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Entry version 158 (13 Feb 2019)
Sequence version 1 (01 Dec 2001)
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Protein

Serine/threonine-protein phosphatase 1 regulatory subunit 10

Gene

PPP1R10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri906 – 934C3H1-typePROSITE-ProRule annotationAdd BLAST29

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Protein phosphatase inhibitor, RNA-binding
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 1 regulatory subunit 10
Alternative name(s):
MHC class I region proline-rich protein CAT53
PP1-binding protein of 114 kDa
Phosphatase 1 nuclear targeting subunit
Protein FB19
p99
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPP1R10
Synonyms:CAT53, FB19, PNUTS
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000204569.9

Human Gene Nomenclature Database

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HGNCi
HGNC:9284 PPP1R10

Online Mendelian Inheritance in Man (OMIM)

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MIMi
603771 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96QC0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
5514

Open Targets

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OpenTargetsi
ENSG00000204569

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33612

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PPP1R10

Domain mapping of disease mutations (DMDM)

More...
DMDMi
61214507

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000715101 – 940Serine/threonine-protein phosphatase 1 regulatory subunit 10Add BLAST940

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki179Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei256PhosphothreonineCombined sources1
Cross-linki262Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei313PhosphoserineCombined sources1
Modified residuei382PhosphoserineCombined sources1
Modified residuei398PhosphoserineCombined sources1
Modified residuei545PhosphoserineCombined sources1
Modified residuei591PhosphoserineCombined sources1
Modified residuei665Omega-N-methylarginineCombined sources1
Modified residuei693Omega-N-methylarginineCombined sources1
Modified residuei738Omega-N-methylarginineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on Ser-398 by PKA within the region necessary for interaction with PPP1CA.By similarity

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q96QC0

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96QC0

MaxQB - The MaxQuant DataBase

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MaxQBi
Q96QC0

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96QC0

PeptideAtlas

More...
PeptideAtlasi
Q96QC0

PRoteomics IDEntifications database

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PRIDEi
Q96QC0

ProteomicsDB human proteome resource

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ProteomicsDBi
77851

Consortium for Top Down Proteomics

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TopDownProteomicsi
Q96QC0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q96QC0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q96QC0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000204569 Expressed in 214 organ(s), highest expression level in lung

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96QC0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96QC0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB025501
HPA047248
HPA056756

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1CC. Interacts with PPP1CA, WDR82 and TOX4 (By similarity).By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
PPP1CAP621363EBI-1210346,EBI-357253

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
111506, 50 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q96QC0

Database of interacting proteins

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DIPi
DIP-39343N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q96QC0

Protein interaction database and analysis system

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IntActi
Q96QC0, 22 interactors

Molecular INTeraction database

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MINTi
Q96QC0

STRING: functional protein association networks

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STRINGi
9606.ENSP00000365694

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q96QC0

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini73 – 147TFIIS N-terminalPROSITE-ProRule annotationAdd BLAST75

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 348Interaction with TOX4By similarityAdd BLAST348
Regioni382 – 450Essential for PPP1CA inhibitionBy similarityAdd BLAST69
Regioni388 – 417Necessary for interaction with PPP1CABy similarityAdd BLAST30
Regioni393 – 408Necessary for interaction with PPP1CC1 PublicationAdd BLAST16
Regioni418 – 619Interaction with WDR82By similarityAdd BLAST202

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi420 – 423PP1-binding motif4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi304 – 310Poly-Lys7
Compositional biasi540 – 904Gly-richAdd BLAST365

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri906 – 934C3H1-typePROSITE-ProRule annotationAdd BLAST29

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IGTC Eukaryota
ENOG410XP4M LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000159263

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000049285

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG053646

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96QC0

KEGG Orthology (KO)

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KOi
K17552

Identification of Orthologs from Complete Genome Data

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OMAi
MMNGPPN

Database of Orthologous Groups

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OrthoDBi
999354at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q96QC0

