UniProtKB - Q96QD9 (UIF_HUMAN)
Protein
UAP56-interacting factor
Gene
FYTTD1
Organism
Homo sapiens (Human)
Status
Functioni
Required for mRNA export from the nucleus to the cytoplasm. Acts as an adapter that uses the DDX39B/UAP56-NFX1 pathway to ensure efficient mRNA export and delivering to the nuclear pore. Associates with spliced and unspliced mRNAs simultaneously with ALYREF/THOC4.1 Publication
GO - Molecular functioni
- mRNA binding Source: UniProtKB
- RNA binding Source: UniProtKB
GO - Biological processi
- mRNA export from nucleus Source: UniProtKB
Keywordsi
Molecular function | RNA-binding |
Biological process | mRNA transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q96QD9 |
Reactomei | R-HSA-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-72187, mRNA 3'-end processing R-HSA-73856, RNA Polymerase II Transcription Termination |
Names & Taxonomyi
Protein namesi | Recommended name: UAP56-interacting factorAlternative name(s): Forty-two-three domain-containing protein 1 Short name: Protein 40-2-3 |
Gene namesi | Name:FYTTD1 Synonyms:UIF |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25407, FYTTD1 |
MIMi | 616933, gene |
neXtProti | NX_Q96QD9 |
VEuPathDBi | HostDB:ENSG00000122068.12 |
Subcellular locationi
Nucleus
- nucleoplasm 1 Publication
- Nucleus speckle 1 Publication
Nucleus
- nuclear speck Source: UniProtKB
- nucleoplasm Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 84248 |
OpenTargetsi | ENSG00000122068 |
PharmGKBi | PA134946373 |
Miscellaneous databases
Pharosi | Q96QD9, Tbio |
Genetic variation databases
BioMutai | FYTTD1 |
DMDMi | 284018159 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000287441 | 1 – 318 | UAP56-interacting factorAdd BLAST | 318 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 14 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 16 | PhosphoserineCombined sources | 1 | |
Modified residuei | 23 | PhosphoserineCombined sources | 1 | |
Modified residuei | 61 | PhosphoserineCombined sources | 1 | |
Modified residuei | 118 | PhosphoserineCombined sources | 1 | |
Cross-linki | 140 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) | ||
Cross-linki | 261 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q96QD9 |
jPOSTi | Q96QD9 |
MassIVEi | Q96QD9 |
MaxQBi | Q96QD9 |
PaxDbi | Q96QD9 |
PeptideAtlasi | Q96QD9 |
PRIDEi | Q96QD9 |
ProteomicsDBi | 77857 [Q96QD9-1] 77858 [Q96QD9-2] 77859 [Q96QD9-3] 77860 [Q96QD9-4] |
TopDownProteomicsi | Q96QD9-1 [Q96QD9-1] |
PTM databases
iPTMneti | Q96QD9 |
PhosphoSitePlusi | Q96QD9 |
Expressioni
Tissue specificityi
Expressed in a wide variety of cancer types.1 Publication
Gene expression databases
Bgeei | ENSG00000122068, Expressed in quadriceps femoris and 217 other tissues |
ExpressionAtlasi | Q96QD9, baseline and differential |
Genevisiblei | Q96QD9, HS |
Organism-specific databases
HPAi | ENSG00000122068, Tissue enhanced (skeletal) |
Interactioni
Subunit structurei
Interacts with CHTOP (By similarity).
Interacts with DDX39B/UAP56 and NXF1; interaction with DDX39B/UAP56 and NXF1 are mutually exclusive.
Interacts with SSRP1; required for its recruitment to mRNAs.
