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Protein

ATPase family AAA domain-containing protein 5

Gene

ATAD5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in DNA damage response. Involved in a RAD9A-related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis. Modulates the RAD9A interaction with BCL2 and thereby induces DNA damages-induced apoptosis.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1132 – 1139ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • DNA binding Source: GO_Central
  • DNA clamp unloader activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA damage
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATPase family AAA domain-containing protein 5
Alternative name(s):
Chromosome fragility-associated gene 1 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATAD5
Synonyms:C17orf41, FRAG1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000176208.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25752 ATAD5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609534 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96QE3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1169S → A: No effect on the RAD9A interaction after MMS exposure. Resists to DNA damage after MMS exposure. 1 Publication1
Mutagenesisi1187S → A: Weakly affects the RAD9A interaction after MMS exposure. 1 Publication1
Mutagenesisi1430C → G: Abolishes RB1 binding. Abolishes RB1 binding; when associated with K-1432. Weakly detected after methyl methane-sulfonate (MMS) treatment. Expression detected after MMS treatment; when associated with K-1432. Weakly affects the RAD9A interaction after MMS exposure. No effect on the RAD9A interaction after MMS exposure; when associated with K-1432. Resists to DNA damage after MMS exposure; when associated with K-1432. 1 Publication1
Mutagenesisi1432E → K: Abolishes RB1 binding; when associated with G-1430. Expression detected after methyl methane-sulfonate (MMS) treatment; when associated with G-1430. No effect on the RAD9A interaction after MMS exposure; when associated with G-1430. Resists to DNA damage after MMS exposure; when associated with G-1430. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
79915

Open Targets

More...
OpenTargetsi
ENSG00000176208

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162377100

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1741209

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ATAD5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296439460

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003176181 – 1844ATPase family AAA domain-containing protein 5Add BLAST1844

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei44PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki127Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei219PhosphoserineCombined sources1
Modified residuei306PhosphoserineCombined sources1
Modified residuei311PhosphoserineCombined sources1
Modified residuei354PhosphoserineBy similarity1
Modified residuei369PhosphoserineCombined sources1
Modified residuei602PhosphoserineCombined sources1
Modified residuei614PhosphoserineCombined sources1
Modified residuei621PhosphoserineCombined sources1
Modified residuei817PhosphoserineCombined sources1
Modified residuei1116PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

ATR may stimulate the RAD9A dissociation.

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96QE3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96QE3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96QE3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96QE3

PeptideAtlas

More...
PeptideAtlasi
Q96QE3

PRoteomics IDEntifications database

More...
PRIDEi
Q96QE3

ProteomicsDB human proteome resource

More...
ProteomicsDBi
77862
77863 [Q96QE3-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96QE3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96QE3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000176208 Expressed in 108 organ(s), highest expression level in buccal mucosa cell

CleanEx database of gene expression profiles

More...
CleanExi
HS_ATAD5

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96QE3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96QE3 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RB1 predominantly in G1 phase via its LXCXE motif. Interacts with RAD9A in growing cells. The interaction with RAD9A is reduced after exposure to DNA replication-inhibiting agents. Interacts with BRD4.2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122994, 27 interactors

Database of interacting proteins

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DIPi
DIP-62118N

Protein interaction database and analysis system

More...
IntActi
Q96QE3, 9 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000313171

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q96QE3

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1428 – 1432LXCXE motif5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1589 – 1599Poly-SerAdd BLAST11

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1968 Eukaryota
ENOG410YF58 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153469

