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UniProtKB - Q96QP1 (ALPK1_HUMAN)

Entry version 149 (29 Sep 2021)
Sequence version 3 (05 Oct 2010)
Previous versions | rss
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Protein

Alpha-protein kinase 1

Gene

ALPK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine-protein kinase that detects bacterial pathogen-associated molecular pattern metabolites (PAMPs) and initiates an innate immune response, a critical step for pathogen elimination and engagement of adaptive immunity (PubMed:28877472, PubMed:28222186, PubMed:30111836).

Specifically recognizes and binds ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria (PubMed:30111836).

ADP-Heptose-binding stimulates its kinase activity to phosphorylate and activate TIFA, triggering proinflammatory NF-kappa-B signaling (PubMed:30111836).

May be involved in monosodium urate monohydrate (MSU)-induced inflammation by mediating phosphorylation of unconventional myosin MYO9A (PubMed:27169898).

May also play a role in apical protein transport by mediating phosphorylation of unconventional myosin MYO1A (PubMed:15883161).

May play a role in ciliogenesis (PubMed:30967659).

6 Publications

Caution

D-glycero-beta-D-manno-heptose 1,7-bisphosphate (HBP) was initially thought to constitute the bacterial pathogen-associated molecular pattern metabolite (PAMP) triggering the ALPK1-TIFA innate immunune response (PubMed:28877472, PubMed:28222186). It was however shown that ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose) constitutes the main PAMP that activates the kinase activity of ALPK1 (PubMed:30111836).3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Serine/threonine-protein kinase activity is stimulated upon ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose)-binding.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei61ADP-D-glycero-beta-D-manno-heptose1 Publication1
Binding sitei67ADP-D-glycero-beta-D-manno-heptose1 Publication1
Binding sitei116ADP-D-glycero-beta-D-manno-heptose1 Publication1
Binding sitei231ADP-D-glycero-beta-D-manno-heptose1 Publication1
Binding sitei233ADP-D-glycero-beta-D-manno-heptose1 Publication1
Binding sitei295ADP-D-glycero-beta-D-manno-heptose1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processCilium biogenesis/degradation, Immunity, Innate immunity

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96QP1

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-9645460, Alpha-protein kinase 1 signaling pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha-protein kinase 11 Publication (EC:2.7.11.12 Publications)
Alternative name(s):
Chromosome 4 kinase1 Publication
Lymphocyte alpha-protein kinaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ALPK11 PublicationImported
Synonyms:KIAA15271 Publication, LAKImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:20917, ALPK1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607347, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96QP1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000073331

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Retinal dystrophy, optic nerve edema, splenomegaly, anhidrosis, and migraine headache syndrome (ROSAH)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant disorder characterized by decreased vision associated with optic nerve edema, evident in childhood. Low-grade ocular inflammation is common in affected individuals. Later in childhood or the second decade of life, patients have increasing visual impairment, abnormal cone function and loss of rod function. By the third decade of life, visual acuity ranges from counting fingers to no light perception. Patients also show anhidrosis, splenomegaly, mild pancytopenia, and most experience headaches that may be migraine-like in nature.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_084993237T → M in ROSAH. 2 Publications1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi67Q → A: Impaired ADP-D-glycero-beta-D-manno-heptose-binding and ability to activate the serine/threonine-protein kinase activity; when associated with A-231. 1 Publication1
Mutagenesisi116R → A: Impaired ADP-D-glycero-beta-D-manno-heptose-binding and ability to activate the serine/threonine-protein kinase activity. 1 Publication1
Mutagenesisi150R → A: Impaired ADP-D-glycero-beta-D-manno-heptose-binding and ability to activate the serine/threonine-protein kinase activity. 1 Publication1
Mutagenesisi153R → A: Impaired ADP-D-glycero-beta-D-manno-heptose-binding and ability to activate the serine/threonine-protein kinase activity. 1 Publication1
Mutagenesisi231D → A: Impaired ADP-D-glycero-beta-D-manno-heptose-binding and ability to activate the serine/threonine-protein kinase activity; when associated with A-67. 1 Publication1
Mutagenesisi233K → A: Impaired ADP-D-glycero-beta-D-manno-heptose-binding and ability to activate the serine/threonine-protein kinase activity. 1 Publication1
Mutagenesisi237T → E: Impaired ADP-D-glycero-beta-D-manno-heptose-binding and ability to activate the serine/threonine-protein kinase activity; when associated with K-295. 1 Publication1
Mutagenesisi295F → K: Impaired ADP-D-glycero-beta-D-manno-heptose-binding and ability to activate the serine/threonine-protein kinase activity; when associated with E-237. 1 Publication1
Mutagenesisi1067K → M: Abolishes the serine/threonine-protein kinase and ability to initiate the innate immune response. 1 Publication1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		80216
MIMi614979, phenotype

