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Entry version 120 (02 Dec 2020)
Sequence version 1 (01 Dec 2001)
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Protein

Acidic repeat-containing protein

Gene

GCNA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q96QF7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Acidic repeat-containing protein1 Publication
Alternative name(s):
Germ cell nuclear antigen1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GCNAImported
Synonyms:ACRC1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...
EuPathDBi
HostDB:ENSG00000147174.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:15805, GCNA

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300369, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96QF7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
93953

Open Targets

More...
OpenTargetsi
ENSG00000147174

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24453

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96QF7, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GCNA

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74732669

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003173871 – 691Acidic repeat-containing proteinAdd BLAST691

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96QF7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96QF7

PeptideAtlas

More...
PeptideAtlasi
Q96QF7

PRoteomics IDEntifications database

More...
PRIDEi
Q96QF7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
77875

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96QF7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96QF7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in germ cells of the testis (at protein level) (PubMed:27718356). Detected in skeletal muscle, liver, kidney, pancreas, heart, lung and brain (PubMed:11714101).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000147174, Expressed in testis and 156 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96QF7, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000147174, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
125058, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q96QF7, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000362799

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96QF7, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini522 – 677SprT-likeAdd BLAST156

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi125 – 331Asp/Ser-richAdd BLAST207
Compositional biasi412 – 518Arg/Lys/Pro-richAdd BLAST107

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3854, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00440000040163

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_026277_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96QF7

Identification of Orthologs from Complete Genome Data

More...
OMAi
SEAPDNN

Database of Orthologous Groups

More...
OrthoDBi
1063317at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96QF7

TreeFam database of animal gene trees

More...
TreeFami
TF316140

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006640, SprT-like_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10263, SprT-like, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00731, SprT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q96QF7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDGCKKELPR LQEPEEDEDC YILNVQSSSD DTSGSSVARR APKRQASCIL
60 70 80 90 100
NVQSRSGDTS GSSVARRAPK RQASSVVVID SDSDEECHTH EEKKAKLLEI
110 120 130 140 150
NSDDESPECC HVKPAIQEPP IVISDDDNDD DNGNDLEVPD DNSDDSEAPD
160 170 180 190 200
DNSDDSEAPD DNSDDSEAPD DNSDDSEAPD DNSDDSDVPD DNSDDSSDDN
210 220 230 240 250
SDDSSDDNSD DSDVPDDKSD DSDVPDDSSD DSDVPDDSSD DSEAPDDSSD
260 270 280 290 300
DSEAPDDSSD DSEAPDDSSD DSEAPDDSSD DSEASDDSSD DSEASDDSSD
310 320 330 340 350
DSEAPDDKSD DSDVPEDKSD DSDVPDDNSD DLEVPVPAED LCNEGQIASD
360 370 380 390 400
EEELVEAAAA VSQHDSSDDA GEQDLGENLS KPPSDPEANP EVSERKLPTE
410 420 430 440 450
EEPAPVVEQS GKRKSKTKTI VEPPRKRQTK TKNIVEPPRK RQTKTKNIVE
460 470 480 490 500
PLRKRKAKTK NVSVTPGHKK RGPSKKKPGA AKVEKRKTRT PKCKVPGCFL
510 520 530 540 550
QDLEKSKKYS GKNLKRNKDE LVQRIYDLFN RSVCDKKLPE KLRIGWNNKM
560 570 580 590 600
VKTAGLCSTG EMWYPKWRRF AKIQIGLKVC DSADRIRDTL IHEMCHAASW
610 620 630 640 650
LIDGIHDSHG DAWKYYARKS NRIHPELPRV TRCHNYKINY KVHYECTGCK
660 670 680 690
TRIGCYTKSL DTSRFICAKC KGSLVMVPLT QKDGTRIVPH V
Length:691
Mass (Da):76,112
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF6B63CBF9A7CE1EA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050634471R → H. Corresponds to variant dbSNP:rs10217999Ensembl.1
Natural variantiVAR_038520662T → I. Corresponds to variant dbSNP:rs2280962Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ311392 mRNA Translation: CAC60255.1
AK097433 mRNA Translation: BAC05051.1
BC136259 mRNA Translation: AAI36260.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS35326.1

NCBI Reference Sequences

More...
RefSeqi
NP_443189.1, NM_052957.4
XP_006724779.1, XM_006724716.3
XP_011529366.1, XM_011531064.1
XP_016885454.1, XM_017029965.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000373695; ENSP00000362799; ENSG00000147174
ENST00000373696; ENSP00000362800; ENSG00000147174

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
93953

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:93953

UCSC genome browser

More...
UCSCi
uc004eae.3, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ311392 mRNA Translation: CAC60255.1
AK097433 mRNA Translation: BAC05051.1
BC136259 mRNA Translation: AAI36260.1
CCDSiCCDS35326.1
RefSeqiNP_443189.1, NM_052957.4
XP_006724779.1, XM_006724716.3
XP_011529366.1, XM_011531064.1
XP_016885454.1, XM_017029965.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi125058, 1 interactor
IntActiQ96QF7, 1 interactor
STRINGi9606.ENSP00000362799

PTM databases

iPTMnetiQ96QF7
PhosphoSitePlusiQ96QF7

Polymorphism and mutation databases

BioMutaiGCNA
DMDMi74732669

Proteomic databases

MassIVEiQ96QF7
PaxDbiQ96QF7
PeptideAtlasiQ96QF7
PRIDEiQ96QF7
ProteomicsDBi77875

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
13638, 90 antibodies

Genome annotation databases

EnsembliENST00000373695; ENSP00000362799; ENSG00000147174
ENST00000373696; ENSP00000362800; ENSG00000147174
GeneIDi93953
KEGGihsa:93953
UCSCiuc004eae.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
93953
DisGeNETi93953
EuPathDBiHostDB:ENSG00000147174.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GCNA
HGNCiHGNC:15805, GCNA
HPAiENSG00000147174, Tissue enriched (testis)
MIMi300369, gene
neXtProtiNX_Q96QF7
OpenTargetsiENSG00000147174
PharmGKBiPA24453

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3854, Eukaryota
GeneTreeiENSGT00440000040163
HOGENOMiCLU_026277_0_0_1
InParanoidiQ96QF7
OMAiSEAPDNN
OrthoDBi1063317at2759
PhylomeDBiQ96QF7
TreeFamiTF316140

Enzyme and pathway databases

PathwayCommonsiQ96QF7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
93953, 1 hit in 472 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ACRC, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Acidic_repeat-containing_protein

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
93953
PharosiQ96QF7, Tbio

Protein Ontology

More...
PROi
PR:Q96QF7
RNActiQ96QF7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000147174, Expressed in testis and 156 other tissues
GenevisibleiQ96QF7, HS

Family and domain databases

InterProiView protein in InterPro
IPR006640, SprT-like_domain
PfamiView protein in Pfam
PF10263, SprT-like, 1 hit
SMARTiView protein in SMART
SM00731, SprT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiACRC_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96QF7
Secondary accession number(s): B9EG62
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 1, 2001
Last modified: December 2, 2020
This is version 120 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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