UniProtKB - Q96QK1 (VPS35_HUMAN)
Vacuolar protein sorting-associated protein 35
VPS35
Functioni
Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35; however, these interactions seem to be of low affinity and retromer SNX proteins may also contribute to cargo selectivity thus questioning the classical function of the CSC. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway (PubMed:30213940).
The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R and SLC11A2. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (PubMed:15078903, PubMed:15247922, PubMed:20164305).
Required for endosomal localization of WASHC2C (PubMed:22070227, PubMed:28892079).
Mediates the association of the CSC with the WASH complex via WASHC2 (PubMed:22070227, PubMed:24980502, PubMed:24819384).
Required for the endosomal localization of TBC1D5 (PubMed:20923837).
4 Publications10 Publications(Microbial infection) The heterotrimeric retromer cargo-selective complex (CSC) mediates the exit of human papillomavirus from the early endosome and the delivery to the Golgi apparatus.
2 PublicationsGO - Molecular functioni
- D1 dopamine receptor binding Source: ParkinsonsUK-UCL
GO - Biological processi
- endocytic recycling Source: UniProtKB
- intracellular protein transport Source: GO_Central
- lysosome organization Source: Ensembl
- mitochondrial fragmentation involved in apoptotic process Source: ParkinsonsUK-UCL
- mitochondrion to lysosome transport Source: ParkinsonsUK-UCL
- negative regulation of cell death Source: ParkinsonsUK-UCL
- negative regulation of gene expression Source: Ensembl
- negative regulation of inflammatory response Source: ParkinsonsUK-UCL
- negative regulation of late endosome to lysosome transport Source: UniProtKB
- negative regulation of lysosomal protein catabolic process Source: Ensembl
- negative regulation of neuron death Source: ParkinsonsUK-UCL
- negative regulation of protein homooligomerization Source: Ensembl
- negative regulation of protein localization Source: Ensembl
- neurotransmitter receptor transport, endosome to plasma membrane Source: ParkinsonsUK-UCL
- neurotransmitter receptor transport, endosome to postsynaptic membrane Source: Ensembl
- positive regulation of canonical Wnt signaling pathway Source: Ensembl
- positive regulation of cellular protein catabolic process Source: ParkinsonsUK-UCL
- positive regulation of dopamine biosynthetic process Source: Ensembl
- positive regulation of dopamine receptor signaling pathway Source: ParkinsonsUK-UCL
- positive regulation of gene expression Source: ParkinsonsUK-UCL
- positive regulation of locomotion involved in locomotory behavior Source: Ensembl
- positive regulation of mitochondrial fission Source: ParkinsonsUK-UCL
- positive regulation of Wnt protein secretion Source: Ensembl
- protein destabilization Source: Ensembl
- protein localization to endosome Source: UniProtKB
- regulation of cellular protein metabolic process Source: ParkinsonsUK-UCL
- regulation of dendritic spine maintenance Source: ParkinsonsUK-UCL
- regulation of macroautophagy Source: ParkinsonsUK-UCL
- regulation of mitochondrion organization Source: ParkinsonsUK-UCL
- regulation of presynapse assembly Source: ParkinsonsUK-UCL
- regulation of protein stability Source: ParkinsonsUK-UCL
- regulation of terminal button organization Source: ParkinsonsUK-UCL
- retrograde transport, endosome to Golgi Source: UniProtKB
- synapse assembly Source: Ensembl
- transcytosis Source: UniProtKB
- vesicle-mediated transport in synapse Source: Ensembl
- voluntary musculoskeletal movement Source: Ensembl
- Wnt signaling pathway Source: ParkinsonsUK-UCL
Keywordsi
Biological process | Host-virus interaction, Protein transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q96QK1 |
Reactomei | R-HSA-3238698, WNT ligand biogenesis and trafficking |
SignaLinki | Q96QK1 |
SIGNORi | Q96QK1 |
Protein family/group databases
TCDBi | 9.A.3.1.1, the sorting nexin27 (snx27)-retromer assembly apparatus (retromeraa) family |
Names & Taxonomyi
Protein namesi | Recommended name: Vacuolar protein sorting-associated protein 35Short name: hVPS35 Alternative name(s): Maternal-embryonic 3 Vesicle protein sorting 35 |
Gene namesi | ORF Names:TCCCTA00141 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13487, VPS35 |
MIMi | 601501, gene |