Open Targets

More...OpenTargetsi		ENSG00000073331

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134891785

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96QP1, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ALPK1

Domain mapping of disease mutations (DMDM)

More...DMDMi		308153632

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002600281 – 1244Alpha-protein kinase 1Add BLAST1244

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96QP1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96QP1

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96QP1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96QP1

PeptideAtlas

More...PeptideAtlasi		Q96QP1

PRoteomics IDEntifications database

More...PRIDEi		Q96QP1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		25531
77886 [Q96QP1-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96QP1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96QP1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in liver. Expressed in the optic nerve and retinal pigmented epithelium. Lower expression is observed in the macula and extramacular retina (PubMed:30967659).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000073331, Expressed in amniotic fluid and 217 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96QP1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96QP1, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000073331, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		123183, 6 interactors

Protein interaction database and analysis system

More...IntActi		Q96QP1, 3 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000398048

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96QP1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11244
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96QP1

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1017 – 1237Alpha-type protein kinasePROSITE-ProRule annotationAdd BLAST221

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni150 – 153ADP-D-glycero-beta-D-manno-heptose binding1 Publication4
Regioni236 – 237ADP-D-glycero-beta-D-manno-heptose binding1 Publication2
Regioni650 – 675DisorderedSequence analysisAdd BLAST26
Regioni701 – 737DisorderedSequence analysisAdd BLAST37
Regioni757 – 798DisorderedSequence analysisAdd BLAST42
Regioni824 – 848DisorderedSequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi703 – 733Polar residuesSequence analysisAdd BLAST31

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QX1X, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159753

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_007421_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96QP1

Identification of Orthologs from Complete Genome Data

More...OMAi		WHHFIDV

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96QP1

TreeFam database of animal gene trees

More...TreeFami		TF316085

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR043529, ALPK1
IPR011009, Kinase-like_dom_sf
IPR004166, MHCK_EF2_kinase

