Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 175 (22 Apr 2020)
Sequence version 2 (17 Oct 2006)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Protocadherin-15

Gene

PCDH15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium-dependent cell-adhesion protein. Essential for maintenance of normal retinal and cochlear function.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion, Hearing
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protocadherin-15
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PCDH15
Synonyms:USH1F
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14674 PCDH15

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605514 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96QU1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini27 – 1376ExtracellularSequence analysisAdd BLAST1350
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1377 – 1397HelicalSequence analysisAdd BLAST21
Topological domaini1398 – 1955CytoplasmicSequence analysisAdd BLAST558

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Usher syndrome 1F (USH1F)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionUSH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa with sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH1 is characterized by profound congenital sensorineural deafness, absent vestibular function and prepubertal onset of progressive retinitis pigmentosa leading to blindness.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_071696134R → Q in USH1F. 1 PublicationCorresponds to variant dbSNP:rs767966376Ensembl.1
Natural variantiVAR_0240371342Q → K in USH1F. 1 PublicationCorresponds to variant dbSNP:rs61731387EnsemblClinVar.1
Natural variantiVAR_0240381867Missing in USH1F. 1 Publication1
Isoform 4 (identifier: Q96QU1-4)
Natural variantiVAR_0828011611E → A in USH1F. 1 Publication1
Usher syndrome 1D/F (USH1DF)2 Publications
The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry.
Disease descriptionUSH1DF patients are heterozygous for mutations in CDH23 and PCDH15, indicating a digenic inheritance pattern.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_069297178D → G in USH1DF. 1 Publication1
Deafness, autosomal recessive, 23 (DFNB23)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024035134R → G in DFNB23. 2 PublicationsCorresponds to variant dbSNP:rs137853003EnsemblClinVar.1
Natural variantiVAR_024036262G → D in DFNB23. 1 PublicationCorresponds to variant dbSNP:rs137853002EnsemblClinVar.1
Natural variantiVAR_0795071576 – 1955Missing in DFNB23. 1 PublicationAdd BLAST380

Keywords - Diseasei

Deafness, Disease mutation, Non-syndromic deafness, Retinitis pigmentosa, Usher syndrome

Organism-specific databases

DisGeNET

More...
DisGeNETi
65217

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
PCDH15

MalaCards human disease database

More...
MalaCardsi
PCDH15
MIMi276900 phenotype
601067 phenotype
602083 phenotype
609533 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000150275

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
90636 Autosomal recessive non-syndromic sensorineural deafness type DFNB
231169 Usher syndrome type 1

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA32999

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96QU1 Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL6112

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PCDH15

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116242702

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000399827 – 1955Protocadherin-15Add BLAST1929

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi32 ↔ 120By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi52N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi97N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi201N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi419N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi559N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi662N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi724N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi768N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi821N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi851N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1064N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1084N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1175N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96QU1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96QU1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96QU1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96QU1

PeptideAtlas

More...
PeptideAtlasi
Q96QU1

PRoteomics IDEntifications database

More...
PRIDEi
Q96QU1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
77903 [Q96QU1-1]
77904 [Q96QU1-2]
77905 [Q96QU1-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96QU1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96QU1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain, lung, kidney, spleen and testis. Found also in the inner and outer synaptic layers, and the nerve fiber layer in adult and fetal retinas. Found in the supporting cells, outer sulcus cells and spiral ganglion of fetal cochlea. Expressed in cytotoxic tumor-derived T- and NK-cell lines as well as biopsies of nasal NK/T-cell lymphomas. Not detected in normal or in vitro activated peripheral blood cells, CD4 or CD8 lymphocytes or NK cells. Isoform 3 is expressed in brain, heart, cerebellum and kidney. CD1 isoforms, such as isoform 1, have a limited pattern of expression and is detected in testis, retina and cochlea. CD2 isoforms, such as isoforms 4 and 5, are expressed in heart, kidney, thymus, spleen, testis, retina and cochlea. CD3 isoforms, such as isoform 6, are widely expressed.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000150275 Expressed in corpus callosum and 66 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96QU1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96QU1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000150275 Tissue enhanced (adrenal gland, retina)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Antiparallel heterodimer with CDH23.

Found in a complex with TMIE and LHFPL5.

Interacts with LHFPL5/TMHS; this interaction is required for efficient localization to hair bundles.

