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Entry version 149 (13 Nov 2019)
Sequence version 1 (01 Dec 2001)
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Protein

Exportin-6

Gene

XPO6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the nuclear export of actin and profilin-actin complexes in somatic cells.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • nuclear export signal receptor activity Source: UniProtKB
  • Ran GTPase binding Source: InterPro

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Exportin-6
Short name:
Exp6
Alternative name(s):
Ran-binding protein 20
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:XPO6
Synonyms:KIAA0370, RANBP20
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19733 XPO6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608411 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96QU8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23214

Open Targets

More...
OpenTargetsi
ENSG00000169180

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134989996

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96QU8

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
XPO6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74724278

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002353012 – 1125Exportin-6Add BLAST1124

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei199PhosphoserineBy similarity1
Modified residuei201PhosphothreonineCombined sources1
Modified residuei204PhosphothreonineCombined sources1
Modified residuei208PhosphoserineCombined sources1
Modified residuei224PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96QU8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96QU8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96QU8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96QU8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96QU8

PeptideAtlas

More...
PeptideAtlasi
Q96QU8

PRoteomics IDEntifications database

More...
PRIDEi
Q96QU8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
12772
77908 [Q96QU8-1]

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q96QU8

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96QU8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96QU8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000169180 Expressed in 221 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96QU8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96QU8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA038246

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Found in a complex with XPO6, Ran, ACTB and PFN1.

Interacts with ACTB (PubMed:14592989).

Interacts with ACTB in a RanGTP-dependent manner (PubMed:14592989).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
P371983EBI-10293124,EBI-347978

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116821, 50 interactors

Protein interaction database and analysis system

More...
IntActi
Q96QU8, 21 interactors

Molecular INTeraction database

More...
MINTi
Q96QU8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000302790

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 97Importin N-terminalPROSITE-ProRule annotationAdd BLAST67

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the exportin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2020 Eukaryota
COG5101 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000002810

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96QU8

Identification of Orthologs from Complete Genome Data

More...
OMAi
HRWQYFY

Database of Orthologous Groups

More...
OrthoDBi
214523at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96QU8

TreeFam database of animal gene trees

More...
TreeFami
TF323443

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR013598 Exportin-1/Importin-b-like
IPR001494 Importin-beta_N
IPR040016 XPO6