TreeFam database of animal gene trees

More...
TreeFami
TF105541

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.930.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003617 TFIIS/CRSP70_N_sub
IPR035441 TFIIS/LEDGF_dom_sf
IPR017923 TFIIS_N
IPR000571 Znf_CCCH
IPR036855 Znf_CCCH_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08711 Med26, 1 hit
PF00642 zf-CCCH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00509 TFS2N, 1 hit
SM00356 ZnF_C3H1, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47676 SSF47676, 1 hit
SSF90229 SSF90229, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51319 TFIIS_N, 1 hit
PS50103 ZF_C3H1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q96QC0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSGPIDPKE LLKGLDSFLN RDGEVKSVDG ISKIFSLMKE ARKMVSRCTY
60 70 80 90 100
LNILLQTRSP EILVKFIDVG GYKLLNNWLT YSKTTNNIPL LQQILLTLQH
110 120 130 140 150
LPLTVDHLKQ NNTAKLVKQL SKSSEDEELR KLASVLVSDW MAVIRSQSST
160 170 180 190 200
QPAEKDKKKR KDEGKSRTTL PERPLTEVKA ETRAEEAPEK KREKPKSLRT
210 220 230 240 250
TAPSHAKFRS TGLELETPSL VPVKKNASTV VVSDKYNLKP IPLKRQSNVA
260 270 280 290 300
APGDATPPAE KKYKPLNTTP NATKEIKVKI IPPQPMEGLG FLDALNSAPV
310 320 330 340 350
PGIKIKKKKK VLSPTAAKPS PFEGKTSTEP STAKPSSPEP APPSEAMDAD
360 370 380 390 400
RPGTPVPPVE VPELMDTASL EPGALDAKPV ESPGDPNQLT RKGRKRKSVT
410 420 430 440 450
WPEEGKLREY FYFELDETER VNVNKIKDFG EAAKREILSD RHAFETARRL
460 470 480 490 500
SHDNMEEKVP WVCPRPLVLP SPLVTPGSNS QERYIQAERE KGILQELFLN
510 520 530 540 550
KESPHEPDPE PYEPIPPKLI PLDEECSMDE TPYVETLEPG GSGGSPDGAG
560 570 580 590 600
GSKLPPVLAN LMGSMGAGKG PQGPGGGGIN VQEILTSIMG SPNSHPSEEL
610 620 630 640 650
LKQPDYSDKI KQMLVPHGLL GPGPIANGFP PGGPGGPKGM QHFPPGPGGP
660 670 680 690 700
MPGPHGGPGG PVGPRLLGPP PPPRGGDPFW DGPGDPMRGG PMRGGPGPGP
710 720 730 740 750
GPYHRGRGGR GGNEPPPPPP PFRGARGGRS GGGPPNGRGG PGGGMVGGGG
760 770 780 790 800
HRPHEGPGGG MGNSSGHRPH EGPGGGMGSG HRPHEGPGGS MGGGGGHRPH
810 820 830 840 850
EGPGGGISGG SGHRPHEGPG GGMGAGGGHR PHEGPGGSMG GSGGHRPHEG
860 870 880 890 900
PGHGGPHGHR PHDVPGHRGH DHRGPPPHEH RGHDGPGHGG GGHRGHDGGH
910 920 930 940
SHGGDMSNRP VCRHFMMKGN CRYENNCAFY HPGVNGPPLP
Length:940
Mass (Da):99,058
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i49EE42961D734121
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti225K → E in CAA73697 (PubMed:9784381).Curated1
Sequence conflicti861P → L in CAA73697 (PubMed:9784381).Curated1
Sequence conflicti875P → Q in CAA73697 (PubMed:9784381).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051747173R → P. Corresponds to variant dbSNP:rs16897725Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
Y13247 mRNA Translation: CAA73697.1
AJ544537 mRNA Translation: CAD67521.1
BA000025 Genomic DNA Translation: BAB63324.1
AB088097 Genomic DNA Translation: BAC54929.1
AL662800 Genomic DNA No translation available.
AL662825 Genomic DNA No translation available.
BX248507 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS4681.1

Protein sequence database of the Protein Information Resource

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PIRi
JE0291

NCBI Reference Sequences

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RefSeqi
NP_002705.2, NM_002714.3
XP_006715193.1, XM_006715130.2
XP_011513024.1, XM_011514722.1
XP_016866484.1, XM_017010995.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.106019

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000376511; ENSP00000365694; ENSG00000204569
ENST00000383586; ENSP00000373080; ENSG00000206489
ENST00000420949; ENSP00000413554; ENSG00000230995
ENST00000424446; ENSP00000407181; ENSG00000231737
ENST00000426299; ENSP00000389299; ENSG00000235291
ENST00000429597; ENSP00000407310; ENSG00000238104
ENST00000449113; ENSP00000416060; ENSG00000227804