neXtProti | NX_Q96QK1 |
VEuPathDBi | HostDB:ENSG00000069329 |
Subcellular locationi
Endosome
- Endosome 2 Publications
- Early endosome Curated
- Late endosome Curated
Cytoplasm and Cytosol
Other locations
Note: Localizes to tubular profiles adjacent to endosomes.1 Publication
Cytosol
- cytosol Source: UniProtKB
Endosome
- early endosome Source: UniProtKB
- endosome Source: UniProtKB
- endosome membrane Source: ParkinsonsUK-UCL
- late endosome Source: GO_Central
- tubular endosome Source: UniProtKB
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Lysosome
- lysosomal membrane Source: UniProtKB
- lysosome Source: HPA
Other locations
- glutamatergic synapse Source: Ensembl
- mitochondrion-derived vesicle Source: ParkinsonsUK-UCL
- neuron projection Source: Ensembl
- neuronal cell body Source: Ensembl
- perinuclear region of cytoplasm Source: Ensembl
- postsynaptic density Source: Ensembl
- presynapse Source: Ensembl
- retromer complex Source: UniProtKB
- retromer, cargo-selective complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Endosome, MembranePathology & Biotechi
Involvement in diseasei
Parkinson disease 17 (PARK17)6 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_066659 | 620 | D → N in PARK17; decreases interaction with WASHC2C, FKBP15 and the WASH complex; impairs recruitment of the WASH complex to endosomes; shows reduced retrograde transport of selective cargo between lysosomes and the Golgi apparatus; shows a progressive reduction in neurite length and branching. 6 PublicationsCorresponds to variant dbSNP:rs188286943EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 108 | L → P: Disrupts interaction with VPS26; no effect on interaction with VPS29. 1 Publication | 1 | |
Mutagenesisi | 675 | H → R: Disrupts interaction with VPS29. Does not effect interaction with VPS26. 1 Publication | 1 |
Keywords - Diseasei
Neurodegeneration, Parkinson disease, ParkinsonismOrganism-specific databases
DisGeNETi | 55737 |
GeneReviewsi | VPS35 |
MalaCardsi | VPS35 |
MIMi | 614203, phenotype |
OpenTargetsi | ENSG00000069329 |
Orphaneti | 411602, Hereditary late-onset Parkinson disease |
PharmGKBi | PA37783 |
Miscellaneous databases
Pharosi | Q96QK1, Tbio |
Chemistry databases
ChEMBLi | CHEMBL2216744 |
Genetic variation databases
BioMutai | VPS35 |
DMDMi | 25453321 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000065896 | 1 – 796 | Vacuolar protein sorting-associated protein 35Add BLAST | 796 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 7 | PhosphoserineCombined sources | 1 | |
Modified residuei | 783 | PhosphoserineBy similarity | 1 | |
Modified residuei | 791 | PhosphotyrosineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
CPTACi | CPTAC-605 |
EPDi | Q96QK1 |
jPOSTi | Q96QK1 |
MassIVEi | Q96QK1 |
MaxQBi | Q96QK1 |
PaxDbi | Q96QK1 |
PeptideAtlasi | Q96QK1 |
PRIDEi | Q96QK1 |
ProteomicsDBi | 77884 |
PTM databases
GlyGeni | Q96QK1, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q96QK1 |
PhosphoSitePlusi | Q96QK1 |
SwissPalmi | Q96QK1 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000069329, Expressed in intestine and 125 other tissues |
ExpressionAtlasi | Q96QK1, baseline and differential |
Genevisiblei | Q96QK1, HS |
Organism-specific databases
HPAi | ENSG00000069329, Low tissue specificity |
Interactioni
Subunit structurei
Component of the heterotrimeric retromer cargo-selective complex (CSC), also decribed as vacuolar protein sorting subcomplex (VPS), formed by VPS26 (VPS26A or VPS26B), VPS29 and VPS35 (PubMed:11102511, PubMed:28892079). The CSC has a highly elongated structure with VPS26 and VPS29 binding independently at opposite distal ends of VPS35 as central platform (By similarity). The CSC is believed to associate with variable sorting nexins to form functionally distinct retromer complex variants. The originally described retromer complex (also called SNX-BAR retromer) is a pentamer containing the CSC and a heterodimeric membrane-deforming subcomplex formed between SNX1 or SNX2 and SNX5 or SNX6 (also called SNX-BAR subcomplex); the respective CSC and SNX-BAR subcomplexes associate with low affinity. The CSC associates with SNX3 to form a SNX3-retromer complex. The CSC associates with SNX27, the WASH complex and the SNX-BAR subcomplex to form the SNX27-retromer complex (Probable).
