UniProtKB - Q96QP1 (ALPK1_HUMAN)
Protein
Alpha-protein kinase 1
Gene
ALPK1
Organism
Homo sapiens (Human)
Status
Functioni
Serine/threonine-protein kinase that detects bacterial pathogen-associated molecular pattern metabolites (PAMPs) and initiates an innate immune response, a critical step for pathogen elimination and engagement of adaptive immunity (PubMed:28877472, PubMed:28222186, PubMed:30111836). Specifically recognizes and binds ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria (PubMed:30111836). ADP-Heptose-binding stimulates its kinase activity to phosphorylate and activate TIFA, triggering proinflammatory NF-kappa-B signaling (PubMed:30111836). May be involved in monosodium urate monohydrate (MSU)-induced inflammation by mediating phosphorylation of unconventional myosin MYO9A (PubMed:27169898). May also play a role in apical protein transport by mediating phosphorylation of unconventional myosin MYO1A (PubMed:15883161).5 Publications
Caution
D-glycero-beta-D-manno-heptose 1,7-bisphosphate (HBP) was initially thought to constitute the bacterial pathogen-associated molecular pattern metabolite (PAMP) triggering the ALPK1-TIFA innate immunune response (PubMed:28877472, PubMed:28222186). It was however shown that ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose) constitutes the main PAMP that activates the kinase activity of ALPK1 (PubMed:30111836).3 Publications
Catalytic activityi
Activity regulationi
Serine/threonine-protein kinase activity is stimulated upon ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose)-binding.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 61 | ADP-D-glycero-beta-D-manno-heptose1 Publication | 1 | |
Binding sitei | 67 | ADP-D-glycero-beta-D-manno-heptose1 Publication | 1 | |
Binding sitei | 116 | ADP-D-glycero-beta-D-manno-heptose1 Publication | 1 | |
Binding sitei | 231 | ADP-D-glycero-beta-D-manno-heptose1 Publication | 1 | |
Binding sitei | 233 | ADP-D-glycero-beta-D-manno-heptose1 Publication | 1 | |
Binding sitei | 295 | ADP-D-glycero-beta-D-manno-heptose1 Publication | 1 |
GO - Molecular functioni
- ATP binding Source: InterPro
- monosaccharide binding Source: UniProtKB
- protein serine/threonine kinase activity Source: UniProtKB
- protein serine kinase activity Source: UniProtKB-EC
- protein threonine kinase activity Source: UniProtKB-EC
GO - Biological processi
- cytoplasmic pattern recognition receptor signaling pathway Source: UniProtKB
- innate immune response Source: UniProtKB
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Immunity, Innate immunity |
Enzyme and pathway databases
PathwayCommonsi | Q96QP1 |
Reactomei | R-HSA-9645460, Alpha-protein kinase 1 signaling pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Alpha-protein kinase 11 Publication (EC:2.7.11.12 Publications)Alternative name(s): Chromosome 4 kinase1 Publication Lymphocyte alpha-protein kinaseImported |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20917, ALPK1 |
MIMi | 607347, gene |
neXtProti | NX_Q96QP1 |
VEuPathDBi | HostDB:ENSG00000073331.17 |
Subcellular locationi
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 67 | Q → A: Impaired ADP-D-glycero-beta-D-manno-heptose-binding and ability to activate the serine/threonine-protein kinase activity; when associated with A-231. 1 Publication | 1 | |
