPSPASGLSKGEREREINSTNFGECPI → L
     1027-1027: Missing.
     1028-1038: Missing.
     1039-1094: Missing.
     1241-1256: DPSSDRHGPATGPQGV → GGSNYENIPSFPGMTP
     1257-1288: Missing.
     1289-1491: Missing.

Show »
Length:1,160
Mass (Da):126,898
Checksum:i7E3FEB621B96D1B5
GO
Isoform 5 (identifier: Q96QZ7-5) [UniParc]FASTAAdd to basket
Also known as: MAGI-1B-alpha-beta

The sequence of this isoform differs from the canonical sequence as follows:
     1027-1027: Missing.
     1241-1288: DPSSDRHGPA...LHKSSPHGEK → AMIPPNIAAC...PPPVHKVFRK
     1289-1491: Missing.

Show »
Length:1,287
Mass (Da):140,379
Checksum:i75F4654C0524B753
GO
Isoform 6 (identifier: Q96QZ7-6) [UniParc]FASTAAdd to basket
Also known as: MAGI-1C-beta2

The sequence of this isoform differs from the canonical sequence as follows:
     806-834: PMSPSPASGLSKGEREREINSTNFGECPI → L
     1027-1027: Missing.
     1028-1038: Missing.

Note: No experimental confirmation available.
Show »
Length:1,451
Mass (Da):160,427
Checksum:i1D55FA728ED6FBA5
GO
Isoform 7 (identifier: Q96QZ7-7) [UniParc]FASTAAdd to basket
Also known as: MAGI-1C-beta3

The sequence of this isoform differs from the canonical sequence as follows:
     806-834: PMSPSPASGLSKGEREREINSTNFGECPI → L
     1023-1099: GTTFAGNACV...IIPGDESSNA → VMQCQPPSWC...EVQIYSCNNP

Note: No experimental confirmation available.
Show »
Length:1,425
Mass (Da):157,781
Checksum:i5F60A23E79301C1E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C5T8H7C5T8_HUMAN
Membrane-associated guanylate kinas...
MAGI1
1,014Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C535H7C535_HUMAN
Membrane-associated guanylate kinas...
MAGI1
1,136Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C4U7H7C4U7_HUMAN
Membrane-associated guanylate kinas...
MAGI1
1,131Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WXD2A0A087WXD2_HUMAN
Membrane-associated guanylate kinas...
MAGI1
980Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WT53A0A087WT53_HUMAN
Membrane-associated guanylate kinas...
MAGI1
1,155Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C4S7H7C4S7_HUMAN
Membrane-associated guanylate kinas...
MAGI1
185Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti124S → F in BAA32002 (PubMed:9647739).Curated1
Sequence conflicti124S → F in AAK94064 (PubMed:11969287).Curated1
Sequence conflicti124S → F in AAK94065 (PubMed:11969287).Curated1
Sequence conflicti124S → F in AAK94066 (PubMed:11969287).Curated1
Sequence conflicti124S → F in AAC51326 (PubMed:11969287).Curated1
Sequence conflicti428D → H in BAF82492 (PubMed:14702039).Curated1
Sequence conflicti775A → G in AAC04844 (PubMed:9647693).Curated1
Sequence conflicti1001I → T in BAF82492 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_011664806 – 834PMSPS…GECPI → L in isoform 2, isoform 4, isoform 6 and isoform 7. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_0116651023 – 1099GTTFA…ESSNA → VMQCQPPSWCHSALGGSKHC NSVMGAASLEVQIYSCNNP in isoform 7. CuratedAdd BLAST77
Alternative sequenceiVSP_0116661027Missing in isoform 2, isoform 4, isoform 5 and isoform 6. 1 Publication1
Alternative sequenceiVSP_0116671028 – 1038Missing in isoform 4 and isoform 6. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_0116681039 – 1094Missing in isoform 4. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_0116691241 – 1288DPSSD…PHGEK → AMIPPNIAACMRNEKLGEAC FYLMGHNQTTTPAATATAPP PVHKVFRK in isoform 5. 1 PublicationAdd BLAST48
Alternative sequenceiVSP_0116701241 – 1256DPSSD…GPQGV → GGSNYENIPSFPGMTP in isoform 3 and isoform 4. 3 PublicationsAdd BLAST16
Alternative sequenceiVSP_0116711257 – 1288Missing in isoform 3 and isoform 4. 3 PublicationsAdd BLAST32
Alternative sequenceiVSP_0116721289 – 1491Missing in isoform 3, isoform 4 and isoform 5. 3 PublicationsAdd BLAST203

