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Entry version 162 (17 Jun 2020)
Sequence version 1 (01 Dec 2001)
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Protein

Transient receptor potential cation channel subfamily M member 7

Gene

TRPM7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1624ATPBy similarity1
Binding sitei1648ATPBy similarity1
Binding sitei1720ATPBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1753ZincBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1767Proton acceptorBy similarity1
Binding sitei1769ATPBy similarity1
Binding sitei1777ATPBy similarity1
Metal bindingi1810ZincBy similarity1
Metal bindingi1812ZincBy similarity1
Metal bindingi1816ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1794 – 1800ATPBy similarity7

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channel, Ion channel, Kinase, Serine/threonine-protein kinase, Transferase
Biological processCalcium transport, Ion transport, Necrosis, Transport
LigandATP-binding, Calcium, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3295583 TRP channels

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q96QT4

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.4.5.1 the transient receptor potential ca(2+) channel (trp-cc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transient receptor potential cation channel subfamily M member 7 (EC:2.7.11.1)
Alternative name(s):
Channel-kinase 1
Long transient receptor potential channel 7
Short name:
LTrpC-7
Short name:
LTrpC7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRPM7
Synonyms:CHAK1, LTRPC7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000092439.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17994 TRPM7

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605692 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96QT4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 755CytoplasmicSequence analysisAdd BLAST755
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei756 – 776HelicalSequence analysisAdd BLAST21
Topological domaini777 – 855ExtracellularSequence analysisAdd BLAST79
Transmembranei856 – 876HelicalSequence analysisAdd BLAST21
Topological domaini877 – 918CytoplasmicSequence analysisAdd BLAST42
Transmembranei919 – 939HelicalSequence analysisAdd BLAST21
Topological domaini940 – 962ExtracellularSequence analysisAdd BLAST23
Transmembranei963 – 983HelicalSequence analysisAdd BLAST21
Topological domaini984 – 995CytoplasmicSequence analysisAdd BLAST12
Transmembranei996 – 1016HelicalSequence analysisAdd BLAST21
Topological domaini1017 – 1035ExtracellularSequence analysisAdd BLAST19
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei1036 – 1056Pore-formingSequence analysisAdd BLAST21
Topological domaini1057 – 1074ExtracellularSequence analysisAdd BLAST18
Transmembranei1075 – 1095HelicalSequence analysisAdd BLAST21
Topological domaini1096 – 1865CytoplasmicSequence analysisAdd BLAST770

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 (ALS-PDC1)
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA neurodegenerative disorder characterized by chronic, progressive and uniformly fatal amyotrophic lateral sclerosis and parkinsonism-dementia. Both diseases are known to occur in the same kindred, the same sibship and even the same individual.
Related information in OMIM

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1648K → R: Loss of kinase activity. 1 Publication1
Mutagenesisi1799G → D: Loss of kinase activity. 1 Publication1

Keywords - Diseasei

Amyotrophic lateral sclerosis, Neurodegeneration, Parkinsonism

Organism-specific databases

DisGeNET

More...
DisGeNETi
54822

MalaCards human disease database

More...
MalaCardsi
TRPM7
MIMi105500 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000092439

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
90020 Amyotrophic lateral sclerosis-parkinsonism-dementia complex

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA38273

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96QT4 Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1250412

Drug and drug target database

More...
DrugBanki
DB04447 1,4-Dithiothreitol
DB09481 Magnesium carbonate
DB04395 Phosphoaminophosphonic Acid-Adenylate Ester

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
499

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TRPM7

Domain mapping of disease mutations (DMDM)

More...
DMDMi
56404941

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002153311 – 1865Transient receptor potential cation channel subfamily M member 7Add BLAST1865