By similarity1 PublicationBinary interactionsi
Hide detailsQ96QD9
With | #Exp. | IntAct |
---|---|---|
DDX39B [Q13838] | 3 | EBI-724553,EBI-348622 |
ORF57 [Q2HR75] from Human herpesvirus 8 type P (isolate GK18). | 9 | EBI-724553,EBI-6884751 |
Protein-protein interaction databases
BioGRIDi | 123976, 109 interactors |
DIPi | DIP-62119N |
IntActi | Q96QD9, 56 interactors |
MINTi | Q96QD9 |
STRINGi | 9606.ENSP00000241502 |
Miscellaneous databases
RNActi | Q96QD9, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 26 – 44 | UAP56-binding motifAdd BLAST | 19 |
Sequence similaritiesi
Belongs to the UIF family.Curated
Phylogenomic databases
eggNOGi | ENOG502QWD4, Eukaryota |
GeneTreei | ENSGT00390000012807 |
HOGENOMi | CLU_1948055_0_0_1 |
InParanoidi | Q96QD9 |
OMAi | YRKPEVQ |
PhylomeDBi | Q96QD9 |
TreeFami | TF336232 |
Family and domain databases
InterProi | View protein in InterPro IPR009782, FYTTD1 |
PANTHERi | PTHR21038, PTHR21038, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q96QD9-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNRFGTRLVG ATATSSPPPK ARSNENLDKI DMSLDDIIKL NRKEGKKQNF
60 70 80 90 100
PRLNRRLLQQ SGAQQFRMRV RWGIQQNSGF GKTSLNRRGR VMPGKRRPNG
110 120 130 140 150
VITGLAARKT TGIRKGISPM NRPPLSDKNI EQYFPVLKRK ANLLRQNEGQ
160 170 180 190 200
RKPVAVLKRP SQLSRKNNIP ANFTRSGNKL NHQKDTRQAT FLFRRGLKVQ
210 220 230 240 250
AQLNTEQLLD DVVAKRTRQW RTSTTNGGIL TVSIDNPGAV QCPVTQKPRL
260 270 280 290 300
TRTAVPSFLT KREQSDVKKV PKGVPLQFDI NSVGKQTGMT LNERFGILKE
310
QRATLTYNKG GSRFVTVG
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH9KVD1 | H9KVD1_HUMAN | Forty-two-three domain-containing p... | FYTTD1 | 121 | Annotation score: | ||
H9KVC1 | H9KVC1_HUMAN | Forty-two-three domain-containing p... | FYTTD1 | 71 | Annotation score: | ||
H9KVC6 | H9KVC6_HUMAN | Forty-two-three domain-containing p... | FYTTD1 | 176 | Annotation score: | ||
H9KVD5 | H9KVD5_HUMAN | Forty-two-three domain-containing p... | FYTTD1 | 126 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 178 | N → S in BAH14679 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 263 | E → G in BAB55284 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_062411 | 87 | R → H4 PublicationsCorresponds to variant dbSNP:rs3205525Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_038658 | 1 – 67 | Missing in isoform 3. 1 PublicationAdd BLAST | 67 | |
Alternative sequenceiVSP_038659 | 1 – 35 | MNRFG…DMSLD → MEPSVIMGN in isoform 2. 1 PublicationAdd BLAST | 35 | |
Alternative sequenceiVSP_038660 | 129 | N → K in isoform 4. 1 Publication | 1 | |
Alternative sequenceiVSP_038661 | 130 – 318 | Missing in isoform 4. 1 PublicationAdd BLAST | 189 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ344094 mRNA Translation: CAC51432.1 AL136558 mRNA Translation: CAB66493.1 AK027672 mRNA Translation: BAB55284.1 AK296283 mRNA Translation: BAH12300.1 AK302546 mRNA Translation: BAH13737.1 AK303462 mRNA Translation: BAH13966.1 AK315019 mRNA Translation: BAG37509.1 AK316308 mRNA Translation: BAH14679.1 CR533502 mRNA Translation: CAG38533.1 AC024560 Genomic DNA No translation available. AC055764 Genomic DNA No translation available. CH471252 Genomic DNA Translation: EAW92240.1 BC035006 mRNA Translation: AAH35006.1 BC039734 mRNA Translation: AAH39734.1 |
CCDSi | CCDS3329.1 [Q96QD9-1] CCDS43196.2 [Q96QD9-2] |
RefSeqi | NP_001011537.2, NM_001011537.2 [Q96QD9-2] NP_115664.2, NM_032288.6 [Q96QD9-1] |
Genome annotation databases
Ensembli | ENST00000241502; ENSP00000241502; ENSG00000122068 [Q96QD9-1] ENST00000415708; ENSP00000393746; ENSG00000122068 [Q96QD9-2] ENST00000418169; ENSP00000400191; ENSG00000122068 [Q96QD9-4] ENST00000424384; ENSP00000394631; ENSG00000122068 [Q96QD9-3] |