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000034121

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG101177

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96QE3

Identification of Orthologs from Complete Genome Data

More...
OMAi
WSNPEFS

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96QE3

TreeFam database of animal gene trees

More...
TreeFami
TF329112

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00004 AAA, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96QE3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVGVLAMAAA AAPPPVKDCE IEPCKKRKKD DDTSTCKTIT KYLSPLGKTR
60 70 80 90 100
DRVFAPPKPS NILDYFRKTS PTNEKTQLGK ECKIKSPESV PVDSNKDCTT
110 120 130 140 150
PLEMFSNVEF KKKRKRVNLS HQLNNIKTEN EAPIEISSDD SKEDYSLNND
160 170 180 190 200
FVESSTSVLR YKKQVEVLAE NIQDTKSQPN TMTSLQNSKK VNPKQGTTKN
210 220 230 240 250
DFKKLRKRKC RDVVDLSESL PLAEELNLLK KDGKDTKQME NTTSHANSRD
260 270 280 290 300
NVTEAAQLND SIITVSYEEF LKSHKENKVE EIPDSTMSIC VPSETVDEIV
310 320 330 340 350
KSGYISESEN SEISQQVRFK TVTVLAQVHP IPPKKTGKIP RIFLKQKQFE
360 370 380 390 400
MENSLSDPEN EQTVQKRKSN VVIQEEELEL AVLEAGSSEA VKPKCTLEER
410 420 430 440 450
QQFMKAFRQP ASDALKNGVK KSSDKQKDLN EKCLYEVGRD DNSKKIMENS
460 470 480 490 500
GIQMVSKNGN LQLHTDKGSF LKEKNKKLKK KNKKTLDTGA IPGKNREGNT
510 520 530 540 550
QKKETTFFLK EKQYQNRMSL RQRKTEFFKS STLFNNESLV YEDIANDDLL
560 570 580 590 600
KVSSLCNNNK LSRKTSIPVK DIKLTQSKAE SEASLLNVST PKSTRRSGRI
610 620 630 640 650
SSTPTTETIR GIDSDDVQDN SQLKASTQKA ANLSEKHSLY TAELITVPFD
660 670 680 690 700
SESPIRMKFT RISTPKKSKK KSNKRSEKSE ATDGGFTSQI RKASNTSKNI
710 720 730 740 750
SKAKQLIEKA KALHISRSKV TEEIAIPLRR SSRHQTLPER KKLSETEDSV
760 770 780 790 800
IIIDSSPTAL KHPEKNQKKL QCLNDVLGKK LNTSTKNVPG KMKVAPLFLV
810 820 830 840 850
RKAQKAADPV PSFDESSQDT SEKSQDCDVQ CKAKRDFLMS GLPDLLKRQI
860 870 880 890 900
AKKAAALDVY NAVSTSFQRV VHVQQKDDGC CLWHLKPPSC PLLTKFKELN
910 920 930 940 950
TKVIDLSKCG IALGEFSTLN SKLKSGNSAA VFMRTRKEFT EEVRNLLLEE
960 970 980 990 1000
IRWSNPEFSL KKYFPLLLKK QIEHQVLSSE CHSKQELEAD VSHKETKRKL
1010 1020 1030 1040 1050
VEAENSKSKR KKPNEYSKNL EKTNRKSEEL SKRNNSSGIK LDSSKDSGTE
1060 1070 1080 1090 1100
DMLWTEKYQP QTASELIGNE LAIKKLHSWL KDWKRRAELE ERQNLKGKRD
1110 1120 1130 1140 1150
EKHEDFSGGI DFKGSSDDEE ESRLCNTVLI TGPTGVGKTA AVYACAQELG
1160 1170 1180 1190 1200
FKIFEVNASS QRSGRQILSQ LKEATQSHQV DKQGVNSQKP CFFNSYYIGK
1210 1220 1230 1240 1250
SPKKISSPKK VVTSPRKVPP PSPKSSGPKR ALPPKTLANY FKVSPKPKNN
1260 1270 1280 1290 1300
EEIGMLLENN KGIKNSFEQK QITQTKSTNA TNSNVKDVGA EEPSRKNATS
1310 1320 1330 1340 1350
LILFEEVDVI FDEDAGFLNA IKTFMATTKR PVILTTSDPT FSLMFDGCFE
1360 1370 1380 1390 1400
EIKFSTPSLL NVASYLQMIC LTENFRTDVK DFVTLLTANT CDIRKSILYL
1410 1420 1430 1440 1450
QFWIRSGGGV LEERPLTLYR GNSRNVQLVC SEHGLDNKIY PKNTKKKRVD
1460 1470 1480 1490 1500
LPKCDSGCAE TLFGLKNIFS PSEDLFSFLK HKITMKEEWH KFIQLLTEFQ
1510 1520 1530 1540 1550
MRNVDFLYSN LEFILPLPVD TIPETKNFCG PSVTVDASAA TKSMNCLARK
1560 1570 1580 1590 1600
HSEREQPLKK SQKKKQKKTL VILDDSDLFD TDLDFPDQSI SLSSVSSSSN
1610 1620 1630 1640 1650
AEESKTGDEE SKARDKGNNP ETKKSIPCPP KTTAGKKCSA LVSHCLNSLS
1660 1670 1680 1690 1700
EFMDNMSFLD ALLTDVREQN KYGRNDFSWT NGKVTSGLCD EFSLESNDGW
1710 1720 1730 1740 1750
TSQSSGELKA AAEALSFTKC SSAISKALET LNSCKKLGRD PTNDLTFYVS
1760 1770 1780 1790 1800
QKRNNVYFSQ SAANLDNAWK RISVIKSVFS SRSLLYVGNR QASIIEYLPT
1810 1820 1830 1840
LRNICKTEKL KEQGKSKRRF LHYFEGIHLD IPKETVNTLA ADFP
Length:1,844
Mass (Da):207,570
Last modified:May 18, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA09A3C76CFC77BD1
GO
Isoform 2 (identifier: Q96QE3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1205-1844: Missing.

