UniProtKB - Q96QP1 (ALPK1_HUMAN)

BLAST

>sp|Q96QP1|ALPK1_HUMAN Alpha-protein kinase 1 OS=Homo sapiens OX=9606 GN=ALPK1 PE=1 SV=3
MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWP
FVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYG
LDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGT
WLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLG
ILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAV
NIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFG
LTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQ
VQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNE
QKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWT
HSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNY
HVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEP
SQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSA
SWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKA
SPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVA
EQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPV
LSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVS
LPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSK
KSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFT
DVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVK
LSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSV
DQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT

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History
Entry version 129 (07 Nov 2018)
Sequence version 3 (05 Oct 2010)
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Protein

Alpha-protein kinase 1

Gene

ALPK1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Serine/threonine-protein kinase that detects bacterial pathogen-associated molecular pattern metabolites (PAMPs) and initiates an innate immune response, a critical step for pathogen elimination and engagement of adaptive immunity (PubMed:28877472, PubMed:28222186, PubMed:30111836). Specifically recognizes and binds ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria (PubMed:30111836). ADP-Heptose-binding stimulates its kinase activity to phosphorylate and activate TIFA, triggering proinflammatory NF-kappa-B signaling (PubMed:30111836). May be involved in monosodium urate monohydrate (MSU)-induced inflammation by mediating phosphorylation of unconventional myosin MYO9A (PubMed:27169898). May also play a role in apical protein transport by mediating phosphorylation of unconventional myosin MYO1A (PubMed:15883161).5 Publications

Caution

D-glycero-beta-D-manno-heptose 1,7-bisphosphate (HBP) was initially thought to constitute the bacterial pathogen-associated molecular pattern metabolite (PAMP) triggering the ALPK1-TIFA innate immunune response (PubMed:28877472, PubMed:28222186). It was however shown that ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose) constitutes the main PAMP that activates the kinase activity of ALPK1 (PubMed:30111836).3 Publications

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.2 Publications

Activity regulationⁱ

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	61	ADP-D-glycero-beta-D-manno-heptose1 Publication	1
Binding siteⁱ	67	ADP-D-glycero-beta-D-manno-heptose1 Publication	1
Binding siteⁱ	116	ADP-D-glycero-beta-D-manno-heptose1 Publication	1
Binding siteⁱ	231	ADP-D-glycero-beta-D-manno-heptose1 Publication	1
Binding siteⁱ	233	ADP-D-glycero-beta-D-manno-heptose1 Publication	1
Binding siteⁱ	295	ADP-D-glycero-beta-D-manno-heptose1 Publication	1

GO - Molecular functionⁱ

ATP binding Source: InterPro
monosaccharide binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 30111836
protein serine/threonine kinase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 30111836

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase
Biological process	Immunity, Innate immunity

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Alpha-protein kinase 11 Publication (EC:2.7.11.12 Publications) Alternative name(s): Chromosome 4 kinase1 Publication Lymphocyte alpha-protein kinaseImported
Gene namesⁱ	Name:ALPK11 PublicationImported Synonyms:KIAA15271 Publication, LAKImported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000073331.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:20917 ALPK1
MIMⁱ	607347 gene
neXtProtⁱ	NX_Q96QP1

