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UniProtKB - Q96QF0 (RAB3I_HUMAN)

Entry version 168 (23 Feb 2022)
Sequence version 1 (01 Dec 2001)
Previous versions | rss
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Protein

Rab-3A-interacting protein

Gene

RAB3IP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B (PubMed:12221131, PubMed:26824392).

Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (PubMed:12221131, PubMed:26824392).

Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5 (PubMed:20937701, PubMed:26824392).

Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface (PubMed:12221131).

Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (PubMed:20890297).

4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor
Biological processProtein transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96QF0

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-5620912, Anchoring of the basal body to the plasma membrane
R-HSA-5620916, VxPx cargo-targeting to cilium
R-HSA-5620922, BBSome-mediated cargo-targeting to cilium
R-HSA-8876198, RAB GEFs exchange GTP for GDP on RABs

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q96QF0

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q96QF0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rab-3A-interacting protein
Short name:
Rab3A-interacting protein
Alternative name(s):
Rabin-3
SSX2-interacting protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RAB3IPImported
Synonyms:RABIN8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:16508, RAB3IP

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		608686, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96QF0

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000127328

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		117177

Open Targets

More...OpenTargetsi		ENSG00000127328

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA34136

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96QF0, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RAB3IP

Domain mapping of disease mutations (DMDM)

More...DMDMi		71152025

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000971441 – 476Rab-3A-interacting proteinAdd BLAST476

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei163PhosphoserineCombined sources1
Modified residuei263PhosphoserineBy similarity1
Modified residuei266PhosphoserineCombined sources1
Modified residuei288PhosphoserineCombined sources1
Modified residuei296PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96QF0

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96QF0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96QF0

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96QF0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96QF0

PeptideAtlas

More...PeptideAtlasi		Q96QF0

PRoteomics IDEntifications database

More...PRIDEi		Q96QF0

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		77867 [Q96QF0-1]
77868 [Q96QF0-2]
77869 [Q96QF0-3]
77870 [Q96QF0-4]
77871 [Q96QF0-5]
77872 [Q96QF0-6]
77873 [Q96QF0-7]
77874 [Q96QF0-8]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q96QF0, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96QF0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96QF0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain, kidney, heart, pancreas and placenta. Not detected in skeletal muscle or liver.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000127328, Expressed in corpus callosum and 176 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96QF0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96QF0, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000127328, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the N-terminal region of SSX2 (PubMed:12007189).

Interacts with the GDP-bound forms of RAB8A and RAB8B (PubMed:26824392, PubMed:12221131). The interaction with RAB8A is prevented by phosphorylation of RAB8A at 'Thr-72' (PubMed:26824392).

Interacts with the GDP-bound forms of RAB3A and RAB3D (PubMed:12221131).

Interacts with DCDC1 (PubMed:22159412, PubMed:12007189, PubMed:12221131, PubMed:26824392).

Interacts (via the N-terminal region) with TRAPPC14; this interaction mediates RAB3IP association with the TRAPP II complex (PubMed:31467083).

