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Protein

PHD finger protein 12

Gene

PHF12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a transcriptional repressor. Involved in recruitment of functional SIN3A complexes to DNA. Represses transcription at least in part through the activity of an associated histone deacetylase (HDAC). May also repress transcription in a SIN3A-independent manner through recruitment of functional AES complexes to DNA.1 Publication1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri56 – 105PHD-type 1PROSITE-ProRule annotationAdd BLAST50
Zinc fingeri271 – 321PHD-type 2; atypicalPROSITE-ProRule annotationAdd BLAST51

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PHD finger protein 12
Alternative name(s):
PHD factor 1
Short name:
Pf1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PHF12Imported
Synonyms:KIAA1523Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000109118.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20816 PHF12

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96QT6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
57649

Open Targets

More...
OpenTargetsi
ENSG00000109118

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134954478

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PHF12

Domain mapping of disease mutations (DMDM)

More...
DMDMi
71153050

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000593021 – 1004PHD finger protein 12Add BLAST1004

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei131PhosphoserineCombined sources1
Modified residuei134PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki467Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei555PhosphoserineCombined sources1
Modified residuei557PhosphothreonineCombined sources1
Modified residuei570PhosphothreonineCombined sources1
Modified residuei671PhosphothreonineCombined sources1
Cross-linki900Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki973Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki987Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki991Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96QT6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96QT6

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96QT6

PeptideAtlas

More...
PeptideAtlasi
Q96QT6

PRoteomics IDEntifications database

More...
PRIDEi
Q96QT6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
77899
77900 [Q96QT6-2]
77901 [Q96QT6-3]
77902 [Q96QT6-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96QT6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96QT6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000109118 Expressed in 177 organ(s), highest expression level in blood

CleanEx database of gene expression profiles

More...
CleanExi
HS_PHF12

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96QT6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96QT6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA021410
HPA021452

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Isoform 2 interacts with SIN3A in a complex composed of HDAC1, SAP30 and SIN3A. Interacts with AES.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
MORF4L1Q9UBU8-25EBI-2803760,EBI-10288852

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
121686, 37 interactors

Database of interacting proteins

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DIPi
DIP-59632N

Protein interaction database and analysis system

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IntActi
Q96QT6, 15 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000329933

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11004
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q96QT6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96QT6

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q96QT6

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini815 – 869FHAPROSITE-ProRule annotationAdd BLAST55

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni102 – 273Interaction with SIN3A1 PublicationAdd BLAST172
Regioni105 – 128PBRAdd BLAST24
Regioni300 – 704Interaction with SIN3A1 PublicationAdd BLAST405

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi894 – 897Poly-ArgSequence analysis4
Compositional biasi929 – 932Poly-SerSequence analysis4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The polybasic region (PBR) is responsive to the binding to phosphoinositides (PtdInsPs).

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri56 – 105PHD-type 1PROSITE-ProRule annotationAdd BLAST50
Zinc fingeri271 – 321PHD-type 2; atypicalPROSITE-ProRule annotationAdd BLAST51

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4299 Eukaryota
ENOG410XQQA LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155713

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000220810

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG057884

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96QT6

Identification of Orthologs from Complete Genome Data

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OMAi
QWLCHSC

Database of Orthologous Groups

More...
OrthoDBi
EOG091G055U

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96QT6

TreeFam database of animal gene trees

More...
TreeFami
TF336193

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00060 FHA, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.1860, 1 hit
1.20.920.10, 1 hit
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR036427 Bromodomain-like_sf
IPR000253 FHA_dom
IPR031966 PHF12_MRG-bd
IPR038098 PHF12_MRG-bd_sf
IPR008984 SMAD_FHA_dom_sf
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00628 PHD, 2 hits
PF16737 PHF12_MRG_bd, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00249 PHD, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49879 SSF49879, 1 hit
SSF57903 SSF57903, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50006 FHA_DOMAIN, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1Curated (identifier: Q96QT6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWEKMETKTI VYDLDTSGGL MEQIQALLAP PKTDEAEKRS RKPEKEPRRS
60 70 80 90 100
GRATNHDSCD SCKEGGDLLC CDHCPAAFHL QCCNPPLSEE MLPPGEWMCH
110 120 130 140 150
RCTVRRKKRE QKKELGHVNG LVDKSGKRTT SPSSDTDLLD RSASKTELKA
160 170 180 190 200
IAHARILERR ASRPGTPTSS ASTETPTSEQ NDVDEDIIDV DEEPVAAEPD
210 220 230 240 250
YVQPQLRRPF ELLIAAAMER NPTQFQLPNE LTCTTALPGS SKRRRKEETT
260 270 280 290 300
GKNVKKTQHE LDHNGLVPLP VKVCFTCNRS CRVAPLIQCD YCPLLFHMDC
310 320 330 340 350
LEPPLTAMPL GRWMCPNHIE HVVLNQKNMT LSNRCQVFDR FQDTVSQHVV
360 370 380 390 400
KVDFLNRIHK KHPPNRRVLQ SVKRRSLKVP DAIKSQYQFP PPLIAPAAIR
410 420 430 440 450
DGELICNGIP EESQMHLLNS EHLATQAEQQ EWLCSVVALQ CSILKHLSAK
460 470 480 490 500
QMPSHWDSEQ TEKADIKPVI VTDSSVTTSL QTADKTPTPS HYPLSCPSGI
510 520 530 540 550
STQNSLSCSP PHQSPALEDI GCSSCAEKSK KTPCGTANGP VNTEVKANGP
560 570 580 590 600
HLYSSPTDST DPRRLPGANT PLPGLSHRQG WPRPLTPPAA GGLQNHTVGI
610 620 630 640 650
IVKTENATGP SSCPQRSLVP VPSLPPSIPS SCASIENTST LQRKTVQSQI
660 670 680 690 700
GPPLTDSRPL GSPPNATRVL TPPQAAGDGI LATTANQRFS SPAPSSDGKV
710 720 730 740 750
SPGTLSIGSA LTVPSFPANS TAMVDLTNSL RAFMDVNGEI EINMLDEKLI
760 770 780 790 800
KFLALQRIHQ LFPSRVQPSP GSVGTHQLAS GGHHIEVQRK EVQARAVFYP
810 820 830 840 850
LLGLGGAVNM CYRTLYIGTG ADMDVCLTNY GHCNYVSGKH ACIFYDENTK
860 870 880 890 900
HYELLNYSEH GTTVDNVLYS CDFSEKTPPT PPSSIVAKVQ SVIRRRRHQK
910 920 930 940 950
QDEEPSEEAA MMSSQAQGPQ RRPCNCKASS SSLIGGSGAG WEGTALLHHG
960 970 980 990 1000
SYIKLGCLQF VFSITEFATK QPKGDASLLQ DGVLAEKLSL KPHQGPVLRS