Interacts with VPS26A, VPS26B, VPS29, SNX1, SNX2, IGF2R, SNX3, GOLPH3, LRRK2, SLC11A2, WASHC2A, WASHC2C, FKBP15, WASHC1, RAB7A, SNX27, WASHC5, EHD1 (PubMed:11102511, PubMed:15078903, PubMed:17868075PubMed:22070227, PubMed:19553991, PubMed:21725319, PubMed:22070227, PubMed:22513087, PubMed:23331060, PubMed:23563491, PubMed:23395371, PubMed:24344282, PubMed:24980502, PubMed:17891154, PubMed:19531583, PubMed:30213940).
Interacts with MAGEL2; leading to recruitment of the TRIM27:MAGEL2 E3 ubiquitin ligase complex retromer-containing endosomes (PubMed:23452853).
Interacts with SORCS2 (By similarity).
2 PublicationsBy similarity15 Publications(Microbial infection) Interacts with human papillomavirus 16 minor capsid protein L2 (via C-terminus); this interaction mediates the transport of the capsid from the early endosome to the Golgi apparatus.
1 PublicationBinary interactionsi
Q96QK1
GO - Molecular functioni
- D1 dopamine receptor binding Source: ParkinsonsUK-UCL
Protein-protein interaction databases
BioGRIDi | 120855, 153 interactors |
CORUMi | Q96QK1 |
DIPi | DIP-29076N |
IntActi | Q96QK1, 48 interactors |
MINTi | Q96QK1 |
STRINGi | 9606.ENSP00000299138 |
Chemistry databases
BindingDBi | Q96QK1 |
Miscellaneous databases
RNActi | Q96QK1, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q96QK1 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q96QK1 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 25 – 44 | Interaction with SNX31 PublicationAdd BLAST | 20 | |
Regioni | 205 – 215 | Interaction with SNX31 PublicationAdd BLAST | 11 | |
Regioni | 438 – 796 | Interaction with SLC11A21 PublicationAdd BLAST | 359 | |
Regioni | 500 – 693 | Interaction with IGF2R cytoplasmic domain1 PublicationAdd BLAST | 194 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1107, Eukaryota |
GeneTreei | ENSGT00390000007315 |
HOGENOMi | CLU_005836_1_0_1 |
InParanoidi | Q96QK1 |
OMAi | HLWWATP |
OrthoDBi | 316875at2759 |
PhylomeDBi | Q96QK1 |
TreeFami | TF105659 |
Family and domain databases
Gene3Di | 1.25.40.660, 1 hit |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR005378, Vps35 IPR042491, Vps35_C |
PANTHERi | PTHR11099, PTHR11099, 1 hit |
Pfami | View protein in Pfam PF03635, Vps35, 1 hit |
PIRSFi | PIRSF009375, Retromer_Vps35, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MPTTQQSPQD EQEKLLDEAI QAVKVQSFQM KRCLDKNKLM DALKHASNML
60 70 80 90 100
GELRTSMLSP KSYYELYMAI SDELHYLEVY LTDEFAKGRK VADLYELVQY
110 120 130 140 150
AGNIIPRLYL LITVGVVYVK SFPQSRKDIL KDLVEMCRGV QHPLRGLFLR
160 170 180 190 200
NYLLQCTRNI LPDEGEPTDE ETTGDISDSM DFVLLNFAEM NKLWVRMQHQ
210 220 230 240 250
GHSRDREKRE RERQELRILV GTNLVRLSQL EGVNVERYKQ IVLTGILEQV
260 270 280 290 300
VNCRDALAQE YLMECIIQVF PDEFHLQTLN PFLRACAELH QNVNVKNIII
310 320 330 340 350
ALIDRLALFA HREDGPGIPA DIKLFDIFSQ QVATVIQSRQ DMPSEDVVSL
360 370 380 390 400
QVSLINLAMK CYPDRVDYVD KVLETTVEIF NKLNLEHIAT SSAVSKELTR