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB010894 mRNA Translation: BAA32002.1
AF401655 mRNA Translation: AAK94065.1
AF401656 mRNA Translation: AAK94066.1
AF401654 mRNA Translation: AAK94064.1
AK289803 mRNA Translation: BAF82492.1
AC104438 Genomic DNA No translation available.
AC112516 Genomic DNA No translation available.
AC121493 Genomic DNA No translation available.
AC145425 Genomic DNA No translation available.
U80754 mRNA Translation: AAC04844.1
U96115 mRNA Translation: AAC51326.1 Different termination.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2904.1 [Q96QZ7-3]
CCDS33780.1 [Q96QZ7-2]
CCDS33781.1 [Q96QZ7-5]

Protein sequence database of the Protein Information Resource

More...
PIRi
JE0209

NCBI Reference Sequences

More...
RefSeqi
NP_001028229.1, NM_001033057.1 [Q96QZ7-2]
NP_004733.2, NM_004742.2 [Q96QZ7-3]
NP_056335.1, NM_015520.1 [Q96QZ7-5]
XP_005265621.1, XM_005265564.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.476636

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000330909; ENSP00000331157; ENSG00000151276 [Q96QZ7-5]
ENST00000402939; ENSP00000385450; ENSG00000151276 [Q96QZ7-2]
ENST00000483466; ENSP00000420323; ENSG00000151276 [Q96QZ7-3]
ENST00000497477; ENSP00000424369; ENSG00000151276 [Q96QZ7-4]
ENST00000634409; ENSP00000489444; ENSG00000282956 [Q96QZ7-2]
ENST00000634774; ENSP00000489393; ENSG00000282956 [Q96QZ7-5]
ENST00000635378; ENSP00000489391; ENSG00000282956 [Q96QZ7-3]
ENST00000635471; ENSP00000489322; ENSG00000282956 [Q96QZ7-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9223

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9223

UCSC genome browser

More...
UCSCi
uc003dmm.4 human [Q96QZ7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010894 mRNA Translation: BAA32002.1
AF401655 mRNA Translation: AAK94065.1
AF401656 mRNA Translation: AAK94066.1
AF401654 mRNA Translation: AAK94064.1
AK289803 mRNA Translation: BAF82492.1
AC104438 Genomic DNA No translation available.
AC112516 Genomic DNA No translation available.
AC121493 Genomic DNA No translation available.
AC145425 Genomic DNA No translation available.
U80754 mRNA Translation: AAC04844.1
U96115 mRNA Translation: AAC51326.1 Different termination.
CCDSiCCDS2904.1 [Q96QZ7-3]
CCDS33780.1 [Q96QZ7-2]
CCDS33781.1 [Q96QZ7-5]
PIRiJE0209
RefSeqiNP_001028229.1, NM_001033057.1 [Q96QZ7-2]
NP_004733.2, NM_004742.2 [Q96QZ7-3]
NP_056335.1, NM_015520.1 [Q96QZ7-5]
XP_005265621.1, XM_005265564.1
UniGeneiHs.476636

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WBPX-ray2.40B1382-1390[»]
2KPKNMR-A455-580[»]
2KPLNMR-A455-580[»]
2Q9VX-ray2.00A839-922[»]
2R4HX-ray2.05A/B/C1149-1233[»]
2YSDNMR-A295-338[»]
2YSENMR-A355-401[»]
2ZAJNMR-A355-390[»]
3BPUX-ray1.60A640-721[»]
5N7DX-ray2.30A/B455-558[»]
5N7FX-ray2.30A/B454-558[»]
5N7GX-ray2.95A/B455-558[»]
ProteinModelPortaliQ96QZ7
SMRiQ96QZ7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114655, 91 interactors
ELMiQ96QZ7
IntActiQ96QZ7, 26 interactors
MINTiQ96QZ7
STRINGi9606.ENSP00000385450