Database of genes from NCBI RefSeq genomes

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GeneIDi
5514

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:5514

UCSC genome browser

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UCSCi
uc003nqn.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13247 mRNA Translation: CAA73697.1
AJ544537 mRNA Translation: CAD67521.1
BA000025 Genomic DNA Translation: BAB63324.1
AB088097 Genomic DNA Translation: BAC54929.1
AL662800 Genomic DNA No translation available.
AL662825 Genomic DNA No translation available.
BX248507 Genomic DNA No translation available.
CCDSiCCDS4681.1
PIRiJE0291
RefSeqiNP_002705.2, NM_002714.3
XP_006715193.1, XM_006715130.2
XP_011513024.1, XM_011514722.1
XP_016866484.1, XM_017010995.1
UniGeneiHs.106019

3D structure databases

ProteinModelPortaliQ96QC0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111506, 50 interactors
CORUMiQ96QC0
DIPiDIP-39343N
ELMiQ96QC0
IntActiQ96QC0, 22 interactors
MINTiQ96QC0
STRINGi9606.ENSP00000365694

PTM databases

iPTMnetiQ96QC0
PhosphoSitePlusiQ96QC0

Polymorphism and mutation databases

BioMutaiPPP1R10
DMDMi61214507

Proteomic databases

EPDiQ96QC0
jPOSTiQ96QC0
MaxQBiQ96QC0
PaxDbiQ96QC0
PeptideAtlasiQ96QC0
PRIDEiQ96QC0
ProteomicsDBi77851
TopDownProteomicsiQ96QC0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376511; ENSP00000365694; ENSG00000204569
ENST00000383586; ENSP00000373080; ENSG00000206489
ENST00000420949; ENSP00000413554; ENSG00000230995
ENST00000424446; ENSP00000407181; ENSG00000231737
ENST00000426299; ENSP00000389299; ENSG00000235291
ENST00000429597; ENSP00000407310; ENSG00000238104
ENST00000449113; ENSP00000416060; ENSG00000227804
GeneIDi5514
KEGGihsa:5514
UCSCiuc003nqn.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5514
DisGeNETi5514
EuPathDBiHostDB:ENSG00000204569.9

GeneCards: human genes, protein and diseases

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GeneCardsi
PPP1R10

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0165052
HIX0166290
HIX0166579
HIX0166833
HIX0167082
HIX0167322
HIX0167569
HGNCiHGNC:9284 PPP1R10
HPAiCAB025501
HPA047248
HPA056756
MIMi603771 gene
neXtProtiNX_Q96QC0
OpenTargetsiENSG00000204569
PharmGKBiPA33612

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IGTC Eukaryota
ENOG410XP4M LUCA
GeneTreeiENSGT00940000159263
HOGENOMiHOG000049285
HOVERGENiHBG053646
InParanoidiQ96QC0
KOiK17552
OMAiMMNGPPN
OrthoDBi999354at2759
PhylomeDBiQ96QC0
TreeFamiTF105541

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PPP1R10 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PPP1R10

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5514

Protein Ontology

More...
PROi
PR:Q96QC0

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000204569 Expressed in 214 organ(s), highest expression level in lung
ExpressionAtlasiQ96QC0 baseline and differential
GenevisibleiQ96QC0 HS

Family and domain databases

Gene3Di1.20.930.10, 1 hit
InterProiView protein in InterPro
IPR003617 TFIIS/CRSP70_N_sub
IPR035441 TFIIS/LEDGF_dom_sf
IPR017923 TFIIS_N
IPR000571 Znf_CCCH
IPR036855 Znf_CCCH_sf
PfamiView protein in Pfam
PF08711 Med26, 1 hit
PF00642 zf-CCCH, 1 hit
SMARTiView protein in SMART
SM00509 TFS2N, 1 hit
SM00356 ZnF_C3H1, 1 hit
SUPFAMiSSF47676 SSF47676, 1 hit
SSF90229 SSF90229, 1 hit
PROSITEiView protein in PROSITE
PS51319 TFIIS_N, 1 hit
PS50103 ZF_C3H1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPP1RA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96QC0
Secondary accession number(s): O00405
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: December 1, 2001
Last modified: February 13, 2019
This is version 158 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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