UniProtKB - Q96QT4 (TRPM7_HUMAN)
Transient receptor potential cation channel subfamily M member 7
TRPM7
Functioni
Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).
3 PublicationsCatalytic activityi
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 1624 | ATPBy similarity | 1 | |
Binding sitei | 1648 | ATPBy similarity | 1 | |
Binding sitei | 1720 | ATPBy similarity | 1 | |
Metal bindingi | 1753 | ZincBy similarity | 1 | |
Active sitei | 1767 | Proton acceptorBy similarity | 1 | |
Binding sitei | 1769 | ATPBy similarity | 1 | |
Binding sitei | 1777 | ATPBy similarity | 1 | |
Metal bindingi | 1810 | ZincBy similarity | 1 | |
Metal bindingi | 1812 | ZincBy similarity | 1 | |
Metal bindingi | 1816 | ZincBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 1794 – 1800 | ATPBy similarity | 7 |
GO - Molecular functioni
- actin binding Source: Ensembl
- ATP binding Source: UniProtKB-KW
- calcium channel activity Source: GO_Central
- cation channel activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- myosin binding Source: Ensembl
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: UniProtKB-KW
- protein serine kinase activity Source: RHEA
GO - Biological processi
- actomyosin structure organization Source: Ensembl
- calcium-dependent cell-matrix adhesion Source: Ensembl
- calcium ion transmembrane transport Source: Reactome
- calcium ion transport Source: GO_Central
- cation transmembrane transport Source: GO_Central
- cellular magnesium ion homeostasis Source: InterPro
- divalent inorganic cation homeostasis Source: GO_Central
- necroptotic process Source: UniProtKB
- protein autophosphorylation Source: Ensembl
- protein tetramerization Source: InterPro
Keywordsi
Molecular function | Calcium channel, Ion channel, Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Calcium transport, Ion transport, Necrosis, Transport |
Ligand | ATP-binding, Calcium, Metal-binding, Nucleotide-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q96QT4 |
Reactomei | R-HSA-3295583, TRP channels |
SignaLinki | Q96QT4 |
SIGNORi | Q96QT4 |
Protein family/group databases
TCDBi | 1.A.4.5.1, the transient receptor potential ca(2+) channel (trp-cc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Transient receptor potential cation channel subfamily M member 7 (EC:2.7.11.1)Alternative name(s): Channel-kinase 1 Long transient receptor potential channel 7 Short name: LTrpC-7 Short name: LTrpC7 |
Gene namesi | Name:TRPM7 Synonyms:CHAK1, LTRPC7 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17994, TRPM7 |
MIMi | 605692, gene |
neXtProti | NX_Q96QT4 |
VEuPathDBi | HostDB:ENSG00000092439 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: Reactome
Other locations
- ruffle Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 755 | CytoplasmicSequence analysisAdd BLAST | 755 | |
Transmembranei | 756 – 776 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 777 – 855 | ExtracellularSequence analysisAdd BLAST | 79 | |
Transmembranei | 856 – 876 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 877 – 918 | CytoplasmicSequence analysisAdd BLAST | 42 | |
Transmembranei | 919 – 939 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 940 – 962 | ExtracellularSequence analysisAdd BLAST | 23 | |
Transmembranei | 963 – 983 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 984 – 995 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 996 – 1016 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1017 – 1035 | ExtracellularSequence analysisAdd BLAST | 19 | |
Intramembranei | 1036 – 1056 | Pore-formingSequence analysisAdd BLAST | 21 | |
Topological domaini | 1057 – 1074 | ExtracellularSequence analysisAdd BLAST | 18 | |
