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Protein

Secretoglobin family 3A member 1

Gene

SCGB3A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Secreted cytokine-like protein. Inhibits cell growth in vitro.1 Publication

GO - Molecular functioni

  • cytokine activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionCytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Secretoglobin family 3A member 1
Alternative name(s):
Cytokine HIN-1
High in normal 1
Pneumo secretory protein 2
Short name:
PnSP-2
Uteroglobin-related protein 2
Gene namesi
Name:SCGB3A1
Synonyms:HIN1, PNSP2, UGRP2
ORF Names:UNQ629/PRO1245
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000161055.3
HGNCiHGNC:18384 SCGB3A1
MIMi606500 gene
neXtProtiNX_Q96QR1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi92304
OpenTargetsiENSG00000161055
PharmGKBiPA34994

Polymorphism and mutation databases

BioMutaiSCGB3A1
DMDMi46397901

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 201 PublicationAdd BLAST20
ChainiPRO_000003638321 – 104Secretoglobin family 3A member 1Add BLAST84

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi78InterchainBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ96QR1
PeptideAtlasiQ96QR1
PRIDEiQ96QR1
ProteomicsDBi77887

Expressioni

Tissue specificityi

Highly expressed in lung and prostate (PubMed:11481438). Also found in mammary gland, spleen, pancreas, testis and liver (PubMed:11481438). Detected throughout the airway epithelium in lung, with highest expression in large airways (PubMed:12406855). Found in lung submucosal glands where it localizes to acinar and ductile cells (PubMed:12406855). Not detected in respiratory bronchioles, alveolar ducts or alveolar epithelium (PubMed:12406855). In mammary gland, specifically localizes to luminal epithelial cells (PubMed:11481438).2 Publications

Gene expression databases

BgeeiENSG00000161055 Expressed in 120 organ(s), highest expression level in bronchial epithelial cell
CleanExiHS_SCGB3A1
GenevisibleiQ96QR1 HS

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi124931, 14 interactors
IntActiQ96QR1, 8 interactors
MINTiQ96QR1
STRINGi9606.ENSP00000292641

Structurei

3D structure databases

ProteinModelPortaliQ96QR1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the secretoglobin family. UGRP subfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J536 Eukaryota
ENOG4111BGJ LUCA
GeneTreeiENSGT00420000029848
HOGENOMiHOG000128185
HOVERGENiHBG079305
InParanoidiQ96QR1
OMAiFNPLKFM
PhylomeDBiQ96QR1
TreeFamiTF336928

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96QR1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLAALLGLC VALSCSSAAA FLVGSAKPVA QPVAALESAA EAGAGTLANP
60 70 80 90 100
LGTLNPLKLL LSSLGIPVNH LIEGSQKCVA ELGPQAVGAV KALKALLGAL

TVFG
Length:104
Mass (Da):10,100
Last modified:April 13, 2004 - v2
Checksum:iC1A0951F8FB1455F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19A → R in AAK82942 (PubMed:11481438).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY040564 mRNA Translation: AAK82942.1
AF313458 mRNA Translation: AAL26217.1
AF436839 mRNA Translation: AAQ04481.1
AY359064 mRNA Translation: AAQ89423.1
BC029176 mRNA Translation: AAH29176.1
BC072673 mRNA Translation: AAH72673.1
CCDSiCCDS4456.1
RefSeqiNP_443095.2, NM_052863.2
UniGeneiHs.62492

Genome annotation databases

EnsembliENST00000292641; ENSP00000292641; ENSG00000161055
GeneIDi92304
KEGGihsa:92304
UCSCiuc003mly.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY040564 mRNA Translation: AAK82942.1
AF313458 mRNA Translation: AAL26217.1
AF436839 mRNA Translation: AAQ04481.1
AY359064 mRNA Translation: AAQ89423.1
BC029176 mRNA Translation: AAH29176.1
BC072673 mRNA Translation: AAH72673.1
CCDSiCCDS4456.1
RefSeqiNP_443095.2, NM_052863.2
UniGeneiHs.62492

3D structure databases

ProteinModelPortaliQ96QR1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124931, 14 interactors
IntActiQ96QR1, 8 interactors
MINTiQ96QR1
STRINGi9606.ENSP00000292641

Polymorphism and mutation databases

BioMutaiSCGB3A1
DMDMi46397901

Proteomic databases

PaxDbiQ96QR1
PeptideAtlasiQ96QR1
PRIDEiQ96QR1
ProteomicsDBi77887

Protocols and materials databases

DNASUi92304
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000292641; ENSP00000292641; ENSG00000161055
GeneIDi92304
KEGGihsa:92304
UCSCiuc003mly.4 human

Organism-specific databases

CTDi92304
DisGeNETi92304
EuPathDBiHostDB:ENSG00000161055.3
GeneCardsiSCGB3A1
HGNCiHGNC:18384 SCGB3A1
MIMi606500 gene
neXtProtiNX_Q96QR1
OpenTargetsiENSG00000161055
PharmGKBiPA34994
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J536 Eukaryota
ENOG4111BGJ LUCA
GeneTreeiENSGT00420000029848
HOGENOMiHOG000128185
HOVERGENiHBG079305
InParanoidiQ96QR1
OMAiFNPLKFM
PhylomeDBiQ96QR1
TreeFamiTF336928

Miscellaneous databases

ChiTaRSiSCGB3A1 human
GeneWikiiSCGB3A1
GenomeRNAii92304
PROiPR:Q96QR1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000161055 Expressed in 120 organ(s), highest expression level in bronchial epithelial cell
CleanExiHS_SCGB3A1
GenevisibleiQ96QR1 HS

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiSG3A1_HUMAN
AccessioniPrimary (citable) accession number: Q96QR1
Secondary accession number(s): Q96PL0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: April 13, 2004
Last modified: November 7, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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