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Protein

Pannexin-3

Gene

PANX3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Structural component of the gap junctions and the hemichannels.

GO - Molecular functioni

GO - Biological processi

  • cation transport Source: GO_Central
  • cell-cell signaling Source: GO_Central
  • positive regulation of interleukin-1 secretion Source: InterPro
  • protein hexamerization Source: UniProtKB

Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport

Protein family/group databases

TCDBi1.A.25.2.3 the gap junction-forming innexin (innexin) family

Names & Taxonomyi

Protein namesi
Recommended name:
Pannexin-3
Gene namesi
Name:PANX3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000154143.2
HGNCiHGNC:20573 PANX3
MIMi608422 gene
neXtProtiNX_Q96QZ0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39CytoplasmicSequence analysisAdd BLAST39
Transmembranei40 – 60HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini61 – 113ExtracellularSequence analysisAdd BLAST53
Transmembranei114 – 134HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini135 – 215CytoplasmicSequence analysisAdd BLAST81
Transmembranei216 – 236HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini237 – 267ExtracellularSequence analysisAdd BLAST31
Transmembranei268 – 288HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini289 – 392CytoplasmicSequence analysisAdd BLAST104

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi116337
OpenTargetsiENSG00000154143
PharmGKBiPA134920643

Polymorphism and mutation databases

BioMutaiPANX3
DMDMi20139071

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002084911 – 392Pannexin-3Add BLAST392

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi71N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ96QZ0
PRIDEiQ96QZ0
ProteomicsDBi77913

PTM databases

iPTMnetiQ96QZ0
PhosphoSitePlusiQ96QZ0

Expressioni

Gene expression databases

BgeeiENSG00000154143 Expressed in 17 organ(s), highest expression level in tibia
CleanExiHS_PANX3
GenevisibleiQ96QZ0 HS

Interactioni

Protein-protein interaction databases

BioGridi125498, 1 interactor
IntActiQ96QZ0, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ96QZ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pannexin family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE65 Eukaryota
ENOG410ZSQN LUCA
GeneTreeiENSGT00390000009703
HOGENOMiHOG000063721
HOVERGENiHBG053497
InParanoidiQ96QZ0
KOiK20857
OMAiPQISCFP
OrthoDBiEOG091G086D
PhylomeDBiQ96QZ0
TreeFamiTF333142

Family and domain databases

InterProiView protein in InterPro
IPR000990 Innexin
IPR039099 Pannexin
PANTHERiPTHR15759 PTHR15759, 1 hit
PfamiView protein in Pfam
PF00876 Innexin, 1 hit
PROSITEiView protein in PROSITE
PS51013 PANNEXIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q96QZ0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLAHTAAEY MLSDALLPDR RGPRLKGLRL ELPLDRIVKF VAVGSPLLLM
60 70 80 90 100
SLAFAQEFSS GSPISCFSPS NFSIRQAAYV DSSCWDSLLH HKQDGPGQDK
110 120 130 140 150
MKSLWPHKAL PYSLLALALL MYLPVLLWQY AAVPALSSDL LFIISELDKS
160 170 180 190 200
YNRSIRLVQH MLKIRQKSSD PYVFWNELEK ARKERYFEFP LLERYLACKQ
210 220 230 240 250
RSHSLVATYL LRNSLLLIFT SATYLYLGHF HLDVFFQEEF SCSIKTGLLS
260 270 280 290 300
DETHVPNLIT CRLTSLSIFQ IVSLSSVAIY TILVPVIIYN LTRLCRWDKR
310 320 330 340 350
LLSVYEMLPA FDLLSRKMLG CPINDLNVIL LFLRANISEL ISFSWLSVLC
360 370 380 390
VLKDTTTQKH NIDTVVDFMT LLAGLEPSKP KHLTNSACDE HP
Length:392
Mass (Da):44,683
Last modified:December 1, 2001 - v1
Checksum:i8988F5DCC6E1B050
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03436795G → R. Corresponds to variant dbSNP:rs34498516Ensembl.1
Natural variantiVAR_034368208T → A. Corresponds to variant dbSNP:rs35569094Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF406650 mRNA Translation: AAK95655.1
CCDSiCCDS8447.1
RefSeqiNP_443191.1, NM_052959.2
UniGeneiHs.99235

Genome annotation databases

EnsembliENST00000284288; ENSP00000284288; ENSG00000154143
GeneIDi116337
KEGGihsa:116337
UCSCiuc001qah.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Pannexin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF406650 mRNA Translation: AAK95655.1
CCDSiCCDS8447.1
RefSeqiNP_443191.1, NM_052959.2
UniGeneiHs.99235

3D structure databases

ProteinModelPortaliQ96QZ0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125498, 1 interactor
IntActiQ96QZ0, 1 interactor

Protein family/group databases

TCDBi1.A.25.2.3 the gap junction-forming innexin (innexin) family

PTM databases

iPTMnetiQ96QZ0
PhosphoSitePlusiQ96QZ0

Polymorphism and mutation databases

BioMutaiPANX3
DMDMi20139071

Proteomic databases

PaxDbiQ96QZ0
PRIDEiQ96QZ0
ProteomicsDBi77913

Protocols and materials databases

DNASUi116337
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000284288; ENSP00000284288; ENSG00000154143
GeneIDi116337
KEGGihsa:116337
UCSCiuc001qah.4 human

Organism-specific databases

CTDi116337
DisGeNETi116337
EuPathDBiHostDB:ENSG00000154143.2
GeneCardsiPANX3
HGNCiHGNC:20573 PANX3
MIMi608422 gene
neXtProtiNX_Q96QZ0
OpenTargetsiENSG00000154143
PharmGKBiPA134920643
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE65 Eukaryota
ENOG410ZSQN LUCA
GeneTreeiENSGT00390000009703
HOGENOMiHOG000063721
HOVERGENiHBG053497
InParanoidiQ96QZ0
KOiK20857
OMAiPQISCFP
OrthoDBiEOG091G086D
PhylomeDBiQ96QZ0
TreeFamiTF333142

Miscellaneous databases

GenomeRNAii116337
PROiPR:Q96QZ0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000154143 Expressed in 17 organ(s), highest expression level in tibia
CleanExiHS_PANX3
GenevisibleiQ96QZ0 HS

Family and domain databases

InterProiView protein in InterPro
IPR000990 Innexin
IPR039099 Pannexin
PANTHERiPTHR15759 PTHR15759, 1 hit
PfamiView protein in Pfam
PF00876 Innexin, 1 hit
PROSITEiView protein in PROSITE
PS51013 PANNEXIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPANX3_HUMAN
AccessioniPrimary (citable) accession number: Q96QZ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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