GeneIDi | 84248 |
KEGGi | hsa:84248 |
UCSCi | uc003fyi.3, human [Q96QD9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ344094 mRNA Translation: CAC51432.1 AL136558 mRNA Translation: CAB66493.1 AK027672 mRNA Translation: BAB55284.1 AK296283 mRNA Translation: BAH12300.1 AK302546 mRNA Translation: BAH13737.1 AK303462 mRNA Translation: BAH13966.1 AK315019 mRNA Translation: BAG37509.1 AK316308 mRNA Translation: BAH14679.1 CR533502 mRNA Translation: CAG38533.1 AC024560 Genomic DNA No translation available. AC055764 Genomic DNA No translation available. CH471252 Genomic DNA Translation: EAW92240.1 BC035006 mRNA Translation: AAH35006.1 BC039734 mRNA Translation: AAH39734.1 |
CCDSi | CCDS3329.1 [Q96QD9-1] CCDS43196.2 [Q96QD9-2] |
RefSeqi | NP_001011537.2, NM_001011537.2 [Q96QD9-2] NP_115664.2, NM_032288.6 [Q96QD9-1] |
3D structure databases
SMRi | Q96QD9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 123976, 109 interactors |
DIPi | DIP-62119N |
IntActi | Q96QD9, 56 interactors |
MINTi | Q96QD9 |
STRINGi | 9606.ENSP00000241502 |
PTM databases
iPTMneti | Q96QD9 |
PhosphoSitePlusi | Q96QD9 |
Genetic variation databases
BioMutai | FYTTD1 |
DMDMi | 284018159 |
Proteomic databases
EPDi | Q96QD9 |
jPOSTi | Q96QD9 |
MassIVEi | Q96QD9 |
MaxQBi | Q96QD9 |
PaxDbi | Q96QD9 |
PeptideAtlasi | Q96QD9 |
PRIDEi | Q96QD9 |
ProteomicsDBi | 77857 [Q96QD9-1] 77858 [Q96QD9-2] 77859 [Q96QD9-3] 77860 [Q96QD9-4] |
TopDownProteomicsi | Q96QD9-1 [Q96QD9-1] |
Protocols and materials databases
Antibodypediai | 54015, 133 antibodies |
DNASUi | 84248 |
Genome annotation databases
Ensembli | ENST00000241502; ENSP00000241502; ENSG00000122068 [Q96QD9-1] ENST00000415708; ENSP00000393746; ENSG00000122068 [Q96QD9-2] ENST00000418169; ENSP00000400191; ENSG00000122068 [Q96QD9-4] ENST00000424384; ENSP00000394631; ENSG00000122068 [Q96QD9-3] |
GeneIDi | 84248 |
KEGGi | hsa:84248 |
UCSCi | uc003fyi.3, human [Q96QD9-1] |
Organism-specific databases
CTDi | 84248 |
DisGeNETi | 84248 |
GeneCardsi | FYTTD1 |
HGNCi | HGNC:25407, FYTTD1 |
HPAi | ENSG00000122068, Tissue enhanced (skeletal) |
MIMi | 616933, gene |
neXtProti | NX_Q96QD9 |
OpenTargetsi | ENSG00000122068 |
PharmGKBi | PA134946373 |
VEuPathDBi | HostDB:ENSG00000122068.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QWD4, Eukaryota |
GeneTreei | ENSGT00390000012807 |
HOGENOMi | CLU_1948055_0_0_1 |
InParanoidi | Q96QD9 |
OMAi | YRKPEVQ |
PhylomeDBi | Q96QD9 |
TreeFami | TF336232 |
Enzyme and pathway databases
PathwayCommonsi | Q96QD9 |
Reactomei | R-HSA-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-72187, mRNA 3'-end processing R-HSA-73856, RNA Polymerase II Transcription Termination |
Miscellaneous databases
BioGRID-ORCSi | 84248, 4 hits in 993 CRISPR screens |
ChiTaRSi | FYTTD1, human |
GenomeRNAii | 84248 |
Pharosi | Q96QD9, Tbio |
PROi | PR:Q96QD9 |
RNActi | Q96QD9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000122068, Expressed in quadriceps femoris and 217 other tissues |
ExpressionAtlasi | Q96QD9, baseline and differential |
Genevisiblei | Q96QD9, HS |
Family and domain databases
InterProi | View protein in InterPro IPR009782, FYTTD1 |
PANTHERi | PTHR21038, PTHR21038, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UIF_HUMAN | |
Accessioni | Q96QD9Primary (citable) accession number: Q96QD9 Secondary accession number(s): A8MY74 Q9BQI8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 15, 2007 |
Last sequence update: | January 19, 2010 | |
Last modified: | April 7, 2021 | |
This is version 136 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families