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Protein

Tetraspanin-32

Gene

TSPAN32

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-32
Short name:
Tspan-32
Alternative name(s):
Protein Phemx
Gene namesi
Name:TSPAN32
Synonyms:PHEMX, TSSC6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000064201.15
HGNCiHGNC:13410 TSPAN32
MIMi603853 gene
neXtProtiNX_Q96QS1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21
Transmembranei203 – 223HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10077
OpenTargetsiENSG00000064201
PharmGKBiPA33257

Polymorphism and mutation databases

BioMutaiTSPAN32
DMDMi20139069

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192781 – 320Tetraspanin-32Add BLAST320

Proteomic databases

PaxDbiQ96QS1
PeptideAtlasiQ96QS1
PRIDEiQ96QS1
ProteomicsDBi77889
77890 [Q96QS1-2]
77891 [Q96QS1-3]
77892 [Q96QS1-4]
77893 [Q96QS1-5]

PTM databases

iPTMnetiQ96QS1
PhosphoSitePlusiQ96QS1

Expressioni

Tissue specificityi

Expressed ubiquitously at low levels. High levels of expression are confined to hematopoietic tissues including peripheral blood leukocytes, thymus and spleen.1 Publication

Developmental stagei

Expressed from early embryogenesis through to adulthood.1 Publication

Gene expression databases

BgeeiENSG00000064201 Expressed in 103 organ(s), highest expression level in apex of heart
CleanExiHS_TSPAN32
ExpressionAtlasiQ96QS1 baseline and differential
GenevisibleiQ96QS1 HS

Organism-specific databases

HPAiHPA024135

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000182290

Structurei

3D structure databases

ProteinModelPortaliQ96QS1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IY3A Eukaryota
ENOG410YXBH LUCA
GeneTreeiENSGT00390000003287
HOGENOMiHOG000081817
HOVERGENiHBG053580
InParanoidiQ96QS1
KOiK17359
OMAiCQMLVTS
OrthoDBiEOG091G0JTB
PhylomeDBiQ96QS1
TreeFamiTF336277

Family and domain databases

InterProiView protein in InterPro
IPR018499 Tetraspanin/Peripherin
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
SUPFAMiSSF48652 SSF48652, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist. Experimental confirmation may be lacking for some isoforms.

This entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96QS1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGPWSRVRVA KCQMLVTCFF ILLLGLSVAT MVTLTYFGAH FAVIRRASLE
60 70 80 90 100
KNPYQAVHQW AFSAGLSLVG LLTLGAVLSA AATVREAQGL MAGGFLCFSL
110 120 130 140 150
AFCAQVQVVF WRLHSPTQVE DAMLDTYDLV YEQAMKGTSH VRRQELAAIQ
160 170 180 190 200
DVFLCCGKKS PFSRLGSTEA DLCQGEEAAR EDCLQGIRSF LRTHQQVASS
210 220 230 240 250
LTSIGLALTV SALLFSSFLW FAIRCGCSLD RKGKYTLTPR ACGRQPQEPS
260 270 280 290 300
LLRCSQGGPT HCLHSEAVAI GPRGCSGSLR WLQESDAAPL PLSCHLAAHR
310 320
ALQGRSRGGL SGCPERGLSD
Length:320
Mass (Da):34,631
Last modified:December 1, 2001 - v1
Checksum:i534E4C29767B8E6D
GO
Isoform 2 (identifier: Q96QS1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-30: Missing.

Show »
Length:290
Mass (Da):31,308
Checksum:iB9E86C72A6C9B727
GO
Isoform 3 (identifier: Q96QS1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     241-253: ACGRQPQEPSLLR → SPGQKSRWAQWVP
     254-320: Missing.