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	67	Q → A: Impaired ADP-D-glycero-beta-D-manno-heptose-binding and ability to activate the serine/threonine-protein kinase activity; when associated with A-231. 1 Publication	1
Mutagenesisⁱ	116	R → A: Impaired ADP-D-glycero-beta-D-manno-heptose-binding and ability to activate the serine/threonine-protein kinase activity. 1 Publication	1
Mutagenesisⁱ	150	R → A: Impaired ADP-D-glycero-beta-D-manno-heptose-binding and ability to activate the serine/threonine-protein kinase activity. 1 Publication	1
Mutagenesisⁱ	153	R → A: Impaired ADP-D-glycero-beta-D-manno-heptose-binding and ability to activate the serine/threonine-protein kinase activity. 1 Publication	1
Mutagenesisⁱ	231	D → A: Impaired ADP-D-glycero-beta-D-manno-heptose-binding and ability to activate the serine/threonine-protein kinase activity; when associated with A-67. 1 Publication	1
Mutagenesisⁱ	233	K → A: Impaired ADP-D-glycero-beta-D-manno-heptose-binding and ability to activate the serine/threonine-protein kinase activity. 1 Publication	1
Mutagenesisⁱ	237	T → E: Impaired ADP-D-glycero-beta-D-manno-heptose-binding and ability to activate the serine/threonine-protein kinase activity; when associated with K-295. 1 Publication	1
Mutagenesisⁱ	295	F → K: Impaired ADP-D-glycero-beta-D-manno-heptose-binding and ability to activate the serine/threonine-protein kinase activity; when associated with E-237. 1 Publication	1
Mutagenesisⁱ	1067	K → M: Abolishes the serine/threonine-protein kinase and ability to initiate the innate immune response. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	80216
Open Targets More...OpenTargetsⁱ	ENSG00000073331
PharmGKBⁱ	PA134891785

Polymorphism and mutation databases

BioMutaⁱ	ALPK1
DMDMⁱ	308153632

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000260028	1 – 1244	Alpha-protein kinase 1Add BLAST		1244

Proteomic databases

EPDⁱ	Q96QP1
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96QP1
PaxDbⁱ	Q96QP1
PeptideAtlas More...PeptideAtlasⁱ	Q96QP1
PRIDEⁱ	Q96QP1
ProteomicsDBⁱ	77886

PTM databases

iPTMnetⁱ	Q96QP1
PhosphoSitePlusⁱ	Q96QP1

Expressionⁱ

Tissue specificityⁱ

Highly expressed in liver.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000073331 Expressed in 205 organ(s), highest expression level in amniotic fluid
CleanExⁱ	HS_ALPK1
ExpressionAtlasⁱ	Q96QP1 baseline and differential
Genevisibleⁱ	Q96QP1 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA027435 HPA027443

HPAⁱ

HPA027435
HPA027443

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	123183, 6 interactors
IntActⁱ	Q96QP1, 2 interactors
STRINGⁱ	9606.ENSP00000177648

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	4 – 23	Combined sources	20
Helixⁱ	30 – 41	Combined sources	12
Helixⁱ	45 – 55	Combined sources	11
Turnⁱ	65 – 67	Combined sources	3
Helixⁱ	74 – 76	Combined sources	3
Helixⁱ	80 – 86	Combined sources	7
Helixⁱ	88 – 100	Combined sources	13
Helixⁱ	104 – 120	Combined sources	17
Helixⁱ	124 – 137	Combined sources	14
Helixⁱ	145 – 157	Combined sources	13
Helixⁱ	161 – 173	Combined sources	13
Turnⁱ	174 – 176	Combined sources	3
Beta strandⁱ	184 – 186	Combined sources	3
Helixⁱ	187 – 206	Combined sources	20
Helixⁱ	210 – 225	Combined sources	16
Beta strandⁱ	227 – 229	Combined sources	3
Helixⁱ	232 – 248	Combined sources	17
Helixⁱ	251 – 258	Combined sources	8
Helixⁱ	266 – 270	Combined sources	5
Helixⁱ	274 – 288	Combined sources	15
Turnⁱ	289 – 291	Combined sources	3
Helixⁱ	293 – 311	Combined sources	19
Helixⁱ	318 – 337	Combined sources	20
Helixⁱ	348 – 369	Combined sources	22
Helixⁱ	373 – 394	Combined sources	22
Helixⁱ	398 – 418	Combined sources	21
Helixⁱ	442 – 444	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q96QP1
SMRⁱ	Q96QP1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	1017 – 1237	Alpha-type protein kinasePROSITE-ProRule annotationAdd BLAST		221