5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q96QF0
With#Exp.IntAct
BANP [Q8N9N5]3EBI-747844,EBI-744695
CHCHD3 [Q9NX63]3EBI-747844,EBI-743375
FAM124A [Q86V42]3EBI-747844,EBI-744506
KRT40 [Q6A162]3EBI-747844,EBI-10171697
NAA10 [P41227]3EBI-747844,EBI-747693
PLOD3 [O60568]4EBI-747844,EBI-741582
PPL [O60437]3EBI-747844,EBI-368321
RAB3A [P20336]3EBI-747844,EBI-1045943
RAB3IL1 [Q8TBN0]9EBI-747844,EBI-743796
RAB8A [P61006]5EBI-747844,EBI-722293
RUFY1 [Q96T51]3EBI-747844,EBI-3941207
SFN [P31947]3EBI-747844,EBI-476295
SSX2B [Q16385]4EBI-747844,EBI-2210673
TRAPPC10 [P48553]7EBI-747844,EBI-6160572
TRAPPC6A [O75865]4EBI-747844,EBI-743573
ZNF410 [Q86VK4]3EBI-747844,EBI-720304
2'-O-methyltransferase nsp16 (PRO_0000449633) from Severe acute respiratory syndrome coronavirus 2.4EBI-747844,EBI-25492395
Isoform 2 [Q96QF0-1]
With#Exp.IntAct
BBS1 [Q8NFJ9]2EBI-747860,EBI-1805484
RAB3IP - isoform 1 [Q96QF0-2]
With#Exp.IntAct
PLOD3 [O60568]3EBI-747865,EBI-741582
RAB11A [P62491]8EBI-747865,EBI-745098
RAB11FIP3 - isoform 1 [O75154-1]6EBI-747865,EBI-15605207
itself2EBI-747865,EBI-747865
RAB8A [P61006]2EBI-747865,EBI-722293
SSX2B [Q16385]4EBI-747865,EBI-2210673
Isoform 7 [Q96QF0-7]
With#Exp.IntAct
BAG6 - isoform 2 [P46379-2]3EBI-11984839,EBI-10988864
BANP - isoform 2 [Q8N9N5-2]6EBI-11984839,EBI-11524452
BANP - isoform 7 [Q8N9N5-7]3EBI-11984839,EBI-16429296
CCDC196 [A0A1B0GWI1]3EBI-11984839,EBI-10181422
DMWD [G5E9A7]3EBI-11984839,EBI-10976677
DNAJB13 [P59910]3EBI-11984839,EBI-11514233
DNAJB6 - isoform B [O75190-2]3EBI-11984839,EBI-12593112
DNM2 - isoform 2 [P50570-2]3EBI-11984839,EBI-10968534
GFAP [P14136]3EBI-11984839,EBI-744302
ICAM5 [Q9UMF0]3EBI-11984839,EBI-6398041
JPH3 [Q8WXH2]3EBI-11984839,EBI-1055254
KLF11 [O14901]3EBI-11984839,EBI-948266
MB21D2 [Q8IYB1]3EBI-11984839,EBI-11323212
MBD3 - isoform 2 [O95983-2]3EBI-11984839,EBI-11978579
NAA10 [P41227]3EBI-11984839,EBI-747693
NDUFV2 [P19404]3EBI-11984839,EBI-713665
PEG10 - isoform 2 [Q86TG7-2]3EBI-11984839,EBI-6259410
PKN1 [Q16512]3EBI-11984839,EBI-602382
PMP22 [D3DTS7]3EBI-11984839,EBI-25882629
PPL [O60437]3EBI-11984839,EBI-368321
PRKAB2 [O43741]3EBI-11984839,EBI-1053424
RAB3A [P20336]3EBI-11984839,EBI-1045943
RAB3D [O95716]3EBI-11984839,EBI-3386067
SPRED1 [Q7Z699]3EBI-11984839,EBI-5235340
TBC1D21 [Q8IYX1]3EBI-11984839,EBI-12018146
TEPSIN [Q96N21]3EBI-11984839,EBI-11139477
TOR1A - isoform 2 [O14656-2]3EBI-11984839,EBI-25847109
TRAPPC6A - isoform 2 [O75865-2]3EBI-11984839,EBI-8451480
ZBTB16 [Q05516]3EBI-11984839,EBI-711925
ZNF410 - isoform 3 [Q86VK4-3]3EBI-11984839,EBI-11741890
ZNF76 [P36508]3EBI-11984839,EBI-7254550

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		125566, 108 interactors

Database of interacting proteins

More...DIPi		DIP-41703N

Protein interaction database and analysis system

More...IntActi		Q96QF0, 90 interactors

Molecular INTeraction database

More...MINTi		Q96QF0

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000447300

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96QF0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1476
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96QF0

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni262 – 297DisorderedSequence analysisAdd BLAST36

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili165 – 260Sequence analysisAdd BLAST96

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SEC2 family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4324, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157998

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_038204_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96QF0

Identification of Orthologs from Complete Genome Data

More...OMAi		AFTMAND

Database of Orthologous Groups

More...OrthoDBi		619794at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96QF0

TreeFam database of animal gene trees

More...TreeFami		TF313748

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR040351, RAB3IL/RAB3IP/Sec2
IPR009449, Sec2_N

The PANTHER Classification System

More...PANTHERi		PTHR14430, PTHR14430, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF06428, Sec2p, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 8 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 8 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 21 Publication (identifier: Q96QF0-1) [UniParc]FASTAAdd to basket
Also known as: alpha21 Publication