Transmembranei | 1075 – 1095 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1096 – 1865 | CytoplasmicSequence analysisAdd BLAST | 770 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Involvement in diseasei
Amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 (ALS-PDC1)
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 1648 | K → R: Loss of kinase activity. 1 Publication | 1 | |
Mutagenesisi | 1799 | G → D: Loss of kinase activity. 1 Publication | 1 |
Keywords - Diseasei
Amyotrophic lateral sclerosis, Neurodegeneration, ParkinsonismOrganism-specific databases
DisGeNETi | 54822 |
MalaCardsi | TRPM7 |
MIMi | 105500, phenotype |
OpenTargetsi | ENSG00000092439 |
Orphaneti | 140957, Autosomal dominant macrothrombocytopenia 90020, Parkinson-dementia complex of Guam |
PharmGKBi | PA38273 |
Miscellaneous databases
Pharosi | Q96QT4, Tchem |
Chemistry databases
ChEMBLi | CHEMBL1250412 |
DrugBanki | DB04447, 1,4-Dithiothreitol DB14513, Magnesium DB09481, Magnesium carbonate DB04395, Phosphoaminophosphonic Acid-Adenylate Ester |
GuidetoPHARMACOLOGYi | 499 |
Genetic variation databases
BioMutai | TRPM7 |
DMDMi | 56404941 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000215331 | 1 – 1865 | Transient receptor potential cation channel subfamily M member 7Add BLAST | 1865 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 101 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1224 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1255 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1301 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1386 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1387 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1390 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1395 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1404 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1405 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 1446 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1467 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 1477 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1500 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1504 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1527 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1569 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1851 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q96QT4 |
jPOSTi | Q96QT4 |
MassIVEi | Q96QT4 |
MaxQBi | Q96QT4 |
PaxDbi | Q96QT4 |
PeptideAtlasi | Q96QT4 |
PRIDEi | Q96QT4 |
ProteomicsDBi | 77898 |
PTM databases
CarbonylDBi | Q96QT4 |
iPTMneti | Q96QT4 |
PhosphoSitePlusi | Q96QT4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000092439, Expressed in kidney and 213 other tissues |
ExpressionAtlasi | Q96QT4, baseline and differential |
Genevisiblei | Q96QT4, HS |
Organism-specific databases
HPAi | ENSG00000092439, Tissue enriched (parathyroid) |
Interactioni
Subunit structurei
Homodimer.
Interacts with PLCB1 (By similarity). Forms heterodimers with TRPM6.
By similarity1 PublicationGO - Molecular functioni
- actin binding Source: Ensembl
- myosin binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 120177, 114 interactors |
CORUMi | Q96QT4 |
IntActi | Q96QT4, 16 interactors |
MINTi | Q96QT4 |
STRINGi | 9606.ENSP00000320239 |
Chemistry databases
BindingDBi | Q96QT4 |
Miscellaneous databases
RNActi | Q96QT4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1594 – 1824 | Alpha-type protein kinasePROSITE-ProRule annotationAdd BLAST | 231 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 544 – 575 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 1386 – 1407 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 1492 – 1511 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 1524 – 1543 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 1836 – 1865 | DisorderedSequence analysisAdd BLAST | 30 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1198 – 1250 | By similarityAdd BLAST | 53 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 544 – 562 | Polar residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 1843 – 1865 | Polar residuesSequence analysisAdd BLAST | 23 |