PTM databases

iPTMnetiQ96QZ7
PhosphoSitePlusiQ96QZ7

Polymorphism and mutation databases

BioMutaiMAGI1
DMDMi281185501

Proteomic databases

EPDiQ96QZ7
MaxQBiQ96QZ7
PaxDbiQ96QZ7
PeptideAtlasiQ96QZ7
PRIDEiQ96QZ7
ProteomicsDBi77914
77915 [Q96QZ7-2]
77916 [Q96QZ7-3]
77917 [Q96QZ7-4]
77918 [Q96QZ7-5]
77919 [Q96QZ7-6]
77920 [Q96QZ7-7]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
9223
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330909; ENSP00000331157; ENSG00000151276 [Q96QZ7-5]
ENST00000402939; ENSP00000385450; ENSG00000151276 [Q96QZ7-2]
ENST00000483466; ENSP00000420323; ENSG00000151276 [Q96QZ7-3]
ENST00000497477; ENSP00000424369; ENSG00000151276 [Q96QZ7-4]
ENST00000634409; ENSP00000489444; ENSG00000282956 [Q96QZ7-2]
ENST00000634774; ENSP00000489393; ENSG00000282956 [Q96QZ7-5]
ENST00000635378; ENSP00000489391; ENSG00000282956 [Q96QZ7-3]
ENST00000635471; ENSP00000489322; ENSG00000282956 [Q96QZ7-4]
GeneIDi9223
KEGGihsa:9223
UCSCiuc003dmm.4 human [Q96QZ7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9223
DisGeNETi9223
EuPathDBiHostDB:ENSG00000151276.23

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MAGI1

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0003428
HIX0163431
HGNCiHGNC:946 MAGI1
HPAiHPA031851
HPA031852
HPA031853
MIMi602625 gene
neXtProtiNX_Q96QZ7
OpenTargetsiENSG00000151276
PharmGKBiPA164742006

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3209 Eukaryota
COG5021 LUCA
GeneTreeiENSGT00940000155820
HOGENOMiHOG000113463
HOVERGENiHBG007091
InParanoidiQ96QZ7
KOiK05631
OMAiERMVTNG
OrthoDBiEOG091G0NSY
PhylomeDBiQ96QZ7
TreeFamiTF316816

Enzyme and pathway databases

SignaLinkiQ96QZ7

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MAGI1 human
EvolutionaryTraceiQ96QZ7

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
MAGI1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9223

Protein Ontology

More...
PROi
PR:Q96QZ7

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000151276 Expressed in 224 organ(s), highest expression level in corpus callosum
CleanExiHS_BAP1
HS_MAGI1
ExpressionAtlasiQ96QZ7 baseline and differential
GenevisibleiQ96QZ7 HS

Family and domain databases

CDDicd00201 WW, 2 hits
InterProiView protein in InterPro
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR020590 Guanylate_kinase_CS
IPR030033 MAGI1
IPR027417 P-loop_NTPase
IPR001478 PDZ
IPR036034 PDZ_sf
IPR001202 WW_dom
IPR036020 WW_dom_sf
PANTHERiPTHR10316:SF12 PTHR10316:SF12, 1 hit
PfamiView protein in Pfam
PF00625 Guanylate_kin, 1 hit
PF00595 PDZ, 5 hits
PF00397 WW, 2 hits
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SM00228 PDZ, 6 hits
SM00456 WW, 2 hits
SUPFAMiSSF50156 SSF50156, 6 hits
SSF51045 SSF51045, 2 hits
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00856 GUANYLATE_KINASE_1, 1 hit
PS50052 GUANYLATE_KINASE_2, 1 hit
PS50106 PDZ, 6 hits
PS01159 WW_DOMAIN_1, 2 hits
PS50020 WW_DOMAIN_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMAGI1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96QZ7
Secondary accession number(s): A8K188
, O00309, O43863, O75085, Q96QZ8, Q96QZ9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: December 15, 2009
Last modified: December 5, 2018
This is version 175 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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