Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 131 (31 Jul 2019)
Sequence version 3 (18 May 2010)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Leucine-rich repeat-containing protein 37B

Gene

LRRC37B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 37B
Alternative name(s):
C66 SLIT-like testicular protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LRRC37B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29070 LRRC37B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616558 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96QE4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini28 – 905ExtracellularSequence analysisAdd BLAST878
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei906 – 926HelicalSequence analysisAdd BLAST21
Topological domaini927 – 947CytoplasmicSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
114659

Open Targets

More...
OpenTargetsi
ENSG00000185158

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671525

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LRRC37B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296439308

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Sequence analysisAdd BLAST27
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000023265328 – 947Leucine-rich repeat-containing protein 37BAdd BLAST920

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi358N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi789N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96QE4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96QE4

PeptideAtlas

More...
PeptideAtlasi
Q96QE4

PRoteomics IDEntifications database

More...
PRIDEi
Q96QE4

ProteomicsDB human proteome resource

More...
ProteomicsDBi
61147
77864 [Q96QE4-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96QE4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96QE4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000185158 Expressed in 92 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96QE4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96QE4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA015135

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
125332, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q96QE4, 1 interactor

Molecular INTeraction database

More...
MINTi
Q96QE4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000340519

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati556 – 577LRR 1Add BLAST22
Repeati580 – 601LRR 2Add BLAST22
Repeati604 – 625LRR 3Add BLAST22
Repeati628 – 649LRR 4Add BLAST22
Repeati655 – 676LRR 5Add BLAST22
Repeati679 – 699LRR 6Add BLAST21

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili867 – 897Sequence analysisAdd BLAST31

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJNR Eukaryota
ENOG410YV94 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063282

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000293202

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96QE4

Database of Orthologous Groups

More...
OrthoDBi
181606at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96QE4

TreeFam database of animal gene trees

More...
TreeFami
TF341959

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR015753 LRRC37
IPR032754 LRRC37_N
IPR029423 LRRC37AB_C

The PANTHER Classification System

More...
PANTHERi
PTHR23045 PTHR23045, 4 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13855 LRR_8, 1 hit
PF15779 LRRC37, 2 hits
PF14914 LRRC37AB_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00369 LRR_TYP, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450 LRR, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96QE4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSWLRFWGPW PLLTWQLLSL LVKEAQPLVW VKDPLQLTSN PLGPPEPWSS
60 70 80 90 100
RSSHLPWESP HAPAPPAAPG DFDYLGPSAS SQMSALPQEP TENLAPFLKE
110 120 130 140 150
LDSAGELPLG PEPFLAAHQD LNDKRTPEER LPEVVPLLNR DQNQALVQLP
160 170 180 190 200
RLKWVQTTDL DRAAGHQADE ILVPLDSKVS RPTKFVVSPK NLKKDLAERW
210 220 230 240 250
SLPEIVGIPH QLSKPQRQKQ TLPDDYLSMD TLYPGSLPPE LRVNADEPPG
260 270 280 290 300
PPEQVGLSQF HLEPKSQNPE TLEDIQSSSL QEEAPAQLLQ LPQEVEPSTQ
310 320 330 340 350
QEAPALPPES SMESLAQTPL NHEVTVQPPG EDQAHYNLPK FTVKPADVEV
360 370 380 390 400
TMTSEPKNET ESTQAQQEAP IQPPEEAEPS STALRTTDPP PEHPEVTLPP
410 420 430 440 450
SDKGQAQHSH LTEATVQPLD LELSITTEPT TEVKPSPTTE ETSAQPPDPG
460 470 480 490 500
LAITPEPTTE IGHSTALEKT RAPHPDQVQT LHRSLTEVTG PPTKLESSQD
510 520 530 540 550
SLVQSETAPE EQKASTSTNI CELCTCGDET LSCVGLSPKQ RLRQVPVPEP
560 570 580 590 600
DTYNGIFTTL NFQGNYISYL DGNVWKAYSW TEKLILSENY LTELPKDSFE
610 620 630 640 650
GLLYLQYLDL SCNKIRYIER QTFESLPFLQ YINLGCNLIT KLSLGTFQAW
660 670 680 690 700
HGMQFLHNLI LNRNPLTTVE DPYLFELPAL KYLDMGTTHI TLTTLKNILT
710 720 730 740 750
MTVELEKLIL PSHMACCLCQ FKNSIEAVCK TVKLHCNTAC LTNSIHCPEE
760 770 780 790 800
ASVGNPEGAF MKMLQARKQH MSTQLTIESE APSDSSGINL SGFGGDQLEI
810 820 830 840 850
QLTEQLRSLI PNEDVRKFMS HVIRTLKMEC SETHVQGSCA KLMLRTGLLM
860 870 880 890 900
KLLSEQQEAK ALNVEWDTDQ QKTNYINENM EQNEQKEQKS SELMKEVPGD
910 920 930 940
DYKNKLIFAI SVTVILIILI IIFCLIEVNS HKRASEKYKD NPSISGA
Length:947
Mass (Da):105,567
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2C599D50C8C637AC
GO
Isoform 2 (identifier: Q96QE4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     608-658: Missing.