Interacts with MYO7A.

Interacts with USH1G; this interaction may recruit USH1G to the plasma membrane.

Interacts with TOMT. Isoforms CD1 and CD3 interact with TMC1 (via N-terminus) and TMC2 (via N-terminus).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122407, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q96QU1, 1 interactor

Molecular INTeraction database

More...
MINTi
Q96QU1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000363068

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96QU1 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11955
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96QU1

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini40 – 147Cadherin 1PROSITE-ProRule annotationAdd BLAST108
Domaini148 – 265Cadherin 2PROSITE-ProRule annotationAdd BLAST118
Domaini278 – 395Cadherin 3PROSITE-ProRule annotationAdd BLAST118
Domaini396 – 509Cadherin 4PROSITE-ProRule annotationAdd BLAST114
Domaini510 – 616Cadherin 5PROSITE-ProRule annotationAdd BLAST107
Domaini617 – 717Cadherin 6PROSITE-ProRule annotationAdd BLAST101
Domaini719 – 819Cadherin 7PROSITE-ProRule annotationAdd BLAST101
Domaini820 – 926Cadherin 8PROSITE-ProRule annotationAdd BLAST107
Domaini927 – 1035Cadherin 9PROSITE-ProRule annotationAdd BLAST109
Domaini1037 – 1144Cadherin 10PROSITE-ProRule annotationAdd BLAST108
Domaini1145 – 1259Cadherin 11PROSITE-ProRule annotationAdd BLAST115

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1435 – 1443Poly-Pro9
Compositional biasi1746 – 1752Poly-Pro7
Compositional biasi1815 – 1823Poly-Pro9
Compositional biasi1826 – 1831Poly-Pro6

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Cadherin repeats 1 and 2 mediate calcium-dependent heterophilic interaction with CDH23.By similarity
Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3594 Eukaryota
ENOG410XQHI LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156675

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_286776_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96QU1

KEGG Orthology (KO)

More...
KOi
K16500

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96QU1

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR041149 EC_dom
IPR030718 Protocadherin-15