The PANTHER Classification System

More...
PANTHERi
PTHR21452 PTHR21452, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03810 IBN_N, 1 hit
PF08389 Xpo1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00913 IBN_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50166 IMPORTIN_B_NT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96QU8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASEEASLRA LESLMTEFFH DCTTNERKRE IEELLNNFAQ QIGAWRFCLY
60 70 80 90 100
FLSSTRNDYV MMYSLTVFEN LINKMWLGVP SQDKMEIRSC LPKLLLAHHK
110 120 130 140 150
TLPYFIRNKL CKVIVDIGRQ DWPMFYHDFF TNILQLIQSP VTTPLGLIML
160 170 180 190 200
KTTSEELACP REDLSVARKE ELRKLLLDQV QTVLGLLTGI LETVWDKHSV
210 220 230 240 250
TAATPPPSPT SGESGDLLSN LLQSPSSAKL LNQPIPILDV ESEYICSLAL
260 270 280 290 300
ECLAHLFSWI PLSASITPSL LTTIFHFARF GCDIRARKMA SVNGSSQNCV
310 320 330 340 350
SGQERGRLGV LAMSCINELM SKNCVPMEFE EYLLRMFQQT FYLLQKITKD
360 370 380 390 400
NNAHTVKSRL EELDESYIEK FTDFLRLFVS VHLRRIESYS QFPVVEFLTL
410 420 430 440 450
LFKYTFHQPT HEGYFSCLDI WTLFLDYLTS KIKSRLGDKE AVLNRYEDAL
460 470 480 490 500
VLLLTEVLNR IQFRYNQAQL EELDDETLDD DQQTEWQRYL RQSLEVVAKV
510 520 530 540 550
MELLPTHAFS TLFPVLQDNL EVYLGLQQFI VTSGSGHRLN ITAENDCRRL
560 570 580 590 600
HCSLRDLSSL LQAVGRLAEY FIGDVFAARF NDALTVVERL VKVTLYGSQI
610 620 630 640 650
KLYNIETAVP SVLKPDLIDV HAQSLAALQA YSHWLAQYCS EVHRQNTQQF
660 670 680 690 700
VTLISTTMDA ITPLISTKVQ DKLLLSACHL LVSLATTVRP VFLISIPAVQ
710 720 730 740 750
KVFNRITDAS ALRLVDKAQV LVCRALSNIL LLPWPNLPEN EQQWPVRSIN
760 770 780 790 800
HASLISALSR DYRNLKPSAV APQRKMPLDD TKLIIHQTLS VLEDIVENIS
810 820 830 840 850
GESTKSRQIC YQSLQESVQV SLALFPAFIH QSDVTDEMLS FFLTLFRGLR
860 870 880 890 900
VQMGVPFTEQ IIQTFLNMFT REQLAESILH EGSTGCRVVE KFLKILQVVV
910 920 930 940 950
QEPGQVFKPF LPSIIALCME QVYPIIAERP SPDVKAELFE LLFRTLHHNW
960 970 980 990 1000
RYFFKSTVLA SVQRGIAEEQ MENEPQFSAI MQAFGQSFLQ PDIHLFKQNL
1010 1020 1030 1040 1050
FYLETLNTKQ KLYHKKIFRT AMLFQFVNVL LQVLVHKSHD LLQEEIGIAI
1060 1070 1080 1090 1100
YNMASVDFDG FFAAFLPEFL TSCDGVDANQ KSVLGRNFKM DRDLPSFTQN
1110 1120
VHRLVNDLRY YRLCNDSLPP GTVKL
Length:1,125
Mass (Da):128,883
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i753D5F815EC110A2
GO
Isoform 2 (identifier: Q96QU8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: Missing.

Show »
Length:1,111
Mass (Da):127,394
Checksum:iEF0366D01A789C85
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BR41H3BR41_HUMAN
Exportin-6
XPO6
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L2K0I3L2K0_HUMAN
Exportin-6
XPO6
255Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BMW9H3BMW9_HUMAN
Exportin-6
XPO6
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BPG8H3BPG8_HUMAN
Exportin-6
XPO6
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BRV5H3BRV5_HUMAN
Exportin-6
XPO6
132Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L0S8I3L0S8_HUMAN
Exportin-6
XPO6
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BUP8H3BUP8_HUMAN
Exportin-6
XPO6
21Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BRJ6H3BRJ6_HUMAN
Exportin-6
XPO6
17Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L2D7I3L2D7_HUMAN
Exportin-6
XPO6
19Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA20825 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti378 – 379FV → L in AAI08287 (PubMed:15489334).Curated2
Sequence conflicti811Y → H in AAH78674 (PubMed:15489334).Curated1
Sequence conflicti891K → R in BAD96763 (Ref. 8) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0489611029V → L. Corresponds to variant dbSNP:rs14672Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0557561 – 14Missing in isoform 2. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY026388 mRNA Translation: AAK01471.1
AB002368 mRNA Translation: BAA20825.3 Different initiation.
AK123846 mRNA No translation available.
AC136611 Genomic DNA No translation available.
CH471145 Genomic DNA Translation: EAW55736.1
CH471145 Genomic DNA Translation: EAW55738.1
CH471145 Genomic DNA Translation: EAW55739.1
BC004403 mRNA Translation: AAH04403.1
BC014071 mRNA Translation: AAH14071.2
BC078674 mRNA Translation: AAH78674.1
BC108286 mRNA Translation: AAI08287.1
BC130304 mRNA Translation: AAI30305.1
AK223043 mRNA Translation: BAD96763.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS42135.1 [Q96QU8-1]
CCDS59266.1 [Q96QU8-2]