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	150 – 153	ADP-D-glycero-beta-D-manno-heptose binding1 Publication		4
Regionⁱ	236 – 237	ADP-D-glycero-beta-D-manno-heptose binding1 Publication		2

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	105 – 109	Poly-Ala		5
Compositional biasⁱ	921 – 960	Ser-richAdd BLAST		40

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IFN0 Eukaryota ENOG4110KQR LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00800000124135
HOGENOMⁱ	HOG000169279
HOVERGENⁱ	HBG079770
InParanoidⁱ	Q96QP1
KEGG Orthology (KO) More...KOⁱ	K08868
OMAⁱ	HSVDQKD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G00VW
PhylomeDBⁱ	Q96QP1
TreeFamⁱ	TF316085

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR004166 MHCK_EF2_kinase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02816 Alpha_kinase, 1 hit
SMARTⁱ	View protein in SMART SM00811 Alpha_kinase, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS51158 ALPHA_KINASE, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q96QP1-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNNQKVVAVL LQECKQVLDQ LLLEAPDVSE EDKSEDQRCR ALLPSELRTL 
        60         70         80         90        100
IQEAKEMKWP FVPEKWQYKQ AVGPEDKTNL KDVIGAGLQQ LLASLRASIL 
       110        120        130        140        150
ARDCAAAAAI VFLVDRFLYG LDVSGKLLQV AKGLHKLQPA TPIAPQVVIR 
       160        170        180        190        200
QARISVNSGK LLKAEYILSS LISNNGATGT WLYRNESDKV LVQSVCIQIR 
       210        220        230        240        250
GQILQKLGMW YEAAELIWAS IVGYLALPQP DKKGLSTSLG ILADIFVSMS 
       260        270        280        290        300
KNDYEKFKNN PQINLSLLKE FDHHLLSAAE ACKLAAAFSA YTPLFVLTAV 
       310        320        330        340        350
NIRGTCLLSY SSSNDCPPEL KNLHLCEAKE AFEIGLLTKR DDEPVTGKQE 
       360        370        380        390        400
LHSFVKAAFG LTTVHRRLHG ETGTVHAASQ LCKEAMGKLY NFSTSSRSQD 
       410        420        430        440        450
REALSQEVMS VIAQVKEHLQ VQSFSNVDDR SYVPESFECR LDKLILHGQG 
       460        470        480        490        500
DFQKILDTYS QHHTSVCEVF ESDCGNNKNE QKDAKTGVCI TALKTEIKNI 
       510        520        530        540        550
DTVSTTQEKP HCQRDTGISS SLMGKNVQRE LRRGGRRNWT HSDAFRVSLD 
       560        570        580        590        600
QDVETETEPS DYSNGEGAVF NKSLSGSQTS SAWSNLSGFS SSASWEEVNY 
       610        620        630        640        650
HVDDRSARKE PGKEHLVDTQ CSTALSEELE NDREGRAMHS LHSQLHDLSL 
       660        670        680        690        700
QEPNNDNLEP SQNQPQQQMP LTPFSPHNTP GIFLAPGAGL LEGAPEGIQE 
       710        720        730        740        750
VRNMGPRNTS AHSRPSYRSA SWSSDSGRPK NMGTHPSVQK EEAFEIIVEF 
       760        770        780        790        800
PETNCDVKDR QGKEQGEEIS ERGAGPTFKA SPSWVDPEGE TAESTEDAPL 
       810        820        830        840        850
DFHRVLHNSL GNISMLPCSS FTPNWPVQNP DSRKSGGPVA EQGIDPDAST 
       860        870        880        890        900
VDEEGQLLDS MDVPCTNGHG SHRLCILRQP PGQRAETPNS SVSGNILFPV 
       910        920        930        940        950
LSEDCTTTEE GNQPGNMLNC SQNSSSSSVW WLKSPAFSSG SSEGDSPWSY 
       960        970        980        990       1000
LNSSGSSWVS LPGKMRKEIL EARTLQPDDF EKLLAGVRHD WLFQRLENTG 
      1010       1020       1030       1040       1050
VFKPSQLHRA HSALLLKYSK KSELWTAQET IVYLGDYLTV KKKGRQRNAF 
      1060       1070       1080       1090       1100
WVHHLHQEEI LGRYVGKDYK EQKGLWHHFT DVERQMTAQH YVTEFNKRLY 
      1110       1120       1130       1140       1150
EQNIPTQIFY IPSTILLILE DKTIKGCISV EPYILGEFVK LSNNTKVVKT 
      1160       1170       1180       1190       1200
EYKATEYGLA YGHFSYEFSN HRDVVVDLQG WVTGNGKGLI YLTDPQIHSV 
      1210       1220       1230       1240 
DQKVFTTNFG KRGIFYFFNN QHVECNEICH RLSLTRPSME KPCT