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGLKKMKGLS YDEAFAMAND PLEGFHEVNL ASPTSPDLLG VYESGTQEQT 
        60         70         80         90        100
TSPSVIYRPH PSALSSVPIQ ANALDVSELP TQPVYSSPRR LNCAEISSIS 
       110        120        130        140        150
FHVTDPAPCS TSGVTAGLTK LTTRKDNYNA EREFLQGATI TEACDGSDDI 
       160        170        180        190        200
FGLSTDSLSR LRSPSVLEVR EKGYERLKEE LAKAQRELKL KDEECERLSK 
       210        220        230        240        250
VRDQLGQELE ELTASLFEEA HKMVREANIK QATAEKQLKE AQGKIDVLQA 
       260        270        280        290        300
EVAALKTLVL SSSPTSPTQE PLPGGKTPFK KGHTRNKSTS SAMSGSHQDL 
       310        320        330        340        350
SVIQPIVKDC KEADLSLYNE FRLWKDEPTM DRTCPFLDKI YQEDIFPCLT 
       360        370        380        390        400
FSKSELASAV LEAVENNTLS IEPVGLQPIR FVKASAVECG GPKKCALTGQ 
       410        420        430        440        450
SKSCKHRIKL GDSSNYYYIS PFCRYRITSV CNFFTYIRYI QQGLVKQQDV 
       460        470 
DQMFWEVMQL RKEMSLAKLG YFKEEL
Length:476
Mass (Da):53,021
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDD77781823038F15
GO
Isoform 11 Publication (identifier: Q96QF0-2) [UniParc]FASTAAdd to basket
Also known as: alpha11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: Missing.

Show »
Length:460
Mass (Da):51,250
Checksum:iED659E364B5C75FA
GO
Isoform 31 Publication (identifier: Q96QF0-3) [UniParc]FASTAAdd to basket
Also known as: beta11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: Missing.
     394-411: KCALTGQSKSCKHRIKLG → SLLYVTFLHTFDTFSRDS
     412-476: Missing.

Show »
Length:395
Mass (Da):43,446
Checksum:i00E0F63E76FCEB09
GO
Isoform 41 Publication (identifier: Q96QF0-4) [UniParc]FASTAAdd to basket
Also known as: beta21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     394-411: KCALTGQSKSCKHRIKLG → SLLYVTFLHTFDTFSRDS
     412-476: Missing.

Show »
Length:411
Mass (Da):45,217
Checksum:iB7C472F90DDD661C
GO
Isoform 51 Publication (identifier: Q96QF0-5) [UniParc]FASTAAdd to basket
Also known as: gamma11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: Missing.
     313-320: ADLSLYNE → KMCSHWPE
     321-476: Missing.

Show »
Length:304
Mass (Da):33,234
Checksum:i6C579A473B5C0B52
GO
Isoform 61 Publication (identifier: Q96QF0-6) [UniParc]FASTAAdd to basket
Also known as: gamma21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     313-320: ADLSLYNE → KMCSHWPE
     321-476: Missing.

Show »
Length:320
Mass (Da):35,005
Checksum:i00F8D4526DB2AEFC
GO
Isoform 7Curated (identifier: Q96QF0-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: Missing.
     313-331: ADLSLYNEFRLWKDEPTMD → VTHQGLSPLTLLILVSSHH
     332-476: Missing.

Show »
Length:315
Mass (Da):34,270
Checksum:iB4BCBD28A3C81394
GO
Isoform 8Curated (identifier: Q96QF0-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-222: Missing.

Show »
Length:254
Mass (Da):28,642
Checksum:i33D7F36AA55989C8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VNX9F8VNX9_HUMAN
Rab-3A-interacting protein
RAB3IP
165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YI02H0YI02_HUMAN
Rab-3A-interacting protein
RAB3IP
237Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KPG1J3KPG1_HUMAN
Rab-3A-interacting protein
RAB3IP
369Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YI66H0YI66_HUMAN
Rab-3A-interacting protein
RAB3IP
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VTR6F8VTR6_HUMAN
Rab-3A-interacting protein
RAB3IP
167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YD03H0YD03_HUMAN
Rab-3A-interacting protein
RAB3IP
189Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YHP4H0YHP4_HUMAN
Rab-3A-interacting protein
RAB3IP
21Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti164P → Q in AAH59358 (PubMed:15489334).Curated1
Sequence conflicti286N → D in BAB15391 (PubMed:14702039).Curated1
Sequence conflicti356Missing in BAB15391 (PubMed:14702039).Curated1
Sequence conflicti464M → V in BAB15391 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0517561 – 222Missing in isoform 8. 2 PublicationsAdd BLAST222
Alternative sequenceiVSP_0517551 – 16Missing in isoform 1, isoform 3, isoform 5 and isoform 7. 3 PublicationsAdd BLAST16
Alternative sequenceiVSP_051758313 – 331ADLSL…EPTMD → VTHQGLSPLTLLILVSSHH in isoform 7. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_051757313 – 320ADLSLYNE → KMCSHWPE in isoform 5 and isoform 6. 1 Publication8
Alternative sequenceiVSP_051759321 – 476Missing in isoform 5 and isoform 6. 1 PublicationAdd BLAST156
Alternative sequenceiVSP_051760332 – 476Missing in isoform 7. 1 PublicationAdd BLAST145
Alternative sequenceiVSP_051761394 – 411KCALT…RIKLG → SLLYVTFLHTFDTFSRDS in isoform 3 and isoform 4. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_051762412 – 476Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST65