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei101PhosphoserineCombined sources1
Modified residuei1224PhosphoserineBy similarity1
Modified residuei1255PhosphoserineBy similarity1
Modified residuei1301PhosphoserineBy similarity1
Modified residuei1386PhosphoserineBy similarity1
Modified residuei1387PhosphoserineCombined sources1
Modified residuei1390PhosphoserineCombined sources1
Modified residuei1395PhosphoserineCombined sources1
Modified residuei1404PhosphoserineCombined sources1
Modified residuei1405PhosphothreonineBy similarity1
Modified residuei1446PhosphoserineBy similarity1
Modified residuei1467PhosphothreonineBy similarity1
Modified residuei1477PhosphoserineCombined sources1
Modified residuei1500PhosphoserineBy similarity1
Modified residuei1504PhosphoserineBy similarity1
Modified residuei1527PhosphoserineCombined sources1
Modified residuei1569PhosphoserineCombined sources1
Modified residuei1851PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q96QT4

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96QT4

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q96QT4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96QT4

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96QT4

PeptideAtlas

More...
PeptideAtlasi
Q96QT4

PRoteomics IDEntifications database

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PRIDEi
Q96QT4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
77898

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q96QT4

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q96QT4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96QT4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000092439 Expressed in kidney and 197 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96QT4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96QT4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000092439 Tissue enhanced (parathyroid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with PLCB1 (By similarity). Forms heterodimers with TRPM6.

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
120177, 35 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q96QT4

Protein interaction database and analysis system

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IntActi
Q96QT4, 14 interactors

Molecular INTeraction database

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MINTi
Q96QT4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000320239

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96QT4 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96QT4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1594 – 1824Alpha-type protein kinasePROSITE-ProRule annotationAdd BLAST231

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1198 – 1250By similarityAdd BLAST53

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3614 Eukaryota
ENOG410XR5B LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157091

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96QT4

KEGG Orthology (KO)

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KOi
K04982

Identification of Orthologs from Complete Genome Data

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OMAi
VFEGGPN

Database of Orthologous Groups

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OrthoDBi
738147at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q96QT4

TreeFam database of animal gene trees

More...
TreeFami
TF314204

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.5.1010, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005821 Ion_trans_dom
IPR011009 Kinase-like_dom_sf
IPR004166 MHCK_EF2_kinase
IPR029601 TRPM7
IPR041491 TRPM_SLOG
IPR032415 TRPM_tetra
IPR037162 TRPM_tetra_sf

