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Protein

Transcription elongation factor, mitochondrial

Gene

TEFM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery.1 Publication

GO - Molecular functioni

  • DNA polymerase processivity factor activity Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

  • mitochondrial transcription Source: UniProtKB
  • oxidative phosphorylation Source: UniProtKB
  • transcription elongation from mitochondrial promoter Source: InterPro

Keywordsi

Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription elongation factor, mitochondrial
Gene namesi
Name:TEFM
Synonyms:C17orf42
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000172171.10
HGNCiHGNC:26223 TEFM
MIMi616422 gene
neXtProtiNX_Q96QE5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion, Mitochondrion nucleoid

Pathology & Biotechi

Organism-specific databases

DisGeNETi79736
OpenTargetsiENSG00000172171
PharmGKBiPA142672226

Polymorphism and mutation databases

BioMutaiTEFM
DMDMi74761050

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 35MitochondrionSequence analysisAdd BLAST35
ChainiPRO_000040632936 – 360Transcription elongation factor, mitochondrialAdd BLAST325

Proteomic databases

EPDiQ96QE5
MaxQBiQ96QE5
PaxDbiQ96QE5
PeptideAtlasiQ96QE5
PRIDEiQ96QE5
ProteomicsDBi77865
77866 [Q96QE5-4]

PTM databases

iPTMnetiQ96QE5
PhosphoSitePlusiQ96QE5

Expressioni

Gene expression databases

BgeeiENSG00000172171 Expressed in 209 organ(s), highest expression level in tendon of biceps brachii
CleanExiHS_C17orf42
ExpressionAtlasiQ96QE5 baseline and differential
GenevisibleiQ96QE5 HS

Organism-specific databases

HPAiHPA023788
HPA053044

Interactioni

Subunit structurei

Interacts with POLRMT.1 Publication

Protein-protein interaction databases

BioGridi122850, 63 interactors
IntActiQ96QE5, 16 interactors
MINTiQ96QE5

Structurei

Secondary structure

1360
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ96QE5
SMRiQ96QE5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TEFM family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IHBW Eukaryota
ENOG410XQGF LUCA
GeneTreeiENSGT00390000010581
HOVERGENiHBG107754
InParanoidiQ96QE5
KOiK17658
OMAiDQQNVNI
OrthoDBiEOG091G0EDC
PhylomeDBiQ96QE5
TreeFamiTF325413

Family and domain databases

InterProiView protein in InterPro
IPR012337 RNaseH-like_sf
IPR010994 RuvA_2-like
IPR039150 TEFM
PANTHERiPTHR21053 PTHR21053, 1 hit
SUPFAMiSSF47781 SSF47781, 1 hit
SSF53098 SSF53098, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96QE5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGSVLFTAG ERWRCFLTPS RSSLYWALHN FCCRKKSTTP KKITPNVTFC
60 70 80 90 100
DENAKEPENA LDKLFSSEQQ ASILHVLNTA STKELEAFRL LRGRRSINIV
110 120 130 140 150
EHRENFGPFQ NLESLMNVPL FKYKSTVQVC NSILCPKTGR EKRKSPENRF
160 170 180 190 200
LRKLLKPDIE RERLKAVNSI ISIVFGTRRI AWAHLDRKLT VLDWQQSDRW
210 220 230 240 250
SLMRGIYSSS VYLEEISSII SKMPKADFYV LEKTGLSIQN SSLFPILLHF
260 270 280 290 300
HIMEAMLYAL LNKTFAQDGQ HQVLSMNRNA VGKHFELMIG DSRTSGKELV
310 320 330 340 350
KQFLFDSILK ADPRVFFPSD KIVHYRQMFL STELQRVEEL YDSLLQAIAF
360
YELAVFDSQP
Length:360
Mass (Da):41,676
Last modified:December 1, 2001 - v1
Checksum:i2D3473AC87D2650C
GO
Isoform 2 (identifier: Q96QE5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     166-171: AVNSII → NCLGSP
     172-360: Missing.