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ312896 mRNA Translation: CAC59835.1
AJ312897 mRNA Translation: CAC59836.1
AJ312898 mRNA Translation: CAC59837.1
AJ312899 mRNA Translation: CAC59838.1
AJ312900 mRNA Translation: CAC59839.1
AJ312901 mRNA Translation: CAC59840.1
AK026201 mRNA Translation: BAB15391.1
AK027566 mRNA Translation: BAB55202.1
AK027671 mRNA Translation: BAB55283.1
AC025263 Genomic DNA No translation available.
BC015548 mRNA Translation: AAH15548.1
BC059358 mRNA Translation: AAH59358.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS41811.1 [Q96QF0-4]
CCDS44942.1 [Q96QF0-8]
CCDS8993.1 [Q96QF0-1]
CCDS8995.1 [Q96QF0-2]
CCDS8996.1 [Q96QF0-3]

NCBI Reference Sequences

More...RefSeqi		NP_001019818.1, NM_001024647.3 [Q96QF0-8]
NP_001265331.1, NM_001278402.1 [Q96QF0-8]
NP_071901.2, NM_022456.4 [Q96QF0-2]
NP_783322.1, NM_175623.3 [Q96QF0-1]
NP_783323.1, NM_175624.3 [Q96QF0-3]
NP_783324.1, NM_175625.3 [Q96QF0-4]
XP_016874262.1, XM_017018773.1 [Q96QF0-2]
XP_016874265.1, XM_017018776.1
XP_016874266.1, XM_017018777.1 [Q96QF0-8]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000247833; ENSP00000247833; ENSG00000127328 [Q96QF0-2]
ENST00000362025; ENSP00000355381; ENSG00000127328 [Q96QF0-4]
ENST00000378815; ENSP00000368092; ENSG00000127328 [Q96QF0-7]
ENST00000417413; ENSP00000436304; ENSG00000127328 [Q96QF0-5]
ENST00000483530; ENSP00000419216; ENSG00000127328 [Q96QF0-3]
ENST00000550536; ENSP00000447300; ENSG00000127328
ENST00000551641; ENSP00000448773; ENSG00000127328 [Q96QF0-8]
ENST00000552199; ENSP00000448944; ENSG00000127328 [Q96QF0-6]
ENST00000553099; ENSP00000448027; ENSG00000127328 [Q96QF0-8]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		117177

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:117177

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000247833.12; ENSP00000247833.7; NM_022456.5; NP_071901.2 [Q96QF0-2]

UCSC genome browser

More...UCSCi		uc001svm.5, human [Q96QF0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ312896 mRNA Translation: CAC59835.1
AJ312897 mRNA Translation: CAC59836.1
AJ312898 mRNA Translation: CAC59837.1
AJ312899 mRNA Translation: CAC59838.1
AJ312900 mRNA Translation: CAC59839.1
AJ312901 mRNA Translation: CAC59840.1
AK026201 mRNA Translation: BAB15391.1
AK027566 mRNA Translation: BAB55202.1
AK027671 mRNA Translation: BAB55283.1
AC025263 Genomic DNA No translation available.
BC015548 mRNA Translation: AAH15548.1
BC059358 mRNA Translation: AAH59358.1
CCDSiCCDS41811.1 [Q96QF0-4]
CCDS44942.1 [Q96QF0-8]
CCDS8993.1 [Q96QF0-1]
CCDS8995.1 [Q96QF0-2]
CCDS8996.1 [Q96QF0-3]
RefSeqiNP_001019818.1, NM_001024647.3 [Q96QF0-8]
NP_001265331.1, NM_001278402.1 [Q96QF0-8]
NP_071901.2, NM_022456.4 [Q96QF0-2]
NP_783322.1, NM_175623.3 [Q96QF0-1]
NP_783323.1, NM_175624.3 [Q96QF0-3]
NP_783324.1, NM_175625.3 [Q96QF0-4]
XP_016874262.1, XM_017018773.1 [Q96QF0-2]
XP_016874265.1, XM_017018776.1
XP_016874266.1, XM_017018777.1 [Q96QF0-8]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4LHXX-ray3.05C/D/E/F173-248[»]
4LHYX-ray3.10C/D/E/F173-248[»]
4LHZX-ray3.20C/D/E/F173-248[»]
4UJ3X-ray3.00B/E/H/K/N/Q/T/W286-476[»]
4UJ4X-ray4.20B/E/H/K286-476[»]
4UJ5X-ray2.60C/D286-476[»]
6F6PX-ray2.45A/B/C/D159-261[»]
SMRiQ96QF0
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi125566, 108 interactors
DIPiDIP-41703N
IntActiQ96QF0, 90 interactors
MINTiQ96QF0
STRINGi9606.ENSP00000447300