The PANTHER Classification System

More...PANTHERi		PTHR46747, PTHR46747, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02816, Alpha_kinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00811, Alpha_kinase, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51158, ALPHA_KINASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96QP1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNNQKVVAVL LQECKQVLDQ LLLEAPDVSE EDKSEDQRCR ALLPSELRTL 
        60         70         80         90        100
IQEAKEMKWP FVPEKWQYKQ AVGPEDKTNL KDVIGAGLQQ LLASLRASIL 
       110        120        130        140        150
ARDCAAAAAI VFLVDRFLYG LDVSGKLLQV AKGLHKLQPA TPIAPQVVIR 
       160        170        180        190        200
QARISVNSGK LLKAEYILSS LISNNGATGT WLYRNESDKV LVQSVCIQIR 
       210        220        230        240        250
GQILQKLGMW YEAAELIWAS IVGYLALPQP DKKGLSTSLG ILADIFVSMS 
       260        270        280        290        300
KNDYEKFKNN PQINLSLLKE FDHHLLSAAE ACKLAAAFSA YTPLFVLTAV 
       310        320        330        340        350
NIRGTCLLSY SSSNDCPPEL KNLHLCEAKE AFEIGLLTKR DDEPVTGKQE 
       360        370        380        390        400
LHSFVKAAFG LTTVHRRLHG ETGTVHAASQ LCKEAMGKLY NFSTSSRSQD 
       410        420        430        440        450
REALSQEVMS VIAQVKEHLQ VQSFSNVDDR SYVPESFECR LDKLILHGQG 
       460        470        480        490        500
DFQKILDTYS QHHTSVCEVF ESDCGNNKNE QKDAKTGVCI TALKTEIKNI 
       510        520        530        540        550
DTVSTTQEKP HCQRDTGISS SLMGKNVQRE LRRGGRRNWT HSDAFRVSLD 
       560        570        580        590        600
QDVETETEPS DYSNGEGAVF NKSLSGSQTS SAWSNLSGFS SSASWEEVNY 
       610        620        630        640        650
HVDDRSARKE PGKEHLVDTQ CSTALSEELE NDREGRAMHS LHSQLHDLSL 
       660        670        680        690        700
QEPNNDNLEP SQNQPQQQMP LTPFSPHNTP GIFLAPGAGL LEGAPEGIQE 
       710        720        730        740        750
VRNMGPRNTS AHSRPSYRSA SWSSDSGRPK NMGTHPSVQK EEAFEIIVEF 
       760        770        780        790        800
PETNCDVKDR QGKEQGEEIS ERGAGPTFKA SPSWVDPEGE TAESTEDAPL 
       810        820        830        840        850
DFHRVLHNSL GNISMLPCSS FTPNWPVQNP DSRKSGGPVA EQGIDPDAST 
       860        870        880        890        900
VDEEGQLLDS MDVPCTNGHG SHRLCILRQP PGQRAETPNS SVSGNILFPV 
       910        920        930        940        950
LSEDCTTTEE GNQPGNMLNC SQNSSSSSVW WLKSPAFSSG SSEGDSPWSY 
       960        970        980        990       1000
LNSSGSSWVS LPGKMRKEIL EARTLQPDDF EKLLAGVRHD WLFQRLENTG 
      1010       1020       1030       1040       1050
VFKPSQLHRA HSALLLKYSK KSELWTAQET IVYLGDYLTV KKKGRQRNAF 
      1060       1070       1080       1090       1100
WVHHLHQEEI LGRYVGKDYK EQKGLWHHFT DVERQMTAQH YVTEFNKRLY 
      1110       1120       1130       1140       1150
EQNIPTQIFY IPSTILLILE DKTIKGCISV EPYILGEFVK LSNNTKVVKT 
      1160       1170       1180       1190       1200
EYKATEYGLA YGHFSYEFSN HRDVVVDLQG WVTGNGKGLI YLTDPQIHSV 
      1210       1220       1230       1240 
DQKVFTTNFG KRGIFYFFNN QHVECNEICH RLSLTRPSME KPCT
Length:1,244
Mass (Da):138,861
Last modified:October 5, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i857D353D159A1630
GO
Isoform 2 (identifier: Q96QP1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-92: MNNQKVVAVL...VIGAGLQQLL → MCRKRTRARTSAAE