Sequence similaritiesi
Keywords - Domaini
Coiled coil, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3614, Eukaryota |
GeneTreei | ENSGT00940000157091 |
InParanoidi | Q96QT4 |
OMAi | ENNFQTA |
OrthoDBi | 738147at2759 |
PhylomeDBi | Q96QT4 |
TreeFami | TF314204 |
Family and domain databases
Gene3Di | 1.20.5.1010, 1 hit |
InterProi | View protein in InterPro IPR005821, Ion_trans_dom IPR011009, Kinase-like_dom_sf IPR004166, MHCK_EF2_kinase IPR029601, TRPM7 IPR041491, TRPM_SLOG IPR032415, TRPM_tetra IPR037162, TRPM_tetra_sf |
PANTHERi | PTHR13800:SF8, PTHR13800:SF8, 1 hit |
Pfami | View protein in Pfam PF02816, Alpha_kinase, 1 hit PF00520, Ion_trans, 1 hit PF18139, LSDAT_euk, 1 hit PF16519, TRPM_tetra, 1 hit |
SMARTi | View protein in SMART SM00811, Alpha_kinase, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51158, ALPHA_KINASE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MSQKSWIEST LTKRECVYII PSSKDPHRCL PGCQICQQLV RCFCGRLVKQ
60 70 80 90 100
HACFTASLAM KYSDVKLGDH FNQAIEEWSV EKHTEQSPTD AYGVINFQGG
110 120 130 140 150
SHSYRAKYVR LSYDTKPEVI LQLLLKEWQM ELPKLVISVH GGMQKFELHP
160 170 180 190 200
RIKQLLGKGL IKAAVTTGAW ILTGGVNTGV AKHVGDALKE HASRSSRKIC
210 220 230 240 250
TIGIAPWGVI ENRNDLVGRD VVAPYQTLLN PLSKLNVLNN LHSHFILVDD
260 270 280 290 300
GTVGKYGAEV RLRRELEKTI NQQRIHARIG QGVPVVALIF EGGPNVILTV
310 320 330 340 350
LEYLQESPPV PVVVCEGTGR AADLLAYIHK QTEEGGNLPD AAEPDIISTI
360 370 380 390 400
KKTFNFGQNE ALHLFQTLME CMKRKELITV FHIGSDEHQD IDVAILTALL
410 420 430 440 450
KGTNASAFDQ LILTLAWDRV DIAKNHVFVY GQQWLVGSLE QAMLDALVMD
460 470 480 490 500
RVAFVKLLIE NGVSMHKFLT IPRLEELYNT KQGPTNPMLF HLVRDVKQGN
510 520 530 540 550
LPPGYKITLI DIGLVIEYLM GGTYRCTYTR KRFRLIYNSL GGNNRRSGRN
560 570 580 590 600
TSSSTPQLRK SHESFGNRAD KKEKMRHNHF IKTAQPYRPK IDTVMEEGKK
610 620 630 640 650
KRTKDEIVDI DDPETKRFPY PLNELLIWAC LMKRQVMARF LWQHGEESMA
660 670 680 690 700
KALVACKIYR SMAYEAKQSD LVDDTSEELK QYSNDFGQLA VELLEQSFRQ
710 720 730 740 750
DETMAMKLLT YELKNWSNST CLKLAVSSRL RPFVAHTCTQ MLLSDMWMGR
760 770 780 790 800
LNMRKNSWYK VILSILVPPA ILLLEYKTKA EMSHIPQSQD AHQMTMDDSE
810 820 830 840 850
NNFQNITEEI PMEVFKEVRI LDSNEGKNEM EIQMKSKKLP ITRKFYAFYH
860 870 880 890 900
APIVKFWFNT LAYLGFLMLY TFVVLVQMEQ LPSVQEWIVI AYIFTYAIEK
910 920 930 940 950
VREIFMSEAG KVNQKIKVWF SDYFNISDTI AIISFFIGFG LRFGAKWNFA
960 970 980 990 1000
NAYDNHVFVA GRLIYCLNII FWYVRLLDFL AVNQQAGPYV MMIGKMVANM
1010 1020 1030 1040 1050
FYIVVIMALV LLSFGVPRKA ILYPHEAPSW TLAKDIVFHP YWMIFGEVYA
1060 1070 1080 1090 1100
YEIDVCANDS VIPQICGPGT WLTPFLQAVY LFVQYIIMVN LLIAFFNNVY
1110 1120 1130 1140 1150
LQVKAISNIV WKYQRYHFIM AYHEKPVLPP PLIILSHIVS LFCCICKRRK
1160 1170 1180 1190 1200
KDKTSDGPKL FLTEEDQKKL HDFEEQCVEM YFNEKDDKFH SGSEERIRVT
1210 1220 1230 1240 1250
FERVEQMCIQ IKEVGDRVNY IKRSLQSLDS QIGHLQDLSA LTVDTLKTLT
1260 1270 1280 1290 1300
AQKASEASKV HNEITRELSI SKHLAQNLID DGPVRPSVWK KHGVVNTLSS
1310 1320 1330 1340 1350
SLPQGDLESN NPFHCNILMK DDKDPQCNIF GQDLPAVPQR KEFNFPEAGS
1360 1370 1380 1390 1400
SSGALFPSAV SPPELRQRLH GVELLKIFNK NQKLGSSSTS IPHLSSPPTK
1410 1420 1430 1440 1450
FFVSTPSQPS CKSHLETGTK DQETVCSKAT EGDNTEFGAF VGHRDSMDLQ
1460 1470 1480 1490 1500
RFKETSNKIK ILSNNNTSEN TLKRVSSLAG FTDCHRTSIP VHSKQAEKIS
1510 1520 1530 1540 1550
RRPSTEDTHE VDSKAALIPD WLQDRPSNRE MPSEEGTLNG LTSPFKPAMD
1560 1570 1580 1590 1600
TNYYYSAVER NNLMRLSQSI PFTPVPPRGE PVTVYRLEES SPNILNNSMS