The PANTHER Classification System

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PANTHERi
PTHR13800:SF8 PTHR13800:SF8, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02816 Alpha_kinase, 1 hit
PF00520 Ion_trans, 1 hit
PF18139 LSDAT_euk, 1 hit
PF16519 TRPM_tetra, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00811 Alpha_kinase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51158 ALPHA_KINASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q96QT4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQKSWIEST LTKRECVYII PSSKDPHRCL PGCQICQQLV RCFCGRLVKQ
60 70 80 90 100
HACFTASLAM KYSDVKLGDH FNQAIEEWSV EKHTEQSPTD AYGVINFQGG
110 120 130 140 150
SHSYRAKYVR LSYDTKPEVI LQLLLKEWQM ELPKLVISVH GGMQKFELHP
160 170 180 190 200
RIKQLLGKGL IKAAVTTGAW ILTGGVNTGV AKHVGDALKE HASRSSRKIC
210 220 230 240 250
TIGIAPWGVI ENRNDLVGRD VVAPYQTLLN PLSKLNVLNN LHSHFILVDD
260 270 280 290 300
GTVGKYGAEV RLRRELEKTI NQQRIHARIG QGVPVVALIF EGGPNVILTV
310 320 330 340 350
LEYLQESPPV PVVVCEGTGR AADLLAYIHK QTEEGGNLPD AAEPDIISTI
360 370 380 390 400
KKTFNFGQNE ALHLFQTLME CMKRKELITV FHIGSDEHQD IDVAILTALL
410 420 430 440 450
KGTNASAFDQ LILTLAWDRV DIAKNHVFVY GQQWLVGSLE QAMLDALVMD
460 470 480 490 500
RVAFVKLLIE NGVSMHKFLT IPRLEELYNT KQGPTNPMLF HLVRDVKQGN
510 520 530 540 550
LPPGYKITLI DIGLVIEYLM GGTYRCTYTR KRFRLIYNSL GGNNRRSGRN
560 570 580 590 600
TSSSTPQLRK SHESFGNRAD KKEKMRHNHF IKTAQPYRPK IDTVMEEGKK
610 620 630 640 650
KRTKDEIVDI DDPETKRFPY PLNELLIWAC LMKRQVMARF LWQHGEESMA
660 670 680 690 700
KALVACKIYR SMAYEAKQSD LVDDTSEELK QYSNDFGQLA VELLEQSFRQ
710 720 730 740 750
DETMAMKLLT YELKNWSNST CLKLAVSSRL RPFVAHTCTQ MLLSDMWMGR
760 770 780 790 800
LNMRKNSWYK VILSILVPPA ILLLEYKTKA EMSHIPQSQD AHQMTMDDSE
810 820 830 840 850
NNFQNITEEI PMEVFKEVRI LDSNEGKNEM EIQMKSKKLP ITRKFYAFYH
860 870 880 890 900
APIVKFWFNT LAYLGFLMLY TFVVLVQMEQ LPSVQEWIVI AYIFTYAIEK
910 920 930 940 950
VREIFMSEAG KVNQKIKVWF SDYFNISDTI AIISFFIGFG LRFGAKWNFA
960 970 980 990 1000
NAYDNHVFVA GRLIYCLNII FWYVRLLDFL AVNQQAGPYV MMIGKMVANM
1010 1020 1030 1040 1050
FYIVVIMALV LLSFGVPRKA ILYPHEAPSW TLAKDIVFHP YWMIFGEVYA
1060 1070 1080 1090 1100
YEIDVCANDS VIPQICGPGT WLTPFLQAVY LFVQYIIMVN LLIAFFNNVY
1110 1120 1130 1140 1150
LQVKAISNIV WKYQRYHFIM AYHEKPVLPP PLIILSHIVS LFCCICKRRK
1160 1170 1180 1190 1200
KDKTSDGPKL FLTEEDQKKL HDFEEQCVEM YFNEKDDKFH SGSEERIRVT
1210 1220 1230 1240 1250
FERVEQMCIQ IKEVGDRVNY IKRSLQSLDS QIGHLQDLSA LTVDTLKTLT
1260 1270 1280 1290 1300
AQKASEASKV HNEITRELSI SKHLAQNLID DGPVRPSVWK KHGVVNTLSS
1310 1320 1330 1340 1350
SLPQGDLESN NPFHCNILMK DDKDPQCNIF GQDLPAVPQR KEFNFPEAGS
1360 1370 1380 1390 1400
SSGALFPSAV SPPELRQRLH GVELLKIFNK NQKLGSSSTS IPHLSSPPTK
1410 1420 1430 1440 1450
FFVSTPSQPS CKSHLETGTK DQETVCSKAT EGDNTEFGAF VGHRDSMDLQ
1460 1470 1480 1490 1500
RFKETSNKIK ILSNNNTSEN TLKRVSSLAG FTDCHRTSIP VHSKQAEKIS
1510 1520 1530 1540 1550
RRPSTEDTHE VDSKAALIPD WLQDRPSNRE MPSEEGTLNG LTSPFKPAMD
1560 1570 1580 1590 1600
TNYYYSAVER NNLMRLSQSI PFTPVPPRGE PVTVYRLEES SPNILNNSMS
1610 1620 1630 1640 1650
SWSQLGLCAK IEFLSKEEMG GGLRRAVKVQ CTWSEHDILK SGHLYIIKSF
1660 1670 1680 1690 1700
LPEVVNTWSS IYKEDTVLHL CLREIQQQRA AQKLTFAFNQ MKPKSIPYSP
1710 1720 1730 1740 1750