The PANTHER Classification System

More...
PANTHERi
PTHR24028:SF11 PTHR24028:SF11, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00028 Cadherin, 8 hits
PF18432 ECD, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00205 CADHERIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00112 CA, 11 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49313 SSF49313, 10 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00232 CADHERIN_1, 3 hits
PS50268 CADHERIN_2, 10 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 29 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96QU1-1) [UniParc]FASTAAdd to basket
Also known as: A, CD1-1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFRQFYLWTC LASGIILGSL FEICLGQYDD DCKLARGGPP ATIVAIDEES
60 70 80 90 100
RNGTILVDNM LIKGTAGGPD PTIELSLKDN VDYWVLMDPV KQMLFLNSTG
110 120 130 140 150
RVLDRDPPMN IHSIVVQVQC INKKVGTIIY HEVRIVVRDR NDNSPTFKHE
160 170 180 190 200
SYYATVNELT PVGTTIFTGF SGDNGATDID DGPNGQIEYV IQYNPDDPTS
210 220 230 240 250
NDTFEIPLML TGNIVLRKRL NYEDKTRYFV IIQANDRAQN LNERRTTTTT
260 270 280 290 300
LTVDVLDGDD LGPMFLPCVL VPNTRDCRPL TYQAAIPELR TPEELNPIIV
310 320 330 340 350
TPPIQAIDQD RNIQPPSDRP GILYSILVGT PEDYPRFFHM HPRTAELSLL
360 370 380 390 400
EPVNRDFHQK FDLVIKAEQD NGHPLPAFAG LHIEILDENN QSPYFTMPSY
410 420 430 440 450
QGYILESAPV GATISDSLNL TSPLRIVALD KDIEDTKDPE LHLFLNDYTS
460 470 480 490 500
VFTVTQTGIT RYLTLLQPVD REEQQTYTFS ITAFDGVQES EPVIVNIQVM
510 520 530 540 550
DANDNTPTFP EISYDVYVYT DMRPGDSVIQ LTAVDADEGS NGEITYEILV
560 570 580 590 600
GAQGDFIINK TTGLITIAPG VEMIVGRTYA LTVQAADNAP PAERRNSICT
610 620 630 640 650
VYIEVLPPNN QSPPRFPQLM YSLEISEAMR VGAVLLNLQA TDREGDSITY
660 670 680 690 700
AIENGDPQRV FNLSETTGIL TLGKALDRES TDRYILIITA SDGRPDGTST
710 720 730 740 750
ATVNIVVTDV NDNAPVFDPY LPRNLSVVEE EANAFVGQVK ATDPDAGING
760 770 780 790 800
QVHYSLGNFN NLFRITSNGS IYTAVKLNRE VRDYYELVVV ATDGAVHPRH
810 820 830 840 850
STLTLAIKVL DIDDNSPVFT NSTYTVLVEE NLPAGTTILQ IEAKDVDLGA
860 870 880 890 900
NVSYRIRSPE VKHFFALHPF TGELSLLRSL DYEAFPDQEA SITFLVEAFD
910 920 930 940 950
IYGTMPPGIA TVTVIVKDMN DYPPVFSKRI YKGMVAPDAV KGTPITTVYA
960 970 980 990 1000
EDADPPGLPA SRVRYRVDDV QFPYPASIFE VEEDSGRVIT RVNLNEEPTT
1010 1020 1030 1040 1050
IFKLVVVAFD DGEPVMSSSA TVKILVLHPG EIPRFTQEEY RPPPVSELAT
1060 1070 1080 1090 1100
KGTMVGVISA AAINQSIVYS IVSGNEEDTF GINNITGVIY VNGPLDYETR
1110 1120 1130 1140 1150
TSYVLRVQAD SLEVVLANLR VPSKSNTAKV YIEIQDENNH PPVFQKKFYI
1160 1170 1180 1190 1200
GGVSEDARMF TSVLRVKATD KDTGNYSVMA YRLIIPPIKE GKEGFVVETY
1210 1220 1230 1240 1250
TGLIKTAMLF HNMRRSYFKF QVIATDDYGK GLSGKADVLV SVVNQLDMQV
1260 1270 1280 1290 1300
IVSNVPPTLV EKKIEDLTEI LDRYVQEQIP GAKVVVESIG ARRHGDAFSL
1310 1320 1330 1340 1350
EDYTKCDLTV YAIDPQTNRA IDRNELFKFL DGKLLDINKD FQPYYGEGGR
1360 1370 1380 1390 1400
ILEIRTPEAV TSIKKRGESL GYTEGALLAL AFIIILCCIP AILVVLVSYR
1410 1420 1430 1440 1450
QFKVRQAECT KTARIQAALP AAKPAVPAPA PVAAPPPPPP PPPGAHLYEE
1460 1470 1480 1490 1500
LGDSSILFLL YHFQQSRGNN SVSEDRKHQQ VVMPFSSNTI EAHKSAHVDG
1510 1520 1530 1540 1550
SLKSNKLKSA RKFTFLSDED DLSAHNPLYK ENISQVSTNS DISQRTDFVD
1560 1570 1580 1590 1600
PFSPKIQAKS KSLRGPREKI QRLWSQSVSL PRRLMRKVPN RPEIIDLQQW
1610 1620 1630 1640 1650
QGTRQKAENE NTGICTNKRG SSNPLLTTEE ANLTEKEEIR QGETLMIEGT
1660 1670 1680 1690 1700
EQLKSLSSDS SFCFPRPHFS FSTLPTVSRT VELKSEPNVI SSPAECSLEL
1710 1720 1730 1740 1750
SPSRPCVLHS SLSRRETPIC MLPIETERNI FENFAHPPNI SPSACPLPPP
1760 1770 1780 1790 1800
PPISPPSPPP APAPLAPPPD ISPFSLFCPP PSPPSIPLPL PPPTFFPLSV
1810 1820 1830 1840 1850
STSGPPTPPL LPPFPTPLPP PPPSIPCPPP PSASFLSTEC VCITGVKCTT
1860 1870 1880 1890 1900
NLMPAEKIKS SMTQLSTTTV CKTDPQREPK GILRHVKNLA ELEKSVANMY
1910 1920 1930 1940 1950
SQIEKNYLRT NVSELQTMCP SEVTNMEITS EQNKGSLNNI VEGTEKQSHS

QSTSL
Length:1,955
Mass (Da):216,069
Last modified:October 17, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i23BA3A237CB188E7
GO
Isoform 2 (identifier: Q96QU1-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     1-1118: Missing.
     1119-1125: LRVPSKS → MTFSHSG

Show »
Length:837
Mass (Da):92,358
Checksum:iD7823874BDD9A3A8
GO
Isoform 3 (identifier: Q96QU1-3) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     957-961: GLPAS → VSRRH
     962-1955: Missing.