NSVP
Note: No experimental confirmation available.Curated
Length:1,004
Mass (Da):109,698
Last modified:July 19, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i239223BE9EAF619B
GO
Isoform 21 Publication (identifier: Q96QT6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     697-704: DGKVSPGT → GECCSALG
     705-1004: Missing.

Show »
Length:704
Mass (Da):76,988
Checksum:iD7175FC65EB0B42E
GO
Isoform 3Curated (identifier: Q96QT6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     80-107: LQCCNPPLSEEMLPPGEWMCHRCTVRRK → LVVYQDFVAPISLFHGTFHDGPTCSFAQ
     787-849: VQRKEVQARA...HACIFYDENT → GAHVHTCHHI...SRNKMATTAF
     850-1004: Missing.

Note: Incomplete sequence. No experimental confirmation available.Curated
Show »
Length:849
Mass (Da):92,707
Checksum:iBF045D3AE4254F02
GO
Isoform 4Curated (identifier: Q96QT6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-414: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:590
Mass (Da):62,943
Checksum:iA258D4B3544FC1F9
GO
Isoform 5 (identifier: Q96QT6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     787-849: VQRKEVQARA...HACIFYDENT → GAHVHTCHHI...SRNKMATTAF
     850-1004: Missing.

Note: No experimental confirmation available.
Show »
Length:849
Mass (Da):92,924
Checksum:i9BAC91901BA5DB22
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J9G2C9J9G2_HUMAN
PHD finger protein 12
PHF12
705Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJ43K7EJ43_HUMAN
PHD finger protein 12
PHF12
215Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QQU3J3QQU3_HUMAN
PHD finger protein 12
PHF12
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQP5K7EQP5_HUMAN
PHD finger protein 12
PHF12
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ERZ4K7ERZ4_HUMAN
PHD finger protein 12
PHF12
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJY3K7EJY3_HUMAN
PHD finger protein 12
PHF12
54Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ENU0K7ENU0_HUMAN
PHD finger protein 12
PHF12
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EPF7K7EPF7_HUMAN
PHD finger protein 12
PHF12
273Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJN7K7EJN7_HUMAN
PHD finger protein 12
PHF12
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EMX6K7EMX6_HUMAN
PHD finger protein 12
PHF12
30Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti762F → Y in BAB14875 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0517671 – 414Missing in isoform 4. 1 PublicationAdd BLAST414
Alternative sequenceiVSP_05176880 – 107LQCCN…TVRRK → LVVYQDFVAPISLFHGTFHD GPTCSFAQ in isoform 3. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_051769697 – 704DGKVSPGT → GECCSALG in isoform 2. 2 Publications8
Alternative sequenceiVSP_051770705 – 1004Missing in isoform 2. 2 PublicationsAdd BLAST300
Alternative sequenceiVSP_051771787 – 849VQRKE…YDENT → GAHVHTCHHIIRSPLYVCEW SPCLHGESELPVSQTSLCAF HGLNKAPWFFSEESRNKMAT TAF in isoform 3 and isoform 5. 2 PublicationsAdd BLAST63
Alternative sequenceiVSP_051772850 – 1004Missing in isoform 3 and isoform 5. 2 PublicationsAdd BLAST155