Note: No experimental confirmation available.
Show »
Length:896
Mass (Da):99,568
Checksum:i9271EA5076990C62
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KTP0J3KTP0_HUMAN
Leucine-rich repeat-containing prot...
LRRC37B
908Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H5K1F5H5K1_HUMAN
Leucine-rich repeat-containing prot...
LRRC37B
865Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QSU1J3QSU1_HUMAN
Leucine-rich repeat-containing prot...
LRRC37B
974Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QLI7J3QLI7_HUMAN
Leucine-rich repeat-containing prot...
LRRC37B
720Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QKM3J3QKM3_HUMAN
Leucine-rich repeat-containing prot...
LRRC37B
236Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QL10J3QL10_HUMAN
Leucine-rich repeat-containing prot...
LRRC37B
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QLE7J3QLE7_HUMAN
Leucine-rich repeat-containing prot...
LRRC37B
218Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAR28082 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti6 – 24FWGPW…LLVKE → ITAMAPPYVATIVFTSQG in CAC44536 (PubMed:10843809).CuratedAdd BLAST19
Sequence conflicti198E → G in AAR28082 (Ref. 2) Curated1
Sequence conflicti336Y → H in AAR28082 (Ref. 2) Curated1
Sequence conflicti469K → E in AAR28082 (Ref. 2) Curated1
Sequence conflicti604Y → S in CAC44536 (PubMed:10843809).Curated1
Sequence conflicti621Q → H in CAC44536 (PubMed:10843809).Curated1
Sequence conflicti621Q → H in AAR28082 (Ref. 2) Curated1
Sequence conflicti641K → E in CAC44536 (PubMed:10843809).Curated1
Sequence conflicti702T → S in AAR28082 (Ref. 2) Curated1
Sequence conflicti772S → G in AAR28082 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_054513608 – 658Missing in isoform 2. 1 PublicationAdd BLAST51

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ314647 mRNA Translation: CAC44536.1
AY386261 mRNA Translation: AAR28082.1 Different initiation.
AC090616 Genomic DNA No translation available.
BC117373 mRNA Translation: AAI17374.1
BC143581 mRNA Translation: AAI43582.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32609.1 [Q96QE4-1]

NCBI Reference Sequences

More...
RefSeqi
NP_443120.2, NM_052888.2 [Q96QE4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000341671; ENSP00000340519; ENSG00000185158 [Q96QE4-1]
ENST00000394713; ENSP00000378202; ENSG00000185158 [Q96QE4-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
114659

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:114659

UCSC genome browser

More...
UCSCi
uc060dst.1 human [Q96QE4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ314647 mRNA Translation: CAC44536.1
AY386261 mRNA Translation: AAR28082.1 Different initiation.
AC090616 Genomic DNA No translation available.
BC117373 mRNA Translation: AAI17374.1
BC143581 mRNA Translation: AAI43582.1
CCDSiCCDS32609.1 [Q96QE4-1]
RefSeqiNP_443120.2, NM_052888.2 [Q96QE4-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi125332, 1 interactor
IntActiQ96QE4, 1 interactor
MINTiQ96QE4
STRINGi9606.ENSP00000340519

PTM databases

iPTMnetiQ96QE4
PhosphoSitePlusiQ96QE4

Polymorphism and mutation databases

BioMutaiLRRC37B
DMDMi296439308

Proteomic databases

jPOSTiQ96QE4
PaxDbiQ96QE4
PeptideAtlasiQ96QE4
PRIDEiQ96QE4
ProteomicsDBi61147
77864 [Q96QE4-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
114659
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341671; ENSP00000340519; ENSG00000185158 [Q96QE4-1]
ENST00000394713; ENSP00000378202; ENSG00000185158 [Q96QE4-1]
GeneIDi114659
KEGGihsa:114659
UCSCiuc060dst.1 human [Q96QE4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
114659
DisGeNETi114659

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LRRC37B
HGNCiHGNC:29070 LRRC37B
HPAiHPA015135
MIMi616558 gene
neXtProtiNX_Q96QE4
OpenTargetsiENSG00000185158
PharmGKBiPA142671525

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IJNR Eukaryota
ENOG410YV94 LUCA
GeneTreeiENSGT00530000063282
HOGENOMiHOG000293202
InParanoidiQ96QE4
OrthoDBi181606at2759
PhylomeDBiQ96QE4
TreeFamiTF341959

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LRRC37B human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
114659

Protein Ontology

More...
PROi
PR:Q96QE4

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000185158 Expressed in 92 organ(s), highest expression level in testis
ExpressionAtlasiQ96QE4 baseline and differential
GenevisibleiQ96QE4 HS

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR015753 LRRC37
IPR032754 LRRC37_N
IPR029423 LRRC37AB_C
PANTHERiPTHR23045 PTHR23045, 4 hits
PfamiView protein in Pfam
PF13855 LRR_8, 1 hit
PF15779 LRRC37, 2 hits
PF14914 LRRC37AB_C, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 4 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLR37B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96QE4
Secondary accession number(s): Q17RC9, Q5YKG6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: May 18, 2010
Last modified: July 31, 2019
This is version 131 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again