Mutagenesisi | 116 | R → A: Impaired ADP-D-glycero-beta-D-manno-heptose-binding and ability to activate the serine/threonine-protein kinase activity. 1 Publication | 1 | |
Mutagenesisi | 150 | R → A: Impaired ADP-D-glycero-beta-D-manno-heptose-binding and ability to activate the serine/threonine-protein kinase activity. 1 Publication | 1 | |
Mutagenesisi | 153 | R → A: Impaired ADP-D-glycero-beta-D-manno-heptose-binding and ability to activate the serine/threonine-protein kinase activity. 1 Publication | 1 | |
Mutagenesisi | 231 | D → A: Impaired ADP-D-glycero-beta-D-manno-heptose-binding and ability to activate the serine/threonine-protein kinase activity; when associated with A-67. 1 Publication | 1 | |
Mutagenesisi | 233 | K → A: Impaired ADP-D-glycero-beta-D-manno-heptose-binding and ability to activate the serine/threonine-protein kinase activity. 1 Publication | 1 | |
Mutagenesisi | 237 | T → E: Impaired ADP-D-glycero-beta-D-manno-heptose-binding and ability to activate the serine/threonine-protein kinase activity; when associated with K-295. 1 Publication | 1 | |
Mutagenesisi | 295 | F → K: Impaired ADP-D-glycero-beta-D-manno-heptose-binding and ability to activate the serine/threonine-protein kinase activity; when associated with E-237. 1 Publication | 1 | |
Mutagenesisi | 1067 | K → M: Abolishes the serine/threonine-protein kinase and ability to initiate the innate immune response. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 80216 |
OpenTargetsi | ENSG00000073331 |
PharmGKBi | PA134891785 |
Miscellaneous databases
Pharosi | Q96QP1, Tbio |
Genetic variation databases
BioMutai | ALPK1 |
DMDMi | 308153632 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000260028 | 1 – 1244 | Alpha-protein kinase 1Add BLAST | 1244 |
Proteomic databases
EPDi | Q96QP1 |
MassIVEi | Q96QP1 |
MaxQBi | Q96QP1 |
PaxDbi | Q96QP1 |
PeptideAtlasi | Q96QP1 |
PRIDEi | Q96QP1 |
ProteomicsDBi | 25531 77886 [Q96QP1-1] |
PTM databases
iPTMneti | Q96QP1 |
PhosphoSitePlusi | Q96QP1 |
Expressioni
Tissue specificityi
Highly expressed in liver.1 Publication
Gene expression databases
Bgeei | ENSG00000073331, Expressed in amniotic fluid and 216 other tissues |
ExpressionAtlasi | Q96QP1, baseline and differential |
Genevisiblei | Q96QP1, HS |
Organism-specific databases
HPAi | ENSG00000073331, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 123183, 6 interactors |
IntActi | Q96QP1, 3 interactors |
STRINGi | 9606.ENSP00000398048 |
Miscellaneous databases
RNActi | Q96QP1, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q96QP1 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1017 – 1237 | Alpha-type protein kinasePROSITE-ProRule annotationAdd BLAST | 221 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 150 – 153 | ADP-D-glycero-beta-D-manno-heptose binding1 Publication | 4 | |
Regioni | 236 – 237 | ADP-D-glycero-beta-D-manno-heptose binding1 Publication | 2 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 105 – 109 | Poly-Ala | 5 | |
Compositional biasi | 921 – 960 | Ser-richAdd BLAST | 40 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG502QX1X, Eukaryota |
GeneTreei | ENSGT00940000159753 |
HOGENOMi | CLU_007421_0_0_1 |
InParanoidi | Q96QP1 |
OMAi | AMGKLYT |
PhylomeDBi | Q96QP1 |
TreeFami | TF316085 |