Length:1,244

Mass (Da):138,861

Last modified:October 5, 2010 - v3

Checksum:ⁱ857D353D159A1630

Isoform 2 (identifier: Q96QP1-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-92: MNNQKVVAVL...VIGAGLQQLL → MCRKRTRARTSAAE

« Hide

        10         20         30         40         50
MCRKRTRART SAAEASLRAS ILARDCAAAA AIVFLVDRFL YGLDVSGKLL 
        60         70         80         90        100
QVAKGLHKLQ PATPIAPQVV IRQARISVNS GKLLKAEYIL SSLISNNGAT 
       110        120        130        140        150
GTWLYRNESD KVLVQSVCIQ IRGQILQKLG MWYEAAELIW ASIVGYLALP 
       160        170        180        190        200
QPDKKGLSTS LGILADIFVS MSKNDYEKFK NNPQINLSLL KEFDHHLLSA 
       210        220        230        240        250
AEACKLAAAF SAYTPLFVLT AVNIRGTCLL SYSSSNDCPP ELKNLHLCEA 
       260        270        280        290        300
KEAFEIGLLT KRDDEPVTGK QELHSFVKAA FGLTTVHRRL HGETGTVHAA 
       310        320        330        340        350
SQLCKEAMGK LYNFSTSSRS QDREALSQEV MSVIAQVKEH LQVQSFSNVD 
       360        370        380        390        400
DRSYVPESFE CRLDKLILHG QGDFQKILDT YSQHHTSVCE VFESDCGNNK 
       410        420        430        440        450
NEQKDAKTGV CITALKTEIK NIDTVSTTQE KPHCQRDTGI SSSLMGKNVQ 
       460        470        480        490        500
RELRRGGRRN WTHSDAFRVS LDQDVETETE PSDYSNGEGA VFNKSLSGSQ 
       510        520        530        540        550
TSSAWSNLSG FSSSASWEEV NYHVDDRSAR KEPGKEHLVD TQCSTALSEE 
       560        570        580        590        600
LENDREGRAM HSLHSQLHDL SLQEPNNDNL EPSQNQPQQQ MPLTPFSPHN 
       610        620        630        640        650
TPGIFLAPGA GLLEGAPEGI QEVRNMGPRN TSAHSRPSYR SASWSSDSGR 
       660        670        680        690        700
PKNMGTHPSV QKEEAFEIIV EFPETNCDVK DRQGKEQGEE ISERGAGPTF 
       710        720        730        740        750
KASPSWVDPE GETAESTEDA PLDFHRVLHN SLGNISMLPC SSFTPNWPVQ 
       760        770        780        790        800
NPDSRKSGGP VAEQGIDPDA STVDEEGQLL DSMDVPCTNG HGSHRLCILR 
       810        820        830        840        850
QPPGQRAETP NSSVSGNILF PVLSEDCTTT EEGNQPGNML NCSQNSSSSS 
       860        870        880        890        900
VWWLKSPAFS SGSSEGDSPW SYLNSSGSSW VSLPGKMRKE ILEARTLQPD 
       910        920        930        940        950
DFEKLLAGVR HDWLFQRLEN TGVFKPSQLH RAHSALLLKY SKKSELWTAQ 
       960        970        980        990       1000
ETIVYLGDYL TVKKKGRQRN AFWVHHLHQE EILGRYVGKD YKEQKGLWHH 
      1010       1020       1030       1040       1050
FTDVERQMTA QHYVTEFNKR LYEQNIPTQI FYIPSTILLI LEDKTIKGCI 
      1060       1070       1080       1090       1100
SVEPYILGEF VKLSNNTKVV KTEYKATEYG LAYGHFSYEF SNHRDVVVDL 
      1110       1120       1130       1140       1150
QGWVTGNGKG LIYLTDPQIH SVDQKVFTTN FGKRGIFYFF NNQHVECNEI 
      1160 
CHRLSLTRPS MEKPCT

