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Protein

Transcriptional activator protein Pur-beta

Gene

PURB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has capacity to bind repeated elements in single-stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Plays a role in the control of vascular smooth muscle (VSM) alpha-actin gene transcription as repressor in myoblasts and fibroblasts. Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine-rich negative regulatory (PNR) element. Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs (By similarity).By similarity1 Publication

Miscellaneous

Defects in PURB may be a cause of progression of myelodysplastic syndrome (MDS) towards acute myelogenous leukemia (AML). MDS refers to a heterogeneous group of closely related hematopoietic disorders. All are characterized by a cellular marrow with impaired morphology and maturation (dysmyelopoiesis) and peripheral blood cytopenias, resulting from ineffective blood cell production. Some patients with MDS develop acute myelogenous leukemia (AML), a malignant disease in which hematopoietic precursors are arrested in an early stage of development.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi28 – 254By similarityAdd BLAST227

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNORiQ96QR8

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional activator protein Pur-beta
Alternative name(s):
Purine-rich element-binding protein B
Gene namesi
Name:PURB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000146676.6
HGNCiHGNC:9702 PURB
MIMi608887 gene
neXtProtiNX_Q96QR8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi5814
OpenTargetsiENSG00000146676
PharmGKBiPA34046

Polymorphism and mutation databases

DMDMi74732688

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002256152 – 312Transcriptional activator protein Pur-betaAdd BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei6PhosphoserineCombined sources1
Modified residuei8PhosphoserineCombined sources1
Modified residuei24Omega-N-methylarginineBy similarity1
Modified residuei31PhosphothreonineBy similarity1
Modified residuei101PhosphoserineCombined sources1
Modified residuei152Omega-N-methylarginineBy similarity1
Modified residuei267N6-acetyllysineBy similarity1
Modified residuei294Omega-N-methylarginineBy similarity1
Modified residuei298PhosphoserineCombined sources1
Modified residuei304PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ96QR8
MaxQBiQ96QR8
PaxDbiQ96QR8
PeptideAtlasiQ96QR8
PRIDEiQ96QR8
ProteomicsDBi77888

PTM databases

iPTMnetiQ96QR8
PhosphoSitePlusiQ96QR8

Expressioni

Tissue specificityi

Expressed in myocardium of heart failure patients.1 Publication

Gene expression databases

BgeeiENSG00000146676
CleanExiHS_PURB
GenevisibleiQ96QR8 HS

Organism-specific databases

HPAiHPA048766

Interactioni

Subunit structurei

Homodimer, heterodimer with PURA and heterotrimer with PURA and YBX1/Y-box protein 1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111773, 42 interactors
IntActiQ96QR8, 12 interactors
STRINGi9606.ENSP00000379051

Structurei

3D structure databases

ProteinModelPortaliQ96QR8
SMRiQ96QR8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi153 – 222Gly-richAdd BLAST70

Sequence similaritiesi

Belongs to the PUR DNA-binding protein family.Curated

Phylogenomic databases

eggNOGiKOG3074 Eukaryota
ENOG410ZKKR LUCA
GeneTreeiENSGT00390000015406
HOGENOMiHOG000232132
HOVERGENiHBG006888
InParanoidiQ96QR8
KOiK21799
OMAiFQPAPRG
OrthoDBiEOG091G0JS7
PhylomeDBiQ96QR8
TreeFamiTF313701

Family and domain databases

InterProiView protein in InterPro
IPR006628 PUR-bd_fam
IPR030499 PURbeta
PANTHERiPTHR12611 PTHR12611, 1 hit
PTHR12611:SF4 PTHR12611:SF4, 1 hit
PfamiView protein in Pfam
PF04845 PurA, 1 hit
SMARTiView protein in SMART
SM00712 PUR, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96QR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADGDSGSER GGGGGPCGFQ PASRGGGEQE TQELASKRLD IQNKRFYLDV
60 70 80 90 100
KQNAKGRFLK IAEVGAGGSK SRLTLSMAVA AEFRDSLGDF IEHYAQLGPS
110 120 130 140 150
SPEQLAAGAE EGGGPRRALK SEFLVRENRK YYLDLKENQR GRFLRIRQTV
160 170 180 190 200
NRGGGGFGAG PGPGGLQSGQ TIALPAQGLI EFRDALAKLI DDYGGEDDEL
210 220 230 240 250
AGGPGGGAGG PGGGLYGELP EGTSITVDSK RFFFDVGCNK YGVFLRVSEV
260 270 280 290 300
KPSYRNAITV PFKAWGKFGG AFCRYADEMK EIQERQRDKL YERRGGGSGG
310
GEESEGEEVD ED
Length:312
Mass (Da):33,241
Last modified:January 23, 2007 - v3
Checksum:iE39E84E8D2957A18
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY039216 mRNA Translation: AAK72462.1
AC004854 Genomic DNA Translation: AAS00366.1
CH236960 Genomic DNA Translation: EAL23749.1
CH471128 Genomic DNA Translation: EAW61073.1
BC101735 mRNA Translation: AAI01736.1
BC101737 mRNA Translation: AAI01738.1
CCDSiCCDS5499.1
PIRiB45036
RefSeqiNP_150093.1, NM_033224.4
UniGeneiHs.349150
Hs.596321

Genome annotation databases

EnsembliENST00000395699; ENSP00000379051; ENSG00000146676
GeneIDi5814
KEGGihsa:5814
UCSCiuc003tme.5 human

Similar proteinsi

Entry informationi

Entry nameiPURB_HUMAN
AccessioniPrimary (citable) accession number: Q96QR8
Secondary accession number(s): A4D2L7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 143 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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