Family and domain databases
InterProi | View protein in InterPro IPR043529, ALPK1 IPR011009, Kinase-like_dom_sf IPR004166, MHCK_EF2_kinase |
PANTHERi | PTHR46747, PTHR46747, 1 hit |
Pfami | View protein in Pfam PF02816, Alpha_kinase, 1 hit |
SMARTi | View protein in SMART SM00811, Alpha_kinase, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51158, ALPHA_KINASE, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q96QP1-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNNQKVVAVL LQECKQVLDQ LLLEAPDVSE EDKSEDQRCR ALLPSELRTL
60 70 80 90 100
IQEAKEMKWP FVPEKWQYKQ AVGPEDKTNL KDVIGAGLQQ LLASLRASIL
110 120 130 140 150
ARDCAAAAAI VFLVDRFLYG LDVSGKLLQV AKGLHKLQPA TPIAPQVVIR
160 170 180 190 200
QARISVNSGK LLKAEYILSS LISNNGATGT WLYRNESDKV LVQSVCIQIR
210 220 230 240 250
GQILQKLGMW YEAAELIWAS IVGYLALPQP DKKGLSTSLG ILADIFVSMS
260 270 280 290 300
KNDYEKFKNN PQINLSLLKE FDHHLLSAAE ACKLAAAFSA YTPLFVLTAV
310 320 330 340 350
NIRGTCLLSY SSSNDCPPEL KNLHLCEAKE AFEIGLLTKR DDEPVTGKQE
360 370 380 390 400
LHSFVKAAFG LTTVHRRLHG ETGTVHAASQ LCKEAMGKLY NFSTSSRSQD
410 420 430 440 450
REALSQEVMS VIAQVKEHLQ VQSFSNVDDR SYVPESFECR LDKLILHGQG
460 470 480 490 500
DFQKILDTYS QHHTSVCEVF ESDCGNNKNE QKDAKTGVCI TALKTEIKNI
510 520 530 540 550
DTVSTTQEKP HCQRDTGISS SLMGKNVQRE LRRGGRRNWT HSDAFRVSLD
560 570 580 590 600
QDVETETEPS DYSNGEGAVF NKSLSGSQTS SAWSNLSGFS SSASWEEVNY
610 620 630 640 650
HVDDRSARKE PGKEHLVDTQ CSTALSEELE NDREGRAMHS LHSQLHDLSL
660 670 680 690 700
QEPNNDNLEP SQNQPQQQMP LTPFSPHNTP GIFLAPGAGL LEGAPEGIQE
710 720 730 740 750
VRNMGPRNTS AHSRPSYRSA SWSSDSGRPK NMGTHPSVQK EEAFEIIVEF
760 770 780 790 800
PETNCDVKDR QGKEQGEEIS ERGAGPTFKA SPSWVDPEGE TAESTEDAPL
810 820 830 840 850
DFHRVLHNSL GNISMLPCSS FTPNWPVQNP DSRKSGGPVA EQGIDPDAST
860 870 880 890 900
VDEEGQLLDS MDVPCTNGHG SHRLCILRQP PGQRAETPNS SVSGNILFPV
910 920 930 940 950
LSEDCTTTEE GNQPGNMLNC SQNSSSSSVW WLKSPAFSSG SSEGDSPWSY
960 970 980 990 1000
LNSSGSSWVS LPGKMRKEIL EARTLQPDDF EKLLAGVRHD WLFQRLENTG
1010 1020 1030 1040 1050
VFKPSQLHRA HSALLLKYSK KSELWTAQET IVYLGDYLTV KKKGRQRNAF
1060 1070 1080 1090 1100
WVHHLHQEEI LGRYVGKDYK EQKGLWHHFT DVERQMTAQH YVTEFNKRLY
1110 1120 1130 1140 1150
EQNIPTQIFY IPSTILLILE DKTIKGCISV EPYILGEFVK LSNNTKVVKT
1160 1170 1180 1190 1200
EYKATEYGLA YGHFSYEFSN HRDVVVDLQG WVTGNGKGLI YLTDPQIHSV
1210 1220 1230 1240
DQKVFTTNFG KRGIFYFFNN QHVECNEICH RLSLTRPSME KPCT
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB4E0R2 | B4E0R2_HUMAN | Alpha-protein kinase 1 | ALPK1 | 168 | Annotation score: | ||
B3KUH8 | B3KUH8_HUMAN | Alpha-protein kinase 1 | ALPK1 | 304 | Annotation score: | ||
D6RB29 | D6RB29_HUMAN | Alpha-protein kinase 1 | ALPK1 | 133 | Annotation score: | ||
D6RDN6 | D6RDN6_HUMAN | Alpha-protein kinase 1 | ALPK1 | 109 | Annotation score: |
Sequence cautioni
The sequence BAC85140 differs from that shown. Reason: Frameshift.Curated
The sequence BAC85140 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BC060780 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 83 | V → L in BAC85140 (Ref. 5) Curated | 1 | |
Sequence conflicti | 577 | S → G in BAG65473 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_041511 | 67 | Q → R1 PublicationCorresponds to variant dbSNP:rs33943680EnsemblClinVar. | 1 | |
Natural variantiVAR_028982 | 175 | N → D1 PublicationCorresponds to variant dbSNP:rs6533616Ensembl. | 1 | |