Note: No experimental confirmation available.

Show »

Length:1,166

Mass (Da):129,951

Checksum:ⁱ1996AB197A4DDEEC

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B4E0R2	B4E0R2_HUMAN	Alpha-protein kinase 1 Alpha-protein kinase 1 (cDNA FLJ61015, highly similar to Homo sapiens alpha-kinase 1 (ALPK1), mRNA)	ALPK1	168	Annotation score:
B3KUH8	B3KUH8_HUMAN	Alpha-protein kinase 1 Alpha-protein kinase 1 (cDNA FLJ39927 fis, clone SPLEN2021194, highly similar to Homo sapiens alpha-kinase 1 (ALPK1), mRNA)	ALPK1	304	Annotation score:
D6RDN6	D6RDN6_HUMAN	Alpha-protein kinase 1 Alpha-protein kinase 1	ALPK1	109	Annotation score:
D6RB29	D6RB29_HUMAN	Alpha-protein kinase 1 Alpha-protein kinase 1	ALPK1	133	Annotation score:

Sequence cautionⁱ

The sequence BAC85140 differs from that shown. Intron retention.Curated

The sequence BAC85140 differs from that shown. Reason: Frameshift at positions 208 and 1022.Curated

The sequence BAC85140 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BC060780 differs from that shown. Reason: Frameshift at position 1044.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	83	V → L in BAC85140 (Ref. 5) Curated		1
Sequence conflictⁱ	577	S → G in BAG65473 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_041511	67	Q → R1 PublicationCorresponds to variant dbSNP:rs33943680Ensembl.	1
Natural variantⁱVAR_028982	175	N → D1 PublicationCorresponds to variant dbSNP:rs6533616Ensembl.	1
Natural variantⁱVAR_041512	292	T → M1 PublicationCorresponds to variant dbSNP:rs34120296Ensembl.	1
Natural variantⁱVAR_041513	320	L → M1 Publication	1
Natural variantⁱVAR_041514	339	K → E in an ovarian mucinous carcinoma sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_041515	383	K → E1 PublicationCorresponds to variant dbSNP:rs147641444Ensembl.	1
Natural variantⁱVAR_028983	565	G → D5 PublicationsCorresponds to variant dbSNP:rs2074388Ensembl.	1
Natural variantⁱVAR_028984	642	H → R5 PublicationsCorresponds to variant dbSNP:rs13148353Ensembl.	1
Natural variantⁱVAR_041516	660	P → L1 PublicationCorresponds to variant dbSNP:rs35389530Ensembl.	1
Natural variantⁱVAR_041517	681	G → D2 PublicationsCorresponds to variant dbSNP:rs35519493Ensembl.	1
Natural variantⁱVAR_028985	732	M → I5 PublicationsCorresponds to variant dbSNP:rs2074379Ensembl.	1
Natural variantⁱVAR_028986	861	M → T5 PublicationsCorresponds to variant dbSNP:rs11726117Ensembl.	1
Natural variantⁱVAR_028987	870	G → S1 PublicationCorresponds to variant dbSNP:rs2074380Ensembl.	1
Natural variantⁱVAR_041518	873	R → I1 PublicationCorresponds to variant dbSNP:rs34946272Ensembl.	1
Natural variantⁱVAR_041519	910	E → D1 PublicationCorresponds to variant dbSNP:rs35308602Ensembl.	1
Natural variantⁱVAR_028988	916	N → D1 PublicationCorresponds to variant dbSNP:rs2074381Ensembl.	1
Natural variantⁱVAR_041520	935	P → L1 PublicationCorresponds to variant dbSNP:rs34780600Ensembl.	1
Natural variantⁱVAR_057741	1008	H → P. Corresponds to variant dbSNP:rs34079946Ensembl.	1
Natural variantⁱVAR_041521	1084	R → Q1 PublicationCorresponds to variant dbSNP:rs34677416Ensembl.	1
Natural variantⁱVAR_041522	1117	L → P1 PublicationCorresponds to variant dbSNP:rs35756863Ensembl.	1
Natural variantⁱVAR_041523	1160	A → G1 PublicationCorresponds to variant dbSNP:rs55696324Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_044735	1 – 92	MNNQK…LQQLL → MCRKRTRARTSAAE in isoform 2. 1 PublicationAdd BLAST		92