410 420 430 440 450
LLKIPVDTYN NILTVLKLKH FHPLFEYFDY ESRKSMSCYV LSNVLDYNTE
460 470 480 490 500
IVSQDQVDSI MNLVSTLIQD QPDQPVEDPD PEDFADEQSL VGRFIHLLRS
510 520 530 540 550
EDPDQQYLIL NTARKHFGAG GNQRIRFTLP PLVFAAYQLA FRYKENSKVD
560 570 580 590 600
DKWEKKCQKI FSFAHQTISA LIKAELAELP LRLFLQGALA AGEIGFENHE
610 620 630 640 650
TVAYEFMSQA FSLYEDEISD SKAQLAAITL IIGTFERMKC FSEENHEPLR
660 670 680 690 700
TQCALAASKL LKKPDQGRAV STCAHLFWSG RNTDKNGEEL HGGKRVMECL
710 720 730 740 750
KKALKIANQC MDPSLQVQLF IEILNRYIYF YEKENDAVTI QVLNQLIQKI
760 770 780 790
REDLPNLESS EETEQINKHF HNTLEHLRLR RESPESEGPI YEGLIL
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BRJ7 | H3BRJ7_HUMAN | Vacuolar protein sorting-associated... | VPS35 | 48 | Annotation score: | ||
I3L4S0 | I3L4S0_HUMAN | Vacuolar protein sorting-associated... | VPS35 | 41 | Annotation score: | ||
A0A1W2PP10 | A0A1W2PP10_HUMAN | Vacuolar protein sorting-associated... | VPS35 | 46 | Annotation score: | ||
A0A3B3ITD4 | A0A3B3ITD4_HUMAN | Vacuolar protein sorting-associated... | VPS35 | 47 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 42 | A → S in CAB66822 (PubMed:11230166).Curated | 1 | |
Sequence conflicti | 160 | I → T in BAB14626 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 168 | T → P in AAF89953 (PubMed:11102511).Curated | 1 | |
Sequence conflicti | 453 | S → F in AAH10362 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 526 | R → G in BAA91790 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 694 | K → E in BAA91790 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 796 | L → H in BAA91137 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_066653 | 51 | G → S1 PublicationCorresponds to variant dbSNP:rs193077277EnsemblClinVar. | 1 | |
Natural variantiVAR_066654 | 57 | M → I1 PublicationCorresponds to variant dbSNP:rs183554824EnsemblClinVar. | 1 | |
Natural variantiVAR_066655 | 82 | T → R1 PublicationCorresponds to variant dbSNP:rs188245364Ensembl. | 1 | |
Natural variantiVAR_066656 | 241 | I → M Found in a patient with Parkinson disease. 1 PublicationCorresponds to variant dbSNP:rs192783364EnsemblClinVar. | 1 | |
Natural variantiVAR_066657 | 316 | P → S Found in a patient with Parkinson disease. 1 PublicationCorresponds to variant dbSNP:rs770029606EnsemblClinVar. | 1 | |
Natural variantiVAR_080769 | 469 | Q → P Found in a consanguineous family with intellectual disability; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_066658 | 524 | R → W Found in a patient with Parkinson disease. 1 PublicationCorresponds to variant dbSNP:rs184277092EnsemblClinVar. | 1 | |
Natural variantiVAR_054046 | 602 | V → D. Corresponds to variant dbSNP:rs34687100Ensembl. | 1 | |