Show »
Length:1,166
Mass (Da):129,951
Checksum:i1996AB197A4DDEEC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4E0R2B4E0R2_HUMAN
Alpha-protein kinase 1
ALPK1
168Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B3KUH8B3KUH8_HUMAN
Alpha-protein kinase 1
ALPK1
304Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RB29D6RB29_HUMAN
Alpha-protein kinase 1
ALPK1
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RDN6D6RDN6_HUMAN
Alpha-protein kinase 1
ALPK1
109Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC85140 differs from that shown. Intron retention.Curated
The sequence BAC85140 differs from that shown. Reason: Frameshift.Curated
The sequence BAC85140 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BC060780 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti83V → L in BAC85140 (Ref. 5) Curated1
Sequence conflicti577S → G in BAG65473 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04151167Q → R1 PublicationCorresponds to variant dbSNP:rs33943680EnsemblClinVar.1
Natural variantiVAR_028982175N → D1 PublicationCorresponds to variant dbSNP:rs6533616Ensembl.1
Natural variantiVAR_084993237T → M in ROSAH. 2 Publications1
Natural variantiVAR_041512292T → M1 PublicationCorresponds to variant dbSNP:rs34120296Ensembl.1
Natural variantiVAR_041513320L → M1 PublicationCorresponds to variant dbSNP:rs757602009Ensembl.1
Natural variantiVAR_041514339K → E in an ovarian mucinous carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041515383K → E1 PublicationCorresponds to variant dbSNP:rs147641444Ensembl.1
Natural variantiVAR_028983565G → D5 PublicationsCorresponds to variant dbSNP:rs2074388Ensembl.1
Natural variantiVAR_028984642H → R5 PublicationsCorresponds to variant dbSNP:rs13148353Ensembl.1
Natural variantiVAR_041516660P → L1 PublicationCorresponds to variant dbSNP:rs35389530Ensembl.1
Natural variantiVAR_041517681G → D2 PublicationsCorresponds to variant dbSNP:rs35519493Ensembl.1
Natural variantiVAR_028985732M → I5 PublicationsCorresponds to variant dbSNP:rs2074379Ensembl.1
Natural variantiVAR_028986861M → T5 PublicationsCorresponds to variant dbSNP:rs11726117Ensembl.1
Natural variantiVAR_028987870G → S1 PublicationCorresponds to variant dbSNP:rs2074380Ensembl.1
Natural variantiVAR_041518873R → I1 PublicationCorresponds to variant dbSNP:rs34946272EnsemblClinVar.1
Natural variantiVAR_041519910E → D1 PublicationCorresponds to variant dbSNP:rs35308602Ensembl.1
Natural variantiVAR_028988916N → D1 PublicationCorresponds to variant dbSNP:rs2074381Ensembl.1
Natural variantiVAR_041520935P → L1 PublicationCorresponds to variant dbSNP:rs34780600Ensembl.1
Natural variantiVAR_0577411008H → P. Corresponds to variant dbSNP:rs34079946Ensembl.1
Natural variantiVAR_0415211084R → Q1 PublicationCorresponds to variant dbSNP:rs34677416Ensembl.1
Natural variantiVAR_0415221117L → P1 PublicationCorresponds to variant dbSNP:rs35756863EnsemblClinVar.1
Natural variantiVAR_0415231160A → G1 PublicationCorresponds to variant dbSNP:rs55696324Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0447351 – 92MNNQK…LQQLL → MCRKRTRARTSAAE in isoform 2. 1 PublicationAdd BLAST92

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY044164 mRNA Translation: AAK94675.1
AK304708 mRNA Translation: BAG65473.1
AC004049 Genomic DNA No translation available.
AC109347 Genomic DNA No translation available.
BC060780 mRNA No translation available.
AK131090 mRNA Translation: BAC85140.1 Sequence problems.
AB040960 mRNA Translation: BAA96051.1
AB075877 mRNA Translation: BAD38659.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3697.1 [Q96QP1-1]
CCDS58923.1 [Q96QP1-2]

NCBI Reference Sequences

More...RefSeqi		NP_001095876.1, NM_001102406.1 [Q96QP1-1]
NP_001240813.1, NM_001253884.1 [Q96QP1-2]
NP_079420.3, NM_025144.3 [Q96QP1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000177648; ENSP00000177648; ENSG00000073331 [Q96QP1-1]
ENST00000458497; ENSP00000398048; ENSG00000073331 [Q96QP1-1]
ENST00000504176; ENSP00000426044; ENSG00000073331 [Q96QP1-2]
ENST00000650871; ENSP00000498374; ENSG00000073331 [Q96QP1-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		80216