RFLEVFLLYC HSAGQWFAVE ECMTGEFRKY NNNNGDEIIP TNTLEEIMLA
1760 1770 1780 1790 1800
FSHWTYEYTR GELLVLDLQG VGENLTDPSV IKAEEKRSCD MVFGPANLGE
1810 1820 1830 1840 1850
DAIKNFRAKH HCNSCCRKLK LPDLKRNDYT PDKIIFPQDE PSDLNLQPGN
1860
STKESESTNS VRLML
Length:1,865
Mass (Da):212,697
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBE732674D52D7485
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YLN8H0YLN8_HUMAN
Transient receptor potential cation...
TRPM7 hCG_39859
1,864Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DGL2A0A0C4DGL2_HUMAN
Transient receptor potential cation...
TRPM7
535Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YNM0H0YNM0_HUMAN
Transient receptor potential cation...
TRPM7
234Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC11462 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD18773 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti573 – 575EKM → KKK in BAD18773 (PubMed:14702039).Curated3
Sequence conflicti998A → S (PubMed:15489334).Curated1
Sequence conflicti1496Missing in AAK19738 (PubMed:14594813).Curated1
Sequence conflicti1520D → V in AAK19738 (PubMed:14594813).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04239568G → V1 PublicationCorresponds to variant dbSNP:rs56064201Ensembl.1
Natural variantiVAR_042396406S → C in an ovarian serous carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_042397459I → T1 PublicationCorresponds to variant dbSNP:rs55924090Ensembl.1
Natural variantiVAR_042398574K → N1 PublicationCorresponds to variant dbSNP:rs56040619Ensembl.1
Natural variantiVAR_042399720T → S in a breast infiltrating ductal carcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1040254222Ensembl.1
Natural variantiVAR_042400830M → V in a gastric adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_042401949F → Y1 PublicationCorresponds to variant dbSNP:rs55681028Ensembl.1
Natural variantiVAR_0523811033A → G. Corresponds to variant dbSNP:rs34530969Ensembl.1
Natural variantiVAR_0424021064Q → R1 PublicationCorresponds to variant dbSNP:rs56298128Ensembl.1
Natural variantiVAR_0523821145I → V. Corresponds to variant dbSNP:rs34711809Ensembl.1
Natural variantiVAR_0424031211I → T1 PublicationCorresponds to variant dbSNP:rs56090496Ensembl.1
Natural variantiVAR_0424041254A → V1 PublicationCorresponds to variant dbSNP:rs56288221Ensembl.1
Natural variantiVAR_0424051306D → E1 PublicationCorresponds to variant dbSNP:rs55970334Ensembl.1
Natural variantiVAR_0424061444R → K1 PublicationCorresponds to variant dbSNP:rs55840070Ensembl.1
Natural variantiVAR_0199671482T → I Mutant channels are functional but show increased susceptibility to inhibition by intracellular magnesium concentrations compared to wild-type channels. 3 PublicationsCorresponds to variant dbSNP:rs8042919EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY032950 mRNA Translation: AAK44211.1
AF346629 mRNA Translation: AAK19738.2
AK000124 mRNA Translation: BAA90958.1
AK172800 mRNA Translation: BAD18773.1 Different initiation.
AK075193 mRNA Translation: BAC11462.1 Different initiation.
BC051024 mRNA Translation: AAH51024.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42035.1