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY044164 mRNA Translation: AAK94675.1 AK304708 mRNA Translation: BAG65473.1 AC004049 Genomic DNA No translation available. AC109347 Genomic DNA No translation available. BC060780 mRNA No translation available. AK131090 mRNA Translation: BAC85140.1 Sequence problems. AB040960 mRNA Translation: BAA96051.1 AB075877 mRNA Translation: BAD38659.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3697.1 [Q96QP1-1] CCDS58923.1 [Q96QP1-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001095876.1, NM_001102406.1 [Q96QP1-1] NP_001240813.1, NM_001253884.1 [Q96QP1-2] NP_079420.3, NM_025144.3 [Q96QP1-1]
UniGeneⁱ	Hs.652825

Genome annotation databases

Ensemblⁱ	ENST00000177648; ENSP00000177648; ENSG00000073331 [Q96QP1-1] ENST00000458497; ENSP00000398048; ENSG00000073331 [Q96QP1-1] ENST00000504176; ENSP00000426044; ENSG00000073331 [Q96QP1-2]
GeneIDⁱ	80216
KEGGⁱ	hsa:80216
UCSC genome browser More...UCSCⁱ	uc003ian.5 human [Q96QP1-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q96QP1	Uncharacterized protein		AOTNA		1262	UniRef90_Q96QP1
Uncharacterized protein		PANPA		1246
Uncharacterized protein		PAPAN		1245
Uncharacterized protein		MACNE		1245
Uncharacterized protein		MACMU		1245
+82

Protein	Similar proteins		Species	Score	Length	Source
Q96QP1	Alpha-protein kinase 1		MOUSE		1231	UniRef50_Q96QP1
Uncharacterized protein		AOTNA		1262
Uncharacterized protein		PANPA		1246
Uncharacterized protein		MACNE		1245
Uncharacterized protein		RHIBE		1245
+295

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY044164 mRNA Translation: AAK94675.1 AK304708 mRNA Translation: BAG65473.1 AC004049 Genomic DNA No translation available. AC109347 Genomic DNA No translation available. BC060780 mRNA No translation available. AK131090 mRNA Translation: BAC85140.1 Sequence problems. AB040960 mRNA Translation: BAA96051.1 AB075877 mRNA Translation: BAD38659.1
CCDSⁱ	CCDS3697.1 [Q96QP1-1] CCDS58923.1 [Q96QP1-2]
RefSeqⁱ	NP_001095876.1, NM_001102406.1 [Q96QP1-1] NP_001240813.1, NM_001253884.1 [Q96QP1-2] NP_079420.3, NM_025144.3 [Q96QP1-1]
UniGeneⁱ	Hs.652825