Show »
Length:253
Mass (Da):27,844
Checksum:iA616383C45BE67E6
GO
Isoform 4 (identifier: Q96QS1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-30: Missing.
     137-154: GTSHVRRQELAAIQDVFL → VSVLWEEVSFQPSGEHRG
     155-320: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:124
Mass (Da):13,643
Checksum:i29B8FF48896D8BB8
GO
Isoform 5 (identifier: Q96QS1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     210-258: VSALLFSSFL...PSLLRCSQGG → LGPQGQIHPD...SCYWSKRMLG
     259-320: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:258
Mass (Da):28,211
Checksum:i4564FAB7C7C2E9F4
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YTD1D3YTD1_HUMAN
Tetraspanin-32
TSPAN32
309Annotation score:
G3XAG6G3XAG6_HUMAN
Tetraspanin 32, isoform CRA_e
TSPAN32 hCG_15479
265Annotation score:
F8WCN6F8WCN6_HUMAN
Tetraspanin-32
TSPAN32
143Annotation score:
F8WB10F8WB10_HUMAN
Tetraspanin-32
TSPAN32
137Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0039321 – 30Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST30
Alternative sequenceiVSP_003933137 – 154GTSHV…QDVFL → VSVLWEEVSFQPSGEHRG in isoform 4. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_003934155 – 320Missing in isoform 4. 1 PublicationAdd BLAST166
Alternative sequenceiVSP_003935210 – 258VSALL…CSQGG → LGPQGQIHPDPTSMWPPAPG AQPLEMLPGWTHTLSPLRSS CYWSKRMLG in isoform 5. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_003937241 – 253ACGRQ…PSLLR → SPGQKSRWAQWVP in isoform 3. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_003938254 – 320Missing in isoform 3. 1 PublicationAdd BLAST67
Alternative sequenceiVSP_003936259 – 320Missing in isoform 5. 1 PublicationAdd BLAST62

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF125569 mRNA Translation: AAD23580.1
AY039001 mRNA Translation: AAK84431.1
BC016693 mRNA Translation: AAH16693.1
AF176070 mRNA Translation: AAG15840.1
AF176071 mRNA Translation: AAG15841.1
CCDSiCCDS7733.1 [Q96QS1-1]
RefSeqiNP_620591.3, NM_139022.2 [Q96QS1-1]
UniGeneiHs.271954

Genome annotation databases

EnsembliENST00000182290; ENSP00000182290; ENSG00000064201 [Q96QS1-1]
ENST00000381121; ENSP00000370513; ENSG00000064201 [Q96QS1-3]
ENST00000446063; ENSP00000395018; ENSG00000064201 [Q96QS1-5]
GeneIDi10077
KEGGihsa:10077
UCSCiuc001lvy.2 human [Q96QS1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF125569 mRNA Translation: AAD23580.1
AY039001 mRNA Translation: AAK84431.1
BC016693 mRNA Translation: AAH16693.1
AF176070 mRNA Translation: AAG15840.1
AF176071 mRNA Translation: AAG15841.1
CCDSiCCDS7733.1 [Q96QS1-1]
RefSeqiNP_620591.3, NM_139022.2 [Q96QS1-1]
UniGeneiHs.271954

3D structure databases

ProteinModelPortaliQ96QS1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000182290

PTM databases

iPTMnetiQ96QS1
PhosphoSitePlusiQ96QS1

Polymorphism and mutation databases

BioMutaiTSPAN32
DMDMi20139069

Proteomic databases

PaxDbiQ96QS1
PeptideAtlasiQ96QS1
PRIDEiQ96QS1
ProteomicsDBi77889
77890 [Q96QS1-2]
77891 [Q96QS1-3]
77892 [Q96QS1-4]
77893 [Q96QS1-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000182290; ENSP00000182290; ENSG00000064201 [Q96QS1-1]
ENST00000381121; ENSP00000370513; ENSG00000064201 [Q96QS1-3]
ENST00000446063; ENSP00000395018; ENSG00000064201 [Q96QS1-5]
GeneIDi10077
KEGGihsa:10077
UCSCiuc001lvy.2 human [Q96QS1-1]

Organism-specific databases

CTDi10077
DisGeNETi10077
EuPathDBiHostDB:ENSG00000064201.15
GeneCardsiTSPAN32
HGNCiHGNC:13410 TSPAN32
HPAiHPA024135
MIMi603853 gene
neXtProtiNX_Q96QS1
OpenTargetsiENSG00000064201
PharmGKBiPA33257
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IY3A Eukaryota
ENOG410YXBH LUCA
GeneTreeiENSGT00390000003287
HOGENOMiHOG000081817
HOVERGENiHBG053580
InParanoidiQ96QS1
KOiK17359
OMAiCQMLVTS
OrthoDBiEOG091G0JTB
PhylomeDBiQ96QS1
TreeFamiTF336277

Miscellaneous databases

ChiTaRSiTSPAN32 human
GeneWikiiTSPAN32
GenomeRNAii10077
PROiPR:Q96QS1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000064201 Expressed in 103 organ(s), highest expression level in apex of heart
CleanExiHS_TSPAN32
ExpressionAtlasiQ96QS1 baseline and differential
GenevisibleiQ96QS1 HS

Family and domain databases

InterProiView protein in InterPro
IPR018499 Tetraspanin/Peripherin
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
SUPFAMiSSF48652 SSF48652, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTSN32_HUMAN
AccessioniPrimary (citable) accession number: Q96QS1
Secondary accession number(s): Q96KX4
, Q9HC50, Q9HC51, Q9Y5U1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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