NCBI Reference Sequences

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RefSeqi
NP_001257869.1, NM_001270940.1 [Q96QU8-2]
NP_055986.1, NM_015171.3 [Q96QU8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000304658; ENSP00000302790; ENSG00000169180 [Q96QU8-1]
ENST00000565698; ENSP00000457341; ENSG00000169180 [Q96QU8-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23214

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23214

UCSC genome browser

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UCSCi
uc002dpa.4 human [Q96QU8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY026388 mRNA Translation: AAK01471.1
AB002368 mRNA Translation: BAA20825.3 Different initiation.
AK123846 mRNA No translation available.
AC136611 Genomic DNA No translation available.
CH471145 Genomic DNA Translation: EAW55736.1
CH471145 Genomic DNA Translation: EAW55738.1
CH471145 Genomic DNA Translation: EAW55739.1
BC004403 mRNA Translation: AAH04403.1
BC014071 mRNA Translation: AAH14071.2
BC078674 mRNA Translation: AAH78674.1
BC108286 mRNA Translation: AAI08287.1
BC130304 mRNA Translation: AAI30305.1
AK223043 mRNA Translation: BAD96763.1
CCDSiCCDS42135.1 [Q96QU8-1]
CCDS59266.1 [Q96QU8-2]
RefSeqiNP_001257869.1, NM_001270940.1 [Q96QU8-2]
NP_055986.1, NM_015171.3 [Q96QU8-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi116821, 50 interactors
IntActiQ96QU8, 21 interactors
MINTiQ96QU8
STRINGi9606.ENSP00000302790

PTM databases

CarbonylDBiQ96QU8
iPTMnetiQ96QU8
PhosphoSitePlusiQ96QU8

Polymorphism and mutation databases

BioMutaiXPO6
DMDMi74724278

Proteomic databases

EPDiQ96QU8
jPOSTiQ96QU8
MassIVEiQ96QU8
MaxQBiQ96QU8
PaxDbiQ96QU8
PeptideAtlasiQ96QU8
PRIDEiQ96QU8
ProteomicsDBi12772
77908 [Q96QU8-1]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
23214

Genome annotation databases

EnsembliENST00000304658; ENSP00000302790; ENSG00000169180 [Q96QU8-1]
ENST00000565698; ENSP00000457341; ENSG00000169180 [Q96QU8-2]
GeneIDi23214
KEGGihsa:23214
UCSCiuc002dpa.4 human [Q96QU8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23214
DisGeNETi23214

GeneCards: human genes, protein and diseases

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GeneCardsi
XPO6
HGNCiHGNC:19733 XPO6
HPAiHPA038246
MIMi608411 gene
neXtProtiNX_Q96QU8
OpenTargetsiENSG00000169180
PharmGKBiPA134989996

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2020 Eukaryota
COG5101 LUCA
GeneTreeiENSGT00390000002810
InParanoidiQ96QU8
OMAiHRWQYFY
OrthoDBi214523at2759
PhylomeDBiQ96QU8
TreeFamiTF323443

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
XPO6 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
XPO6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23214
PharosiQ96QU8

Protein Ontology

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PROi
PR:Q96QU8

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000169180 Expressed in 221 organ(s), highest expression level in blood
ExpressionAtlasiQ96QU8 baseline and differential
GenevisibleiQ96QU8 HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR013598 Exportin-1/Importin-b-like
IPR001494 Importin-beta_N
IPR040016 XPO6
PANTHERiPTHR21452 PTHR21452, 1 hit
PfamiView protein in Pfam
PF03810 IBN_N, 1 hit
PF08389 Xpo1, 1 hit
SMARTiView protein in SMART
SM00913 IBN_N, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50166 IMPORTIN_B_NT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiXPO6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96QU8
Secondary accession number(s): A1L3W4
, D3DWF9, Q2YDX3, Q53G88, Q68G50, Q76N88, Q96CP8, Q9BT21
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 1, 2001
Last modified: November 13, 2019
This is version 149 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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