Show »
Length:171
Mass (Da):19,736
Checksum:i2BD2D48E6C8D115A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KTG7J3KTG7_HUMAN
Transcription elongation factor, mi...
TEFM
226Annotation score:

Sequence cautioni

The sequence AAH73169 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence BAB15468 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti232E → K in AAH09025 (PubMed:15489334).Curated1
Sequence conflicti232E → K in AAH73169 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_045689348I → V. Corresponds to variant dbSNP:rs2433Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_040808166 – 171AVNSII → NCLGSP in isoform 2. 2 Publications6
Alternative sequenceiVSP_040809172 – 360Missing in isoform 2. 2 PublicationsAdd BLAST189

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ314645 mRNA Translation: CAC44534.1
AK026382 mRNA Translation: BAB15468.1 Sequence problems.
CH471147 Genomic DNA Translation: EAW80290.1
CH471147 Genomic DNA Translation: EAW80292.1
BC009025 mRNA Translation: AAH09025.2
BC073169 mRNA Translation: AAH73169.1 Sequence problems.
CR457360 mRNA Translation: CAG33641.1
CCDSiCCDS42291.1 [Q96QE5-1]
RefSeqiNP_078959.3, NM_024683.3 [Q96QE5-1]
UniGeneiHs.317340

Genome annotation databases

EnsembliENST00000306049; ENSP00000306574; ENSG00000172171 [Q96QE5-4]
ENST00000581216; ENSP00000462963; ENSG00000172171 [Q96QE5-1]
GeneIDi79736
KEGGihsa:79736
UCSCiuc002hfu.3 human [Q96QE5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ314645 mRNA Translation: CAC44534.1
AK026382 mRNA Translation: BAB15468.1 Sequence problems.
CH471147 Genomic DNA Translation: EAW80290.1
CH471147 Genomic DNA Translation: EAW80292.1
BC009025 mRNA Translation: AAH09025.2
BC073169 mRNA Translation: AAH73169.1 Sequence problems.
CR457360 mRNA Translation: CAG33641.1
CCDSiCCDS42291.1 [Q96QE5-1]
RefSeqiNP_078959.3, NM_024683.3 [Q96QE5-1]
UniGeneiHs.317340

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5OL8X-ray1.90A/B/C/D51-360[»]
5OL9X-ray1.30A36-134[»]
5OLAX-ray3.90A/B/C/D136-360[»]
ProteinModelPortaliQ96QE5
SMRiQ96QE5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122850, 63 interactors
IntActiQ96QE5, 16 interactors
MINTiQ96QE5

PTM databases

iPTMnetiQ96QE5
PhosphoSitePlusiQ96QE5

Polymorphism and mutation databases

BioMutaiTEFM
DMDMi74761050

Proteomic databases

EPDiQ96QE5
MaxQBiQ96QE5
PaxDbiQ96QE5
PeptideAtlasiQ96QE5
PRIDEiQ96QE5
ProteomicsDBi77865
77866 [Q96QE5-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306049; ENSP00000306574; ENSG00000172171 [Q96QE5-4]
ENST00000581216; ENSP00000462963; ENSG00000172171 [Q96QE5-1]
GeneIDi79736
KEGGihsa:79736
UCSCiuc002hfu.3 human [Q96QE5-1]

Organism-specific databases

CTDi79736
DisGeNETi79736
EuPathDBiHostDB:ENSG00000172171.10
GeneCardsiTEFM
HGNCiHGNC:26223 TEFM
HPAiHPA023788
HPA053044
MIMi616422 gene
neXtProtiNX_Q96QE5
OpenTargetsiENSG00000172171
PharmGKBiPA142672226
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHBW Eukaryota
ENOG410XQGF LUCA
GeneTreeiENSGT00390000010581
HOVERGENiHBG107754
InParanoidiQ96QE5
KOiK17658
OMAiDQQNVNI
OrthoDBiEOG091G0EDC
PhylomeDBiQ96QE5
TreeFamiTF325413

Miscellaneous databases

GenomeRNAii79736
PROiPR:Q96QE5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172171 Expressed in 209 organ(s), highest expression level in tendon of biceps brachii
CleanExiHS_C17orf42
ExpressionAtlasiQ96QE5 baseline and differential
GenevisibleiQ96QE5 HS

Family and domain databases

InterProiView protein in InterPro
IPR012337 RNaseH-like_sf
IPR010994 RuvA_2-like
IPR039150 TEFM
PANTHERiPTHR21053 PTHR21053, 1 hit
SUPFAMiSSF47781 SSF47781, 1 hit
SSF53098 SSF53098, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTEFM_HUMAN
AccessioniPrimary (citable) accession number: Q96QE5
Secondary accession number(s): E1P655
, Q6GPG5, Q6PJ19, Q96H04, Q9H5Z9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  6. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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