Note: No experimental confirmation available.
Show »
Length:1,204
Mass (Da):135,878
Checksum:iC3AA49F312542EED
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A075B754A0A075B754_HUMAN
ATPase family AAA domain-containing...
ATAD5
1,224Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH15051 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAB14248 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti95N → D in CAH10412 (PubMed:17974005).Curated1
Sequence conflicti465T → A in CAH10412 (PubMed:17974005).Curated1
Sequence conflicti475N → D in BAB14248 (PubMed:14702039).Curated1
Sequence conflicti612I → T in CAH10412 (PubMed:17974005).Curated1
Sequence conflicti1203K → S in BAB14248 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03857235T → S. Corresponds to variant dbSNP:rs9910051Ensembl.1
Natural variantiVAR_03857387P → S. Corresponds to variant dbSNP:rs3816780Ensembl.1
Natural variantiVAR_038574135E → G1 PublicationCorresponds to variant dbSNP:rs11080134Ensembl.1
Natural variantiVAR_079496215D → N1 PublicationCorresponds to variant dbSNP:rs367699401Ensembl.1
Natural variantiVAR_038575249R → K. Corresponds to variant dbSNP:rs17826219Ensembl.1
Natural variantiVAR_038576699N → H. Corresponds to variant dbSNP:rs3764421Ensembl.1
Natural variantiVAR_0385771419Y → H. Corresponds to variant dbSNP:rs11657270Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0310971205 – 1844Missing in isoform 2. 1 PublicationAdd BLAST640

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AJ314648 mRNA Translation: CAC44537.2
AY557611 mRNA Translation: AAT52049.1
AL832103 mRNA Translation: CAH10412.1
BC015051 mRNA Translation: AAH15051.1 Sequence problems.
AK022797 mRNA Translation: BAB14248.1 Different initiation.
AC127024 Genomic DNA No translation available.
AC130324 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS11260.1 [Q96QE3-1]

NCBI Reference Sequences

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RefSeqi
NP_079133.3, NM_024857.4 [Q96QE3-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.528902

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000321990; ENSP00000313171; ENSG00000176208 [Q96QE3-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
79915

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:79915

UCSC genome browser

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UCSCi
uc002hfs.2 human [Q96QE3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ314648 mRNA Translation: CAC44537.2
AY557611 mRNA Translation: AAT52049.1
AL832103 mRNA Translation: CAH10412.1
BC015051 mRNA Translation: AAH15051.1 Sequence problems.
AK022797 mRNA Translation: BAB14248.1 Different initiation.
AC127024 Genomic DNA No translation available.
AC130324 Genomic DNA No translation available.
CCDSiCCDS11260.1 [Q96QE3-1]
RefSeqiNP_079133.3, NM_024857.4 [Q96QE3-1]
UniGeneiHs.528902

3D structure databases

ProteinModelPortaliQ96QE3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122994, 27 interactors
DIPiDIP-62118N
IntActiQ96QE3, 9 interactors
STRINGi9606.ENSP00000313171

Chemistry databases

ChEMBLiCHEMBL1741209

PTM databases

iPTMnetiQ96QE3
PhosphoSitePlusiQ96QE3

Polymorphism and mutation databases

BioMutaiATAD5
DMDMi296439460

Proteomic databases

EPDiQ96QE3
jPOSTiQ96QE3
MaxQBiQ96QE3
PaxDbiQ96QE3
PeptideAtlasiQ96QE3
PRIDEiQ96QE3
ProteomicsDBi77862
77863 [Q96QE3-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
79915
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321990; ENSP00000313171; ENSG00000176208 [Q96QE3-1]
GeneIDi79915
KEGGihsa:79915
UCSCiuc002hfs.2 human [Q96QE3-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
79915
DisGeNETi79915
EuPathDBiHostDB:ENSG00000176208.8

GeneCards: human genes, protein and diseases

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GeneCardsi
ATAD5
HGNCiHGNC:25752 ATAD5
MIMi609534 gene
neXtProtiNX_Q96QE3
OpenTargetsiENSG00000176208
PharmGKBiPA162377100

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1968 Eukaryota
ENOG410YF58 LUCA
GeneTreeiENSGT00940000153469
HOGENOMiHOG000034121
HOVERGENiHBG101177
InParanoidiQ96QE3
OMAiWSNPEFS
PhylomeDBiQ96QE3
TreeFamiTF329112

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ATAD5 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
79915

Protein Ontology

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PROi
PR:Q96QE3

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000176208 Expressed in 108 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_ATAD5
ExpressionAtlasiQ96QE3 baseline and differential
GenevisibleiQ96QE3 HS

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00004 AAA, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATAD5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96QE3
Secondary accession number(s): Q05DH0, Q69YR6, Q9H9I1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 18, 2010
Last modified: January 16, 2019
This is version 141 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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