Show »
Length:961
Mass (Da):106,613
Checksum:iE4B429F6BDB9A547
GO
Isoform 4 (identifier: Q96QU1-4) [UniParc]FASTAAdd to basket
Also known as: CD2-1

The sequence of this isoform differs from the canonical sequence as follows:
     435-435: D → DVPPSGVP
     1456-1776: ILFLLYHFQQ...PPPDISPFSL → MYEMPQYGSR...ANSEGYNTAL
     1777-1955: Missing.

Show »
Length:1,783
Mass (Da):197,906
Checksum:i8048D1CB309C6654
GO
Isoform 5 (identifier: Q96QU1-6) [UniParc]FASTAAdd to basket
Also known as: CD3-1

The sequence of this isoform differs from the canonical sequence as follows:
     1456-1675: ILFLLYHFQQ...RPHFSFSTLP → MYEMPQYGSR...NNLHIPMTKL
     1676-1955: Missing.

Show »
Length:1,675
Mass (Da):185,964
Checksum:iCA24BBAF836E93E1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 29 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A3D8A2A3D8_HUMAN
Protocadherin-15
PCDH15
1,962Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WTR6A0A087WTR6_HUMAN
Protocadherin-15
PCDH15
1,539Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WZN9A0A087WZN9_HUMAN
Protocadherin-15
PCDH15
1,790Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WZW3A0A087WZW3_HUMAN
Protocadherin-15
PCDH15
1,789Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7ZBT8B7ZBT8_HUMAN
Protocadherin-15
PCDH15
1,150Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y6C0A0A2R8Y6C0_HUMAN
Protocadherin-15
PCDH15
1,740Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A3E3A2A3E3_HUMAN
Protocadherin-15
PCDH15
1,540Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A3E7A2A3E7_HUMAN
Protocadherin-15
PCDH15
1,957Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A3E8A2A3E8_HUMAN
Protocadherin-15
PCDH15
1,932Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A3E6A2A3E6_HUMAN
Protocadherin-15
PCDH15
1,952Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence ACF76477 differs from that shown. Unlikely isoform. Probable cloning artifact.Curated
The sequence CAD38850 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti261L → S in AAK31581 (PubMed:11487575).Curated1
Sequence conflicti467Q → L in AAK31581 (PubMed:11487575).Curated1
Sequence conflicti1276Q → R in AAK31581 (PubMed:11487575).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02828919S → A2 PublicationsCorresponds to variant dbSNP:rs11004439EnsemblClinVar.1
Natural variantiVAR_024035134R → G in DFNB23. 2 PublicationsCorresponds to variant dbSNP:rs137853003EnsemblClinVar.1
Natural variantiVAR_071696134R → Q in USH1F. 1 PublicationCorresponds to variant dbSNP:rs767966376Ensembl.1
Natural variantiVAR_071697174N → S1 PublicationCorresponds to variant dbSNP:rs145037203EnsemblClinVar.1
Natural variantiVAR_069297178D → G in USH1DF. 1 Publication1
Natural variantiVAR_024036262G → D in DFNB23. 1 PublicationCorresponds to variant dbSNP:rs137853002EnsemblClinVar.1
Natural variantiVAR_028290380G → S1 PublicationCorresponds to variant dbSNP:rs10825269EnsemblClinVar.1
Natural variantiVAR_028291435D → A2 PublicationsCorresponds to variant dbSNP:rs4935502EnsemblClinVar.1
Natural variantiVAR_028292929R → Q3 PublicationsCorresponds to variant dbSNP:rs2135720EnsemblClinVar.1
Natural variantiVAR_0716981273R → S1 PublicationCorresponds to variant dbSNP:rs111033363EnsemblClinVar.1
Natural variantiVAR_0240371342Q → K in USH1F. 1 PublicationCorresponds to variant dbSNP:rs61731387EnsemblClinVar.1
Natural variantiVAR_0795071576 – 1955Missing in DFNB23. 1 PublicationAdd BLAST380
Natural variantiVAR_0240381867Missing in USH1F. 1 Publication1
Isoform 4 (identifier: Q96QU1-4)
Natural variantiVAR_0828011611E → A in USH1F. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0282571 – 1118Missing in isoform 2. 1 PublicationAdd BLAST1118
Alternative sequenceiVSP_046616435D → DVPPSGVP in isoform 4. 1 Publication1
Alternative sequenceiVSP_028259957 – 961GLPAS → VSRRH in isoform 3. 1 Publication5
Alternative sequenceiVSP_028260962 – 1955Missing in isoform 3. 1 PublicationAdd BLAST994
Alternative sequenceiVSP_0282581119 – 1125LRVPSKS → MTFSHSG in isoform 2. 1 Publication7
Alternative sequenceiVSP_0466171456 – 1776ILFLL…SPFSL → MYEMPQYGSRRRLLPPAGQE EYGEVVGEAEEEYEEEEEEP KKIKKPKVEIREPSEEEEVV VTIEKPPAAEPTYTTWKRAR IFPMIFKKVRGLADKRGIVD LEGEEWQRRLEEEDKDYLKL TLDQEEATESTVESEEESSS DYTEYSEEESEFSESETTEE ESESETPSEEEESSTPESEE SESTESEGEKARKNIVLARR RPMVEEVKEVKGRKEEPQEE QKEPKMEEEEHSEEEESGPA PVEESTDPEAQDIPEEGSAE SASVEGGVESEEESESGSSS SSSESQSGGPWGYQVPAYDR SKNANQKKSPGANSEGYNTA L in isoform 4. 1 PublicationAdd BLAST321
Alternative sequenceiVSP_0466181456 – 1675ILFLL…FSTLP → MYEMPQYGSRRRLLPPAGQE EYGEVVGEAEEEYEEEEWAR KRMIKLVVDREYETSSTGED SAPECQRNRLHHPSIHSNIN GNIYIAQNGSVVRTRRACLT DNLKVASPVRLGGPFKKLDK LAVTHEENVPLNTLSKGPFS TEKMNARPTLVTFAPCPVGT DNTAVKPLRNRLKSTVEQES MIDSKNIKEALEFHSDHTQS DDEELWMGPWNNLHIPMTKL in isoform 5. 1 PublicationAdd BLAST220
Alternative sequenceiVSP_0466211676 – 1955Missing in isoform 5. 1 PublicationAdd BLAST280
Alternative sequenceiVSP_0466221777 – 1955Missing in isoform 4. 1 PublicationAdd BLAST179

