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Protein

Serine/threonine-protein kinase H2

Gene

PSKH2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Asn-183 is present instead of the conserved Asp which is expected to be an active site residue.Curated

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei92ATPPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi69 – 77ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ96QS6

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase H2 (EC:2.7.11.1)
Alternative name(s):
Protein serine kinase H2
Short name:
PSK-H2
Gene namesi
Name:PSKH2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000147613.7
HGNCiHGNC:18997 PSKH2
neXtProtiNX_Q96QS6

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134961168

Polymorphism and mutation databases

BioMutaiPSKH2
DMDMi74762688

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000861711 – 385Serine/threonine-protein kinase H2Add BLAST385

Proteomic databases

PaxDbiQ96QS6
PeptideAtlasiQ96QS6
PRIDEiQ96QS6
ProteomicsDBi77897

PTM databases

iPTMnetiQ96QS6
PhosphoSitePlusiQ96QS6

Expressioni

Gene expression databases

BgeeiENSG00000147613 Expressed in 7 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_PSKH2
GenevisibleiQ96QS6 HS

Organism-specific databases

HPAiHPA015095

Interactioni

Protein-protein interaction databases

BioGridi124556, 13 interactors
IntActiQ96QS6, 5 interactors
STRINGi9606.ENSP00000276616

Structurei

3D structure databases

ProteinModelPortaliQ96QS6
SMRiQ96QS6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 320Protein kinasePROSITE-ProRule annotationAdd BLAST258

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0032 Eukaryota
ENOG410XRMJ LUCA
GeneTreeiENSGT00760000118944
HOGENOMiHOG000233016
HOVERGENiHBG108055
InParanoidiQ96QS6
KOiK08808
OMAiFAIKVME
OrthoDBiEOG091G0HK9
PhylomeDBiQ96QS6
TreeFamiTF314166

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequencei

Sequence statusi: Complete.

Q96QS6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGCGASRKVV PGPPALAWAK HEGQNQAGVG GAGPGPEAAA QAAQRIQVAR
60 70 80 90 100
FRAKFDPRVL ARYDIKALIG TGSFSRVVRV EQKTTKKPFA IKVMETRERE
110 120 130 140 150
GREACVSELS VLRRVSHRYI VQLMEIFETE DQVYMVMELA TGGELFDRLI
160 170 180 190 200
AQGSFTERDA VRILQMVADG IRYLHALQIT HRNLKPENLL YYHPGEESKI
210 220 230 240 250
LITDFGLAYS GKKSGDWTMK TLCGTPEYIA PEVLLRKPYT SAVDMWALGV
260 270 280 290 300
ITYALLSGFL PFDDESQTRL YRKILKGKYN YTGEPWPSIS HLAKDFIDKL
310 320 330 340 350
LILEAGHRMS AGQALDHPWV ITMAAGSSMK NLQRAISRNL MQRASPHSQS
360 370 380
PGSAQSSKSH YSHKSRHMWS KRNLRIVESP LSALL
Length:385
Mass (Da):43,027
Last modified:December 1, 2001 - v1
Checksum:i6472D63BC7688334
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04061572G → D1 PublicationCorresponds to variant dbSNP:rs56407605Ensembl.1
Natural variantiVAR_04061679R → K1 PublicationCorresponds to variant dbSNP:rs35315725Ensembl.1
Natural variantiVAR_040617114R → Q1 PublicationCorresponds to variant dbSNP:rs35915498Ensembl.1
Natural variantiVAR_040618116S → I in a lung adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_040619132Q → R1 PublicationCorresponds to variant dbSNP:rs16879427Ensembl.1
Natural variantiVAR_040620148R → Q1 PublicationCorresponds to variant dbSNP:rs56356246Ensembl.1
Natural variantiVAR_040621176A → S1 PublicationCorresponds to variant dbSNP:rs6998760Ensembl.1
Natural variantiVAR_040622211G → R1 PublicationCorresponds to variant dbSNP:rs36074412Ensembl.1
Natural variantiVAR_040623212K → I in a lung adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs778066815Ensembl.1
Natural variantiVAR_040624225T → A1 PublicationCorresponds to variant dbSNP:rs34457516Ensembl.1
Natural variantiVAR_040625266S → R1 PublicationCorresponds to variant dbSNP:rs34037815Ensembl.1
Natural variantiVAR_040626336I → V1 PublicationCorresponds to variant dbSNP:rs16876805Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY037806 mRNA Translation: AAK59985.1
BC126180 mRNA Translation: AAI26181.1
BC126182 mRNA Translation: AAI26183.1
CCDSiCCDS6240.1
RefSeqiNP_149117.1, NM_033126.2
UniGeneiHs.566854
Hs.680136

Genome annotation databases

EnsembliENST00000276616; ENSP00000276616; ENSG00000147613
GeneIDi85481
KEGGihsa:85481
UCSCiuc011lfy.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY037806 mRNA Translation: AAK59985.1
BC126180 mRNA Translation: AAI26181.1
BC126182 mRNA Translation: AAI26183.1
CCDSiCCDS6240.1
RefSeqiNP_149117.1, NM_033126.2
UniGeneiHs.566854
Hs.680136

3D structure databases

ProteinModelPortaliQ96QS6
SMRiQ96QS6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124556, 13 interactors
IntActiQ96QS6, 5 interactors
STRINGi9606.ENSP00000276616

PTM databases

iPTMnetiQ96QS6
PhosphoSitePlusiQ96QS6

Polymorphism and mutation databases

BioMutaiPSKH2
DMDMi74762688

Proteomic databases

PaxDbiQ96QS6
PeptideAtlasiQ96QS6
PRIDEiQ96QS6
ProteomicsDBi77897

Protocols and materials databases

DNASUi85481
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276616; ENSP00000276616; ENSG00000147613
GeneIDi85481
KEGGihsa:85481
UCSCiuc011lfy.3 human

Organism-specific databases

CTDi85481
EuPathDBiHostDB:ENSG00000147613.7
GeneCardsiPSKH2
HGNCiHGNC:18997 PSKH2
HPAiHPA015095
neXtProtiNX_Q96QS6
PharmGKBiPA134961168
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0032 Eukaryota
ENOG410XRMJ LUCA
GeneTreeiENSGT00760000118944
HOGENOMiHOG000233016
HOVERGENiHBG108055
InParanoidiQ96QS6
KOiK08808
OMAiFAIKVME
OrthoDBiEOG091G0HK9
PhylomeDBiQ96QS6
TreeFamiTF314166

Enzyme and pathway databases

SignaLinkiQ96QS6

Miscellaneous databases

GenomeRNAii85481
PROiPR:Q96QS6

Gene expression databases

BgeeiENSG00000147613 Expressed in 7 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_PSKH2
GenevisibleiQ96QS6 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKPSH2_HUMAN
AccessioniPrimary (citable) accession number: Q96QS6
Secondary accession number(s): A0AV22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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Main funding by: National Institutes of Health

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