NCBI Reference Sequences

More...
RefSeqi
NP_001288141.1, NM_001301212.1
NP_060142.3, NM_017672.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000646667; ENSP00000495860; ENSG00000092439

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54822

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54822

UCSC genome browser

More...
UCSCi
uc001zyt.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY032950 mRNA Translation: AAK44211.1
AF346629 mRNA Translation: AAK19738.2
AK000124 mRNA Translation: BAA90958.1
AK172800 mRNA Translation: BAD18773.1 Different initiation.
AK075193 mRNA Translation: BAC11462.1 Different initiation.
BC051024 mRNA Translation: AAH51024.1
CCDSiCCDS42035.1
RefSeqiNP_001288141.1, NM_001301212.1
NP_060142.3, NM_017672.5

3D structure databases

SMRiQ96QT4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120177, 35 interactors
CORUMiQ96QT4
IntActiQ96QT4, 14 interactors
MINTiQ96QT4
STRINGi9606.ENSP00000320239

Chemistry databases

ChEMBLiCHEMBL1250412
DrugBankiDB04447 1,4-Dithiothreitol
DB09481 Magnesium carbonate
DB04395 Phosphoaminophosphonic Acid-Adenylate Ester
GuidetoPHARMACOLOGYi499

Protein family/group databases

TCDBi1.A.4.5.1 the transient receptor potential ca(2+) channel (trp-cc) family

PTM databases

CarbonylDBiQ96QT4
iPTMnetiQ96QT4
PhosphoSitePlusiQ96QT4

Polymorphism and mutation databases

BioMutaiTRPM7
DMDMi56404941

Proteomic databases

EPDiQ96QT4
jPOSTiQ96QT4
MassIVEiQ96QT4
MaxQBiQ96QT4
PaxDbiQ96QT4
PeptideAtlasiQ96QT4
PRIDEiQ96QT4
ProteomicsDBi77898

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
24755 435 antibodies

Genome annotation databases

EnsembliENST00000646667; ENSP00000495860; ENSG00000092439
GeneIDi54822
KEGGihsa:54822
UCSCiuc001zyt.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54822
DisGeNETi54822
EuPathDBiHostDB:ENSG00000092439.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TRPM7
HGNCiHGNC:17994 TRPM7
HPAiENSG00000092439 Tissue enhanced (parathyroid)
MalaCardsiTRPM7
MIMi105500 phenotype
605692 gene
neXtProtiNX_Q96QT4
OpenTargetsiENSG00000092439
Orphaneti90020 Amyotrophic lateral sclerosis-parkinsonism-dementia complex
PharmGKBiPA38273

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3614 Eukaryota
ENOG410XR5B LUCA
GeneTreeiENSGT00940000157091
InParanoidiQ96QT4
KOiK04982
OMAiVFEGGPN
OrthoDBi738147at2759
PhylomeDBiQ96QT4
TreeFamiTF314204

Enzyme and pathway databases

ReactomeiR-HSA-3295583 TRP channels
SIGNORiQ96QT4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
54822 369 hits in 816 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TRPM7 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TRPM7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
54822
PharosiQ96QT4 Tchem

Protein Ontology

More...
PROi
PR:Q96QT4
RNActiQ96QT4 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000092439 Expressed in kidney and 197 other tissues
ExpressionAtlasiQ96QT4 baseline and differential
GenevisibleiQ96QT4 HS

Family and domain databases

Gene3Di1.20.5.1010, 1 hit
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR011009 Kinase-like_dom_sf
IPR004166 MHCK_EF2_kinase
IPR029601 TRPM7
IPR041491 TRPM_SLOG
IPR032415 TRPM_tetra
IPR037162 TRPM_tetra_sf
PANTHERiPTHR13800:SF8 PTHR13800:SF8, 1 hit
PfamiView protein in Pfam
PF02816 Alpha_kinase, 1 hit
PF00520 Ion_trans, 1 hit
PF18139 LSDAT_euk, 1 hit
PF16519 TRPM_tetra, 1 hit
SMARTiView protein in SMART
SM00811 Alpha_kinase, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51158 ALPHA_KINASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRPM7_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96QT4
Secondary accession number(s): Q6ZMF5
, Q86VJ4, Q8NBW2, Q9BXB2, Q9NXQ2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: December 1, 2001
Last modified: June 17, 2020
This is version 162 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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