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY029205 mRNA Translation: AAK31581.1
AY029237 mRNA Translation: AAK31804.1
AY388963 mRNA Translation: AAR26468.1
EU718480 mRNA Translation: ACF76476.1
EU718481 mRNA Translation: ACF76477.1 Sequence problems.
EU718482 mRNA Translation: ACF76478.1
AL834134 mRNA Translation: CAD38850.2 Different termination.
AC013737 Genomic DNA No translation available.
AC016817 Genomic DNA No translation available.
AC024073 Genomic DNA No translation available.
AC027671 Genomic DNA No translation available.
AL353784 Genomic DNA No translation available.
AL356114 Genomic DNA No translation available.
AL360214 Genomic DNA No translation available.
AL365496 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7248.1 [Q96QU1-1]
CCDS86093.1 [Q96QU1-3]
CCDS86094.1 [Q96QU1-6]
CCDS86095.1 [Q96QU1-4]

NCBI Reference Sequences

More...
RefSeqi
NP_149045.3, NM_033056.3 [Q96QU1-1]
XP_016872061.1, XM_017016572.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000320301; ENSP00000322604; ENSG00000150275 [Q96QU1-1]
ENST00000373955; ENSP00000363066; ENSG00000150275 [Q96QU1-3]
ENST00000395445; ENSP00000378832; ENSG00000150275 [Q96QU1-4]
ENST00000616114; ENSP00000483745; ENSG00000150275 [Q96QU1-6]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
65217