1610 1620 1630 1640 1650
SWSQLGLCAK IEFLSKEEMG GGLRRAVKVQ CTWSEHDILK SGHLYIIKSF
1660 1670 1680 1690 1700
LPEVVNTWSS IYKEDTVLHL CLREIQQQRA AQKLTFAFNQ MKPKSIPYSP
1710 1720 1730 1740 1750
RFLEVFLLYC HSAGQWFAVE ECMTGEFRKY NNNNGDEIIP TNTLEEIMLA
1760 1770 1780 1790 1800
FSHWTYEYTR GELLVLDLQG VGENLTDPSV IKAEEKRSCD MVFGPANLGE
1810 1820 1830 1840 1850
DAIKNFRAKH HCNSCCRKLK LPDLKRNDYT PDKIIFPQDE PSDLNLQPGN
1860
STKESESTNS VRLML
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YLN8 | H0YLN8_HUMAN | Non-specific serine/threonine prote... | TRPM7 hCG_39859 | 1,864 | Annotation score: | ||
H0YNM0 | H0YNM0_HUMAN | Transient receptor potential cation... | TRPM7 | 234 | Annotation score: | ||
A0A0C4DGL2 | A0A0C4DGL2_HUMAN | Transient receptor potential cation... | TRPM7 | 535 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 573 – 575 | EKM → KKK in BAD18773 (PubMed:14702039).Curated | 3 | |
Sequence conflicti | 998 | A → S (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 1496 | Missing in AAK19738 (PubMed:14594813).Curated | 1 | |
Sequence conflicti | 1520 | D → V in AAK19738 (PubMed:14594813).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_042395 | 68 | G → V1 PublicationCorresponds to variant dbSNP:rs56064201Ensembl. | 1 | |
Natural variantiVAR_042396 | 406 | S → C in an ovarian serous carcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_042397 | 459 | I → T1 PublicationCorresponds to variant dbSNP:rs55924090Ensembl. | 1 | |
Natural variantiVAR_042398 | 574 | K → N1 PublicationCorresponds to variant dbSNP:rs56040619Ensembl. | 1 | |
Natural variantiVAR_042399 | 720 | T → S in a breast infiltrating ductal carcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1040254222Ensembl. | 1 | |
Natural variantiVAR_042400 | 830 | M → V in a gastric adenocarcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_042401 | 949 | F → Y1 PublicationCorresponds to variant dbSNP:rs55681028EnsemblClinVar. | 1 | |
Natural variantiVAR_052381 | 1033 | A → G. Corresponds to variant dbSNP:rs34530969Ensembl. | 1 | |
Natural variantiVAR_042402 | 1064 | Q → R1 PublicationCorresponds to variant dbSNP:rs56298128Ensembl. | 1 | |
Natural variantiVAR_052382 | 1145 | I → V. Corresponds to variant dbSNP:rs34711809Ensembl. | 1 | |
Natural variantiVAR_042403 | 1211 | I → T1 PublicationCorresponds to variant dbSNP:rs56090496Ensembl. | 1 | |
Natural variantiVAR_042404 | 1254 | A → V1 PublicationCorresponds to variant dbSNP:rs56288221Ensembl. | 1 | |
Natural variantiVAR_042405 | 1306 | D → E1 PublicationCorresponds to variant dbSNP:rs55970334Ensembl. | 1 | |
Natural variantiVAR_042406 | 1444 | R → K1 PublicationCorresponds to variant dbSNP:rs55840070Ensembl. | 1 | |
Natural variantiVAR_019967 | 1482 | T → I Mutant channels are functional but show increased susceptibility to inhibition by intracellular magnesium concentrations compared to wild-type channels. 3 PublicationsCorresponds to variant dbSNP:rs8042919EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY032950 mRNA Translation: AAK44211.1 AF346629 mRNA Translation: AAK19738.2 AK000124 mRNA Translation: BAA90958.1 AK172800 mRNA Translation: BAD18773.1 Different initiation. AK075193 mRNA Translation: BAC11462.1 Different initiation. BC051024 mRNA Translation: AAH51024.1 |
CCDSi | CCDS42035.1 |
RefSeqi | NP_001288141.1, NM_001301212.1 NP_060142.3, NM_017672.5 |
Genome annotation databases
Ensembli | ENST00000646667.1; ENSP00000495860.1; ENSG00000092439.16 |
GeneIDi | 54822 |
KEGGi | hsa:54822 |
MANE-Selecti | ENST00000646667.1; ENSP00000495860.1; NM_017672.6; NP_060142.3 |