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:80216

UCSC genome browser

More...UCSCi		uc003ian.5, human [Q96QP1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY044164 mRNA Translation: AAK94675.1
AK304708 mRNA Translation: BAG65473.1
AC004049 Genomic DNA No translation available.
AC109347 Genomic DNA No translation available.
BC060780 mRNA No translation available.
AK131090 mRNA Translation: BAC85140.1 Sequence problems.
AB040960 mRNA Translation: BAA96051.1
AB075877 mRNA Translation: BAD38659.1
CCDSiCCDS3697.1 [Q96QP1-1]
CCDS58923.1 [Q96QP1-2]
RefSeqiNP_001095876.1, NM_001102406.1 [Q96QP1-1]
NP_001240813.1, NM_001253884.1 [Q96QP1-2]
NP_079420.3, NM_025144.3 [Q96QP1-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5Z2CX-ray2.59A/B/C/D/E/F/G/H/I1-446[»]
SMRiQ96QP1
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi123183, 6 interactors
IntActiQ96QP1, 3 interactors
STRINGi9606.ENSP00000398048

PTM databases

iPTMnetiQ96QP1
PhosphoSitePlusiQ96QP1

Genetic variation databases

BioMutaiALPK1
DMDMi308153632

Proteomic databases

EPDiQ96QP1
MassIVEiQ96QP1
MaxQBiQ96QP1
PaxDbiQ96QP1
PeptideAtlasiQ96QP1
PRIDEiQ96QP1
ProteomicsDBi25531
77886 [Q96QP1-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		26436, 97 antibodies

The DNASU plasmid repository

More...DNASUi		80216

Genome annotation databases

EnsembliENST00000177648; ENSP00000177648; ENSG00000073331 [Q96QP1-1]
ENST00000458497; ENSP00000398048; ENSG00000073331 [Q96QP1-1]
ENST00000504176; ENSP00000426044; ENSG00000073331 [Q96QP1-2]
ENST00000650871; ENSP00000498374; ENSG00000073331 [Q96QP1-1]
GeneIDi80216
KEGGihsa:80216
UCSCiuc003ian.5, human [Q96QP1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		80216
DisGeNETi80216

GeneCards: human genes, protein and diseases

More...GeneCardsi		ALPK1
HGNCiHGNC:20917, ALPK1
HPAiENSG00000073331, Low tissue specificity
MIMi607347, gene
614979, phenotype
neXtProtiNX_Q96QP1
OpenTargetsiENSG00000073331
PharmGKBiPA134891785
VEuPathDBiHostDB:ENSG00000073331

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QX1X, Eukaryota
GeneTreeiENSGT00940000159753
HOGENOMiCLU_007421_0_0_1
InParanoidiQ96QP1
OMAiWHHFIDV
PhylomeDBiQ96QP1
TreeFamiTF316085

Enzyme and pathway databases

PathwayCommonsiQ96QP1
ReactomeiR-HSA-9645460, Alpha-protein kinase 1 signaling pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		80216, 3 hits in 1012 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ALPK1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ALPK1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		80216
PharosiQ96QP1, Tbio

Protein Ontology

More...PROi		PR:Q96QP1
RNActiQ96QP1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000073331, Expressed in amniotic fluid and 217 other tissues
ExpressionAtlasiQ96QP1, baseline and differential
GenevisibleiQ96QP1, HS

Family and domain databases

InterProiView protein in InterPro
IPR043529, ALPK1
IPR011009, Kinase-like_dom_sf
IPR004166, MHCK_EF2_kinase
PANTHERiPTHR46747, PTHR46747, 1 hit
PfamiView protein in Pfam
PF02816, Alpha_kinase, 1 hit
SMARTiView protein in SMART
SM00811, Alpha_kinase, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51158, ALPHA_KINASE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiALPK1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96QP1
Secondary accession number(s): B4E3G1
, F5H138, Q68CI9, Q6P9F9, Q6ZNK4, Q9P201
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 5, 2010
Last modified: September 29, 2021
This is version 149 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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