PTM databases

GlyGeniQ96QF0, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ96QF0
PhosphoSitePlusiQ96QF0

Genetic variation databases

BioMutaiRAB3IP
DMDMi71152025

Proteomic databases

EPDiQ96QF0
jPOSTiQ96QF0
MassIVEiQ96QF0
MaxQBiQ96QF0
PaxDbiQ96QF0
PeptideAtlasiQ96QF0
PRIDEiQ96QF0
ProteomicsDBi77867 [Q96QF0-1]
77868 [Q96QF0-2]
77869 [Q96QF0-3]
77870 [Q96QF0-4]
77871 [Q96QF0-5]
77872 [Q96QF0-6]
77873 [Q96QF0-7]
77874 [Q96QF0-8]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		29437, 219 antibodies from 24 providers

The DNASU plasmid repository

More...DNASUi		117177

Genome annotation databases

EnsembliENST00000247833; ENSP00000247833; ENSG00000127328 [Q96QF0-2]
ENST00000362025; ENSP00000355381; ENSG00000127328 [Q96QF0-4]
ENST00000378815; ENSP00000368092; ENSG00000127328 [Q96QF0-7]
ENST00000417413; ENSP00000436304; ENSG00000127328 [Q96QF0-5]
ENST00000483530; ENSP00000419216; ENSG00000127328 [Q96QF0-3]
ENST00000550536; ENSP00000447300; ENSG00000127328
ENST00000551641; ENSP00000448773; ENSG00000127328 [Q96QF0-8]
ENST00000552199; ENSP00000448944; ENSG00000127328 [Q96QF0-6]
ENST00000553099; ENSP00000448027; ENSG00000127328 [Q96QF0-8]
GeneIDi117177
KEGGihsa:117177
MANE-SelectiENST00000247833.12; ENSP00000247833.7; NM_022456.5; NP_071901.2 [Q96QF0-2]
UCSCiuc001svm.5, human [Q96QF0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		117177
DisGeNETi117177

GeneCards: human genes, protein and diseases

More...GeneCardsi		RAB3IP
HGNCiHGNC:16508, RAB3IP
HPAiENSG00000127328, Low tissue specificity
MIMi608686, gene
neXtProtiNX_Q96QF0
OpenTargetsiENSG00000127328
PharmGKBiPA34136
VEuPathDBiHostDB:ENSG00000127328

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4324, Eukaryota
GeneTreeiENSGT00940000157998
HOGENOMiCLU_038204_2_0_1
InParanoidiQ96QF0
OMAiAFTMAND
OrthoDBi619794at2759
PhylomeDBiQ96QF0
TreeFamiTF313748

Enzyme and pathway databases

PathwayCommonsiQ96QF0
ReactomeiR-HSA-5620912, Anchoring of the basal body to the plasma membrane
R-HSA-5620916, VxPx cargo-targeting to cilium
R-HSA-5620922, BBSome-mediated cargo-targeting to cilium
R-HSA-8876198, RAB GEFs exchange GTP for GDP on RABs
SignaLinkiQ96QF0
SIGNORiQ96QF0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		117177, 6 hits in 1047 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RAB3IP, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		RAB3IP

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		117177
PharosiQ96QF0, Tbio

Protein Ontology

More...PROi		PR:Q96QF0
RNActiQ96QF0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000127328, Expressed in corpus callosum and 176 other tissues
ExpressionAtlasiQ96QF0, baseline and differential
GenevisibleiQ96QF0, HS

Family and domain databases

InterProiView protein in InterPro
IPR040351, RAB3IL/RAB3IP/Sec2
IPR009449, Sec2_N
PANTHERiPTHR14430, PTHR14430, 1 hit
PfamiView protein in Pfam
PF06428, Sec2p, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRAB3I_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96QF0
Secondary accession number(s): B7WPJ6
, Q6PCE4, Q96A24, Q96QE6, Q96QE7, Q96QE8, Q96QE9, Q96QF1, Q9H673
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: December 1, 2001
Last modified: February 23, 2022
This is version 168 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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