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY030283 mRNA Translation: AAK38349.1
AK024290 mRNA Translation: BAB14875.1
AK160370 mRNA Translation: BAD18713.1
AC024267 Genomic DNA No translation available.
CH471159 Genomic DNA Translation: EAW51166.1
BC001657 mRNA Translation: AAH01657.1 Sequence problems.
BC110882 mRNA Translation: AAI10883.1
BC121044 mRNA Translation: AAI21045.1
AB040956 mRNA Translation: BAA96047.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11247.1 [Q96QT6-2]
CCDS32598.1 [Q96QT6-1]
CCDS76981.1 [Q96QT6-5]

NCBI Reference Sequences

More...
RefSeqi
NP_001028733.1, NM_001033561.1 [Q96QT6-1]
NP_001277060.1, NM_001290131.1 [Q96QT6-5]
NP_065940.1, NM_020889.2 [Q96QT6-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.444173

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000268756; ENSP00000268756; ENSG00000109118 [Q96QT6-2]
ENST00000332830; ENSP00000329933; ENSG00000109118 [Q96QT6-1]
ENST00000577226; ENSP00000465161; ENSG00000109118 [Q96QT6-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
57649

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:57649

UCSC genome browser

More...
UCSCi
uc002hdg.2 human [Q96QT6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY030283 mRNA Translation: AAK38349.1
AK024290 mRNA Translation: BAB14875.1
AK160370 mRNA Translation: BAD18713.1
AC024267 Genomic DNA No translation available.
CH471159 Genomic DNA Translation: EAW51166.1
BC001657 mRNA Translation: AAH01657.1 Sequence problems.
BC110882 mRNA Translation: AAI10883.1
BC121044 mRNA Translation: AAI21045.1
AB040956 mRNA Translation: BAA96047.1
CCDSiCCDS11247.1 [Q96QT6-2]
CCDS32598.1 [Q96QT6-1]
CCDS76981.1 [Q96QT6-5]
RefSeqiNP_001028733.1, NM_001033561.1 [Q96QT6-1]
NP_001277060.1, NM_001290131.1 [Q96QT6-5]
NP_065940.1, NM_020889.2 [Q96QT6-2]
UniGeneiHs.444173

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2L9SNMR-A200-241[»]
2LKMNMR-A200-241[»]
ProteinModelPortaliQ96QT6
SMRiQ96QT6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121686, 37 interactors
DIPiDIP-59632N
IntActiQ96QT6, 15 interactors
STRINGi9606.ENSP00000329933

PTM databases

iPTMnetiQ96QT6
PhosphoSitePlusiQ96QT6

Polymorphism and mutation databases

BioMutaiPHF12
DMDMi71153050

Proteomic databases

EPDiQ96QT6
MaxQBiQ96QT6
PaxDbiQ96QT6
PeptideAtlasiQ96QT6
PRIDEiQ96QT6
ProteomicsDBi77899
77900 [Q96QT6-2]
77901 [Q96QT6-3]
77902 [Q96QT6-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000268756; ENSP00000268756; ENSG00000109118 [Q96QT6-2]
ENST00000332830; ENSP00000329933; ENSG00000109118 [Q96QT6-1]
ENST00000577226; ENSP00000465161; ENSG00000109118 [Q96QT6-5]
GeneIDi57649
KEGGihsa:57649
UCSCiuc002hdg.2 human [Q96QT6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57649
DisGeNETi57649
EuPathDBiHostDB:ENSG00000109118.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PHF12

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0202392
HGNCiHGNC:20816 PHF12
HPAiHPA021410
HPA021452
neXtProtiNX_Q96QT6
OpenTargetsiENSG00000109118
PharmGKBiPA134954478

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4299 Eukaryota
ENOG410XQQA LUCA
GeneTreeiENSGT00940000155713
HOGENOMiHOG000220810
HOVERGENiHBG057884
InParanoidiQ96QT6
OMAiQWLCHSC
OrthoDBiEOG091G055U
PhylomeDBiQ96QT6
TreeFamiTF336193

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PHF12 human
EvolutionaryTraceiQ96QT6

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PHF12

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
57649

Protein Ontology

More...
PROi
PR:Q96QT6

Gene expression databases

BgeeiENSG00000109118 Expressed in 177 organ(s), highest expression level in blood
CleanExiHS_PHF12
ExpressionAtlasiQ96QT6 baseline and differential
GenevisibleiQ96QT6 HS

Family and domain databases

CDDicd00060 FHA, 1 hit
Gene3Di1.10.10.1860, 1 hit
1.20.920.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR036427 Bromodomain-like_sf
IPR000253 FHA_dom
IPR031966 PHF12_MRG-bd
IPR038098 PHF12_MRG-bd_sf
IPR008984 SMAD_FHA_dom_sf
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00628 PHD, 2 hits
PF16737 PHF12_MRG_bd, 1 hit
SMARTiView protein in SMART
SM00249 PHD, 2 hits
SUPFAMiSSF49879 SSF49879, 1 hit
SSF57903 SSF57903, 2 hits
PROSITEiView protein in PROSITE
PS50006 FHA_DOMAIN, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPHF12_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96QT6
Secondary accession number(s): Q0VAI5
, Q2TAK2, Q6ZML2, Q9BV34, Q9H7U9, Q9P205
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: December 5, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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