Natural variantiVAR_041512 | 292 | T → M1 PublicationCorresponds to variant dbSNP:rs34120296Ensembl. | 1 | |
Natural variantiVAR_041513 | 320 | L → M1 PublicationCorresponds to variant dbSNP:rs757602009Ensembl. | 1 | |
Natural variantiVAR_041514 | 339 | K → E in an ovarian mucinous carcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_041515 | 383 | K → E1 PublicationCorresponds to variant dbSNP:rs147641444Ensembl. | 1 | |
Natural variantiVAR_028983 | 565 | G → D5 PublicationsCorresponds to variant dbSNP:rs2074388Ensembl. | 1 | |
Natural variantiVAR_028984 | 642 | H → R5 PublicationsCorresponds to variant dbSNP:rs13148353Ensembl. | 1 | |
Natural variantiVAR_041516 | 660 | P → L1 PublicationCorresponds to variant dbSNP:rs35389530Ensembl. | 1 | |
Natural variantiVAR_041517 | 681 | G → D2 PublicationsCorresponds to variant dbSNP:rs35519493Ensembl. | 1 | |
Natural variantiVAR_028985 | 732 | M → I5 PublicationsCorresponds to variant dbSNP:rs2074379Ensembl. | 1 | |
Natural variantiVAR_028986 | 861 | M → T5 PublicationsCorresponds to variant dbSNP:rs11726117Ensembl. | 1 | |
Natural variantiVAR_028987 | 870 | G → S1 PublicationCorresponds to variant dbSNP:rs2074380Ensembl. | 1 | |
Natural variantiVAR_041518 | 873 | R → I1 PublicationCorresponds to variant dbSNP:rs34946272EnsemblClinVar. | 1 | |
Natural variantiVAR_041519 | 910 | E → D1 PublicationCorresponds to variant dbSNP:rs35308602Ensembl. | 1 | |
Natural variantiVAR_028988 | 916 | N → D1 PublicationCorresponds to variant dbSNP:rs2074381Ensembl. | 1 | |
Natural variantiVAR_041520 | 935 | P → L1 PublicationCorresponds to variant dbSNP:rs34780600Ensembl. | 1 | |
Natural variantiVAR_057741 | 1008 | H → P. Corresponds to variant dbSNP:rs34079946Ensembl. | 1 | |
Natural variantiVAR_041521 | 1084 | R → Q1 PublicationCorresponds to variant dbSNP:rs34677416Ensembl. | 1 | |
Natural variantiVAR_041522 | 1117 | L → P1 PublicationCorresponds to variant dbSNP:rs35756863EnsemblClinVar. | 1 | |
Natural variantiVAR_041523 | 1160 | A → G1 PublicationCorresponds to variant dbSNP:rs55696324Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_044735 | 1 – 92 | MNNQK…LQQLL → MCRKRTRARTSAAE in isoform 2. 1 PublicationAdd BLAST | 92 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY044164 mRNA Translation: AAK94675.1 AK304708 mRNA Translation: BAG65473.1 AC004049 Genomic DNA No translation available. AC109347 Genomic DNA No translation available. BC060780 mRNA No translation available. AK131090 mRNA Translation: BAC85140.1 Sequence problems. AB040960 mRNA Translation: BAA96051.1 AB075877 mRNA Translation: BAD38659.1 |
CCDSi | CCDS3697.1 [Q96QP1-1] CCDS58923.1 [Q96QP1-2] |
RefSeqi | NP_001095876.1, NM_001102406.1 [Q96QP1-1] NP_001240813.1, NM_001253884.1 [Q96QP1-2] NP_079420.3, NM_025144.3 [Q96QP1-1] |
Genome annotation databases
Ensembli | ENST00000177648; ENSP00000177648; ENSG00000073331 [Q96QP1-1] ENST00000458497; ENSP00000398048; ENSG00000073331 [Q96QP1-1] ENST00000504176; ENSP00000426044; ENSG00000073331 [Q96QP1-2] ENST00000650871; ENSP00000498374; ENSG00000073331 [Q96QP1-1] |
GeneIDi | 80216 |
KEGGi | hsa:80216 |