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5Z2C	X-ray	2.59	A/B/C/D/E/F/G/H/I	1-446	[»]
ProteinModelPortalⁱ	Q96QP1
SMRⁱ	Q96QP1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	123183, 6 interactors
IntActⁱ	Q96QP1, 2 interactors
STRINGⁱ	9606.ENSP00000177648

PTM databases

iPTMnetⁱ	Q96QP1
PhosphoSitePlusⁱ	Q96QP1

Polymorphism and mutation databases

BioMutaⁱ	ALPK1
DMDMⁱ	308153632

Proteomic databases

EPDⁱ	Q96QP1
MaxQBⁱ	Q96QP1
PaxDbⁱ	Q96QP1
PeptideAtlasⁱ	Q96QP1
PRIDEⁱ	Q96QP1
ProteomicsDBⁱ	77886

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	80216
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000177648; ENSP00000177648; ENSG00000073331 [Q96QP1-1] ENST00000458497; ENSP00000398048; ENSG00000073331 [Q96QP1-1] ENST00000504176; ENSP00000426044; ENSG00000073331 [Q96QP1-2]
GeneIDⁱ	80216
KEGGⁱ	hsa:80216
UCSCⁱ	uc003ian.5 human [Q96QP1-1]

Organism-specific databases

CTDⁱ	80216
DisGeNETⁱ	80216
EuPathDBⁱ	HostDB:ENSG00000073331.17
GeneCardsⁱ	ALPK1
H-InvDBⁱ	HIX0004446
HGNCⁱ	HGNC:20917 ALPK1
HPAⁱ	HPA027435 HPA027443
MIMⁱ	607347 gene
neXtProtⁱ	NX_Q96QP1
OpenTargetsⁱ	ENSG00000073331
PharmGKBⁱ	PA134891785
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IFN0 Eukaryota ENOG4110KQR LUCA
GeneTreeⁱ	ENSGT00800000124135
HOGENOMⁱ	HOG000169279
HOVERGENⁱ	HBG079770
InParanoidⁱ	Q96QP1
KOⁱ	K08868
OMAⁱ	HSVDQKD
OrthoDBⁱ	EOG091G00VW
PhylomeDBⁱ	Q96QP1
TreeFamⁱ	TF316085

Miscellaneous databases

ChiTaRSⁱ	ALPK1 human
GeneWikiⁱ	ALPK1
GenomeRNAiⁱ	80216
Protein Ontology More...PROⁱ	PR:Q96QP1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000073331 Expressed in 205 organ(s), highest expression level in amniotic fluid
CleanExⁱ	HS_ALPK1
ExpressionAtlasⁱ	Q96QP1 baseline and differential
Genevisibleⁱ	Q96QP1 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR004166 MHCK_EF2_kinase
Pfamⁱ	View protein in Pfam PF02816 Alpha_kinase, 1 hit
SMARTⁱ	View protein in SMART SM00811 Alpha_kinase, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS51158 ALPHA_KINASE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ALPK1_HUMAN
Accessionⁱ	Q96QP1Primary (citable) accession number: Q96QP1 Secondary accession number(s): B4E3G1 , F5H138, Q68CI9, Q6P9F9, Q6ZNK4, Q9P201
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
	Last sequence update:	October 5, 2010
	Last modified:	November 7, 2018
	This is version 129 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human and mouse protein kinases
Human and mouse protein kinases: classification and index

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UniProtKB - Q96QP1 (ALPK1_HUMAN)

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Alpha-protein kinase 1

ALPK1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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Proteomic databases

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<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

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<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

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<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

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<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

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Keywords - Coding sequence diversityi

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PTM databases

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Proteomic databases

Protocols and materials databases

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Gene expression databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