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:65217

UCSC genome browser

More...
UCSCi
uc001jju.2 human [Q96QU1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029205 mRNA Translation: AAK31581.1
AY029237 mRNA Translation: AAK31804.1
AY388963 mRNA Translation: AAR26468.1
EU718480 mRNA Translation: ACF76476.1
EU718481 mRNA Translation: ACF76477.1 Sequence problems.
EU718482 mRNA Translation: ACF76478.1
AL834134 mRNA Translation: CAD38850.2 Different termination.
AC013737 Genomic DNA No translation available.
AC016817 Genomic DNA No translation available.
AC024073 Genomic DNA No translation available.
AC027671 Genomic DNA No translation available.
AL353784 Genomic DNA No translation available.
AL356114 Genomic DNA No translation available.
AL360214 Genomic DNA No translation available.
AL365496 Genomic DNA No translation available.
CCDSiCCDS7248.1 [Q96QU1-1]
CCDS86093.1 [Q96QU1-3]
CCDS86094.1 [Q96QU1-6]
CCDS86095.1 [Q96QU1-4]
RefSeqiNP_149045.3, NM_033056.3 [Q96QU1-1]
XP_016872061.1, XM_017016572.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4XHZX-ray2.80A816-1144[»]
5T4MX-ray2.24A/B263-616[»]
5T4NX-ray2.70A/B263-616[»]
5ULYX-ray2.64A/B/C/D143-390[»]
6E8FX-ray2.99A/B/C263-608[»]
6EB5X-ray2.60A/B143-390[»]
SMRiQ96QU1
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi122407, 2 interactors
IntActiQ96QU1, 1 interactor
MINTiQ96QU1
STRINGi9606.ENSP00000363068

Chemistry databases

ChEMBLiCHEMBL6112

PTM databases

iPTMnetiQ96QU1
PhosphoSitePlusiQ96QU1

Polymorphism and mutation databases

BioMutaiPCDH15
DMDMi116242702

Proteomic databases

EPDiQ96QU1
MassIVEiQ96QU1
MaxQBiQ96QU1
PaxDbiQ96QU1
PeptideAtlasiQ96QU1
PRIDEiQ96QU1
ProteomicsDBi77903 [Q96QU1-1]
77904 [Q96QU1-2]
77905 [Q96QU1-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
27955 92 antibodies

Genome annotation databases

EnsembliENST00000320301; ENSP00000322604; ENSG00000150275 [Q96QU1-1]
ENST00000373955; ENSP00000363066; ENSG00000150275 [Q96QU1-3]
ENST00000395445; ENSP00000378832; ENSG00000150275 [Q96QU1-4]
ENST00000616114; ENSP00000483745; ENSG00000150275 [Q96QU1-6]
GeneIDi65217
KEGGihsa:65217
UCSCiuc001jju.2 human [Q96QU1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
65217
DisGeNETi65217

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PCDH15
GeneReviewsiPCDH15
HGNCiHGNC:14674 PCDH15
HPAiENSG00000150275 Tissue enhanced (adrenal gland, retina)
MalaCardsiPCDH15
MIMi276900 phenotype
601067 phenotype
602083 phenotype
605514 gene
609533 phenotype
neXtProtiNX_Q96QU1
OpenTargetsiENSG00000150275
Orphaneti90636 Autosomal recessive non-syndromic sensorineural deafness type DFNB
231169 Usher syndrome type 1
PharmGKBiPA32999

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00940000156675
HOGENOMiCLU_286776_0_0_1
InParanoidiQ96QU1
KOiK16500
PhylomeDBiQ96QU1

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PCDH15 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PCDH15

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
65217
PharosiQ96QU1 Tbio

Protein Ontology

More...
PROi
PR:Q96QU1
RNActiQ96QU1 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000150275 Expressed in corpus callosum and 66 other tissues
ExpressionAtlasiQ96QU1 baseline and differential
GenevisibleiQ96QU1 HS

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR041149 EC_dom
IPR030718 Protocadherin-15
PANTHERiPTHR24028:SF11 PTHR24028:SF11, 3 hits
PfamiView protein in Pfam
PF00028 Cadherin, 8 hits
PF18432 ECD, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 11 hits
SUPFAMiSSF49313 SSF49313, 10 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 3 hits
PS50268 CADHERIN_2, 10 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPCD15_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96QU1
Secondary accession number(s): A6NL19
, C6ZEF5, C6ZEF6, C6ZEF7, Q5VY38, Q5VY39, Q6TRH8, Q8NDB9, Q96QT8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: October 17, 2006
Last modified: April 22, 2020
This is version 175 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again