UCSCi | uc003ian.5, human [Q96QP1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY044164 mRNA Translation: AAK94675.1 AK304708 mRNA Translation: BAG65473.1 AC004049 Genomic DNA No translation available. AC109347 Genomic DNA No translation available. BC060780 mRNA No translation available. AK131090 mRNA Translation: BAC85140.1 Sequence problems. AB040960 mRNA Translation: BAA96051.1 AB075877 mRNA Translation: BAD38659.1 |
CCDSi | CCDS3697.1 [Q96QP1-1] CCDS58923.1 [Q96QP1-2] |
RefSeqi | NP_001095876.1, NM_001102406.1 [Q96QP1-1] NP_001240813.1, NM_001253884.1 [Q96QP1-2] NP_079420.3, NM_025144.3 [Q96QP1-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5Z2C | X-ray | 2.59 | A/B/C/D/E/F/G/H/I | 1-446 | [»] | |
SMRi | Q96QP1 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 123183, 6 interactors |
IntActi | Q96QP1, 3 interactors |
STRINGi | 9606.ENSP00000398048 |
PTM databases
iPTMneti | Q96QP1 |
PhosphoSitePlusi | Q96QP1 |
Genetic variation databases
BioMutai | ALPK1 |
DMDMi | 308153632 |
Proteomic databases
EPDi | Q96QP1 |
MassIVEi | Q96QP1 |
MaxQBi | Q96QP1 |
PaxDbi | Q96QP1 |
PeptideAtlasi | Q96QP1 |
PRIDEi | Q96QP1 |
ProteomicsDBi | 25531 77886 [Q96QP1-1] |
Protocols and materials databases
Antibodypediai | 26436, 86 antibodies |
DNASUi | 80216 |
Genome annotation databases
Ensembli | ENST00000177648; ENSP00000177648; ENSG00000073331 [Q96QP1-1] ENST00000458497; ENSP00000398048; ENSG00000073331 [Q96QP1-1] ENST00000504176; ENSP00000426044; ENSG00000073331 [Q96QP1-2] ENST00000650871; ENSP00000498374; ENSG00000073331 [Q96QP1-1] |
GeneIDi | 80216 |
KEGGi | hsa:80216 |
UCSCi | uc003ian.5, human [Q96QP1-1] |
Organism-specific databases
CTDi | 80216 |
DisGeNETi | 80216 |
GeneCardsi | ALPK1 |
HGNCi | HGNC:20917, ALPK1 |
HPAi | ENSG00000073331, Low tissue specificity |
MIMi | 607347, gene |
neXtProti | NX_Q96QP1 |
OpenTargetsi | ENSG00000073331 |
PharmGKBi | PA134891785 |
VEuPathDBi | HostDB:ENSG00000073331.17 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QX1X, Eukaryota |
GeneTreei | ENSGT00940000159753 |
HOGENOMi | CLU_007421_0_0_1 |
InParanoidi | Q96QP1 |
OMAi | AMGKLYT |
PhylomeDBi | Q96QP1 |
TreeFami | TF316085 |
Enzyme and pathway databases
PathwayCommonsi | Q96QP1 |
Reactomei | R-HSA-9645460, Alpha-protein kinase 1 signaling pathway |
Miscellaneous databases
BioGRID-ORCSi | 80216, 3 hits in 876 CRISPR screens |
ChiTaRSi | ALPK1, human |
GeneWikii | ALPK1 |
GenomeRNAii | 80216 |
Pharosi | Q96QP1, Tbio |
PROi | PR:Q96QP1 |
RNActi | Q96QP1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000073331, Expressed in amniotic fluid and 216 other tissues |
ExpressionAtlasi | Q96QP1, baseline and differential |
Genevisiblei | Q96QP1, HS |
Family and domain databases
InterProi | View protein in InterPro IPR043529, ALPK1 IPR011009, Kinase-like_dom_sf IPR004166, MHCK_EF2_kinase |
PANTHERi | PTHR46747, PTHR46747, 1 hit |
Pfami | View protein in Pfam PF02816, Alpha_kinase, 1 hit |
SMARTi | View protein in SMART SM00811, Alpha_kinase, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51158, ALPHA_KINASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ALPK1_HUMAN | |
Accessioni | Q96QP1Primary (citable) accession number: Q96QP1 Secondary accession number(s): B4E3G1 Q9P201 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 28, 2006 |
Last sequence update: | October 5, 2010 | |
Last modified: | February 10, 2021 | |
This is version 146 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families