Natural variantiVAR_066659 | 620 | D → N in PARK17; decreases interaction with WASHC2C, FKBP15 and the WASH complex; impairs recruitment of the WASH complex to endosomes; shows reduced retrograde transport of selective cargo between lysosomes and the Golgi apparatus; shows a progressive reduction in neurite length and branching. 6 PublicationsCorresponds to variant dbSNP:rs188286943EnsemblClinVar. | 1 | |
Natural variantiVAR_066660 | 737 | A → V1 PublicationCorresponds to variant dbSNP:rs749516404EnsemblClinVar. | 1 | |
Natural variantiVAR_066661 | 774 | L → M1 PublicationCorresponds to variant dbSNP:rs192419029EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF191298 mRNA Translation: AAF02778.2 AF186382 mRNA Translation: AAG40619.1 AF175265 mRNA Translation: AAF89953.1 AF183418 mRNA Translation: AAG09687.1 AK001614 mRNA Translation: BAA91790.1 AK023650 mRNA Translation: BAB14626.1 Different initiation. AK000395 mRNA Translation: BAA91137.1 Different initiation. AL136888 mRNA Translation: CAB66822.1 AL512769 mRNA Translation: CAC21686.1 BC002414 mRNA Translation: AAH02414.1 BC010362 mRNA Translation: AAH10362.1 BC093036 mRNA Translation: AAH93036.1 AY007112 mRNA Translation: AAG01989.1 Different initiation. |
CCDSi | CCDS10721.1 |
PIRi | JC7516 |
RefSeqi | NP_060676.2, NM_018206.5 |
Genome annotation databases
Ensembli | ENST00000299138; ENSP00000299138; ENSG00000069329 |
GeneIDi | 55737 |
KEGGi | hsa:55737 |
MANE-Selecti | ENST00000299138.12; ENSP00000299138.7; NM_018206.6; NP_060676.2 |
UCSCi | uc002eef.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF191298 mRNA Translation: AAF02778.2 AF186382 mRNA Translation: AAG40619.1 AF175265 mRNA Translation: AAF89953.1 AF183418 mRNA Translation: AAG09687.1 AK001614 mRNA Translation: BAA91790.1 AK023650 mRNA Translation: BAB14626.1 Different initiation. AK000395 mRNA Translation: BAA91137.1 Different initiation. AL136888 mRNA Translation: CAB66822.1 AL512769 mRNA Translation: CAC21686.1 BC002414 mRNA Translation: AAH02414.1 BC010362 mRNA Translation: AAH10362.1 BC093036 mRNA Translation: AAH93036.1 AY007112 mRNA Translation: AAG01989.1 Different initiation. |
CCDSi | CCDS10721.1 |
PIRi | JC7516 |
RefSeqi | NP_060676.2, NM_018206.5 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2R17 | X-ray | 2.80 | C/D | 483-780 | [»] | |
5F0J | X-ray | 2.70 | A | 14-470 | [»] | |
5F0K | X-ray | 3.07 | A/B/C/D/E | 14-470 | [»] | |
5F0L | X-ray | 3.20 | A | 14-470 | [»] | |
5F0M | X-ray | 3.10 | A | 14-470 | [»] | |
5F0P | X-ray | 2.78 | A | 14-470 | [»] | |
5OSH | X-ray | 4.30 | B/E/H/K | 482-780 | [»] | |
5OSI | X-ray | 2.52 | B/E/H/K | 471-781 | [»] | |
7BLN | electron microscopy | 8.90 | A/C | 1-796 | [»] | |
7BLO | electron microscopy | 9.50 | A/C | 12-363 | [»] | |
SMRi | Q96QK1 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 120855, 153 interactors |
CORUMi | Q96QK1 |
DIPi | DIP-29076N |
IntActi | Q96QK1, 48 interactors |
MINTi | Q96QK1 |
STRINGi | 9606.ENSP00000299138 |
Chemistry databases
BindingDBi | Q96QK1 |