UCSCi | uc001zyt.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY032950 mRNA Translation: AAK44211.1 AF346629 mRNA Translation: AAK19738.2 AK000124 mRNA Translation: BAA90958.1 AK172800 mRNA Translation: BAD18773.1 Different initiation. AK075193 mRNA Translation: BAC11462.1 Different initiation. BC051024 mRNA Translation: AAH51024.1 |
CCDSi | CCDS42035.1 |
RefSeqi | NP_001288141.1, NM_001301212.1 NP_060142.3, NM_017672.5 |
3D structure databases
AlphaFoldDBi | Q96QT4 |
SMRi | Q96QT4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 120177, 114 interactors |
CORUMi | Q96QT4 |
IntActi | Q96QT4, 16 interactors |
MINTi | Q96QT4 |
STRINGi | 9606.ENSP00000320239 |
Chemistry databases
BindingDBi | Q96QT4 |
ChEMBLi | CHEMBL1250412 |
DrugBanki | DB04447, 1,4-Dithiothreitol DB14513, Magnesium DB09481, Magnesium carbonate DB04395, Phosphoaminophosphonic Acid-Adenylate Ester |
GuidetoPHARMACOLOGYi | 499 |
Protein family/group databases
TCDBi | 1.A.4.5.1, the transient receptor potential ca(2+) channel (trp-cc) family |
PTM databases
CarbonylDBi | Q96QT4 |
iPTMneti | Q96QT4 |
PhosphoSitePlusi | Q96QT4 |
Genetic variation databases
BioMutai | TRPM7 |
DMDMi | 56404941 |
Proteomic databases
EPDi | Q96QT4 |
jPOSTi | Q96QT4 |
MassIVEi | Q96QT4 |
MaxQBi | Q96QT4 |
PaxDbi | Q96QT4 |
PeptideAtlasi | Q96QT4 |
PRIDEi | Q96QT4 |
ProteomicsDBi | 77898 |
Protocols and materials databases
Antibodypediai | 24755, 467 antibodies from 39 providers |
DNASUi | 54822 |
Genome annotation databases
Ensembli | ENST00000646667.1; ENSP00000495860.1; ENSG00000092439.16 |
GeneIDi | 54822 |
KEGGi | hsa:54822 |
MANE-Selecti | ENST00000646667.1; ENSP00000495860.1; NM_017672.6; NP_060142.3 |
UCSCi | uc001zyt.5, human |
Organism-specific databases
CTDi | 54822 |
DisGeNETi | 54822 |
GeneCardsi | TRPM7 |
HGNCi | HGNC:17994, TRPM7 |
HPAi | ENSG00000092439, Tissue enriched (parathyroid) |
MalaCardsi | TRPM7 |
MIMi | 105500, phenotype 605692, gene |
neXtProti | NX_Q96QT4 |
OpenTargetsi | ENSG00000092439 |
Orphaneti | 140957, Autosomal dominant macrothrombocytopenia 90020, Parkinson-dementia complex of Guam |
PharmGKBi | PA38273 |
VEuPathDBi | HostDB:ENSG00000092439 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3614, Eukaryota |
GeneTreei | ENSGT00940000157091 |
InParanoidi | Q96QT4 |
OMAi | ENNFQTA |
OrthoDBi | 738147at2759 |
PhylomeDBi | Q96QT4 |
TreeFami | TF314204 |
Enzyme and pathway databases
PathwayCommonsi | Q96QT4 |
Reactomei | R-HSA-3295583, TRP channels |
SignaLinki | Q96QT4 |
SIGNORi | Q96QT4 |
Miscellaneous databases
BioGRID-ORCSi | 54822, 391 hits in 1114 CRISPR screens |
ChiTaRSi | TRPM7, human |
GeneWikii | TRPM7 |
GenomeRNAii | 54822 |
Pharosi | Q96QT4, Tchem |
PROi | PR:Q96QT4 |
RNActi | Q96QT4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000092439, Expressed in kidney and 213 other tissues |
ExpressionAtlasi | Q96QT4, baseline and differential |
Genevisiblei | Q96QT4, HS |
Family and domain databases
Gene3Di | 1.20.5.1010, 1 hit |
InterProi | View protein in InterPro IPR005821, Ion_trans_dom IPR011009, Kinase-like_dom_sf IPR004166, MHCK_EF2_kinase IPR029601, TRPM7 IPR041491, TRPM_SLOG IPR032415, TRPM_tetra IPR037162, TRPM_tetra_sf |
PANTHERi | PTHR13800:SF8, PTHR13800:SF8, 1 hit |
Pfami | View protein in Pfam PF02816, Alpha_kinase, 1 hit PF00520, Ion_trans, 1 hit PF18139, LSDAT_euk, 1 hit PF16519, TRPM_tetra, 1 hit |
SMARTi | View protein in SMART SM00811, Alpha_kinase, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51158, ALPHA_KINASE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TRPM7_HUMAN | |
Accessioni | Q96QT4Primary (citable) accession number: Q96QT4 Secondary accession number(s): Q6ZMF5 Q9NXQ2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 7, 2004 |
Last sequence update: | December 1, 2001 | |
Last modified: | May 25, 2022 | |
This is version 170 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families