ChEMBLi | CHEMBL2216744 |
Protein family/group databases
TCDBi | 9.A.3.1.1, the sorting nexin27 (snx27)-retromer assembly apparatus (retromeraa) family |
PTM databases
GlyGeni | Q96QK1, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q96QK1 |
PhosphoSitePlusi | Q96QK1 |
SwissPalmi | Q96QK1 |
Genetic variation databases
BioMutai | VPS35 |
DMDMi | 25453321 |
Proteomic databases
CPTACi | CPTAC-605 |
EPDi | Q96QK1 |
jPOSTi | Q96QK1 |
MassIVEi | Q96QK1 |
MaxQBi | Q96QK1 |
PaxDbi | Q96QK1 |
PeptideAtlasi | Q96QK1 |
PRIDEi | Q96QK1 |
ProteomicsDBi | 77884 |
Protocols and materials databases
Antibodypediai | 28023, 253 antibodies from 41 providers |
DNASUi | 55737 |
Genome annotation databases
Ensembli | ENST00000299138; ENSP00000299138; ENSG00000069329 |
GeneIDi | 55737 |
KEGGi | hsa:55737 |
MANE-Selecti | ENST00000299138.12; ENSP00000299138.7; NM_018206.6; NP_060676.2 |
UCSCi | uc002eef.5, human |
Organism-specific databases
CTDi | 55737 |
DisGeNETi | 55737 |
GeneCardsi | VPS35 |
GeneReviewsi | VPS35 |
HGNCi | HGNC:13487, VPS35 |
HPAi | ENSG00000069329, Low tissue specificity |
MalaCardsi | VPS35 |
MIMi | 601501, gene 614203, phenotype |
neXtProti | NX_Q96QK1 |
OpenTargetsi | ENSG00000069329 |
Orphaneti | 411602, Hereditary late-onset Parkinson disease |
PharmGKBi | PA37783 |
VEuPathDBi | HostDB:ENSG00000069329 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1107, Eukaryota |
GeneTreei | ENSGT00390000007315 |
HOGENOMi | CLU_005836_1_0_1 |
InParanoidi | Q96QK1 |
OMAi | HLWWATP |
OrthoDBi | 316875at2759 |
PhylomeDBi | Q96QK1 |
TreeFami | TF105659 |
Enzyme and pathway databases
PathwayCommonsi | Q96QK1 |
Reactomei | R-HSA-3238698, WNT ligand biogenesis and trafficking |
SignaLinki | Q96QK1 |
SIGNORi | Q96QK1 |
Miscellaneous databases
BioGRID-ORCSi | 55737, 380 hits in 1061 CRISPR screens |
ChiTaRSi | VPS35, human |
EvolutionaryTracei | Q96QK1 |
GeneWikii | VPS35 |
GenomeRNAii | 55737 |
Pharosi | Q96QK1, Tbio |
PROi | PR:Q96QK1 |
RNActi | Q96QK1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000069329, Expressed in intestine and 125 other tissues |
ExpressionAtlasi | Q96QK1, baseline and differential |
Genevisiblei | Q96QK1, HS |
Family and domain databases
Gene3Di | 1.25.40.660, 1 hit |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR005378, Vps35 IPR042491, Vps35_C |
PANTHERi | PTHR11099, PTHR11099, 1 hit |
Pfami | View protein in Pfam PF03635, Vps35, 1 hit |
PIRSFi | PIRSF009375, Retromer_Vps35, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | VPS35_HUMAN | |
Accessioni | Q96QK1Primary (citable) accession number: Q96QK1 Secondary accession number(s): Q561W2 Q9NZK2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 25, 2002 |
Last sequence update: | November 25, 2002 | |
Last modified: | February 23, 2022 | |
This is version 198 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families